Browsing by Subject "HUMAN ADENOVIRUS"

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  • Hong, Chuan; Oksanen, Hanna M.; Liu, Xiangan; Jakana, Joanita; Bamford, Dennis H.; Chiu, Wah (2014)
  • Azinas, S.; Bano, F.; Torca, I.; Bamford, D. H.; Schwartz, G. A.; Esnaola, J.; Oksanen, H. M.; Richter, R. P.; Abrescia, N. G. (2018)
    The protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provides a greater stability against mechanical stress than that achieved by the majority of dsDNA icosahedral viruses that lack a membrane. We propose that the combination of a stiff and brittle proteinaceous shell coupled with a soft and compliant membrane vesicle yields a tough composite nanomaterial well-suited to protect the viral DNA during extracellular transport.