Browsing by Subject "195 COUNTRIES"

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  • Andersen, Petter I.; Ianevski, Aleksandr; Lysvand, Hilde; Oksenych, Valentyn; Bjørås, Magnar; Telling, Kaidi; Lutsar, Irja; Dampis, Uga; Irie, Yasuhiko; Tenson, Tanel; Kantele, Anu; Kainov, Denis (2020)
    Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
  • James, Spencer L.; Castle, Chris D.; Dingels, Zachary; Fox, Jack T.; Hamilton, Erin B.; Liu, Zichen; Roberts, Nicholas L. S.; Sylte, Dillon O.; Bertolacci, Gregory J.; Cunningham, Matthew; Henry, Nathaniel J.; LeGrand, Kate E.; Abdelalim, Ahmed; Abdollahpour, Ibrahim; Abdulkader, Rizwan Suliankatchi; Abedi, Aidin; Abegaz, Kedir Hussein; Abosetugn, Akine Eshete; Abushouk, Abdelrahman; Adebayo, Oladimeji M.; Adsuar, Jose C.; Advani, Shailesh M.; Agudelo-Botero, Marcela; Ahmad, Tauseef; Ahmed, Muktar Beshir; Ahmed, Rushdia; Aichour, Miloud Taki Eddine; Alahdab, Fares; Alanezi, Fahad Mashhour; Alema, Niguse Meles; Alemu, Biresaw Wassihun; Alghnam, Suliman A.; Ali, Beriwan Abdulqadir; Ali, Saqib; Alinia, Cyrus; Alipour, Vahid; Aljunid, Syed Mohamed; Almasi-Hashiani, Amir; Almasri, Nihad A.; Altirkawi, Khalid; Amer, Yasser Sami Abdeldayem; Andrei, Catalina Liliana; Ansari-Moghaddam, Alireza; Antonio, Carl Abelardo T.; Anvari, Davood; Appiah, Seth Christopher Yaw; Arabloo, Jalal; Arab-Zozani, Morteza; Arefi, Zohreh; Aremu, Olatunde; Ariani, Filippo; Arora, Amit; Asaad, Malke; Ayala Quintanilla, Beatriz Paulina; Ayano, Getinet; Ayanore, Martin Amogre; Azarian, Ghasem; Badawi, Alaa; Badiye, Ashish D.; Baig, Atif Amin; Bairwa, Mohan; Bakhtiari, Ahad; Balachandran, Arun; Banach, Maciej; Banerjee, Srikanta K.; Banik, Palash Chandra; Banstola, Amrit; Barker-Collo, Suzanne Lyn; Baernighausen, Till Winfried; Barzegar, Akbar; Bayati, Mohsen; Bazargan-Hejazi, Shahrzad; Bedi, Neeraj; Behzadifar, Masoud; Belete, Habte; Bennett, Derrick A.; Bensenor, Isabela M.; Berhe, Kidanemaryam; Bhagavathula, Akshaya Srikanth; Bhardwaj, Pankaj; Bhat, Anusha Ganapati; Bhattacharyya, Krittika; Bhutta, Zulfiqar A.; Bibi, Sadia; Bijani, Ali; Boloor, Archith; Borges, Guilherme; Borschmann, Rohan; Borzi, Antonio Maria; Boufous, Soufiane; Braithwaite, Dejana; Briko, Nikolay Ivanovich; Brugha, Traolach; Budhathoki, Shyam S.; Car, Josip; Cardenas, Rosario; Carvalho, Felix; Castaldelli-Maia, Joao Mauricio; Castaneda-Orjuela, Carlos A.; Castelpietra, Giulio; Catala-Lopez, Ferran; Cerin, Ester; Chandan, Joht S.; Chapman, Jens Robert; Chattu, Vijay Kumar; Chattu, Soosanna Kumary; Chatziralli, Irini; Chaudhary, Neha; Cho, Daniel Youngwhan; Choi, Jee-Young J.; Chowdhury, Mohiuddin Ahsanul Kabir; Christopher, Devasahayam J.; Dinh-Toi Chu,; Cicuttini, Flavia M.; Coelho, Joao M.; Costa, Vera M.; Dahlawi, Saad M. A.; Daryani, Ahmad; Alberto Davila-Cervantes, Claudio; De Leo, Diego; Demeke, Feleke Mekonnen; Demoz, Gebre Teklemariam; Demsie, Desalegn Getnet; Deribe, Kebede; Desai, Rupak; Nasab, Mostafa Dianati; da Silva, Diana Dias; Forooshani, Zahra Sadat Dibaji; Hoa Thi Do,; Doyle, Kerrie E.; Driscoll, Tim Robert; Dubljanin, Eleonora; Adema, Bereket Duko; Eagan, Arielle Wilder; Elemineh, Demelash Abewa; El-Jaafary, Shaimaa; El-Khatib, Ziad; Ellingsen, Christian Lycke; Zaki, Maysaa El Sayed; Eskandarieh, Sharareh; Eyawo, Oghenowede; Faris, Pawan Sirwan; Faro, Andre; Farzadfar, Farshad; Fereshtehnejad, Seyed-Mohammad; Fernandes, Eduarda; Ferrara, Pietro; Fischer, Florian; Folayan, Morenike Oluwatoyin; Fomenkov, Artem Alekseevich; Foroutan, Masoud; Francis, Joel Msafiri; Franklin, Richard Charles; Fukumoto, Takeshi; Geberemariyam, Biniyam Sahiledengle; Gebremariam, Hadush; Gebremedhin, Ketema Bizuwork; Gebremeskel, Leake G.; Gebremeskel, Gebreamlak Gebremedhn; Gebremichael, Berhe; Gedefaw, Getnet Azeze; Geta, Birhanu; Getenet, Agegnehu Bante; Ghafourifard, Mansour; Ghamari, Farhad; Gheshlagh, Reza Ghanei; Gholamian, Asadollah; Gilani, Syed Amir; Gill, Tiffany K.; Goudarzian, Amir Hossein; Goulart, Alessandra C.; Grada, Ayman; Grivna, Michal; Guimaraes, Rafael Alves; Guo, Yuming; Gupta, Gaurav; Haagsma, Juanita A.; Hall, Brian James; Hamadeh, Randah R.; Hamidi, Samer; Handiso, Demelash Woldeyohannes; Haro, Josep Maria; Hasanzadeh, Amir; Hassan, Shoaib; Hassanipour, Soheil; Hassankhani, Hadi; Hassen, Hamid Yimam; Havmoeller, Rasmus; Hendrie, Delia; Heydarpour, Fatemeh; Hijar, Martha; Ho, Hung Chak; Chi Linh Hoang,; Hole, Michael K.; Holla, Ramesh; Hossain, Naznin; Hosseinzadeh, Mehdi; Hostiuc, Sorin; Hu, Guoqing; Ibitoye, Segun Emmanuel; Ilesanmi, Olayinka Stephen; Inbaraj, Leeberk Raja; Irvani, Seyed Sina Naghibi; Islam, M. Mofizul; Islam, Sheikh Mohammed Shariful; Ivers, Rebecca Q.; Jahani, Mohammad Ali; Jakovljevic, Mihajlo; Jalilian, Farzad; Jayaraman, Sudha; Jayatilleke, Achala Upendra; Jha, Ravi Prakash; John-Akinola, Yetunde O.; Jonas, Jost B.; Jones, Kelly M.; Joseph, Nitin; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Jungari, Suresh Banayya; Jurisson, Mikk; Kabir, Ali; Kahsay, Amaha; Kalankesh, Leila R.; Kalhor, Rohollah; Kamil, Teshome Abegaz; Kanchan, Tanuj; Kapoor, Neeti; Karami, Manoochehr; Kasaeian, Amir; Kassaye, Hagazi Gebremedhin; Kavetskyy, Taras; Kayode, Gbenga A.; Keiyoro, Peter Njenga; Kelbore, Abraham Getachew; Khader, Yousef Saleh; Khafaie, Morteza Abdullatif; Khalid, Nauman; Khalil, Ibrahim A.; Khalilov, Rovshan; Khan, Maseer; Khan, Ejaz Ahmad; Khan, Junaid; Khanna, Tripti; Khazaei, Salman; Khazaie, Habibolah; Khundkar, Roba; Kiirithio, Daniel N.; Kim, Young-Eun; Kim, Yun Jin; Kim, Daniel; Kisa, Sezer; Kisa, Adnan; Komaki, Hamidreza; Kondlahalli, Shivakumar K. M.; Koolivand, Ali; Korshunov, Vladimir Andreevich; Koyanagi, Ai; Kraemer, Moritz U. G.; Krishan, Kewal; Defo, Barthelemy Kuate; Bicer, Burcu Kucuk; Kugbey, Nuworza; Kumar, Nithin; Kumar, Manasi; Kumar, Vivek; Kumar, Narinder; Kumaresh, Girikumar; Lami, Faris Hasan; Lansingh, Van C.; Lasrado, Savita; Latifi, Arman; Lauriola, Paolo; La Vecchia, Carlo; Leasher, Janet L.; Lee, Shaun Wen Huey; Li, Shanshan; Liu, Xuefeng; Lopez, Alan D.; Lotufo, Paulo A.; Lyons, Ronan A.; Machado, Daiane Borges; Madadin, Mohammed; Abd El Razek, Muhammed Magdy; Mahotra, Narayan Bahadur; Majdan, Marek; Majeed, Azeem; Maled, Venkatesh; Malta, Deborah Carvalho; Manafi, Navid; Manafi, Amir; Manda, Ana-Laura; Manjunatha, Narayana; Mansour-Ghanaei, Fariborz; Mansournia, Mohammad Ali; Maravilla, Joemer C.; Mason-Jones, Amanda J.; Masoumi, Seyedeh Zahra; Massenburg, Benjamin Ballard; Maulik, Pallab K.; Mehndiratta, Man Mohan; Melketsedik, Zeleke Aschalew; Memiah, Peter T. N.; Mendoza, Walter; Menezes, Ritesh G.; Mengesha, Melkamu Merid; Meretoja, Tuomo J.; Meretoja, Atte; Merie, Hayimro Edemealem; Mestrovic, Tomislav; Miazgowski, Bartosz; Miazgowski, Tomasz; Miller, Ted R.; Mini, G. K.; Mirica, Andreea; Mirrakhimov, Erkin M.; Mirzaei-Alavijeh, Mehdi; Mithra, Prasanna; Moazen, Babak; Moghadaszadeh, Masoud; Mohamadi, Efat; Mohammad, Yousef; Darwesh, Aso Mohammad; Mohammadian-Hafshejani, Abdollah; Mohammadpourhodki, Reza; Mohammed, Shafiu; Mohammed, Jemal Abdu; Mohebi, Farnam; Bandpei, Mohammad A. Mohseni; Molokhia, Mariam; Monasta, Lorenzo; Moodley, Yoshan; Moradi, Masoud; Moradi, Ghobad; Moradi-Lakeh, Maziar; Moradzadeh, Rahmatollah; Morawska, Lidia; Moreno Velasquez, Ilais; Morrison, Shane Douglas; Mossie, Tilahun Belete; Muluneh, Atalay Goshu; Musa, Kamarul Imran; Mustafa, Ghulam; Naderi, Mehdi; Nagarajan, Ahamarshan Jayaraman; Naik, Gurudatta; Naimzada, Mukhammad David; Najafi, Farid; Nangia, Vinay; Nascimento, Bruno Ramos; Naserbakht, Morteza; Nayak, Vinod; Nazari, Javad; Ndwandwe, Duduzile Edith; Negoi, Ionut; Ngunjiri, Josephine W.; Trang Huyen Nguyen,; Cuong Tat Nguyen,; Diep Ngoc Nguyen,; Huong Lan Thi Nguyen,; Nikbakhsh, Rajan; Ningrum, Dina Nur Anggraini; Nnaji, Chukwudi A.; Ofori-Asenso, Richard; Ogbo, Felix Akpojene; Oghenetega, Onome Bright; Oh, In-Hwan; Olagunju, Andrew T.; Olagunju, Tinuke O.; Bali, Ahmed Omar; Onwujekwe, Obinna E.; Orpana, Heather M.; Ota, Erika; Otstavnov, Nikita; Otstavnov, Stanislav S.; Mahesh, P. A.; Padubidri, Jagadish Rao; Pakhale, Smita; Pakshir, Keyvan; Panda-Jonas, Songhomitra; Park, Eun-Kee; Patel, Sangram Kishor; Pathak, Ashish; Pati, Sanghamitra; Paulos, Kebreab; Peden, Amy E.; Pepito, Veincent Christian Filipino; Pereira, Jeevan; Phillips, Michael R.; Polibin, Roman; Polinder, Suzanne; Pourmalek, Farshad; Pourshams, Akram; Poustchi, Hossein; Prakash, Swayam; Pribadi, Dimas Ria Angga; Puri, Parul; Syed, Zahiruddin Quazi; Rabiee, Navid; Rabiee, Mohammad; Radfar, Amir; Rafay, Anwar; Rafiee, Ata; Rafiei, Alireza; Rahim, Fakher; Rahimi, Siavash; Rahman, Muhammad Aziz; Rajabpour-Sanati, Ali; Rajati, Fatemeh; Rakovac, Ivo; Rao, Sowmya J.; Rashedi, Vahid; Rastogi, Prateek; Rathi, Priya; Rawaf, Salman; Rawal, Lal; Rawassizadeh, Reza; Renjith, Vishnu; Resnikoff, Serge; Rezapour, Aziz; Ribeiro, Ana Isabel; Rickard, Jennifer; Rios Gonzalez, Carlos Miguel; Roever, Leonardo; Ronfani, Luca; Roshandel, Gholamreza; Saddik, Basema; Safarpour, Hamid; Safdarian, Mahdi; Sajadi, S. Mohammad; Salamati, Payman; Salem, Marwa R. Rashad; Salem, Hosni; Salz, Inbal; Samy, Abdallah M.; Sanabria, Juan; Riera, Lidia Sanchez; Milicevic, Milena M. Santric; Sarker, Abdur Razzaque; Sarveazad, Arash; Sathian, Brijesh; Sawhney, Monika; Sayyah, Mehdi; Schwebel, David C.; Seedat, Soraya; Senthilkumaran, Subramanian; Seyedmousavi, Seyedmojtaba; Sha, Feng; Shaahmadi, Faramarz; Shahabi, Saeed; Shaikh, Masood Ali; Shams-Beyranvand, Mehran; Sheikh, Aziz; Shigematsu, Mika; Shin, Jae Il; Shiri, Rahman; Siabani, Soraya; Sigfusdottir, Inga Dora; Singh, Jasvinder A.; Singh, Pankaj Kumar; Sinha, Dhirendra Narain; Soheili, Amin; Soriano, Joan B.; Sorrie, Muluken Bekele; Soyiri, Ireneous N.; Stokes, Mark A.; Sufiyan, Mu'awiyyah Babale; Sykes, Bryan L.; Tabares-Seisdedos, Rafael; Tabb, Karen M.; Taddele, Biruk Wogayehu; Tefera, Yonatal Mesfin; Tehrani-Banihashemi, Arash; Tekulu, Gebretsadkan Hintsa; Tesema, Ayenew Kassie Tesema; Tesfay, Berhe Etsay; Thapar, Rekha; Titova, Mariya Vladimirovna; Tlaye, Kenean Getaneh; Tohidinik, Hamid Reza; Topor-Madry, Roman; Khanh Bao Tran,; Bach Xuan Tran,; Tripathy, Jaya Prasad; Tsai, Alexander C.; Tsatsakis, Aristidis; Car, Lorainne Tudor; Ullah, Irfan; Ullah, Saif; Unnikrishnan, Bhaskaran; Upadhyay, Era; Uthman, Olalekan A.; Valdez, Pascual R.; Vasankari, Tommi Juhani; Veisani, Yousef; Venketasubramanian, Narayanaswamy; Violante, Francesco S.; Vlassov, Vasily; Waheed, Yasir; Wang, Yuan-Pang; Wiangkham, Taweewat; Wolde, Haileab Fekadu; Woldeyes, Dawit Habte; Wondmeneh, Temesgen Gebeyehu; Wondmieneh, Adam Belay; Wu, Ai-Min; Wyper, Grant M. A.; Yadav, Rajaram; Yadollahpour, Ali; Yano, Yuichiro; Yaya, Sanni; Yazdi-Feyzabadi, Vahid; Ye, Pengpeng; Yip, Paul; Yisma, Engida; Yonemoto, Naohiro; Yoon, Seok-Jun; Youm, Yoosik; Younis, Mustafa Z.; Yousefi, Zabihollah; Yu, Chuanhua; Yu, Yong; Moghadam, Telma Zahirian; Zaidi, Zoubida; Bin Zaman, Sojib; Zamani, Mohammad; Zandian, Hamed; Zarei, Fatemeh; Zhang, Zhi-Jiang; Zhang, Yunquan; Ziapour, Arash; Zodpey, Sanjay; Dandona, Rakhi; Dharmaratne, Samath Dhamminda; Hay, Simon; Mokdad, Ali H.; Pigott, David M.; Reiner, Robert C.; Vos, Theo (2020)
    Background While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future.
  • Global Burden Dis 2019; Abbafati, Cristiana; Abbas, Kaja M.; Abbasi, Mohammad; Kivimaki, Mika; Lallukka, Tea; Meretoja, Atte; Meretoja, Tuomo J.; Shiri, Rahman (2020)
    The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.
  • James, Spencer L.; Castle, Chris D.; Dingels, Zachary; Fox, Jack T.; Hamilton, Erin B.; Liu, Zichen; Roberts, Nicholas L. S.; Sylte, Dillon O.; Henry, Nathaniel J.; LeGrand, Kate E.; Abdelalim, Ahmed; Abdoli, Amir; Abdollahpour, Ibrahim; Abdulkader, Rizwan Suliankatchi; Abedi, Aidin; Abosetugn, Akine Eshete; Abushouk, Abdelrahman; Adebayo, Oladimeji M.; Agudelo-Botero, Marcela; Ahmad, Tauseef; Ahmed, Rushdia; Ahmed, Muktar Beshir; Aichour, Miloud Taki Eddine; Alahdab, Fares; Alamene, Genet Melak; Alanezi, Fahad Mashhour; Alebel, Animut; Alema, Niguse Meles; Alghnam, Suliman A.; Al-Hajj, Samar; Ali, Beriwan Abdulqadir; Ali, Saqib; Alikhani, Mahtab; Alinia, Cyrus; Alipour, Vahid; Aljunid, Syed Mohamed; Almasi-Hashiani, Amir; Almasri, Nihad A.; Altirkawi, Khalid; Amer, Yasser Sami Abdeldayem; Amini, Saeed; Amit, Arianna Maever Loreche; Andrei, Catalina Liliana; Ansari-Moghaddam, Alireza; Antonio, Carl Abelardo T.; Appiah, Seth Christopher Yaw; Arabloo, Jalal; Arab-Zozani, Morteza; Arefi, Zohreh; Aremu, Olatunde; Ariani, Filippo; Arora, Amit; Asaad, Malke; Asghari, Babak; Awoke, Nefsu; Quintanilla, Beatriz Paulina Ayala; Ayano, Getinet; Ayanore, Martin Amogre; Azari, Samad; Azarian, Ghasem; Badawi, Alaa; Badiye, Ashish D.; Bagli, Eleni; Baig, Atif Amin; Bairwa, Mohan; Bakhtiari, Ahad; Balachandran, Arun; Banach, Maciej; Banerjee, Srikanta K.; Banik, Palash Chandra; Banstola, Amrit; Barker-Collo, Suzanne Lyn; Baernighausen, Till Winfried; Barrero, Lope H.; Barzegar, Akbar; Bayati, Mohsen; Baye, Bayisa Abdissa; Bedi, Neeraj; Behzadifar, Masoud; Bekuma, Tariku Tesfaye; Belete, Habte; Benjet, Corina; Bennett, Derrick A.; Bensenor, Isabela M.; Berhe, Kidanemaryam; Bhardwaj, Pankaj; Bhat, Anusha Ganapati; Bhattacharyya, Krittika; Bibi, Sadia; Bijani, Ali; Bin Sayeed, Muhammad Shahdaat; Borges, Guilherme; Borzi, Antonio Maria; Boufous, Soufiane; Brazinova, Alexandra; Briko, Nikolay Ivanovich; Budhathoki, Shyam S.; Car, Josip; Cardenas, Rosario; Carvalho, Felix; Mauricio Castaldelli-Maia, Joao; Castaneda-Orjuela, Carlos A.; Castelpietra, Giulio; Catala-Lopez, Ferran; Cerin, Ester; Chandan, Joht S.; Chanie, Wagaye Fentahun; Chattu, Soosanna Kumary; Chattu, Vijay Kumar; Chatziralli, Irini; Chaudhary, Neha; Cho, Daniel Youngwhan; Chowdhury, Mohiuddin Ahsanul Kabir; Chu, Dinh-Toi; Colquhoun, Samantha M.; Constantin, Maria-Magdalena; Costa, Vera M.; Damiani, Giovanni; Daryani, Ahmad; Alberto Davila-Cervantes, Claudio; Demeke, Feleke Mekonnen; Demis, Asmamaw Bizuneh; Demoz, Gebre Teklemariam; Demsie, Desalegn Getnet; Derakhshani, Afshin; Deribe, Kebede; Desai, Rupak; Nasab, Mostafa Dianati; da Silva, Diana Dias; Forooshani, Zahra Sadat Dibaji; Doyle, Kerrie E.; Driscoll, Tim Robert; Dubljanin, Eleonora; Adema, Bereket Duko; Eagan, Arielle Wilder; Eftekhari, Aziz; Ehsani-Chimeh, Elham; Zaki, Maysaa El Sayed; Elemineh, Demelash Abewa; El-Jaafary, Shaimaa; El-Khatib, Ziad; Ellingsen, Christian Lycke; Emamian, Mohammad Hassan; Endalew, Daniel Adane; Eskandarieh, Sharareh; Faris, Pawan Sirwan; Faro, Andre; Farzadfar, Farshad; Fatahi, Yousef; Fekadu, Wubalem; Ferede, Tomas Y.; Fereshtehnejad, Seyed-Mohammad; Fernandes, Eduarda; Ferrara, Pietro; Feyissa, Garumma Tolu; Filip, Irina; Fischer, Florian; Folayan, Morenike Oluwatoyin; Foroutan, Masoud; Francis, Joel Msafiri; Franklin, Richard Charles; Fukumoto, Takeshi; Geberemariyam, Biniyam Sahiledengle; Gebre, Abadi Kahsu; Gebremedhin, Ketema Bizuwork; Gebremeskel, Gebreamlak Gebremedhn; Gebremichael, Berhe; Gedefaw, Getnet Azeze; Geta, Birhanu; Ghafourifard, Mansour; Ghamari, Farhad; Ghashghaee, Ahmad; Gholamian, Asadollah; Gill, Tiffany K.; Goulart, Alessandra C.; Grada, Ayman; Grivna, Michal; Gubari, Mohammed Ibrahim Mohialdeen; Guimaraes, Rafael Alves; Guo, Yuming; Gupta, Gaurav; Haagsma, Juanita A.; Hafezi-Nejad, Nima; Bidgoli, Hassan Haghparast; Hall, Brian James; Hamadeh, Randah R.; Hamidi, Samer; Maria Haro, Josep; Hasan, Mehedi; Hasanzadeh, Amir; Hassanipour, Soheil; Hassankhani, Hadi; Hassen, Hamid Yimam; Havmoeller, Rasmus; Hayat, Khezar; Hendrie, Delia; Heydarpour, Fatemeh; Hijar, Martha; Ho, Hung Chak; Chi Linh Hoang,; Hole, Michael K.; Holla, Ramesh; Hossain, Naznin; Hosseinzadeh, Mehdi; Hostiuc, Sorin; Hu, Guoqing; Ibitoye, Segun Emmanuel; Ilesanmi, Olayinka Stephen; Ilic, Irena; Ilic, Milena D.; Inbaraj, Leeberk Raja; Indriasih, Endang; Irvani, Seyed Sina Naghibi; Islam, Sheikh Mohammed Shariful; Islam, M. Mofizul; Ivers, Rebecca Q.; Jacobsen, Kathryn H.; Jahani, Mohammad Ali; Jahanmehr, Nader; Jakovljevic, Mihajlo; Jalilian, Farzad; Jayaraman, Sudha; Jayatilleke, Achala Upendra; Jha, Ravi Prakash; John-Akinola, Yetunde O.; Jonas, Jost B.; Joseph, Nitin; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Jungari, Suresh Banayya; Jurisson, Mikk; Kabir, Ali; Kadel, Rajendra; Kahsay, Amaha; Kalankesh, Leila R.; Kalhor, Rohollah; Kamil, Teshome Abegaz; Kanchan, Tanuj; Kapoor, Neeti; Karami, Manoochehr; Kasaeian, Amir; Kassaye, Hagazi Gebremedhin; Kavetskyy, Taras; Kebede, Hafte Kahsay; Keiyoro, Peter Njenga; Kelbore, Abraham Getachew; Kelkay, Bayew; Khader, Yousef Saleh; Khafaie, Morteza Abdullatif; Khalid, Nauman; Khalil, Ibrahim A.; Khalilov, Rovshan; Khammarnia, Mohammad; Khan, Ejaz Ahmad; Khan, Maseer; Khanna, Tripti; Khazaie, Habibolah; Shadmani, Fatemeh Khosravi; Khundkar, Roba; Kiirithio, Daniel N.; Kim, Young-Eun; Kim, Daniel; Kim, Yun Jin; Kisa, Adnan; Kisa, Sezer; Komaki, Hamidreza; Kondlahalli, Shivakumar K. M.; Korshunov, Vladimir Andreevich; Koyanagi, Ai; Kraemer, Moritz U. G.; Krishan, Kewal; Bicer, Burcu Kucuk; Kugbey, Nuworza; Kumar, Vivek; Kumar, Nithin; Kumar, G. Anil; Kumar, Manasi; Kumaresh, Girikumar; Kurmi, Om P.; Kuti, Oluwatosin; La Vecchia, Carlo; Lami, Faris Hasan; Lamichhane, Prabhat; Lang, Justin J.; Lansingh, Van C.; Laryea, Dennis Odai; Lasrado, Savita; Latifi, Arman; Lauriola, Paolo; Leasher, Janet L.; Lee, Shaun Wen Huey; Lenjebo, Tsegaye Lolaso; Levi, Miriam; Li, Shanshan; Linn, Shai; Liu, Xuefeng; Lopez, Alan D.; Lotufo, Paulo A.; Lunevicius, Raimundas; Lyons, Ronan A.; Madadin, Mohammed; Abd El Razek, Muhammed Magdy; Mahotra, Narayan Bahadur; Majdan, Marek; Majeed, Azeem; Malagon-Rojas, Jeadran N.; Maled, Venkatesh; Malekzadeh, Reza; Malta, Deborah Carvalho; Manafi, Navid; Manafi, Amir; Manda, Ana-Laura; Manjunatha, Narayana; Mansour-Ghanaei, Fariborz; Mansouri, Borhan; Mansournia, Mohammad Ali; Maravilla, Joemer C.; March, Lyn M.; Mason-Jones, Amanda J.; Masoumi, Seyedeh Zahra; Massenburg, Benjamin Ballard; Maulik, Pallab K.; Meles, Gebrekiros Gebremichael; Melese, Addisu; Melketsedik, Zeleke Aschalew; Memiah, Peter T. N.; Mendoza, Walter; Menezes, Ritesh G.; Mengesha, Meresa Berwo; Mengesha, Melkamu Merid; Meretoja, Tuomo J.; Meretoja, Atte; Merie, Hayimro Edemealem; Mestrovic, Tomislav; Miazgowski, Bartosz; Miazgowski, Tomasz; Miller, Ted R.; Mini, G. K.; Mirica, Andreea; Mirrakhimov, Erkin M.; Mirzaei-Alavijeh, Mehdi; Mithra, Prasanna; Moazen, Babak; Moghadaszadeh, Masoud; Mohamadi, Efat; Mohammad, Yousef; Mohammad, Karzan Abdulmuhsin; Darwesh, Aso Mohammad; Mezerji, Naser Mohammad Gholi; Mohammadian-Hafshejani, Abdollah; Mohammadoo-Khorasani, Milad; Mohammadpourhodki, Reza; Mohammed, Shafiu; Mohammed, Jemal Abdu; Mohebi, Farnam; Molokhia, Mariam; Monasta, Lorenzo; Moodley, Yoshan; Moosazadeh, Mahmood; Moradi, Masoud; Moradi, Ghobad; Moradi-Lakeh, Maziar; Moradpour, Farhad; Morawska, Lidia; Moreno Velasquez, Ilais; Morisaki, Naho; Morrison, Shane Douglas; Mossie, Tilahun Belete; Muluneh, Atalay Goshu; Murthy, Srinivas; Musa, Kamarul Imran; Mustafa, Ghulam; Nabhan, Ashraf F.; Nagarajan, Ahamarshan Jayaraman; Naik, Gurudatta; Naimzada, Mukhammad David; Najafi, Farid; Nangia, Vinay; Nascimento, Bruno Ramos; Naserbakht, Morteza; Nayak, Vinod; Ndwandwe, Duduzile Edith; Negoi, Ionut; Ngunjiri, Josephine W.; Cuong Tat Nguyen,; Huong Lan Thi Nguyen,; Nikbakhsh, Rajan; Ningrum, Dina Nur Anggraini; Nnaji, Chukwudi A.; Nyasulu, Peter S.; Ogbo, Felix Akpojene; Oghenetega, Onome Bright; Oh, In-Hwan; Okunga, Emmanuel Wandera; Olagunju, Andrew T.; Olagunju, Tinuke O.; Bali, Ahmed Omar; Onwujekwe, Obinna E.; Asante, Kwaku Oppong; Orpana, Heather M.; Ota, Erika; Otstavnov, Nikita; Otstavnov, Stanislav S.; Mahesh, P. A.; Padubidri, Jagadish Rao; Pakhale, Smita; Pakshir, Keyvan; Panda-Jonas, Songhomitra; Park, Eun-Kee; Patel, Sangram Kishor; Pathak, Ashish; Pati, Sanghamitra; Patton, George C.; Paulos, Kebreab; Peden, Amy E.; Filipino Pepito, Veincent Christian; Pereira, Jeevan; Hai Quang Pham,; Phillips, Michael R.; Pinheiro, Marina; Polibin, Roman; Polinder, Suzanne; Poustchi, Hossein; Prakash, Swayam; Pribadi, Dimas Ria Angga; Puri, Parul; Syed, Zahiruddin Quazi; Rabiee, Mohammad; Rabiee, Navid; Radfar, Amir; Rafay, Anwar; Rafiee, Ata; Rafiei, Alireza; Rahim, Fakher; Rahimi, Siavash; Rahimi-Movaghar, Vafa; Rahman, Muhammad Aziz; Rajabpour-Sanati, Ali; Rajati, Fatemeh; Rakovac, Ivo; Ranganathan, Kavitha; Rao, Sowmya J.; Rashedi, Vahid; Rastogi, Prateek; Rathi, Priya; Rawaf, Salman; Rawal, Lal; Rawassizadeh, Reza; Renjith, Vishnu; Renzaho, Andre M. N.; Resnikoff, Serge; Rezapour, Aziz; Ribeiro, Ana Isabel; Rickard, Jennifer; Rios Gonzalez, Carlos Miguel; Ronfani, Luca; Roshandel, Gholamreza; Saad, Anas M.; Sabde, Yogesh Damodar; Sabour, Siamak; Saddik, Basema; Safari, Saeed; Safari-Faramani, Roya; Safarpour, Hamid; Safdarian, Mahdi; Sajadi, S. Mohammad; Salamati, Payman; Salehi, Farkhonde; Zahabi, Saleh Salehi; Salem, Marwa R. Rashad; Salem, Hosni; Salman, Omar; Salz, Inbal; Samy, Abdallah M.; Sanabria, Juan; Riera, Lidia Sanchez; Milicevic, Milena M. Santric; Sarker, Abdur Razzaque; Sarveazad, Arash; Sathian, Brijesh; Sawhney, Monika; Sawyer, Susan M.; Saxena, Sonia; Sayyah, Mehdi; Schwebel, David C.; Seedat, Soraya; Senthilkumaran, Subramanian; Sepanlou, Sadaf G.; Seyedmousavi, Seyedmojtaba; Sha, Feng; Shaahmadi, Faramarz; Shahabi, Saeed; Shaikh, Masood Ali; Shams-Beyranvand, Mehran; Shamsizadeh, Morteza; Sharif-Alhoseini, Mahdi; Sharifi, Hamid; Sheikh, Aziz; Shigematsu, Mika; Shin, Jae Il; Shiri, Rahman; Siabani, Soraya; Sigfusdottir, Inga Dora; Singh, Pankaj Kumar; Singh, Jasvinder A.; Sinha, Dhirendra Narain; Smarandache, Catalin-Gabriel; Smith, Emma U. R.; Soheili, Amin; Soleymani, Bija; Soltanian, Ali Reza; Soriano, Joan B.; Sorrie, Muluken Bekele; Soyiri, Ireneous N.; Stein, N. J.; Stokes, Mark A.; Sufiyan, Mu'awiyyah Babale; Suleria, Hafiz Ansar Rasul; Sykes, Bryan L.; Tabares-Seisdedos, Rafael; Tabb, Karen M.; Taddele, Biruk Wogayehu; Tadesse, Degena Bahrey; Tamiru, Animut Tagele; Tarigan, Ingan Ukur; Tefera, Yonatal Mesfin; Tehrani-Banihashemi, Arash; Tekle, Merhawi Gebremedhin; Tekulu, Gebretsadkan Hintsa; Tesema, Ayenew Kassie; Tesfay, Berhe Etsay; Thapar, Rekha; Tilahune, Asres Bedaso; Tlaye, Kenean Getaneh; Tohidinik, Hamid Reza; Topor-Madry, Roman; Bach Xuan Tran,; Khanh Bao Tran,; Tripathy, Jaya Prasad; Tsai, Alexander C.; Car, Lorainne Tudor; Ullah, Saif; Ullah, Irfan; Umar, Maida; Unnikrishnan, Bhaskaran; Upadhyay, Era; Uthman, Olalekan A.; Valdez, Pascual R.; Vasankari, Tommi Juhani; Venketasubramanian, Narayanaswamy; Violante, Francesco S.; Vlassov, Vasily; Waheed, Yasir; Weldesamuel, Girmay Teklay; Werdecker, Andrea; Wiangkham, Taweewat; Wolde, Haileab Fekadu; Woldeyes, Dawit Habte; Wondafrash, Dawit Zewdu; Wondmeneh, Temesgen Gebeyehu; Wondmieneh, Adam Belay; Wu, Ai-Min; Yadav, Rajaram; Yadollahpour, Ali; Yano, Yuichiro; Yaya, Sanni; Yazdi-Feyzabadi, Vahid; Yip, Paul; Yisma, Engida; Yonemoto, Naohiro; Yoon, Seok-Jun; Youm, Yoosik; Younis, Mustafa Z.; Yousefi, Zabihollah; Yu, Yong; Yu, Chuanhua; Yusefzadeh, Hasan; Moghadam, Telma Zahirian; Zaidi, Zoubida; Bin Zaman, Sojib; Zamani, Mohammad; Zamanian, Maryam; Zandian, Hamed; Zarei, Ahmad; Zare, Fatemeh; Zhang, Zhi-Jiang; Zhang, Yunquan; Zodpey, Sanjay; Dandona, Lalit; Dandona, Rakhi; Degenhardt, Louisa; Dharmaratne, Samath Dhamminda; Hay, Simon; Mokdad, Ali H.; Reiner, Robert C.; Sartorius, Benn; Vos, Theo (2020)
    Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
  • Crowe, Christopher Stephen; Massenburg, Benjamin Ballard; Morrison, Shane Douglas; Chang, James; Friedrich, Jeffrey Barton; Abady, Gdiom Gebreheat; Alahdab, Fares; Alipour, Vahid; Arabloo, Jalal; Asaad, Malke; Banach, Maciej; Bijani, Ali; Borzi, Antonio Maria; Briko, Nikolay Ivanovich; Castle, Chris D.; Cho, Daniel Youngwhan; Chung, Michael T.; Daryani, Ahmad; Demoz, Gebre Teklemariam; Dingels, Zachary; Hoa Thi Do,; Fischer, Florian; Fox, Jack T.; Fukumoto, Takeshi; Gebre, Abadi Kahsu; Gebremichael, Berhe; Haagsma, Juanita A.; Haj-Mirzaian, Arvin; Handiso, Demelash Woldeyohannes; Hay, Simon; Chi Linh Hoang,; Irvani, Seyed Sina Naghibi; Jozwiak, Jacek Jerzy; Kalhor, Rohollah; Kasaeian, Amir; Khader, Yousef Saleh; Khalilov, Rovshan; Khan, Ejaz Ahmad; Khundkar, Roba; Kisa, Sezer; Kisa, Adnan; Liu, Zichen; Majdan, Marek; Manafi, Navid; Manafi, Ali; Manda, Ana-Laura; Meretoja, Tuomo J.; Miller, Ted R.; Mohammadian-Hafshejani, Abdollah; Mohammadpourhodki, Reza; Bandpei, Mohammad A. Mohseni; Mokdad, Ali H.; Naimzada, Mukhammad David; Ndwandwe, Duduzile Edith; Cuong Tat Nguyen,; Huong Lan Thi Nguyen,; Olagunju, Andrew T.; Olagunju, Tinuke O.; Hai Quang Pham,; Pribadi, Dimas Ria Angga; Rabiee, Navid; Ramezanzadeh, Kiana; Ranganathan, Kavitha; Roberts, Nicholas L. S.; Roever, Leonardo; Safari, Saeed; Samy, Abdallah M.; Riera, Lidia Sanchez; Shahabi, Saeed; Smarandache, Catalin-Gabriel; Sylte, Dillon O.; Tesfay, Berhe Etsay; Bach Xuan Tran,; Ullah, Irfan; Vahedi, Parviz; Vahedian-Azimi, Amir; Theo Vos,; Woldeyes, Dawit Habte; Wondmieneh, Adam Belay; Zhang, Zhi-Jiang; James, Spencer L. (2020)
    Background As global rates of mortality decrease, rates of non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this global pattern of non-fatal injury would be demonstrated in regard to bony hand and wrist trauma over the 27-year study period. Methods The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 was used to estimate prevalence, age-standardised incidence and years lived with disability for hand trauma in 195 countries from 1990 to 2017. Individual injuries included hand and wrist fractures, thumb amputations and non-thumb digit amputations. Results The global incidence of hand trauma has only modestly decreased since 1990. In 2017, the age-standardised incidence of hand and wrist fractures was 179 per 100 000 (95% uncertainty interval (UI) 146 to 217), whereas the less common injuries of thumb and non-thumb digit amputation were 24 (95% UI 17 to 34) and 56 (95% UI 43 to 74) per 100 000, respectively. Rates of injury vary greatly by region, and improvements have not been equally distributed. The highest burden of hand trauma is currently reported in high SDI countries. However, low-middle and middle SDI countries have increasing rates of hand trauma by as much at 25%. Conclusions Certain regions are noted to have high rates of hand trauma over the study period. Low-middle and middle SDI countries, however, have demonstrated increasing rates of fracture and amputation over the last 27 years. This trend is concerning as access to quality and subspecialised surgical hand care is often limiting in these resource-limited regions.
  • Global Burden Dis Hlth Financing; Micah, Angela E.; Su, Yanfang; Bachmeier, Steven D.; Meretoja, Tuomo J.; Meretoja, Atte (2020)
    Background Sustainable Development Goal (SDG) 3 aims to "ensure healthy lives and promote well-being for all at all ages". While a substantial effort has been made to quantify progress towards SDG3, less research has focused on tracking spending towards this goal. We used spending estimates to measure progress in financing the priority areas of SDG3, examine the association between outcomes and financing, and identify where resource gains are most needed to achieve the SDG3 indicators for which data are available. Methods We estimated domestic health spending, disaggregated by source (government, out-of-pocket, and prepaid private) from 1995 to 2017 for 195 countries and territories. For disease-specific health spending, we estimated spending for HIV/AIDS and tuberculosis for 135 low-income and middle-income countries, and malaria in 106 malaria-endemic countries, from 2000 to 2017. We also estimated development assistance for health (DAH) from 1990 to 2019, by source, disbursing development agency, recipient, and health focus area, including DAH for pandemic preparedness. Finally, we estimated future health spending for 195 countries and territories from 2018 until 2030. We report all spending estimates in inflation-adjusted 2019 US$, unless otherwise stated. Findings Since the development and implementation of the SDGs in 2015, global health spending has increased, reaching $7.9 trillion (95% uncertainty interval 7.8-8.0) in 2017 and is expected to increase to $11.0 trillion (10.7-11.2) by 2030. In 2017, in low-income and middle-income countries spending on HIV/AIDS was $20.2 billion (17.0-25.0) and on tuberculosis it was $10.9 billion (10.3-11.8), and in malaria-endemic countries spending on malaria was $5.1 billion (4.9-5.4). Development assistance for health was $40.6 billion in 2019 and HIV/AIDS has been the health focus area to receive the highest contribution since 2004. In 2019, $374 million of DAH was provided for pandemic preparedness, less than 1% of DAH. Although spending has increased across HIV/AIDS, tuberculosis, and malaria since 2015, spending has not increased in all countries, and outcomes in terms of prevalence, incidence, and per-capita spending have been mixed. The proportion of health spending from pooled sources is expected to increase from 81.6% (81.6-81.7) in 2015 to 83.1% (82.8-83.3) in 2030. Interpretation Health spending on SDG3 priority areas has increased, but not in all countries, and progress towards meeting the SDG3 targets has been mixed and has varied by country and by target. The evidence on the scale-up of spending and improvements in health outcomes suggest a nuanced relationship, such that increases in spending do not always results in improvements in outcomes. Although countries will probably need more resources to achieve SDG3, other constraints in the broader health system such as inefficient allocation of resources across interventions and populations, weak governance systems, human resource shortages, and drug shortages, will also need to be addressed. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.
  • GBD Lower Resp Infect; Troeger, Christopher E.; Khalil, Ibrahim A.; Meretoja, Tuomo J. (2020)
    Background Despite large reductions in under-5 lower respiratory infection (LRI) mortality in many locations, the pace of progress for LRIs has generally lagged behind that of other childhood infectious diseases. To better inform programmes and policies focused on preventing and treating LRIs, we assessed the contributions and patterns of risk factor attribution, intervention coverage, and sociodemographic development in 195 countries and territories by drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) LRI estimates. Methods We used four strategies to model LRI burden: the mortality due to LRIs was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive ensemble modelling tool; the incidence of LRIs was modelled using population representative surveys, health-care utilisation data, and scientific literature in a compartmental meta-regression tool; the attribution of risk factors for LRI mortality was modelled in a counterfactual framework; and trends in LRI mortality were analysed applying changes in exposure to risk factors over time. In GBD, infectious disease mortality, including that due to LRI, is among HIV-negative individuals. We categorised locations based on their burden in 1990 to make comparisons in the changing burden between 1990 and 2017 and evaluate the relative percent change in mortality rate, incidence, and risk factor exposure to explain differences in the health loss associated with LRIs among children younger than 5 years. Findings In 2017, LRIs caused 808 920 deaths (95% uncertainty interval 747 286-873 591) in children younger than 5 years. Since 1990, there has been a substantial decrease in the number of deaths (from 2 337 538 to 808 920 deaths; 65.4% decrease, 61.5-68.5) and in mortality rate (from 362.7 deaths [3304-392.0] per 100 000 children to 118.9 deaths [109.8-128.3] per 100 000 children; 67.2% decrease, 63.5-70.1). LRI incidence dedined globally (32.4% decrease, 27.2-37.5). The percent change in under-5 mortality rate and incidence has varied across locations. Among the risk factors assessed in this study, those responsible for the greatest decrease in under-5 LRI mortality between 1990 and 2017 were increased coverage of vaccination against Haemophilus influenza type b (11.4% decrease, 0.0-24.5), increased pneumococcal vaccine coverage (6.3% decrease, 6.1-6.3), and reductions in household air pollution (8.4%, 6 8-9.2). Interpretation Our findings show that there have been substantial but uneven declines in LRI mortality among countries between 1990 and 2017. Although improvements in indicators of sociodemographic development could explain some of these trends, changes in exposure to modifiable risk factors are related to the rates of decline in LRI mortality. No single intervention would universally accelerate reductions in health loss associated with LRIs in all settings, but emphasising the most dominant risk factors, particularly in countries with high case fatality, can contribute to the reduction of preventable deaths. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.
  • Franklin, Richard Charles; Peden, Amy E.; Hamilton, Erin B.; Bisignano, Catherine; Castle, Chris D.; Dingels, Zachary; Hay, Simon; Liu, Zichen; Mokdad, Ali H.; Roberts, Nicholas L. S.; Sylte, Dillon O.; Theo Vos,; Abady, Gdiom Gebreheat; Abosetugn, Akine Eshete; Ahmed, Rushdia; Alahdab, Fares; Andrei, Catalina Liliana; Antonio, Carl Abelardo T.; Arabloo, Jalal; Arba, Aseb Arba Kinfe; Badiye, Ashish D.; Bakkannavar, Shankar M.; Banach, Maciej; Banik, Palash Chandra; Banstola, Amrit; Barker-Collo, Suzanne Lyn; Barzegar, Akbar; Bayati, Mohsen; Bhardwaj, Pankaj; Bhaumik, Soumyadeep; Bhutta, Zulfiqar A.; Bijani, Ali; Boloor, Archith; Carvalho, Felix; Chowdhury, Mohiuddin Ahsanul Kabir; Dinh-Toi Chu,; Colquhoun, Samantha M.; Dagne, Henok; Dagnew, Baye; Dandona, Lalit; Dandona, Rakhi; Daryani, Ahmad; Dharmaratne, Samath Dhamminda; Forooshani, Zahra Sadat Dibaji; Hoa Thi Do,; Driscoll, Tim Robert; Eagan, Arielle Wilder; El-Khatib, Ziad; Fernandes, Eduarda; Filip, Irina; Fischer, Florian; Gebremichael, Berhe; Gupta, Gaurav; Haagsma, Juanita A.; Hassan, Shoaib; Hendrie, Delia; Chi Linh Hoang,; Hole, Michael K.; Holla, Ramesh; Hostiuc, Sorin; Househ, Mowafa; Ilesanmi, Olayinka Stephen; Inbaraj, Leeberk Raja; Irvani, Seyed Sina Naghibi; Islam, M. Mofizul; Ivers, Rebecca Q.; Jayatilleke, Achala Upendra; Joukar, Farahnaz; Kalhor, Rohollah; Kanchan, Tanuj; Kapoor, Neeti; Kasaeian, Amir; Khan, Maseer; Khan, Ejaz Ahmad; Khubchandani, Jagdish; Krishan, Kewal; Kumar, G. Anil; Lauriola, Paolo; Lopez, Alan D.; Madadin, Mohammed; Majdan, Marek; Maled, Venkatesh; Manafi, Navid; Manafi, Ali; McKee, Martin; Meles, Hagazi Gebre; Menezes, Ritesh G.; Meretoja, Tuomo J.; Miller, Ted R.; Mithra, Prasanna; Mohammadian-Hafshejani, Abdollah; Mohammadpourhodki, Reza; Mohebi, Farnam; Molokhia, Mariam; Mustafa, Ghulam; Negoi, Ionut; Cuong Tat Nguyen,; Huong Lan Thi Nguyen,; Olagunju, Andrew T.; Olagunju, Tinuke O.; Padubidri, Jagadish Rao; Pakshir, Keyvan; Pathak, Ashish; Polinder, Suzanne; Pribadi, Dimas Ria Angga; Rabiee, Navid; Radfar, Amir; Rana, Saleem Muhammad; Rickard, Jennifer; Safari, Saeed; Salamati, Payman; Samy, Abdallah M.; Sarker, Abdur Razzaque; Schwebel, David C.; Senthilkumaran, Subramanian; Shaahmadi, Faramarz; Shaikh, Masood Ali; Shin, Jae Il; Singh, Pankaj Kumar; Soheili, Amin; Stokes, Mark A.; Suleria, Hafiz Ansar Rasul; Tarigan, Ingan Ukur; Temsah, Mohamad-Hani; Tesfay, Berhe Etsay; Valdez, Pascual R.; Veisani, Yousef; Ye, Pengpeng; Yonemoto, Naohiro; Yu, Chuanhua; Yusefzadeh, Hasan; Bin Zaman, Sojib; Zhang, Zhi-Jiang; James, Spencer L. (2020)
    Background Drowning is a leading cause of injury-related mortality globally. Unintentional drowning (International Classification of Diseases (ICD) 10 codes W65-74 and ICD9 E910) is one of the 30 mutually exclusive and collectively exhaustive causes of injury-related mortality in the Global Burden of Disease (GBD) study. This study's objective is to describe unintentional drowning using GBD estimates from 1990 to 2017. Methods Unintentional drowning from GBD 2017 was estimated for cause-specific mortality and years of life lost (YLLs), age, sex, country, region, Socio-demographic Index (SDI) quintile, and trends from 1990 to 2017. GBD 2017 used standard GBD methods for estimating mortality from drowning. Results Globally, unintentional drowning mortality decreased by 44.5% between 1990 and 2017, from 531 956 (uncertainty interval (UI): 484 107 to 572 854) to 295 210 (284 493 to 306 187) deaths. Global age-standardised mortality rates decreased 57.4%, from 9.3 (8.5 to 10.0) in 1990 to 4.0 (3.8 to 4.1) per 100 000 per annum in 2017. Unintentional drowning-associated mortality was generally higher in children, males and in low-SDI to middle-SDI countries. China, India, Pakistan and Bangladesh accounted for 51.2% of all drowning deaths in 2017. Oceania was the region with the highest rate of age-standardised YLLs in 2017, with 45 434 (40 850 to 50 539) YLLs per 100 000 across both sexes. Conclusions There has been a decline in global drowning rates. This study shows that the decline was not consistent across countries. The results reinforce the need for continued and improved policy, prevention and research efforts, with a focus on low- and middle-income countries.
  • GBD 2017 Childhood Canc Collaborat (2019)
    Background Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years (DALYs). Methods Using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 methodology, childhood (ages 0-19 years) cancer mortality was estimated by use of vital registration system data, verbal autopsy data, and population-based cancer registry incidence data, which were transformed to mortality estimates through modelled mortality-to-incidence ratios (MIRs). Childhood cancer incidence was estimated using the mortality estimates and corresponding MIRs. Prevalence estimates were calculated by using MIR to model survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated by multiplying age-specific cancer deaths by the difference between the age of death and a reference life expectancy. DALYs were calculated as the sum of YLLs and YLDs. Final point estimates are reported with 95% uncertainty intervals. Findings Globally, in 2017, there were 11.5 million (95% uncertainty interval 10.6-12.3) DALYs due to childhood cancer, 97.3% (97.3-97.3) of which were attributable to YLLs and 2.7% (2.7-2.7) of which were attributable to YLDs. Childhood cancer was the sixth leading cause of total cancer burden globally and the ninth leading cause of childhood disease burden globally. 82.2% (82.1-82.2) of global childhood cancer DALYs occurred in low, low-middle, or middle Socio-demographic Index locations, whereas 50.3% (50.3-50.3) of adult cancer DALYs occurred in these same locations. Cancers that are uncategorised in the current GBD framework comprised 26.5% (26.5-26.5) of global childhood cancer DALYs. Interpretation The GBD 2017 results call attention to the substantial burden of childhood cancer globally, which disproportionately affects populations in resource-limited settings. The use of DALY-based estimates is crucial in demonstrating that childhood cancer burden represents an important global cancer and child health concern. (C) 2019 The Author(s). Published by Elsevier Ltd.