Browsing by Subject "CHOLECYSTECTOMY"

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  • Siiki, Antti; Rinta-Kiikka, Irina; Sand, Juhani; Laukkarinen, Johanna (2018)
    Background and Aims: Self-expanding biodegradable biliary stents (BDBSs) have recently become available for use in endoscopic retrograde cholangiography (ERC). The aim was to evaluate the effectiveness and safety of novel BDBSs in iatrogenic cystic duct leaks and benign biliary strictures (BBSs). Methods: Patients providing informed consent were recruited for the prospective study. Braided self-expanding poly-dioxanone BDBSs were inserted using ERC during from 2014 to 2016. Repeated liver function tests and magnetic resonance imaging were performed during follow-up. The main outcomes were treatment success and adverse events. Results: Thirteen patients, 5 women, median age 67 years (range, 43-79) underwent BDBS insertion for iatrogenic cystic duct leak (n = 7) or BBS (n = 6). Stent insertion using ERC was successful in all cases. All bile leaks were treated uneventfully with BDBSs. In BBSs, the clinical success rate of BDBS therapy was 83% in a median of 21 months of follow-up (range, 14-25). Early ERC-related adverse events included 1 cholangitis (8%) and 1 pancreatitis (8%), both in the stricture group. During the first 90 days, 23% of patients were readmitted for mild cholangitis. Conclusions: The short-and long-term safety of endoscopically inserted poly-dioxanone BDBSs was satisfactory. The management of cystic duct leaks and benign distal common bile duct strictures was highly successful. Episodes of mild cholangitis during stent indwelling seemed to be typical of BDBSs. The advantage of BDBSs is the avoidance of repeated endoscopy for stent removal. (Clinical trial registration number: NCT02353286.)
  • Sartelli, Massimo; Catena, Fausto; Ansaloni, Luca; Coccolini, Federico; Corbella, Davide; Moore, Ernest E.; Malangoni, Mark; Velmahos, George; Coimbra, Raul; Koike, Kaoru; Leppaniemi, Ari; Biffl, Walter; Balogh, Zsolt; Bendinelli, Cino; Gupta, Sanjay; Kluger, Yoram; Agresta, Ferdinando; Di Saverio, Salomone; Tugnoli, Gregorio; Jovine, Elio; Ordonez, Carlos A.; Whelan, James F.; Fraga, Gustavo P.; Gomes, Carlos Augusto; Pereira Junior, Gerson Alves; Yuan, Kuo-Ching; Bala, Miklosh; Peev, Miroslav P.; Ben-Ishay, Offir; Cui, Yunfeng; Marwah, Sanjay; Zachariah, Sanoop; Wani, Imtiaz; Rangarajan, Muthukumaran; Sakakushev, Boris; Kong, Victor; Ahmed, Adamu; Abbas, Ashraf; Teixeira Gonsaga, Ricardo Alessandro; Guercioni, Gianluca; Vettoretto, Nereo; Poiasina, Elia; Diaz-Nieto, Rafael; Massalou, Damien; Skrovina, Matej; Gerych, Ihor; Augustin, Goran; Kenig, Jakub; Khokha, Vladimir; Trana, Cristian; Kok, Kenneth Yuh Yen; Mefire, Alain Chichom; Lee, Jae Gil; Hong, Suk-Kyung; Lohse, Helmut Alfredo Segovia; Ghnnam, Wagih; Verni, Alfredo; Lohsiriwat, Varut; Siribumrungwong, Boonying; El Zalabany, Tamer; Tavares, Alberto; Baiocchi, Gianluca; Das, Koray; Jarry, Julien; Zida, Maurice; Sato, Norio; Murata, Kiyoshi; Shoko, Tomohisa; Irahara, Takayuki; Hamedelneel, Ahmed O.; Naidoo, Noel; Adesunkanmi, Abdul Rashid Kayode; Kobe, Yoshiro; Ishii, Wataru; Oka, Kazuyuki; Izawa, Yoshimitsu; Hamid, Hytham; Khan, Iqbal; Attri, A. K.; Sharma, Rajeev; Sanjuan, Juan; Badiel, Marisol; Barnabe, Rita (2014)
  • Kakela, Pirjo; Mannisto, Ville; Ilves, Imre; Vaittinen, Maija; Tauriainen, Milla-Maria; Eskelinen, Matti; Gylling, Helena; Paajanen, Hannu; Pihlajamaki, Jussi (2017)
    Gallstone disease (GD) has been associated with low serum levels of plant sterols. We evaluated the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and non-alcoholic fatty liver disease (NAFLD) on the association of GD with low levels of serum plant sterols. Two hundred forty-two consecutive morbidly obese patients were recruited to this prospective study. Histological analysis of liver biopsy to diagnose NAFLD was performed. Bile sample was taken during the LRYGB. Associations of GD with serum non-cholesterol sterol to cholesterol ratios, measured using gas liquid chromatography and with mRNA expression of genes participating in the cholesterol, bile, and fatty acid metabolism in the liver, were analyzed. Out of the 242 participants, 95 had GD. Lower weight (p = 0.002) and female sex (p = 0.0006) were associated with GD. Serum plant sterols, campesterol (p = 0.003), sitosterol (p = 0.002), and avenasterol (p = 0.015), were lower in patients with GD compared to those without GD. This association remained significant after adjustment for NAFLD, use of statin medication, and previous laparoscopic cholecystectomy (LCC). Levels of sitosterol (p = 0.001) and campesterol (p = 0.001) remained lower in obese individuals with GD also after obesity surgery. Liver mRNA expression of genes regulating cholesterol synthesis and bile metabolism was increased in individuals with GD. Serum plant sterols were lower in patients with GD independent of NAFLD, history of LCC, use of statin medication, and weight loss after LRYGB. Low serum plant sterols in patients with GD suggest potentially inherited alterations in sterol absorption and biliary transport in subjects susceptible for GD.