Browsing by Subject "Family history"

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  • Lofvenborg, Josefin E.; Ahlqvist, Emma; Alfredsson, Lars; Andersson, Tomas; Groop, Leif; Tuomi, Tiinamaija; Wolk, Alicja; Carlsson, Sofia (2021)
    Purpose Red meat consumption is positively associated with type 1 (T1D) and type 2 (T2D) diabetes. We investigated if red meat consumption increases the risk of latent autoimmune diabetes in adults (LADA) and T2D, and potential interaction with family history of diabetes (FHD), HLA and TCF7L2 genotypes. Methods Analyses were based on Swedish case-control data comprising incident cases of LADA (n = 465) and T2D (n = 1528) with matched, population-based controls (n = 1789; n = 1553 in genetic analyses). Multivariable-adjusted ORs in relation to self-reported processed and unprocessed red meat intake were estimated by conditional logistic regression models. Attributable proportion (AP) due to interaction was used to assess departure from additivity of effects. Results Consumption of processed red meat was associated with increased risk of LADA (per one servings/day OR 1.27, 95% CI 1.07-1.52), whereas no association was observed for unprocessed red meat. For T2D, there was no association with red meat intake once BMI was taken into account. The combination of high (> 0.3 servings/day vs. less) processed red meat intake and high-risk HLA-DQB1 and -DRB1 genotypes yielded OR 8.05 (95% CI 4.86-13.34) for LADA, with indications of significant interaction (AP 0.53, 95% CI 0.32-0.73). Results were similar for the combination of FHD-T1D and processed red meat. No interaction between processed red meat intake and FHD-T2D or risk variants of TCF7L2 was seen in relation to LADA or T2D. Conclusion Consumption of processed but not unprocessed red meat may increase the risk of LADA, especially in individuals with FHD-T1D or high-risk HLA genotypes.
  • Ylinen, Anni (Helsingin yliopisto, 2019)
    Personer med typ 1-diabetes har en ökad risk att insjukna i stroke. Målet med denna studie är att utreda familjära riskfaktorers betydelse för stroke vid typ 1-diabetes. Vi ämnar undersöka hur riskfaktorer så som hypertoni, diabetes, stroke och hjärtinfarkt hos föräldrarna påverkar risken för personerna med typ 1-diabetes att insjukna i stroke. I denna undersökning ingår 4011 personer med typ 1-diabetes som deltagit i FinnDiane-studien sedan den grundades 1997 och som inte har haft en tidigare stroke. Personer med stroke identifierades från frågeformulär, dödscertifikat och vårdanmälningssystemet. Under medianuppföljningstiden på 12,4 (10,9 - 14,2) år insjuknade 188 personer i sin första stroke, varav 134 i hjärninfarkt och 54 i hjärnblödning. Cox-regressionsanalyser utfördes för att undersöka familjära riskfaktorernas betydelse för strokerisken. I studien framkom det att stroke hos modern medförde en 2,86-faldig risk att insjukna i hjärnblödning, även efter korrigering för förklarande faktorer. Inga andra signifikanta samband mellan föräldrarnas sjukdomshistoria och insjuknandet i hjärninfarkt eller hjärnblödning hos personerna med typ 1-diabetes framkom. Stroke hos modern ökar risken för personer med typ 1-diabetes att insjukna i en hjärnblödning. Familjära riskfaktorer verkar för övrigt ha liten betydelse för strokerisken vid typ 1-diabetes.
  • Reuter, Anni Maria (2021)
    In this article, I explore the memory and great transformation of Ingrian Finnish families originally from Ingria (a historical area around Saint Petersburg) in the Soviet Union during deportations, Stalinist terror, and clashes of ideologies and practice. In an Ingrian Finnish memory culture, families were an important source and carrier of memories of exile and repression from one generation to another. I used the family archival material of letters, life histories and family narratives, poetry, family trees, and photographs as research material and analyzed the social genealogy of repressed Ingrian Finnish families. The case study of an extended family included several nuclear families, and 33 members and three generations in the 1930s. The family histories demonstrated the great transformation and social collapse of the Ingrian Finnish family members in the 1930s and early 1940s from independent peasants to poor deportees, forced labourers, refugees and prisoners in the Gulag. Members of the extended family were repressed during Stalin’s time, with some managing to take refuge in Finland and Sweden. Two out of three family members were deported in the 1930s and one in three during the Second World War. Half of those deported in the 1930s escaped. Several family members experienced many repressions during their life span; some women were deported several times and most men were deported, arrested, and died at an early age. At least five men were killed in the political violence, four of them were executed in the Stalinist terror in 1938. The nuclear families studied were violently broken up, leaving them without a father. I found a range of family mobilities from escape to education. Based on my analyses, I argue that family histories of repressions were a meeting point with life histories and the minority/national history of Ingrian Finns. Family histories of repressed families build a bridge over the personal and collective memories in the context of Ingrian Finnish memory culture.
  • Fagerholm, Rainer; Faltinova, Maria; Aaltonen, Kirsi; Aittomaki, Kristiina; Heikkila, Paivi; Halttunen-Nieminen, Mervi; Nevanlinna, Heli; Blomqvist, Carl (2018)
    Long term use of postmenopausal hormone therapy (HT) has been reported to increase breast cancer risk. On the other hand, observational studies suggest that breast cancers diagnosed during HT may have a more favorable prognosis. While family history is a risk factor for breast cancer, and genetic factors also influence prognosis, the role of family history in combination with HT use has been little studied. We investigated the relationship between HT, family history, and prognosis in 584 (267 exposed) familial and 952 (460 exposed) non-familial breast cancer cases, using three survival end points: death from breast cancer (BCS), distant disease free survival (DDFS), and local recurrence free survival (LRFS). Among non-familial cases, HT was associated with better BCS (HR 0.63, 95% CI 0.41-0.94; p = 0.025), and DDFS (HR 0.58, 95% CI 0.40-0.85; p = 0.005), with a consistent but not statistically significant effect in LRFS. This effect was not seen in familial cases (HR > 1.0), and family history was found to interact with HT in BCS (p((interaction)) = 0.0067) (BC-death) and DDFS (p((interaction)) = 0.0070). There was phenotypic heterogeneity between HT-associated tumors in familial and non-familial cases, particularly on estrogen receptor (ER) status, although the interaction between HT and family history appears to be at least partially independent of these markers (p = 0.0370 after adjustment for standard prognostic factors). If confirmed by further studies, our results suggest that family history should be taken into consideration in clinical counseling before beginning a HT regimen.
  • Finnish Pediat Diabet Register; Parkkola, Anna; Turtinen, Maaret; Härkönen, Taina; Ilonen, Jorma; Knip, Mikael (2021)
    Aims/hypothesis Shared aetiopathogenetic factors have been proposed in type 1 diabetes and type 2 diabetes and both diseases have been shown to cluster in families. Characteristics related to type 2 diabetes have been described in patients with type 1 diabetes with a positive family history of type 2 diabetes. We wanted to characterise the family history of type 2 diabetes and its possible effects on the phenotype and genotype of type 1 diabetes in affected children at diagnosis. Methods A total of 4993 children under the age of 15 years with newly diagnosed type 1 diabetes from the Finnish Pediatric Diabetes Register were recruited (56.6% boys, median age of 8.2 years) for a cross-sectional, observational, population-based investigation. The family history of diabetes at diagnosis was determined by a structured questionnaire, and markers of metabolic derangement, autoantibodies and HLA class II genetics at diagnosis were analysed. Results Two per cent of the children had an immediate family member and 36% had grandparents with type 2 diabetes. Fathers and grandfathers were affected by type 2 diabetes more often than mothers and grandmothers. The children with a positive family history for type 2 diabetes were older at the diagnosis of type 1 diabetes (p <0.001), had higher BMI-for-age (p = 0.01) and more often tested negative for all diabetes-related autoantibodies (p = 0.02). Conclusions/interpretation Features associated with type 2 diabetes, such as higher body weight, older age at diagnosis and autoantibody negativity, are more frequently already present at the diagnosis of type 1 diabetes in children with a positive family history of type 2 diabetes.