Browsing by Subject "ACCURACY"

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  • Maukonen, Mirkka; Mannisto, Satu; Tolonen, Hanna (2018)
    Aims: Up-to-date information on the accuracy between different anthropometric data collection methods is vital for the reliability of anthropometric data. A previous review on this matter was conducted a decade ago. Our aim was to conduct a literature review on the accuracy of self-reported height, weight, and body mass index (BMI) against measured values for assessing obesity in adults. To obtain an overview of the present situation, we included studies published after the previous review. Differences according to sex, BMI groups, and continents were also assessed. Methods: Studies published between January 2006 and April 2017 were identified from a literature search on PubMed. Results: Our search retrieved 62 publications on adult populations that showed a tendency for self-reported height to be overestimated and weight to be underestimated when compared with measured values. The findings were similar for both sexes. BMI derived from self-reported height and weight was underestimated; there was a clear tendency for underestimation of overweight (from 1.8%-points to 9.8%-points) and obesity (from 0.7%-points to 13.4%-points) prevalence by self-report. The bias was greater in overweight and obese participants than those of normal weight. Studies conducted in North America showed a greater bias, whereas the bias in Asian studies seemed to be lower than those from other continents. Conclusions: With globally rising obesity rates, accurate estimation of obesity is essential for effective public health policies to support obesity prevention. As self-report bias tends to be higher among overweight and obese individuals, measured anthropometrics provide a more reliable tool for assessing the prevalence of obesity.
  • Kanclerz, Piotr; Tuuminen, Raimo (2022)
  • Harve-Rytsälä, Heini; Ångerman, Susanne; Kirves, Hetti; Nurmi, Jouni (2021)
    Background Normoventilation is crucial for many critically ill patients. Ventilation is routinely guided by end-tidal capnography during prehospital anaesthesia, based on the assumption of the gap between arterial partial pressure of carbon dioxide (PaCO2) and end-tidal carbon dioxide partial pressure (PetCO(2)) of approximately 0.5 kPa (3.8 mmHg). Methods We retrospectively analysed the airway registry and patient chart data of patients who had been anaesthetised and intubated endotracheally by the prehospital critical care team and had their prehospital arterial blood gases analysed. Bland-Altman analysis was used to estimate the bias and limits of agreement. Results Altogether 502 patients were included in the study, with a median age of 58 years. The most common patient groups were post-resuscitation (155, 31%), neurological emergencies (96, 19%), intoxication (75, 15%) and trauma (68, 14%). The median of the gap between PaCO2 and PetCO(2) was 1.3 kPa (interquartile range 0.7 to 2.2) (9.8 (5.3-16.5) mmHg). Mean bias of PetCO(2) was -1.6 kPa/12.0 mmHg (standard deviation 1.7 kPa/12.8 mmHg) with 95% confidence limits of agreement -4.9 to 1.9 kPa (-36.8 to 14.3 mmHg). The gap was >= 1.0 kPa (>7.5 mmHg) in 297 (66%, 95% confidence interval 55 to 63) patients. Conclusion Our results suggest that end-tidal capnography alone might not be an adequate method to achieve normoventilation for critically ill patients intubated and mechanically ventilated in prehospital setting. Thus, an arterial blood gas analysis might be useful to recognize patients with an increased gap between PaCO2 and PetCO(2).
  • Luoma, Ville; Saarinen, Ninni; Wulder, Michael A.; White, Joanne C.; Vastaranta, Mikko; Holopainen, Markus; Hyyppä, Juha (2017)
    Forest resource information has a hierarchical structure: individual tree attributes are summed at the plot level and then in turn, plot-level estimates are used to derive stand or large-area estimates of forest resources. Due to this hierarchy, it is imperative that individual tree attributes are measured with accuracy and precision. With the widespread use of different measurement tools, it is also important to understand the expected degree of precision associated with these measurements. The most prevalent tree attributes measured in the field are tree species, stem diameter-at-breast-height (dbh), and tree height. For dbh and height, the most commonly used measuring devices are calipers and clinometers, respectively. The aim of our study was to characterize the precision of individual tree dbh and height measurements in boreal forest conditions when using calipers and clinometers. The data consisted of 319 sample trees at a study area in Evo, southern Finland. The sample trees were measured independently by four trained mensurationists. The standard deviation in tree dbh and height measurements was 0.3 cm (1.5%) and 0.5 m (2.9%), respectively. Precision was also assessed by tree species and tree size classes; however, there were no statistically significant differences between the mensurationists for dbh or height measurements. Our study offers insights into the expected precision of tree dbh and height as measured with the most commonly used devices. These results are important when using sample plot data in forest inventory applications, especially now, at a time when new tree attribute measurement techniques based on remote sensing are being developed and compared to the conventional caliper and clinometer measurements.
  • Yu, Xiaowei; Litkey, Paula; Hyyppa, Juha; Holopainen, Markus; Vastaranta, Mikko (2014)
  • Liu, Jingbin; Liang, Xinlian; Hyyppä, Juha; Yu, Xiaowei; Lehtomäki, Matti; Pyörälä, Jiri; Zhu, Lingli; Wang, Yunsheng; Chen, Ruizhi (2017)
    Terrestrial laser scanning has been widely used to analyze the 3D structure of a forest in detail and to generate data at the level of a reference plot for forest inventories without destructive measurements. Multi-scan terrestrial laser scanning is more commonly applied to collect plot-level data so that all of the stems can be detected and analyzed. However, it is necessary to match the point clouds of multiple scans to yield a point cloud with automated processing. Mismatches between datasets will lead to errors during the processing of multi-scan data. Classic registration methods based on flat surfaces cannot be directly applied in forest environments; therefore, artificial reference objects have conventionally been used to assist with scan matching. The use of artificial references requires additional labor and expertise, as well as greatly increasing the cost. In this study, we present an automated processing method for plot-level stem mapping that matches multiple scans without artificial references. In contrast to previous studies, the registration method developed in this study exploits the natural geometric characteristics among a set of tree stems in a plot and combines the point clouds of multiple scans into a unified coordinate system. Integrating multiple scans improves the overall performance of stem mapping in terms of the correctness of tree detection, as well as the bias and the root-mean-square errors of forest attributes such as diameter at breast height and tree height. In addition, the automated processing method makes stem mapping more reliable and consistent among plots, reduces the costs associated with plot-based stem mapping, and enhances the efficiency. (C) 2016 The Authors. Published by Elsevier B.V.
  • Cheng, Lu; Walker, Alan W.; Corander, Jukka (2012)
  • Ylikauma, Laura Anneli; Ohtonen, Pasi Petteri; Erkinaro, Tiina Mari; Vakkala, Merja Annika; Liisanantti, Janne Henrik; Satta, Jari Uolevi; Juvonen, Tatu Sakari; Kaakinen, Timo Ilari (2022)
    The pulmonary artery catheter (PAC) is considered the gold standard for cardiac index monitoring. Recently new and less invasive methods to assess cardiac performance have been developed. The aim of our study was to assess the reliability of a non-invasive monitor utilizing bioreactance (Starling SV) and a non-calibrated mini-invasive pulse contour device (FloTrac/EV1000, fourth-generation software) compared to bolus thermodilution technique with PAC (TDCO) during off-pump coronary artery bypass surgery (OPCAB). In this prospective study, 579 simultaneous intra- and postoperative cardiac index measurements obtained with Starling SV, FloTrac/EV1000 and TDCO were compared in 20 patients undergoing OPCAB. The agreement of data was investigated by Bland-Altman plots, while trending ability was assessed by four-quadrant plots with error grids. In comparison with TDCO, Starling SV was associated with a bias of 0.13 L min(-1) m(-2) (95% confidence interval, 95% CI, 0.07 to 0.18), wide limits of agreement (LOA, - 1.23 to 1.51 L min(-1) m(-2)), a percentage error (PE) of 60.7%, and poor trending ability. In comparison with TDCO, FloTrac was associated with a bias of 0.01 L min(-1) m(-2) (95% CI - 0.05 to 0.06), wide LOA (- 1.27 to 1.29 L min(-1) m(-2)), a PE of 56.8% and poor trending ability. Both Starling SV and fourth-generation FloTrac showed acceptable mean bias but imprecision due to wide LOA and high PE, and poor trending ability. These findings indicate limited reliability in monitoring cardiac index in patients undergoing OPCAB.
  • Niinikoski, Laura; Hukkinen, Katja; Leidenius, Marjut H. K.; Ståhls, Anders; Meretoja, Tuomo J. (2018)
    Objectives: This study aims to evaluate the feasibility of Breast Lesion Excision System (BLES) in the treatment of intraductal papillomas. Material and methods: All patients with a needle biopsy-based suspicion of an intraductal papilloma who consequently underwent a BLES procedure at Helsinki University Hospital between 2011 and 2016 were included in this retrospective study. The purpose of the BLES procedure was either to excise the entire lesion or in few cases to achieve better sampling. Results: In total, 74 patients underwent 80 BLES procedures. Pathological diagnosis after the BLES biopsy confirmed an intraductal papilloma without atypia in 43 lesions, whereas 10 lesions were upgraded to high-risk lesions (HRL) with either atypical ductal hyperplasia or lobular carcinoma in situ. Five cases were upgraded to malignancy, two were invasive ductal carcinomas and three were ductal carcinoma in situ. Additionally, 18 lesions were diagnosed as other benign lesions. Four procedures failed. Complete excision with BLES was achieved in 19 out of 43 intraductal papillomas, 6 out of 10 HRL and two out of five malignant lesions. No major complications occurred. The BLES procedure was adequate in the management of the 71 breast lesions. Conclusion: The BLES procedure is an acceptable method for the management of small benign and high-risk breast lesions such as intraductal papillomas in selected patients. Thus, a great amount of diagnostic surgical biopsies can be avoided. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
  • Olafsson, Anton Stahl; Purves, Ross S.; Wartmann, Flurina M.; -Martin, Maria Garcia; Fagerholm, Nora; Torralba, Mario; Albert, Christian; Verbrugge, Laura N. H.; Heikinheimo, Vuokko; Plieninger, Tobias; Bieling, Claudia; Kaaronen, Roope; Hartmann, Maximilian; Raymond, Christopher M. (2022)
  • Olafsson, Anton Stahl; Purves, Ross S.; Wartmann, Flurina M.; -Martin, Maria Garcia; Fagerholm, Nora; Torralba, Mario; Albert, Christian; Verbrugge, Laura N. H.; Heikinheimo, Vuokko; Plieninger, Tobias; Bieling, Claudia; Kaaronen, Roope; Hartmann, Maximilian; Raymond, Christopher M. (2022)
  • Suojanen, Juho; Järvinen, Sanna; Kotaniemi, Karoliina V. M.; Reunanen, Justus; Palotie, Tuula; Stoor, Patricia; Leikola, Junnu (2018)
    Individually designed osteotomies and milled or printed patient-specific osteosynthesis materials are rapidly becoming a standard in maxillofacial reconstructive surgery. The benefits of using patient-specific implants (PSIs) in orthognathic surgery are especially clear in complex cases, and for this reason they are rapidly becoming common practice. We have earlier reported the benefits related to the use of PSIs as reposition and fixation system in Le Fort I osteotomy. The aim of this study was to compare complications associated with fixation with PSIs (31 patients) versus conventional mini-plates (37 patients) in Le Fort I osteotomy. No statistically significant differences in infection, reoperations or soft tissue problems were observed between the two systems used. Interestingly, three of the 37 patients in the mini-plate group underwent reoperation due to insufficient advancement or malocclusion, whereas none of the patients in the PSI group needed reoperation. In conclusion, PSIs are reliable for use in orthognathic surgery, with no signs of infection associated complications. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • Kotaniemi, Karoliina V. M.; Heliövaara, Arja; Kotaniemi, Miika; Stoor, Patricia; Leikola, Junnu; Palotie, Tuula; Suojanen, Juho (2019)
    Background: Three-dimensionally (3D) designed osteotomies and customised osteosynthesis are rapidly becoming standard in maxillofacial reconstructive and deformity surgery. Patient-specific implants (PSIs) have been in use for a few years in orthognathic surgery as well. In Le Fort I osteotomy, wafer-free fixation of the maxillary segment can be performed by individually manufactured cutting and drill guides together with PSIs. Aim: This retrospective study was performed to compare the postoperative skeletal stability of the maxillary segment fixed by patient-specific implants versus mini-plates after Le Fort I osteotomy. Patients: Fifty-one patients were divided into subgroups according to the fixation method and the advancement of the sub-spinal point. The postoperative skeletal stability of the maxillary segment was evaluated from lateral cephalometric radiographs one year postoperatively. Results: No statistically significant differences were found between the postoperative skeletal stability of the PSI and mini-plate fixed maxillae. Prospective studies, possibly with 3D fusion analysis, are warranted to confirm the results. Conclusion: The choice between the two fixation methods does not seem to affect the postoperative skeletal stability of the maxillary segments. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • Lauronen, Sirkka-Liisa; Kalliomäki, Maija-Liisa; Kalliovalkama, Jarkko; Aho, Antti; Huhtala, Heini; Yli-Hankala, Arvi M.; Mäkinen, Marja-Tellervo (2022)
    Because of the difficulties involved in the invasive monitoring of conscious patients, core temperature monitoring is frequently neglected during neuraxial anaesthesia. Zero heat flux (ZHF) and double sensor (DS) are non-invasive methods that measure core temperature from the forehead skin. Here, we compare these methods in patients under spinal anaesthesia. Sixty patients scheduled for elective unilateral knee arthroplasty were recruited and divided into two groups. Of these, thirty patients were fitted with bilateral ZHF sensors (ZHF group), and thirty patients were fitted with both a ZHF sensor and a DS sensor (DS group). Temperatures were saved at 5-min intervals from the beginning of prewarming up to one hour postoperatively. Bland-Altman analysis for repeated measurements was performed and a proportion of differences within 0.5 degrees C was calculated as well as Lin`s concordance correlation coefficient (LCCC). A total of 1261 and 1129 measurement pairs were obtained. The mean difference between ZHF sensors was 0.05 degrees C with 95% limits of agreement - 0.36 to 0.47 degrees C, 99% of the readings were within 0.5 degrees C and LCCC was 0.88. The mean difference between ZHF and DS sensors was 0.33 degrees C with 95% limits of agreement - 0.55 to 1.21 degrees C, 66% of readings were within 0.5 degrees C and LCCC was 0.59. Bilaterally measured ZHF temperatures were almost identical. DS temperatures were mostly lower than ZHF temperatures. The mean difference between ZHF and DS temperatures increased when the core temperature decreased. Trial registration: The study was registered in ClinicalTrials.gov on 13th May 2019, Code NCT03408197.
  • White, Joanne C.; Saarinen, Ninni; Kankare, Ville; Wulder, Michael A.; Hermosilla, Txomin; Coops, Nicholas C.; Pickell, Paul D.; Holopainen, Markus; Hyyppä, Juha; Vastaranta, Mikko (2018)
    Landsat time series (LTS) enable the characterization of forest recovery post-disturbance over large areas; however, there is a gap in our current knowledge concerning the linkage between spectral measures of recovery derived from LTS and actual manifestations of forest structure in regenerating stands. Airborne laser scanning (ALS) data provide useful measures of forest structure that can be used to corroborate spectral measures of forest recovery. The objective of this study was to evaluate the utility of a spectral index of recovery based on the Normalized Burn Ratio (NBR): the years to recovery, or Y2R metric, as an indicator of the return of forest vegetation following forest harvest (clearcutting). The Y2R metric has previously been defined as the number of years required for a pixel to return to 80% of its pre-disturbance NBR (NBRpre) value. In this study, the Composite2Change (C2C) algorithm was used to generate a time series of gap-free, cloud-free Landsat surface reflectance composites (1985–2012), associated change metrics, and a spatially-explicit dataset of detected changes for an actively managed forest area in southern Finland (5.3 Mha). The overall accuracy of change detection, determined using independent validation data, was 89%. Areas of forest harvesting in 1991 were then used to evaluate the Y2R metric. Four alternative recovery scenarios were evaluated, representing variations in the spectral threshold used to define Y2R: 60%, 80%, and 100% of NBRpre, and a critical value of z (i.e. the year in which the pixel's NBR value is no longer significantly different from NBRpre). The Y2R for each scenario were classified into five groups: recovery within 17 years, and not recovered. Measures of forest structure (canopy height and cover) were obtained from ALS data. Benchmarks for height (>5 m) and canopy cover (>10%) were applied to each recovery scenario, and the percentage of pixels that attained both of these benchmarks for each recovery group, was determined for each Y2R scenario. Our results indicated that the Y2R metric using the 80% threshold provided the most realistic assessment of forest recovery: all pixels considered in our analysis were spectrally recovered within the analysis period, with 88.88% of recovered pixels attaining the benchmarks for both cover and height. Moreover, false positives (pixels that had recovered spectrally, but not structurally) and false negatives (pixels that had recovered structurally, but not spectrally) were minimized with the 80% threshold. This research demonstrates the efficacy of LTS-derived assessments of recovery, which can be spatially exhaustive and retrospective, providing important baseline data for forest monitoring.
  • Liimatainen, K.; Carteret, X.; Dima, B.; Kytovuori, I.; Bidaud, A.; Reumaux, P.; Niskanen, T.; Ammirati, J. F.; Bellanger, J-M. (2017)
    Cortinarius is the largest genus of ectomycorrhizal fungi worldwide. Recent molecular studies have shown high levels of morphological homoplasy within the genus. Importantly, DNA phylogenies can reveal characteristics that have been either over- or underemphasized in taxonomic studies. Here we sequenced and phylogenetically analysed a large set of pan-European and North American collections taxonomically studied and placed in Cortinarius sect. Bicolores and sect. Saturnini, according to traditional morpho-anatomical criteria. Our goal was to circumscribe the evolutionary boundaries of the two sections, to stabilize both the limits and nomenclature of relevant species, and to identify described taxa which, according to our current understanding, belong to other lineages. Our analysis resolves two clades: /Bicolores, including 12 species, one of which is new to science, and /Saturnini, including 6 species. Fifteen binomials, traditionally treated in these two sections based on morphology, do not belong to the above two phylogenetic clades. Instead, six of these latter are clearly placed in other clades that represent sect. Bovini, sect. Sciophylli, sect. Duracini and sect. Brunneotincti. The presence or absence of blue pigments and the detection of specific odours emerge as clearly misleading taxonomic features, but more surprisingly, spore size and ecology can be misleading as well. A total of 63 type specimens were sequenced, 4 neotypes and 2 epitypes are proposed here, and 1 new combination is made.
  • Miettinen, Jukka; Carlier, Simon; Häme, Lauri; Mäkelä, Annikki; Minunno, Francesco; Penttilä, Juho; Pisl, Jan; Rasinmäki, Jussi; Rauste, Yrjo; Seitsonen, Lauri; Tian, Xianglin; Häme, Tuomas (2021)
    Forest biomass and carbon monitoring play a key role in climate change mitigation. Operational large area monitoring approaches are needed to enable forestry stakeholders to meet the increasing monitoring and reporting requirements. Here, we demonstrate the functionality of a cloud-based approach utilizing Sentinel-2 composite imagery and process-based ecosystem model to produce large area forest volume and primary production estimates. We describe the main components of the approach and implementation of the processing pipeline into the Forestry TEP cloud processing platform and produce four large area output maps: (1) Growing stock volume (GSV), (2) Gross primary productivity (GPP), (3) Net primary productivity (NPP) and (4) Stem volume increment (SVI), covering Finland and the Russian boreal forests until the Ural Mountains in 10 m spatial resolution. The accuracy of the forest structural variables evaluated in Finland reach pixel level relative Root Mean Square Error (RMSE) values comparable to earlier studies (basal area 39.4%, growing stock volume 58.5%, diameter 35.5% and height 33.5%), although most of the earlier studies have concentrated on smaller study areas. This can be considered a positive sign for the feasibility of the approach for large area primary production modelling, since forest structural variables are the main input for the process-based ecosystem model used in the study. The full coverage output maps show consistent quality throughout the target area, with major regional variations clearly visible, and with noticeable fine details when zoomed into full resolution. The demonstration conducted in this study lays foundation for further development of an operational large area forest monitoring system that allows annual reporting of forest biomass and carbon balance from forest stand level to regional analyses. The system is seamlessly aligned with process based ecosystem modelling, enabling forecasting and future scenario simulation.
  • Metsäniitty, Mari; Waltimo-Siren, Janna; Ranta, Helena; Fieuws, Steffen; Thevissen, Patrick (2019)
    Estimation of an individual's age has important applications in forensics. In young individuals, it often relies on separate evaluations of permanent teeth (PT) and third molars (TM) development. Here, we analysed the age prediction performance of combined information from PT and TM in an unusual sample of healthy Somalis, born and living in Finland. PT development was staged according to Demirjian et al. (Hum Biol, 1973) and TM development according to Kohler et al. (Ann Anat, 1994), using panoramic radiographs from 803 subjects (397 males, 406 females) aged 3-23years. A sex-specific Bayesian age-estimation model for the multivariate distribution of the stages conditional on age was fitted on PT, TM and PT and TM combined. The age-estimation performances were validated and quantified. The approach combining PT and TM only overestimated age with an ME of -0.031years in males and -0.011years in females, indicating the best age prediction performance.
  • Metsäniitty, Mari; Waltimo-Siren, Janna; Ranta, Helena; Fieuws, Steffen; Thevissen, Patrick (2018)
    AimThe aim of the current study was to retrospectively collect dental panoramic radiographs from Somali children living in Finland, to use the radiographic data to develop a new age estimation model based on the model established by Willems et al. (J Forensic Sci 46(4):893-895, 2001), and to compare the age prediction performances of the Willems et al. model (WM) and the newly developed model.Material and methodsDental panoramic radiographs from 808 healthy Somalis born in Finland were selected. The development of the seven left mandibular permanent teeth, from the central incisor to the second molar, was staged according to Demirjian et al. (Hum Biol 45(2):211-227, 1973). Radiographs with all listed permanent teeth completely developed were excluded. The studied sample consisted of 635 subjects (311 females, 324 males) ranging in age from 4 to 18years. Kappa and weighted Kappa statistics were used to quantify intra- and inter-observer agreement in stage allocation. The collected dataset was used to validate the WM, constructed on a Belgian Caucasian reference sample, and to establish a Somali-specific age estimation model (SM) based on the WM. Both models were validated and their age prediction performances quantified using mean error (ME), mean absolute error (MAE) and root mean squared error (RMSE).ResultsThe SM resulted in a slight underestimation of age when the sex groups were analysed separately or combined, with ME varying between 0.04 (standard deviation (SD) 1.01) and 0.05 (SD 1.04) years, MAE between 0.77 and 0.80years and RMSE between 1.01 and 1.04years. The WM statistically significantly underestimated the age of females, with an ME of 0.20 (SD 1.01) years (p=0.0006). For males, and for females and males combined, no statistically significant ME was observed.ConclusionThe WM and SM were similar in their age prediction performances, and the use of the WM in dental age assessment in the Somali population is justified.
  • Masika, Moses Muia; Korhonen, Essi M.; Smura, Teemu; Uusitalo, Ruut; Vapalahti, Katariina; Mwaengo, Dufton; Jääskeläinen, Anne J.; Anzala, Omu; Vapalahti, Olli; Huhtamo, Eili (2020)
    Dengue virus (DENV) has caused recent outbreaks in coastal cities of Kenya, but the epidemiological situation in other areas of Kenya is largely unknown. We investigated the role of DENV infection as a cause of acute febrile disease in non-epidemic settings in rural and urban study areas in Kenya. Altogether, 560 patients were sampled in 2016-2017 in rural Taita-Taveta County (n = 327) and urban slums of Kibera, Nairobi (n = 233). The samples were studied for DENV IgM, IgG, NS1 antigen and flaviviral RNA. IgG seroprevalence was found to be higher in Taita-Taveta (14%) than in Nairobi (3%). Five Taita-Taveta patients were positive for flaviviral RNA, all identified as DENV-2, cosmopolitan genotype. Local transmission in Taita-Taveta was suspected in a patient without travel history. The sequence analysis suggested that DENV-2 strains circulating in coastal and southern Kenya likely arose from a single introduction from India. The molecular clock analyses dated the most recent ancestor to the Kenyan strains a year before the large 2013 outbreak in Mombasa. After this, the virus has been detected in Kilifi in 2014, from our patients in Taita-Taveta in 2016, and in an outbreak in Malindi in 2017. The results highlight that silent transmission occurs between epidemics and also affects rural areas. More information is needed to understand the local epidemiological characteristics and future risks of dengue in Kenya. Author summary Dengue virus (DENV) is an emerging mosquito-borne global health threat in the tropics and subtropics. The majority of the world's population live in areas at risk of dengue that can cause a wide variety of symptoms from febrile illness to haemorrhagic fever. Information of DENV in Africa is limited and fragmented. In Kenya, dengue is a recognized disease in coastal cities that have experienced recent outbreaks. We investigated the role of DENV infection as a cause of acute febrile disease in non-epidemic settings in rural and urban study areas in Kenya. We found DENV-2 in five febrile patients from rural Taita-Taveta, where no dengue has been reported before. Genetic analysis of the virus suggests it to be most likely of Indian origin. This Indian origin DENV-2 was detected in the Mombasa outbreak in 2013, in Kilifi in 2014, in Taita-Taveta in 2016 (our study samples) and again in the Malindi outbreak in 2017. The results suggest that dengue is unrecognized in rural Kenya and more studies are needed for local risk assessment. Our findings of virus transmission between epidemics contribute to better understanding of the epidemiological situation and origins of DENV in Kenya.