Browsing by Subject "Apical periodontitis"

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  • Virtanen, Eunice; Nurmi, Tapio; Soder, Per-Osten; Airila-Mansson, Stella; Soder, Birgitta; Meurman, Jukka H. (2017)
    Background: Periodontal disease associates with systemic diseases but corresponding links regarding apical periodontitis (AP) are not so clear. Hence our aim was to study association between AP and the prevalence of systemic diseases in a study population from Sweden. Methods: The subjects were 150 patients from a randomly selected epidemiological sample of 1676 individuals. 120 accepted to participate and their basic and clinical examination data were available for these secondary analyses where dental radiographs were used to record signs for endodontic treatments and AP. Periapical Index and modified Total Dental Index scores were calculated from the x-rays to classify the severity of AP and dental infection burden, respectively. Demographic and hospital record data were collected from the Swedish National Statistics Center. T-test, chi-square and univariate analysis of covariance (ANCOVA) and regressions analyses were used for statistics. Results: Of the 120 patients 41% had AP and 61% had received endodontic treatments of which 52% were radiographically unsatisfactory. AP patients were older and half of them were smokers. AP and periodontitis often appeared in the same patient (32.5%). From all hospital diagnoses, cardiovascular diseases (CVD) were most common, showing 20.4% prevalence in AP patients. Regression analyses, controlled for age, gender, income, smoking and periodontitis, showed AP to associate with CVD with odds ratio 3.83 (95% confidence interval 1.18-12.40; p = 0.025). Conclusions: The results confirmed our hypothesis by showing that AP statistically associated with cardiovascular diseases. The finding that subjects with AP also often had periodontitis indicates an increased oral inflammatory burden.
  • Virtanen, Eunice; Nurmi, Tapio; Söder, Per-Östen; Airila-Månsson, Stella; Söder, Birgitta; Meurman, Jukka H. (BioMed Central, 2017)
    Abstract Background Periodontal disease associates with systemic diseases but corresponding links regarding apical periodontitis (AP) are not so clear. Hence our aim was to study association between AP and the prevalence of systemic diseases in a study population from Sweden. Methods The subjects were 150 patients from a randomly selected epidemiological sample of 1676 individuals. 120 accepted to participate and their basic and clinical examination data were available for these secondary analyses where dental radiographs were used to record signs for endodontic treatments and AP. Periapical Index and modified Total Dental Index scores were calculated from the x-rays to classify the severity of AP and dental infection burden, respectively. Demographic and hospital record data were collected from the Swedish National Statistics Center. T-test, chi-square and univariate analysis of covariance (ANCOVA) and regressions analyses were used for statistics. Results Of the 120 patients 41% had AP and 61% had received endodontic treatments of which 52% were radiographically unsatisfactory. AP patients were older and half of them were smokers. AP and periodontitis often appeared in the same patient (32.5%). From all hospital diagnoses, cardiovascular diseases (CVD) were most common, showing 20.4% prevalence in AP patients. Regression analyses, controlled for age, gender, income, smoking and periodontitis, showed AP to associate with CVD with odds ratio 3.83 (95% confidence interval 1.18–12.40; p = 0.025). Conclusions The results confirmed our hypothesis by showing that AP statistically associated with cardiovascular diseases. The finding that subjects with AP also often had periodontitis indicates an increased oral inflammatory burden.
  • Syrjä, Maija (Helsingin yliopisto, 2018)
    Hampaiden reikiintyminen eli karies on yleisin suun sairaus ja yksi merkittävimmistä kansanterveysongelmista Suomessa. Karies on hampaiden kovakudoksia vaurioittava infektiosairaus, jonka ilmaantuvuus ja laajuus riippuvat suun mikrobistosta, ravinnosta, hammaskudoksen ominaisuuksista, syljen määrästä sekä ajasta, jonka hampaan pinta on pitkäikäisen biofilmin peittämänä. Yleisimmin karieksen syntyyn yhdistetään happoja sietävät mutans- ja sobrinus-streptokokit yhdessä laktobasillien kanssa. Apikaaliparodontiitti on tulehdusreaktio hampaan juurenkärjen eli apexin ympärillä alveoliluun alueella. Terveessä tilanteessa hampaan pulpa sekä apikaalinen parodontium ovat steriilejä, mutta pulpan infektoituessa pitkälle edenneen karieksen, hammastrauman tai parodontiitin vuoksi syntyy puolustusreaktio, jolla pyritään rajaamaan hammasytimeen edennyt mikrobi-infektio juurikanavasysteemiin ja estämään sen leviäminen muualle elimistöön. Apikaalinen parodontiitti on käytännössä aina juurikanavaan päässeiden bakteereiden aiheuttama. Bakteerit ovat lähes poikkeuksetta peräisin suuontelosta. Tämän kirjallisuuskatsauksena toteutettavan tutkielman tavoitteena on selvittää jo tehtyjen tutkimusten avulla karieksen ja apikaaliparodontiitin geneettisiä taustoja, ja mikä on perimän osuus kyseisten sairauksien riskitekijänä. Tutkielmassa käydään myös läpi myös karieksen ja apikaaliparodontiitn patogeneesi ja yleisimmät hoitokäytännöt. Tässä tutkielmassa esitettyjen tutkimustulosten perusteella voidaan todeta, että perimällä on selvä osuus karieksen ja apikaaliparodontiitin riskitekijänä . Karieksen periytyvyyttä käsittelevissä tutkimuksissa perimän osuudeksi karieksen synnyssä on saatu jopa 30%, mutta yksittäistenkin tutkimusten perusteella voidaan siis sanoa, että geeneillä on vaikutusta sekä karieksen että apikaaliparodontiitin ilmaantuvuuteen. Lisätutkimuksia kuitenkin vaaditaan, sillä karieksen ja apikaaliparodontiitin etiologiset tekijät ovat monimuotoiset.