Browsing by Subject "FREQUENCIES"

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  • Mehlig, Kirsten; Bogl, Leonie H.; Hunsberger, Monica; Ahrens, Wolfgang; De Henauw, Stefaan; Iguacel, Isabel; Jilani, Hannah; Molnar, Denes; Pala, Valeria; Russo, Paola; Tornaritis, Michael; Veidebaum, Toomas; Kaprio, Jaakko; Lissner, Lauren (2018)
    Objective: The present study investigated the association between sugar and fat intake in childhood in relation to alcohol use in adolescence. We hypothesized that early exposure to diets high in fat and sugar may affect ingestive behaviours later in life, including alcohol use. Design/Setting/Subjects: Children from the European IDEFICS/I.Family cohort study were examined at ages 5-9 years and followed up at ages 11-16 years. FFQ were completed by parents on behalf of children, and later by adolescents themselves. Complete data were available in 2263 participants. Children's propensities to consume foods high in fat and sugar were calculated and dichotomized at median values. Adolescents' use of alcohol was classified as at least weekly v. less frequent use. Log-binomial regression linked sugar and fat consumption in childhood to risk of alcohol use in adolescence, adjusted for relevant covariates. Results: Five per cent of adolescents reported weekly alcohol consumption. Children with high propensity to consume sugar and fat were at greater risk of later alcohol use, compared with children with low fat and low sugar propensity (relative risk = 2.46; 95% CI 1.47, 4.12), independent of age, sex and survey country. The association was not explained by parental income and education, strict parenting style or child's health-related quality of life and was only partly mediated by sustained consumption of sugar and fat into adolescence. Conclusions: Frequent consumption of foods high in fat and sugar in childhood predicted regular use of alcohol in adolescence.
  • Wennerström, Annika; Vlachopoulou, Efthymia; Lahtela, L. Elisa; Paakkanen, Riitta; Eronen, Katja T.; Seppänen, Mikko; Lokki, Marja-Liisa (2013)
  • Clancy, Jonna; Ritari, Jarmo; Lobier, Muriel; Niittyvuopio, Riitta; Salmenniemi, Urpu; Putkonen, Mervi; Itälä-Remes, Maija; Partanen, Jukka; Koskela, Satu (2019)
    HLA matching is a prerequisite for successful allogeneic hematopoietic stem cell transplantation (HSCT) because it lowers the occurrence and severity of graft-versus-host disease (GVHD). However, matching a few alleles of the classic HLA genes only may not ensure matching of the entire MHC region. HLA haplotype matching has been reported to be beneficial in HSCT because of the variation relevant to GVHD risk in the non-HLA region. Because polymorphism in the MHC is highly population specific, we hypothesized that donors from the Finnish registry are more likely to be matched at a higher level for the Finnish patients than donors from other registries. In the present study we determined 25 single nucleotide polymorphisms (SNPs) of the complement component 4 (C4) gene in the gamma-block segment of MHC from 115 Finnish HSCT patients and their Finnish (n = 201) and non-Finnish (n = 280) donor candidates. Full matching of HLA alleles and C4 SNPs, independently or additively, occurred more likely in the Finnish-Finnish group as compared with the Finnish non-Finnish group (P <.003). This was most striking in cases with HLA haplotypes typical of the Finnish population. Patients with ancestral HLA haplotypes (AH) were more likely to find a full HLA and C4 matched donor, regardless of donor origin, as compared with patients without AH (P <.0001). Despite the clear differences at the population level, we could not find a statistical association between C4 matching and clinical outcome. The results suggest that screening C4 SNPs can be advantageous when an extended MHC matching or HLA haplotype matching in HSCT is required. This study also supports the need for small population-specific stem cell registries. (C) 2018 American Society for Blood and Marrow Transplantation.
  • Greenleaf, Allan; Kurylev, Yaroslav; Lassas, Matti; Uhlmann, Gunther (2008)
  • Morosan, Diana E.; Carley, Eoin P.; Hayes, Laura A.; Murray, Sophie A.; Zucca, Pietro; Fallows, Richard A.; McCauley, Joe; Kilpua, Emilia K. J.; Mann, Gottfried; Vocks, Christian; Gallagher, Peter T. (2019)
    The Sun is an active star that can launch large eruptions of magnetized plasma into the heliosphere, known as corona! mass ejections (CMEs). These can drive shocks that accelerate particles to high energies, often resulting in radio emission at low frequencies (