Browsing by Subject "EUROPEAN INNOVATION PARTNERSHIP"

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  • Mobile Airways Sentinel Network M; Bousquet, Jean; Hellings, Peter W.; Agache, Ioana; Haahtela, T.; Toppila-Salmi, S.; Kuitunen, M.; Valovirta, E.; Salimäki, Johanna; Vasankari, Tuula; Eklund, P.; Karjalainen, J.; Zuberbier, Torsten (2019)
    Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
  • Calderon, M. A.; Demoly, P.; Casale, T.; Akdis, C. A.; Bachert, C.; Bewick, M.; Bilo, B. M.; Bohle, B.; Bonini, S.; Bush, A.; Caimmi, D. P.; Canonica, G. W.; Cardona, V.; Chiriac, A. M.; Cox, L.; Custovic, A.; De Blay, F.; Devillier, P.; Didier, A.; Di Lorenzo, G.; Du Toit, G.; Durham, S. R.; Eng, P.; Fiocchi, A.; Fox, A. T.; van Wijk, R. Gerth; Gomez, R. M.; Haahtela, Tari Markku Kallevi; Halken, S.; Hellings, P. W.; Jacobsen, L.; Just, J.; Tanno, L. K.; Kleine-Tebbe, J.; Klimek, L.; Knol, E. F.; Kuna, P.; Larenas-Linnemann, D. E.; Linneberg, A.; Matricardi, M.; Malling, H. J.; Moesges, R.; Mullol, J.; Muraro, A.; Papadopoulos, N.; Passalacqua, G.; Pastorello, E.; Pfaar, O.; Price, D.; Rodriguez del Rio, P.; Rueff, R.; Samolinski, B.; Scadding, G. K.; Senti, G.; Shamji, M. H.; Sheikh, A.; Sisul, J. C.; Sole, D.; Sturm, G. J.; Tabar, A.; Van Ree, R.; Ventura, M. T.; Vidal, C.; Varga, E. M.; Worm, M.; Zuberbier, T.; Bousquet, J. (2016)
    Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Sante). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.
  • Bousquet, J.; Hellings, P. W.; Agache, I.; Bedbrook, A.; Bachert, C.; Bergmann, K. C.; Bewick, M.; Bindslev-Jensen, C.; Bosnic-Anticevitch, S.; Bucca, C.; Caimmi, D. P.; Camargos, P. A. M.; Canonica, G. W.; Casale, T.; Chavannes, N. H.; Cruz, A. A.; De Carlo, G.; Dahl, R.; Demoly, P.; Devillier, P.; Fonseca, J.; Fokkens, W. J.; Guldemond, N. A.; Haahtela, T.; Illario, M.; Just, J.; Keil, T.; Klimek, L.; Kuna, P.; Larenas-Linnemann, D.; Morais-Almeida, M.; Mullol, J.; Murray, R.; Naclerio, R.; O'Hehir, R. E.; Papadopoulos, N. G.; Pawankar, R.; Potter, P.; Ryan, D.; Samolinski, B.; Schunemann, H. J.; Sheikh, A.; Simons, F. E. R.; Stellato, C.; Todo-Bom, A.; Tomazic, P. V.; Valiulis, A.; Valovirta, E.; Ventura, M. T.; Wickman, M.; Young, I.; Yorgancioglu, A.; Zuberbier, T.; Aberer, W.; Akdis, C. A.; Akdis, M.; Annesi-Maesano, I.; Ankri, J.; Ansotegui, I. J.; Anto, J. M.; Arnavielhe, S.; Asarnoj, A.; Arshad, H.; Avolio, F.; Baiardini, I.; Barbara, C.; Barbagallo, M.; Bateman, E. D.; Beghe, B.; Bel, E. H.; Bennoor, K. S.; Benson, M.; Bialoszewski, A. Z.; Bieber, T.; Bjermer, L.; Blain, H.; Blasi, F.; Boner, A. L.; Bonini, M.; Bonini, S.; Bosse, I.; Bouchard, J.; Boulet, L. P.; Bourret, R.; Bousquet, P. J.; Braido, F.; Briggs, A. H.; Brightling, C. E.; Brozek, J.; Buhl, R.; Bunu, C.; Burte, E.; Bush, A.; Caballero-Fonseca, F.; Calderon, M. A.; Camuzat, T.; Cardona, V.; Carreiro-Martins, P.; Carriazo, A. M.; Carlsen, K. H.; Carr, W.; Cepeda Sarabia, A. M.; Cesari, M.; Chatzi, L.; Chiron, R.; Chivato, T.; Chkhartishvili, E.; Chuchalin, A. G.; Chung, K. F.; Ciprandi, G.; Correia de Sousa, J.; Cox, L.; Crooks, G.; Custovic, A.; Dahlen, S. E.; Darsow, U.; Dedeu, T.; Deleanu, D.; Denburg, J. A.; De Vries, G.; Didier, A.; Dinh-Xuan, A. T.; Dokic, D.; Douagui, H.; Dray, G.; Dubakiene, R.; Durham, S. R.; Du Toit, G.; Dykewicz, M. S.; Eklund, P.; El-Gamal, Y.; Ellers, E.; Emuzyte, R.; Farrell, J.; Wagner, A. Fink; Fiocchi, A.; Fletcher, M.; Forastiere, F.; Gaga, M.; Gamkrelidze, A.; Gemicioglu, B.; Gereda, J. E.; van Wick, R. Gerth; Gonzalez Diaz, S.; Grisle, I.; Grouse, L.; Gutter, Z.; Guzman, M. A.; Hellquist-Dahl, B.; Heinrich, J.; Horak, F.; Hourihane, J. O'. B.; Humbert, M.; Hyland, M.; Iaccarino, G.; Jares, E. J.; Jeandel, C.; Johnston, S. L.; Joos, G.; Jonquet, O.; Jung, K. S.; Jutel, M.; Kaidashev, I.; Khaitov, M.; Kalayci, O.; Kalyoncu, A. F.; Kardas, P.; Keith, P. K.; Kerkhof, M.; Kerstjens, H. A. M.; Khaltaev, N.; Kogevinas, M.; Kolek, V.; Koppelman, G. H.; Kowalski, M. L.; Kuitunen, M.; Kull, I.; Kvedariene, V.; Lambrecht, B.; Lau, S.; Laune, D.; Le, L. T. T.; Lieberman, P.; Lipworth, B.; Li, J.; Carlsen, K. C. Lodrup; Louis, R.; Lupinek, C.; MacNee, W.; Magar, Y.; Magnan, A.; Mahboub, B.; Maier, D.; Majer, I.; Malva, J.; Manning, P.; De Manuel Keenoy, E.; Marshall, G. D.; Masjedi, M. R.; Mathieu-Dupas, E.; Maurer, M.; Mavale-Manuel, S.; Melen, E.; Melo-Gomes, E.; Meltzer, E. O.; Mercier, J.; Merk, H.; Miculinic, N.; Mihaltan, F.; Milenkovic, B.; Millot-Keurinck, J.; Mohammad, Y.; Momas, I.; Mosges, R.; Muraro, A.; Namazova-Baranova, L.; Nadif, R.; Neffen, H.; Nekam, K.; Nieto, A.; Niggemann, B.; Nogueira-Silva, L.; Nogues, M.; Nyembue, T. D.; Ohta, K.; Okamoto, Y.; Okubo, K.; Olive-Elias, M.; Ouedraogo, S.; Paggiaro, P.; Pali-Schoell, I.; Palkonen, S.; Panzner, P.; Papi, A.; Park, H. S.; Passalacqua, G.; Pedersen, S.; Pereira, A. M.; Pfaar, O.; Picard, R.; Pigearias, B.; Pin, I.; Plavec, D.; Pohl, W.; Popov, T. A.; Portejoie, F.; Postma, D.; Poulsen, L. K.; Price, D.; Rabe, K. F.; Raciborski, F.; Roberts, G.; Robalo-Cordeiro, C.; Rodenas, F.; Rodriguez-Manas, L.; Rolland, C.; Roman Rodriguez, M.; Romano, A.; Rosado-Pinto, J.; Rosario, N.; Rottem, M.; Sanchez-Borges, M.; Sastre-Dominguez, J.; Scadding, G. K.; Scichilone, N.; Schmid-Grendelmeier, P.; Serrano, E.; Shields, M.; Siroux, V.; Sisul, J. C.; Skrindo, I.; Smit, H. A.; Sole, D.; Sooronbaev, T.; Spranger, O.; Stelmach, R.; Sterk, P. J.; Strandberg, T.; Sunyer, J.; Thijs, C.; Triggiani, M.; Valenta, R.; Valero, A.; van Eerd, M.; van Ganse, E.; van Hague, M.; Vandenplas, O.; Varona, L. L.; Vellas, B.; Vezzani, G.; Vazankari, T.; Viegi, G.; Vontetsianos, T.; Wagenmann, M.; Walker, S.; Wang, D. Y.; Wahn, U.; Werfel, T.; Whalley, B.; Williams, D. M.; Williams, S.; Wilson, N.; Wright, J.; Yawn, B. P.; Yiallouros, P. K.; Yusuf, O. M.; Zaidi, A.; Zar, H. J.; Zernotti, M. E.; Zhang, L.; Zhong, N.; Zidarn, M. (2016)
    The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.
  • Bousquet, Jean; Anto, Josep M.; Bachert, Claus; Haahtela, Tari; Zuberbier, Torsten; Czarlewski, Wienczyslawa; Bedbrook, Anna; Bosnic-Anticevich, Sinthia; Walter Canonica, G.; Cardona, Victoria; Costa, Elisio; Cruz, Alvaro A.; Erhola, Marina; Fokkens, Wytske J.; Fonseca, Joao A.; Illario, Maddalena; Ivancevich, Juan-Carlos; Jutel, Marek; Klimek, Ludger; Kuna, Piotr; Kvedariene, Violeta; Le, L. T. T.; Larenas-Linnemann, Desiree E.; Laune, Daniel; Lourenco, Olga M.; Melen, Erik; Mullol, Joaquim; Niedoszytko, Marek; Odemyr, Mikaela; Okamoto, Yoshitaka; Papadopoulos, Nikos G.; Patella, Vincenzo; Pfaar, Oliver; Pham-Thi, Nhan; Rolland, Christine; Samolinski, Boleslaw; Sheikh, Aziz; Sofiev, Mikhail; Suppli Ulrik, Charlotte; Todo-Bom, Ana; Tomazic, Peter-Valentin; Toppila-Salmi, Sanna; Tsiligianni, Ioanna; Valiulis, Arunas; Valovirta, Erkka; Ventura, Maria-Teresa; Walker, Samantha; Williams, Sian; Yorgancioglu, Arzu; Agache, Ioana; Akdis, Cezmi A.; Almeida, Rute; Ansotegui, Ignacio J.; Annesi-Maesano, Isabella; Arnavielhe, Sylvie; Basagana, Xavier; D. Bateman, Eric; Bedard, Annabelle; Bedolla-Barajas, Martin; Becker, Sven; Bennoor, Kazi S.; Benveniste, Samuel; Bergmann, Karl C.; Bewick, Michael; Bialek, Slawomir; E. Billo, Nils; Bindslev-Jensen, Carsten; Bjermer, Leif; Blain, Hubert; Bonini, Matteo; Bonniaud, Philippe; Bosse, Isabelle; Bouchard, Jacques; Boulet, Louis-Philippe; Bourret, Rodolphe; Boussery, Koen; Braido, Fluvio; Briedis, Vitalis; Briggs, Andrew; Brightling, Christopher E.; Brozek, Jan; Brusselle, Guy; Brussino, Luisa; Buhl, Roland; Buonaiuto, Roland; Calderon, Moises A.; Camargos, Paulo; Camuzat, Thierry; Caraballo, Luis; Carriazo, Ana-Maria; Carr, Warner; Cartier, Christine; Casale, Thomas; Cecchi, Lorenzo; Cepeda Sarabia, Alfonso M.; H. Chavannes, Niels; Chkhartishvili, Ekaterine; Chu, Derek K.; Cingi, Cemal; Correia de Sousa, Jaime; Costa, David J.; Courbis, Anne-Lise; Custovic, Adnan; Cvetkosvki, Biljana; D'Amato, Gennaro; da Silva, Jane; Dantas, Carina; Dokic, Dejan; Dauvilliers, Yves; De Feo, Giulia; De Vries, Govert; Devillier, Philippe; Di Capua, Stefania; Dray, Gerard; Dubakiene, Ruta; Durham, Stephen R.; Dykewicz, Marc; Ebisawa, Motohiro; Gaga, Mina; El-Gamal, Yehia; Heffler, Enrico; Emuzyte, Regina; Farrell, John; Fauquert, Jean-Luc; Fiocchi, Alessandro; Fink-Wagner, Antje; Fontaine, Jean-Francois; Fuentes Perez, Jose M.; Gemicioglu, Bilun; Gamkrelidze, Amiran; Garcia-Aymerich, Judith; Gevaert, Philippe; Gomez, Rene Maximiliano; Gonzalez Diaz, Sandra; Gotua, Maia; Guldemond, Nick A.; Guzman, Maria-Antonieta; Hajjam, Jawad; Huerta Villalobos, Yunuen R.; Humbert, Marc; Iaccarino, Guido; Ierodiakonou, Despo; Iinuma, Tomohisa; Jassem, Ewa; Joos, Guy; Jung, Ki-Suck; Kaidashev, Igor; Kalayci, Omer; Kardas, Przemyslaw; Keil, Thomas; Khaitov, Musa; Khaltaev, Nikolai; Kleine-Tebbe, Jorg; Kouznetsov, Rostislav; Kowalski, Marek L.; Kritikos, Vicky; Kull, Inger; La Grutta, Stefania; Leonardini, Lisa; Ljungberg, Henrik; Lieberman, Philip; Lipworth, Brian; Lodrup Carlsen, Karin C.; Lopes-Pereira, Catarina; Loureiro, Claudia C.; Louis, Renaud; Mair, Alpana; Mahboub, Bassam; Makris, Michael; Malva, Joao; Manning, Patrick; Marshall, Gailen D.; Masjedi, Mohamed R.; Maspero, Jorge F.; Carreiro-Martins, Pedro; Makela, Mika; Mathieu-Dupas, Eve; Maurer, Marcus; De Manuel Keenoy, Esteban; Melo-Gomes, Elisabete; Meltzer, Eli O.; Menditto, Enrica; Mercier, Jacques; Micheli, Yann; Miculinic, Neven; Mihaltan, Florin; Milenkovic, Branislava; Mitsias, Dimitirios I.; Moda, Giuliana; Mogica-Martinez, Maria-Dolores; Mohammad, Yousser; Montefort, Steve; Monti, Ricardo; Morais-Almeida, Mario; Mosges, Ralph; Munter, Lars; Muraro, Antonella; Murray, Ruth; Naclerio, Robert; Napoli, Luigi; Namazova-Baranova, Leyla; Neffen, Hugo; Nekam, Kristoff; Neou, Angelo; Nordlund, Bjorn; Novellino, Ettore; Nyembue, Dieudonne; O'Hehir, Robyn; Ohta, Ken; Okubo, Kimi; Onorato, Gabrielle L.; Orlando, Valentina; Ouedraogo, Solange; Palamarchuk, Julia; Pali-Scholl, Isabella; Panzner, Peter; Park, Hae-Sim; Passalacqua, Gianni; Pepin, Jean-Louis; Paulino, Ema; Pawankar, Ruby; Phillips, Jim; Picard, Robert; Pinnock, Hilary; Plavec, Davor; Popov, Todor A.; Portejoie, Fabienne; Price, David; Prokopakis, Emmanuel P.; Psarros, Fotis; Pugin, Benoit; Puggioni, Francesca; Quinones-Delgado, Pablo; Raciborski, Filip; Rajabian-Soderlund, Rojin; Regateiro, Frederico S.; Reitsma, Sietze; Rivero-Yeverino, Daniela; Roberts, Graham; Roche, Nicolas; Rodriguez-Zagal, Erendira; Rolland, Christine; Roller-Wirnsberger, Regina E.; Rosario, Nelson; Romano, Antonino; Rottem, Menachem; Ryan, Dermot; Salimaki, Johanna; Sanchez-Borges, Mario M.; Sastre, Joaquin; Scadding, Glenis K.; Scheire, Sophie; Schmid-Grendelmeier, Peter; Schunemann, Holger J.; Sarquis Serpa, Faradiba; Shamji, Mohamed; Sisul, Juan-Carlos; Sofiev, Mikhail; Sole, Dirceu; Somekh, David; Sooronbaev, Talant; Sova, Milan; Spertini, F.; Spranger, Otto; Stellato, Cristiana; Stelmach, Rafael; Thibaudon, Michel; To, Teresa; Toumi, Mondher; Usmani, Omar; Valero, Antonio A.; Valenta, Rudolph; Valentin-Rostan, Marylin; Pereira, Marilyn Urrutia; van der Kleij, Rianne; Van Eerd, Michiel; Vandenplas, Olivier; Vasankari, Tuula; Vaz Carneiro, Antonio; Vezzani, Giorgio; Viart, Frederic; Viegi, Giovanni; Wallace, Dana; Wagenmann, Martin; Wang, De Yun; Waserman, Susan; Wickman, Magnus; Williams, Dennis M.; Wong, Gary; Wroczynski, Piotr; Yiallouros, Panayiotis K.; Yusuf, Osman M.; Zar, Heather J.; Zeng, Stephane; Zernotti, Mario E.; Zhang, Luo; Shan Zhong, Nan; Zidarn, Mihaela (2021)
    Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
  • Bousquet, J.; Onorato, G. L.; Bachert, C.; Barbolini, M.; Bedbrook, A.; Bjermer, L.; de Sousa, J. Correia; Chavannes, N. H.; Cruz, A. A.; Keenoy, E. De Manuel; Devillier, P.; Fonseca, J.; Hun, S.; Kostka, T.; Hellings, P. W.; Illario, M.; Ivancevich, J. C.; Larenas-Linnemann, D.; Millot-Keurinck, J.; Ryan, D.; Samolinski, B.; Sheikh, A.; Yorgancioglu, A.; Agache, I.; Arnavielhe, S.; Bewick, M.; Annesi-Maesano, I.; Anto, J. M.; Bergmann, K. C.; Bindslev-Jensen, C.; Bosnic-Anticevich, S.; Bouchard, J.; Caimmi, D. P.; Camargos, P.; Canonica, G. W.; Cardona, V.; Carriazo, A. M.; Cingi, C.; Colgan, E.; Custovic, A.; Dahl, R.; Demoly, P.; De Vries, G.; Fokkens, W. J.; Fontaine, J. F.; Gemicioglu, B.; Guldemond, N.; Gutter, Z.; Haahtela, T.; Hellqvist-Dahl, B.; Jares, E.; Joos, G.; Just, J.; Khaltaev, N.; Keil, T.; Klimek, L.; Kowalski, M. L.; Kull, I.; Kuna, P.; Kvedariene, V.; Laune, D.; Louis, R.; Magnan, A.; Malva, J.; Mathieu-Dupas, E.; Melen, E.; Menditto, E.; Morais-Almeida, M.; Mosges, R.; Mullol, J.; Murray, R.; Neffen, H.; O'Hehir, R.; Palkonen, S.; Papadopoulos, N. G.; Passalacqua, G.; Pepin, J. L.; Portejoie, F.; Price, D.; Pugin, B.; Raciborski, F.; Simons, F. E. R.; Sova, M.; Spranger, O.; Stellato, C.; Bom, A. Todo; Tomazic, P. V.; Triggiani, M.; Valero, A.; Valovirta, E.; VandenPlas, O.; Valiulis, A.; Van Eerd, M.; Ventura, M. T.; Wickman, M.; Young, I.; Zuberbier, T.; Zurkuhlen, A.; Senn, A. (2017)
    A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices. SUNFRAIL (Reference Sites Network for Prevention and Care of Frailty and Chronic Conditions in community dwelling persons of EU Countries), a European Union project, assessed whether MASK is in line with the 28 items of JA-CHRODIS. A short summary was proposed for each item and 18 experts, all members of ARIA and SUNFRAIL from 12 countries, assessed the 28 items using a Survey Monkey-based questionnaire. A visual analogue scale (VAS) from 0 (strongly disagree) to 100 (strongly agree) was used. Agreement equal or over 75% was observed for 14 items (50%). MASK is following the JA-CHRODIS recommendations for the evaluation of Good Practices.
  • ARIA Study Grp; MASK Study Grp; Bousquet, J. Jean; Schunemann, Holger J.; Togias, Alkis; Haahtela, Tari; Toppila-Salmi, Sanna (2019)
    Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
  • Bousquet, J.; Anto, J. M.; Akdis, M.; Auffray, C.; Keil, T.; Momas, I.; Postma, D. S.; Valenta, R.; Wickman, M.; Cambon-Thomsen, A.; Haahtela, T.; Lambrecht, B. N.; Carlsen, K. C. Lodrup; Koppelman, G. H.; Sunyer, J.; Zuberbier, T.; Annesi-Maesano, I.; Arno, A.; Bindslev-Jensen, C.; De Carlo, G.; Forastiere, F.; Heinrich, J.; Kowalski, M. L.; Maier, D.; Melen, E.; Palkonen, S.; Smit, H. A.; Standl, M.; Wright, J.; Asarnoj, A.; Benet, M.; Ballardini, N.; Garcia-Aymerich, J.; Gehring, U.; Guerra, S.; Hohman, C.; Kull, I.; Lupinek, C.; Pinart, M.; Skrindo, I.; Westman, M.; Smagghe, D.; Akdis, C.; Albang, R.; Anastasova, V.; Anderson, N.; Bachert, C.; Ballereau, S.; Ballester, F.; Basagana, X.; Bedbrook, A.; Bergstrom, A.; von Berg, A.; Brunekreef, B.; Burte, E.; Carlsen, K. H.; Chatzi, L.; Coquet, J. M.; Curin, M.; Demoly, P.; Eller, E.; Fantini, M. P.; Gerhard, B.; Hammad, H.; von Hertzen, L.; Hovland, V.; Jacquemin, B.; Just, J.; Keller, T.; Kerkhof, M.; Kiss, R.; Kogevinas, M.; Koletzko, S.; Lau, S.; Lehmann, I.; Lemonnier, N.; McEachan, R.; Mäkelä, M.; Mestres, J.; Minina, E.; Mowinckel, P.; Nadif, R.; Nawijn, M.; Oddie, S.; Pellet, J.; Pin, I.; Porta, D.; Ranciere, F.; Rial-Sebbag, A.; Saeys, Y.; Schuijs, M. J.; Siroux, V.; Tischer, C. G.; Torrent, M.; Varraso, R.; De Vocht, J.; Wenger, K.; Wieser, S.; Xu, C. (2016)
    MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.