Browsing by Subject "EASTERN"

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  • Reusken, Chantal; Boonstra, Marrit; Rugebregt, Sharona; Scherbeijn, Sandra; Chandler, Felicity; Avsic-Zupanc, Tatjana; Vapalahti, Olli; Koopmans, Marion; GeurtsvanKessel, Corine H. (2019)
    Background: Tick-borne encephalitis (TBE) is an infectious disease endemic to large parts of Europe and Asia. Diagnosing TBE often relies on the detection of TBEV-specific antibodies in serum and cerebrospinal fluid (CSF) as viral genome is mostly not detectable once neurological symptoms occur. Objectives: We evaluated the performance of TBEV IgM and IgG ELISAs in both serum and CSF of confirmed TBEV patients and discuss the role of (CSF) serology in TBEV diagnostics. Study design: For the assay evaluation we collected specimen from confirmed TBEV patients. Assay specificity was assessed using sera from patients with a related flavivirus infection or other acute infection. A selected ELISA assay was used to analyze TBEV-specific antibodies in CSF and to evaluate the use in confirming TBE diagnosis. Results: In this study the overall sensitivity of the IgM TBEV ELISAs was acceptable (94-100 %). Four out of five IgM ELISA's demonstrated an excellent overall specificity from 94-100% whereas a low overall specificity was observed for the IgG TBEV ELISAs (30-71%). Intrathecal antibody production against TBEV was demonstrated in a subset of TBE patients. Conclusions: In four out of five ELISAs, IgM testing in serum and CSF of TBE patients is specific and confirmative. The lack of IgG specificity in all ELISAs emphasizes the need of confirmatory testing by virus neutralisation, depending on the patient's background and the geographic location of exposure to TBEV. A CSF-serum IgG antibody index can support the diagnosis specifically in chronic disease or once IgM has disappeared.
  • Caprara, Gian Vittorio; Vecchione, Michele; Schwartz, Shalom H.; Schoen, Harald; Bain, Paul G.; Silvester, Jo; Cieciuch, Jan; Pavlopoulos, Vassilis; Bianchi, Gabriel; Kirmanoglu, Hasan; Baslevent, Cem; Mamali, Catalin; Manzi, Jorge; Katayama, Miyuki; Posnova, Tetyana; Tabernero, Carmen; Torres, Claudio; Verkasalo, Markku; Lonnqvist, Jan-Erik; Vondrakova, Eva; Giovanna Caprara, Maria (2017)
    The current study examines the contribution of left-right (or liberal-conservative) ideology to voting, as well as the extent to which basic values account for ideological orientation. Analyses were conducted in 16 countries from five continents (Europe, North America, South America, Asia, and Oceania), most of which have been neglected by previous studies. Results showed that left-right (or liberal-conservative) ideology predicted voting in all countries except Ukraine. Basic values exerted a considerable effect in predicting ideology in most countries, especially in established democracies such as Australia, Finland, Italy, United Kingdom, and Germany. Pattern of relations with the whole set of 10 values revealed that the critical trade-off underlying ideology is between values concerned with tolerance and protection for the welfare of all people (universalism) versus values concerned with preserving the social order and status quo (security). A noteworthy exception was found in European postcommunist countries, where relations of values with ideology were small (Poland) or near to zero (Ukraine, Slovakia).
  • Ruuskanen, Miia; Irjala, Heikki; Minn, Heikki; Vahlberg, Tero; Randen-Brady, Reija; Hagström, Jaana; Syrjänen, Stina; Leivo, Ilmo (2019)
    Background Nasopharyngeal carcinoma (NPC) is related to Epstein-Barr virus (EBV) in endemic areas; however, the role of viruses in nonendemic countries is unclear. Our nationwide study investigated the prevalence and prognostic significance of EBV and human papillomaviruses (HPVs) in Finnish NPC tumors. Methods We analyzed samples from 150 patients diagnosed between 1990 and 2009. Viral status was determined using EBV and HPV RNA in situ hybridizations, and p16 immunohistochemistry. Patient and treatment characteristics were obtained from patient records. Results In our white patient cohort, 93 of 150 (62%) patients were EBV-positive and 21/150 (14%) patients were HPV-positive with no coinfections. Thirty-six (24%) tumors were negative for both viruses. The 5-year disease-specific survival for patients with EBV-positive, HPV-positive, and EBV/HPV-negative tumors was 69%, 63%, and 39%, respectively. In multivariable-adjusted analysis, overall survival was better among patients with EBV-positive (P = .005) and HPV-positive (P = .03) tumors compared to patients with EBV/HPV-negative tumors. Conclusions In our low-incidence population, EBV and HPV are important prognostic factors for NPC.
  • Matilainen, Anne-Maria Kristiina; Koch, Marc; Zivojinovic, Ivana; Lähdesmäki, Merja Riitta; Lidestav, Gun; Karppinen, Heimo Markku Timo; Didolot, Francois; Jarsky, Vilem; Põllumäe, Priit; Colson, Vincent; Hricova, Zuzana; Glavonjic, Predrag; Scriban, Ramona (2019)
    Private forest owners possess a major part of Europe's forests. Therefore, their behaviour plays a significant role in the development and management of European forest resources. At the same time, forest owners' values and objectives are becoming more versatile. There is a need for further understanding of elements affecting forest owners' management behaviour. One aspect of potential impact is how forest ownership is perceived by the forest owners themselves. Understanding how they experience the ownership, especially on the psychological level, can provide new insights into forest owners' management behaviour and aid in planning better services to meet their needs. This paper aims to describe the new NIPF owners' perceptions of forest ownership by qualitative analyses drawn from 23 in-depth interviews covering different contextual settings in Europe. The theory of psychological ownership is used as a theoretical background. The aim is to examine, how psychological ownership is expressed and the ownership feelings are manifested in different forest owning contexts. The results illustrate what kind of ownership values new forest owners set for their forests and discuss how these affect their forest management behavior. At the same time the paper illustrate the potential of the social science approach in forest ownership research.