Browsing by Subject "Environment"

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  • Wegelius, Asko; Pankakoski, Maiju; Tomppo, Liisa; Lehto, Ulriika; Lonnqvist, Jouko; Suvisaari, Jaana; Paunio, Tiina; Hennah, William (2015)
    Pre- and perinatal environmental factors have been shown to increase schizophrenia risk particularly when combined with genetic liability. The investigation of specific gene environment interactions in the etiology of psychiatric disorders has gained momentum. We used multivariate GEE regression modeling to investigate the interaction between genes of the DISCI pathway and birth weight, in relation to schizophrenia susceptibility in a Finnish schizophrenia family cohort. The study sample consisted of 457 subjects with both genotype and birth weight information. Gender and place of birth were adjusted for in the models. We found a significant interaction between birth weight and two NDE1 markers in relation to increased schizophrenia risk: a four SNP haplotype spanning NDE1 (b = 1.26, SE= 0.5, p = 0.012) and one of its constituent SNPs rs4781678 (b = 1.33, SE = 0.51, p = 0.010). Specifically, high birth weight (> 4000 g) was associated with increased schizophrenia risk among subjects homozygous for the previously identified risk alleles. The study was based on a family study sample with high genetic loading for schizophrenia and thus our findings cannot directly be generalized as representing the general population. Our results suggest that the functions mediated by NDE1 during the early stages of neurodevelopment are susceptible to the additional disruptive effects of pre- and perinatal environmental factors associated with high birth weight, augmenting schizophrenia susceptibility. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
  • Sandström, John (Helsingin yliopisto, 2019)
    Finland har världens högsta incidens för typ 1 diabetes (T1D). Incidensen har ökat mångfalt under de senaste årtiondena i Finland och i andra utvecklade länder. Bl.a. detta och sjukdomens säsongberoende natur har riktat blickarna mot säsongberoende miljö-faktorer som utlösare av sjukdomsprocessen. Denna studies syfte var att undersöka om detta säsongberoende kan påvisas också i Finland och hur den förhåller sig till kön och ålder. Studiepopulationen bestod av 0–14 åriga finländska barn som hade diagnosticerats med T1D under åren 2002–2015. Säsonganalyser gällande diagnostidpunkten gjordes med hjälp av Poissons regressionsanalys, som säsongmodifierades. Vi observerade inci-densmönstret i förhållande till debutmånad samt säsongberoendets förhållande till kön och ålder. Diabetikerbarnen jämfördes med den teoretiska populationsenliga riskgrup-pen bestående av totalt antal levande 0–14 åringar i Finland per månad. Vår studie utvisade ett starkt säsongberoende. Säsongberoendet påverkades inte av kön men verkade bli kraftigare med stigande diagnosålder. Incidensen för pojkar var högre än hos flickor. Den årliga incidenstrenden var sjunkande fr.o.m. år 2006. Intressant var också att den yngsta åldersgruppen uppvisade den klart mest sjunkande incidenstrenden bland grupperna vilket väcker frågor om rotavirusvaccinets roll gällande incidensföränd-ringen. Rotavirusvaccinet infogades i det nationella vaccinationsprogrammet år 2009. Resultaten kan generera nya insikter angående sjukdomens patogenes och etiologi.
  • Korpilo, Silviya; Nyberg, Elina; Vierikko, Kati; Nieminen, Hanna; Arciniegas, Gustavo; Raymond, Christopher M. (2023)
    This paper develops, tests and validates a Multi-sensory Public Participation GIS (MSPPGIS) method combining the qualities of soundscapes and landscape values mapping. The development of the method involved: a) Public Participation GIS survey design; b) three-phase evaluation of survey addressing analytical, applicability and usability criteria; c) survey refinement; d) sampling and data collection, and; e) spatial data analysis. The analysis consisted of hotspot mapping involving Kernel Density Estimation, spatial overlap assessment using Jaccard coefficients and value compatibility analysis showing the level of spatial compatibility between positive landscape values and positive and negative soundscapes. Results indicated very low to low spatial overlap between the different landscape values and pleasant/unpleasant sound hotspots, suggesting that landscape values do not necessarily reflect sonic perception of urban green and blue spaces. Pleasant and unpleasant sounds were located closer to home than landscape values (except for urban life values), indicating that respondents' soundscape 'cognitive map' is smaller in spatial range. The MSPPGIS method enables the elicitation of a more dynamic and diverse set of sounds compared to previous soundscape mapping which tend to focus on 'noise' instead of multiple experiences of different sounds. Also, the combination of landscape values and soundscapes in MSPPGIS provides for a more integrated assessment of 'where' and 'how' to design urban green infrastructure.
  • Raymond, Christopher M.; Kenter, Jasper O.; van Riper, Carena J.; Rawluk, Andrea; Kendal, Dave (2019)
    This special feature provides an impression of the plurality of social values for sustainability, taking into account theoretical traditions within mainstream and heterodox economics; positive, social and environmental psychology; human geography; anthropology; sociology; religious and indigenous studies and business management. Papers in this issue respond to questions of: how do we conceptualise social values; how do we integrate or share social values; what are processes for learning about and mechanisms for forming and changing social values; and what are the associations between social values and behaviour or well-being? Consistent with post-normal science, we suggest that there is no one correct way of conceptualising, assessing, integrating or activating social values for sustainability. We present five arguments: (1) the plurality of social values can be conceptualised along many different dimensions, with reference to value, epistemic and procedural lenses; (2) values are nested in different hierarchies, resulting in the potential for different forms of value articulations and pathways of value expression; (3) not all social values are pre-formed and readily drawn upon, instead needing pathways of deliberation or intervention to be activated; (4) social values may change through different processes or pathways of intervention, and; (5) power matters in the formation and assessment of social values. We discuss the tensions that arise when attempting to integrate different perspectives and introduce the notion of ‘navigation’ to begin to address these tensions. Navigation requires scholars to adopt a more critical and reflexive approach to value enquiry than is currently espoused in sustainability science and practice.
  • Hasan, Shah Md. Kamrul; Orro, Toomas; Valros, Anna; Junnikkala, Sami; Peltoniemi, Olli; Oliviero, Claudio (2019)
    The present study investigated sow colostrum yield (CY), colostrum composition and factors affecting them, and their relation to piglet survivability, growth and mortality. The study included 230 sows with 3,210 live-born piglets from five Finnish and one Dutch sow herd. Sow farrowing was supervised, and piglets were individually weighed at birth (BWB) and 24 h after birth of first piglet in order to calculate piglet CI and sow CY. Colostrum nutritional composition, immunoglobulin (Ig), serum amyloid A (SAA) and haptoglobin (Hp) contents were assessed. Sow plasma SAA, Hp and progesterone around farrowing were also assessed. Selected ear-tagged piglets were weighed at 3 to 4 weeks of age to calculate individual average daily gain. Sow CY was positively correlated with plasma Hp (P = 0.029) and number of live-born piglets (P < 0.01). An additional minute of farrowing duration lowered the CY by 2.2 g (P = 0.01). Piglet CI was positively associated with piglet weight at birth (P < 0.001) and negatively associated with the number of live-born piglets in the litter and percentage of protein in the colostrum (P < 0.001). Both piglet CI and birth weight were positively associated with piglet average daily gain (ADG) (P < 0.001). Piglet survival from birth to weaning depends on CI. We established that the risk of piglet death or of a piglet being treated with antibiotic before weaning increases with a decrease in sow back fat thickness at farrowing (P = 0.04). Similarly, we found that piglets from litters with low BWB and low CI had a higher risk of death before weaning (P < 0.001). Piglets born from sows with lower levels of colostrum IgA and SAA and high plasma progesterone at the end of farrowing had a higher risk of neonatal diarrhea (P = 0.04; P = 0.05; P = 0.04). Piglets born from sows having higher back fat thickness at weaning had a higher risk of developing weaning diarrhea (P = 0.02). In conclusion, longer farrowing duration can be detrimental and can negatively influence sow CY. Sow body condition and physiological status around farrowing can also affect CY, and thereby increase piglet mortality and use of antibiotics in neonatal piglets. Neonatal piglets can benefit from higher colostrum immunoglobulins, SAA, and decreased level of plasma progesterone in sows at the end of farrowing.
  • Haahtela, Tari; von Hertzen, Leena; Anto, Josep M.; Bai, Chunxue; Baigenzhin, Abay; Bateman, Eric D.; Behera, Digambar; Bennoor, Kazi; Camargos, Paulo; Chavannes, Niels; de Sousa, Jaime Correia; Cruz, Alvaro; Teixeira, Maria Do Ceu; Erhola, Marina; Furman, Eeva; Gemicioglu, Bilun; Diaz, Sandra Gonzalez; Hellings, Peter W.; Jousilahti, Pekka; Khaltaev, Nikolai; Kolek, Vitezslav; Kuna, Piotr; La Grutta, Stefania; Le Thi Tuyet Lan; Maglakelidze, Tamaz; Masjedi, Mohamed R.; Mihaltan, Florin; Mohammad, Yousser; Nunes, Elizabete; Nyberg, Arvid; Quel, Jorge; Rosado-Pinto, Jose; Sagara, Hironori; Samolinski, Boleslaw; Schraufnagel, Dean; Sooronbaev, Talant; Eldin, Mohamed Tag; To, Teresa; Valiulis, Arunas; Varghese, Cherian; Vasankari, Tuula; Viegi, Giovanni; Winders, Tonya; Yanez, Anahi; Yorgancioglu, Arzu; Yusuf, Osman; Bousquet, Jean; Billo, Nils E. (2019)
    Background: The Nature Step to Respiratory Health was the overarching theme of the 12th General Meeting of the Global Alliance against Chronic Respiratory Diseases (GARD) in Helsinki, August 2018. New approaches are needed to improve respiratory health and reduce premature mortality of chronic diseases by 30% till 2030 (UN Sustainable Development Goals, SDGs). Planetary health is defined as the health of human civilization and the state of the natural systems on which it depends. Planetary health and human health are interconnected, and both need to be considered by individuals and governments while addressing several SDGs. Results: The concept of the Nature Step has evolved from innovative research indicating, how changed lifestyle in urban surroundings reduces contact with biodiverse environments, impoverishes microbiota, affects immune regulation and increases risk of NCDs. The Nature Step calls for strengthening connections to nature. Physical activity in natural environments should be promoted, use of fresh vegetables, fruits and water increased, and consumption of sugary drinks, tobacco and alcohol restricted. Nature relatedness should be part of everyday life and especially emphasized in the care of children and the elderly. Taking "nature" to modern cities in a controlled way is possible but a challenge for urban planning, nature conservation, housing, traffic arrangements, energy production, and importantly for supplying and distributing food. Actions against the well-known respiratory risk factors, air pollution and smoking, should be taken simultaneously. Conclusions: In Finland and elsewhere in Europe, successful programmes have been implemented to reduce the burden of respiratory disorders and other NCDs. Unhealthy behaviour can be changed by well-coordinated actions involving all stakeholders. The growing public health concern caused by NCDs in urban surroundings cannot be solved by health care alone; a multidisciplinary approach is mandatory.
  • Haahtela, Tari; von Hertzen, Leena; Antó, Josep M.; Bai, Chunxue; Baigenzhin, Abay; Bateman, Eric D; Behera, Digambar; Bennoor, Kazi; Camargos, Paulo; Chavannes, Niels; de Sousa, Jaime C; Cruz, Alvaro; Do Céu Teixeira, Maria; Erhola, Marina; Furman, Eeva; Gemicioğlu, Bilun; Gonzalez Diaz, Sandra; Hellings, Peter W; Jousilahti, Pekka; Khaltaev, Nikolai; Kolek, Vitezslav; Kuna, Piotr; La Grutta, Stefania; Lan, Le T T; Maglakelidze, Tamaz; Masjedi, Mohamed R; Mihaltan, Florin; Mohammad, Yousser; Nunes, Elizabete; Nyberg, Arvid; Quel, Jorge; Rosado-Pinto, Jose; Sagara, Hironori; Samoliński, Bolesław; Schraufnagel, Dean; Sooronbaev, Talant; Tag Eldin, Mohamed; To, Teresa; Valiulis, Arunas; Varghese, Cherian; Vasankari, Tuula; Viegi, Giovanni; Winders, Tonya; Yañez, Anahi; Yorgancioglu, Arzu; Yusuf, Osman; Bousquet, Jean; Billo, Nils E (BioMed Central, 2019)
    Abstract Background The Nature Step to Respiratory Health was the overarching theme of the 12th General Meeting of the Global Alliance against Chronic Respiratory Diseases (GARD) in Helsinki, August 2018. New approaches are needed to improve respiratory health and reduce premature mortality of chronic diseases by 30% till 2030 (UN Sustainable Development Goals, SDGs). Planetary health is defined as the health of human civilization and the state of the natural systems on which it depends. Planetary health and human health are interconnected, and both need to be considered by individuals and governments while addressing several SDGs. Results The concept of the Nature Step has evolved from innovative research indicating, how changed lifestyle in urban surroundings reduces contact with biodiverse environments, impoverishes microbiota, affects immune regulation and increases risk of NCDs. The Nature Step calls for strengthening connections to nature. Physical activity in natural environments should be promoted, use of fresh vegetables, fruits and water increased, and consumption of sugary drinks, tobacco and alcohol restricted. Nature relatedness should be part of everyday life and especially emphasized in the care of children and the elderly. Taking “nature” to modern cities in a controlled way is possible but a challenge for urban planning, nature conservation, housing, traffic arrangements, energy production, and importantly for supplying and distributing food. Actions against the well-known respiratory risk factors, air pollution and smoking, should be taken simultaneously. Conclusions In Finland and elsewhere in Europe, successful programmes have been implemented to reduce the burden of respiratory disorders and other NCDs. Unhealthy behaviour can be changed by well-coordinated actions involving all stakeholders. The growing public health concern caused by NCDs in urban surroundings cannot be solved by health care alone; a multidisciplinary approach is mandatory.
  • Haahtela, Tari Markku Kallevi; Valovirta, Erkka; Saarinen, Kimmo; Jantunen, Juha; Kauppi, Paula; Pelkonen, Anna Susanna; Lindström, Irmeli; Tommila, Erja; Petman, Leena; Ketola, Tuula; Mäkinen-Kiljunen, Soili; Csonka, Peter; Hellemaa, Paula; Pajunen, Sirpa; Puolanne, Mervi; Repo, Ilkka; Salava, Alexander; Savolainen, Johannes; Laatikainen, Tiina; Linna, Miika; von Hertzen, Leena C.; Abdulla Hama Salih, Krista; Hannuksela, Matti; Vasankari, Tuula; Mäkelä, Mika J (2020)
    Lähtökohdat : Allergiaohjelma 2008–2018 on kansallinen kansanterveysohjelma, jonka avulla välttö¬strategia on käännetty sietostrategiaksi ja painotettu allergiaterveyttä. Raportoimme 10 vuoden tulokset. Menetelmät : Ohjelmalla oli kuusi tavoitetta, joiden toteuttamiseksi määriteltiin tehtävät, työkalut ja mittarit. Ohjelmaa toteutettiin kouluttamalla terveydenhuoltoa ja viestimällä väestölle. Tulokset : Astman ja allergisen nuhan esiintyvyys tasoittui asevelvollisissa ja Helsingin aikuisväestössä. Helsingin aikuisista astmaatikoista 41 % oli ollut vuoden 2016 kyselyä edeltäneen vuoden oireettomia (31 % 2006). Lasten allergiaruokavaliot vähenivät koko maassa noin puoleen. Työperäiset allergiset sairaudet vähenivät 45 %. Astman sairaalahoidon tarve puolittui, mutta päivystyskäynnit vähenivät oleellisesti vain lapsilla. Anafylaksia aiheutti aiempaa enemmän päivystyskäyntejä. Allergiasta ja astmasta aiheutuvat vuosittaiset suorat ja epäsuorat kustannukset vähenivät 200 miljoonaa euroa ¬(30 %) verrattaessa vuosia 2007 ja 2018. Päätelmät : Allergian ja astman aiheuttama sairastavuus ja niistä koituvat kustannukset vähenivät merkittävästi. Haitat vähenivät aluksi nopeasti, myöhemmin hitaammin. Ammattilaiset ja suuri yleisö hyväksyivät uuden suunnan, jossa painottuivat sietokyky ja terveys allergiasta huolimatta. Tietoon perustuvat systemaattiset ohjelmat ovat vahva keino parantaa kansanterveyttä.
  • Hovatta, Iiris; Hovatta, Outi (2018)
  • Haahtela, Tari; Hanski, Ilkka; Von Hertzen, Leena; Jousilahti, Pekka; Laatikainen, Tiina; Mäkelä, Mika J.; Puska, Pekka; Reijula, Kari; Saarinen, Kimmo; Vartiainen, Erkki; Vasankari, Tuula; Virtanen, Suvi (2017)
  • Heiskala, Hannu (2020)
    • Lapsen kehitykseen vaikuttavat geneettiset, epigeneettiset ja ympäristötekijät. • Lapsi kehittyy parhaimpaansa, kun hänen yksilöllisiin tarpeisiinsa vastataan. Keskeistä on tukeva ja ennustettava huoltajasuhde sekä stimuloiva oppimisympäristö. • Kasvuympäristön ollessa kehitykselle suotuisa terapiainterventioilla voidaan edistää haluttuja spesifisiä taitoja. Interventioilla ei kuitenkaan voida muuttaa kokonaiskehitystä. • Lasten ja perheiden palveluiden osaamis- ja tukikeskukset voisivat arvioida eri interventioiden hyötyjä ja muutenkin tukea perustason moniammatillista työtä.
  • Erhola, Marina; Vuori, Anna; Bruneau, Milla; Halonen, Jaana I.; Haveri, Hanna; Hämäläinen, Riitta-Maija; Kangas, Terhi; Laine, Merjo; Nieminen, Tuomo; Nikula, Jussi; Prass, Marju; Salomaa, Minna-Maija; Sieppi, Päivi; Timonen, Pekka; Virtanen, Suvi; Haahtela, Tari (2022)
    Luontoaskel terveyteen -ohjelma yhdistää Päijät-Hämeen terveys- ja ympäristötavoitteet. Ohjelmatyön taustalla on tieto siitä, että yleistyvät kansansairaudet kytkeytyvät ympäristö- ja elintapa¬muutoksiin.
  • Vennerström, Pia; Maunula, Leena; Välimäki, Elina; Virtala, Anna-Maija (2020)
    After the first outbreak of viral haemorrhagic septicaemia virus (VHSV) in Finnish brackish water rainbow trout Oncorhynchus mykiss farms, infection spread rapidly between the farms. The infrastructure of fish farming did not take into account spreading of infectious fish diseases. To show the presence of VHSV in the environment, we tested seawater, sediment and wild blue mussels Mytilus edulis from VHSV-infected fish farms, and liquid waste from a processing plant that handled infected rainbow trout. Additionally, blue mussels were bath-challenged with VHSV (exposed to cultivated virus or naturally infected rainbow trout). To detect VHSV, virus isolation in cell culture and real-time reverse transcriptase polymerase chain reaction (qRT-PCR) were used. The virus or viral RNA was detected in sea water and in liquid waste from processing plants during wintertime when water temperature is close to 0 degrees C and sunlight is sparse. VHSV did not appear to replicate in blue mussels in our study. Therefore, blue mussels were not considered relevant carriers of VHSV. However, traces of viral RNA were detected up to 29 d post challenge in mussels. Contact with water from processing plants handling VHSV-infected fish populations increases the risk of the disease spreading to susceptible fish populations, especially during cold and dark times of the year.
  • Tuomisto, Hanna; Allan, Scott J.; Ellis, Marianne J. (2022)
    The aim of cellular agriculture is to use cell-culturing technologies to produce alternatives to agricultural products. Cul-tured meat is an example of a cellular agriculture product, made by using tissue engineering methods. This study aims to improve the understanding of the potential environmental impacts of cultured meat production by comparing be-tween different bioprocess design scenarios. This was done by carrying out a life cycle assessment (LCA) for a bioprocess system using hollow fiber bioreactors, and utilizing bench-scale experimental data for C2C12 cell prolifer-ation, differentiation and media metabolism. Scenario and sensitivity analyses were used to test the impact of changes in the system design, data sources, and LCA methods on the results to support process design decision making. We com-pared alternative scenarios to a baseline of C2C12 cells cultured in hollow fiber bioreactors using media consisting of DMEM with serum, for a 16-day proliferation stage and 7-day differentiation stage. The baseline LCA used the average UK electricity mix as the energy source, and heat treatment for wastewater sterilization. The greatest reduction in en-vironmental impacts were achieved with the scenarios using CHO cell metabolism instead of C2C12 cell metabolisim (64-67 % reduction); achieving 128 % cell biomass increase during differentiation instead of no increase (42-56 % reduction); using wind electricity instead of average UK electricity (6-39 % reduction); and adjusting the amino acid use based on experimental data (16-27 % reduction). The use of chemical wastewater treatment instead of heat treatment increased all environmental impacts, except energy demand, by 1-16 %. This study provides valuable insights for the cultured meat field to understand the effects of different process design scenarios on environmental impacts, and therefore provides a framework for deciding where to focus development efforts for improving the envi-ronmental performance of the production system.
  • Rapola, Janne; Heikinheimo, Oskari; Rovasalo, Aki; Mäkisalo, Heikki (2021)
  • Jonauskaite, Domicele; Abdel-Khalek, Ahmed; Abu-Akel, Ahmad; Al-Rasheed, Abdulrahman Saud; Antonietti, Jean-Philippe; Ásgeirsson, Árni Gunnar; Atitsogbe, Kokou Amenyona; Barma, Marodégueba; Barratt, Daniel; Bogushevskaya, Victoria; Bouayed Meziane, Maliha Khadidja; Chamseddine, Amer; Charernboom, Thammanard; Chkonia, Eka; Ciobanu, Teofil; Corona, Violeta; Creed, Allison; Dael, Nele; Daouk, Hassan; Dimitrova, Nevena; Doorenbos, Cornelis B.; Fomins, Sergejs; Fonseca-Pedrero, Eduardo; Gaspar, Augusta; Gizdic, Alena; Griber, Yulia A.; Grimshaw, Gina; Hasan Aya, Ahmed; Havelka, Jelena; Hirnstein, Marco; Karlsson, Bodil S.A.; Kim, Jejoong; Konstantinou, Nikos; Laurent, Eric; Lindeman, Marjaana; Manav, Banu; Marquardt, Lynn; Mefoh, Philip; Mroczko-Wąsowicz, Aleksandra; Mutandwa, Phillip; Muthusi, Steve; Ngabolo, Georgette; Oberfeld, Daniel; Papadatou-Pastou, Marietta; Perchtold, Corinna M.; Pérez-Albéniz, Alicia; Pouyan, Niloufar; Rashid Soron, Tanjir; Roinishvili, Maya; Romanyuk, Lyudmyla; Salgado Montejo, Alejandro; Sultanova, Aygun; Tau, Ramiro; Uusküla, Mari; Vainio, Suvi; Vargas-Soto, Veronica; Volkan, Eliz; Wąsowicz, Grażyna; Zdravković, Sunčica; Zhang, Meng; Mohr, Christine (2019)
    Across cultures, people associate colours with emotions. Here, we test the hypothesis that one driver of this cross-modal correspondence is the physical environment we live in. We focus on a prime example – the association of yellow with joy, – which conceivably arises because yellow is reminiscent of life-sustaining sunshine and pleasant weather. If so, this association should be especially strong in countries where sunny weather is a rare occurrence. We analysed yellow-joy associations of 6625 participants from 55 countries to investigate how yellow-joy associations varied geographically, climatologically, and seasonally. We assessed the distance to the equator, sunshine, precipitation, and daytime hours. Consistent with our hypotheses, participants who live further away from the equator and in rainier countries are more likely to associate yellow with joy. We did not find associations with seasonal variations. Our findings support a role for the physical environment in shaping the affective meaning of colour.
  • Karkman, Antti; Virta, Marko (2017)