Browsing by Subject "Hepatitis C"

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  • Färkkilä, Martti (2016)
  • Häkkinen, Margareeta; Tourunen, Jouni; Pitkänen, Tuuli; Vuoti, Sauli; Simojoki, Kaarlo (2019)
    A-klinikan toteuttama pilottitutkimus osoittaa opioidikorvauspotilaiden C-hepatiitin hoidon onnistuvan päihdehoitopisteissä. Samalla korvaushoito tehostui ja potilaiden elämäntilanne koheni.
  • Färkkilä, Martti; Rautiainen, Henna (2019)
  • Miettinen, Helena; Sane, Timo; Lamminen, Antti; Välimäki, Matti J. (2017)
  • Häkkinen, Margareeta; Tourunen, Jouni; Pitkänen, Tuuli; Simojoki, Kaarlo; Vuoti, Sauli (2022)
    Background Hepatitis C virus (HCV) is common among individuals in opioid agonist therapy (OAT). HCV treatment has previously been unavailable for most HCV positive OAT patients in Finland. The removal of treatment restrictions and attempts to reach HCV elimination goals have increased the number of OAT patients needing HCV treatment. The objectives of this study were 1) to characterize Finnish HCV positive OAT patients and evaluate their eligibility for HCV treatment at addiction service units, and 2) to retrospectively review the outcomes of treated patients. Methods The study focused on HCV positive OAT patients (n = 235). Demographics and clinical parameters were retrospectively reviewed using the patients' medical records. The eligibility of providing HCV treatment to patients at addiction service units were evaluated based on patients' clinical characteristics, such as liver function and patterns of substance use. The outcomes of patients receiving HCV treatment were reviewed. Results Of HCV antibody positive OAT patients, 75% had chronic HCV. Of 103 HCV patients screened for liver fibrosis either with Fibroscan or APRI (aspartate aminotransferase to platelet ratio index), 83 patients (81%) had no indication of severe liver damage. Point of care (POC) HCV tests were used for 46 patients to lower the threshold of attending laboratory testing. All patients preferred POC testing to conventional blood testing. Twenty patients had received HCV treatment, 19 completed the treatment and achieved sustained virologic response (SVR) at the end of the treatment. Of the 18 patients available for evaluation of SVR at 12 weeks after the treatment (SVR12), 17 achieved SVR12. Conclusions The integrated model consisting of HCV diagnostics and treatment at the addiction service unit was successfully implemented within normal OAT practice.
  • Laivuori, Tove (Helsingfors universitet, 2010)
    Tutkimuksen tarkoituksena oli kartoittaa Helsingin ja Uudenmaan sairaanhoitopiirin (HUS) sairaaloissa hoidettujen lasten kroonisten B- ja C-hepatiittien tartuntareittejä ja tartunnan riskitekijöitä sekä selvittää, miten hepatiittien seuranta ja hoito on HUS-piirissä toteutunut. Tutkimusaineisto kerättiin retrospektiivisesti strukturoitua tiedonkeruulomaketta käyttäen HUS-piirin sairaaloiden ja HUSLAB:n arkisto- ja sairauskertomustiedostoja. Potilaiden valintakriteereinä olivat alle 16 vuoden ikä ja laboratoriotutkimuksin varmennettu krooninen B- tai C-hepatiitti vuosien 1996-2006 aikana. B-hepatiittia sairastavista lapsista 61/66 oli syntynyt Suomen ulkopuolella, ja valtaosa heidän tartunnoistaan todettiin maahantulotarkastuksen yhteydessä. C-hepatiittia sairastavista lapsista 28/40 oli syntynyt Suomessa. Maahantulotarkastus sekä päihteiden käyttöön liittyvä seulonta olivat tärkeimmät diagnoosiin johtaneet tutkimustilanteet. Antiviraalisesta lääkehoidosta hyötyi 6/13 B-hepatiittia ja 2/4 C-hepatiittia sairastavista lapsista. HUS-piirissä B-hepatiittia esiintyy lähinnä maahanmuuttajataustaisilla lapsilla. Krooninen C-hepatiitti liittyi lapsen tai hänen vanhempiensa huumeiden käyttöön. Tutkimus korostaa lasten B- ja C-hepatiitin seulonta-, seuranta- ja hoitokäytäntöjä selkeyttävän ohjeistuksen tarvetta.
  • Färkkilä, Martti; Lappalainen, Maija (2020)
    Tämänvuotinen lääketieteen ja fysiologian Nobelin palkinto myönnettiin C-hepatiittiviruksen (HCV) löytäjille, yhdysvaltalaisille Harvey J. Alterille (s. 1935, National Institutes of Health, Bethesda), Charles M. Ricelle (s. 1952, Rockefeller University, New York) ja kanadalaiselle Michael Houghtonille (s. 1949, University of Alberta, Edmonton).
  • Tiittala, Paula; Ristola, Matti; Liitsola, Kirsi; Ollgren, Jukka; Koponen, Päivikki; Surcel, Heljä-Marja; Hiltunen-Back, Eija; Davidkin, Irja; Kivela, Pia (2018)
    Background: Migrants are considered a key population at risk for sexually transmitted and blood-borne diseases in Europe. Prevalence data to support the design of infectious diseases screening protocols are scarce. We aimed to estimate the prevalence of hepatitis B and C, human immunodefiency virus (HIV) infection and syphilis in specific migrant groups in Finland and to assess risk factors for missed diagnosis. Methods: A random sample of 3000 Kurdish, Russian, or Somali origin migrants in Finland was invited to a migrant population-based health interview and examination survey during 2010-2012. Participants in the health examination were offered screening for hepatitis B and C, HIV and syphilis. Notification prevalence in the National Infectious Diseases Register (NIDR) was compared between participants and non-participants to assess non-participation. Missed diagnosis was defined as test-positive case in the survey without previous notification in NIDR. Inverse probability weighting was used to correct for non-participation. Results: Altogether 1000 migrants were screened for infectious diseases. No difference in the notification prevalence among participants and non-participants was observed. Seroprevalence of hepatitis B surface antigen (HBsAg) was 2.3%, hepatitis C antibodies 1.7%, and Treponema pallidum antibodies 1.3%. No cases of HIV were identified. Of all test-positive cases, 61% (34/56) had no previous notification in NIDR. 48% of HBsAg, 62.5% of anti-HCV and 84.6% of anti-Trpa positive cases had been missed. Among the Somali population (n = 261), prevalence of missed hepatitis B diagnosis was 3.0%. Of the 324 Russian migrants, 3.0% had not been previously diagnosed with hepatitis C and 2.4% had a missed syphilis diagnosis. In multivariable regression model missed diagnosis was associated with migrant origin, living alone, poor self-perceived health, daily smoking, and previous diagnosis of another blood-borne infection. Conclusions: More than half of chronic hepatitis and syphilis diagnoses had been missed among migrants in Finland. Undiagnosed hepatitis B among Somali migrants implies post-migration transmission that could be prevented by enhanced screening and vaccinations. Rate of missed diagnoses among Russian migrants supports implementation of targeted hepatitis and syphilis screening upon arrival and also in later health care contacts. Coverage and up-take of current screening among migrants should be evaluated.
  • Tiittala, Paula; Ristola, Matti; Liitsola, Kirsi; Ollgren, Jukka; Koponen, Päivikki; Surcel, Heljä-Marja; Hiltunen-Back, Eija; Davidkin, Irja; Kivelä, Pia (BioMed Central, 2018)
    Abstract Background Migrants are considered a key population at risk for sexually transmitted and blood-borne diseases in Europe. Prevalence data to support the design of infectious diseases screening protocols are scarce. We aimed to estimate the prevalence of hepatitis B and C, human immunodefiency virus (HIV) infection and syphilis in specific migrant groups in Finland and to assess risk factors for missed diagnosis. Methods A random sample of 3000 Kurdish, Russian, or Somali origin migrants in Finland was invited to a migrant population-based health interview and examination survey during 2010–2012. Participants in the health examination were offered screening for hepatitis B and C, HIV and syphilis. Notification prevalence in the National Infectious Diseases Register (NIDR) was compared between participants and non-participants to assess non-participation. Missed diagnosis was defined as test-positive case in the survey without previous notification in NIDR. Inverse probability weighting was used to correct for non-participation. Results Altogether 1000 migrants were screened for infectious diseases. No difference in the notification prevalence among participants and non-participants was observed. Seroprevalence of hepatitis B surface antigen (HBsAg) was 2.3%, hepatitis C antibodies 1.7%, and Treponema pallidum antibodies 1.3%. No cases of HIV were identified. Of all test-positive cases, 61% (34/56) had no previous notification in NIDR. 48% of HBsAg, 62.5% of anti-HCV and 84.6% of anti-Trpa positive cases had been missed. Among the Somali population (n = 261), prevalence of missed hepatitis B diagnosis was 3.0%. Of the 324 Russian migrants, 3.0% had not been previously diagnosed with hepatitis C and 2.4% had a missed syphilis diagnosis. In multivariable regression model missed diagnosis was associated with migrant origin, living alone, poor self-perceived health, daily smoking, and previous diagnosis of another blood-borne infection. Conclusions More than half of chronic hepatitis and syphilis diagnoses had been missed among migrants in Finland. Undiagnosed hepatitis B among Somali migrants implies post-migration transmission that could be prevented by enhanced screening and vaccinations. Rate of missed diagnoses among Russian migrants supports implementation of targeted hepatitis and syphilis screening upon arrival and also in later health care contacts. Coverage and up-take of current screening among migrants should be evaluated.
  • Rembeck, Karolina; Maglio, Cristina; Lagging, Martin; Christensen, Peer Brehm; Färkkilä, Martti Antero; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Morch, Kristine; Norkrans, Gunnar; Hellstrand, Kristoffer; Lindh, Magnus; Pirazzi, Carlo; Burza, Maria Antonella; Romeo, Stefano; Westin, Johan; NORDynamIC Grp (2012)
  • Tuohinto, Krista; Ojala, Päivi (2019)
    Selvittämällä virusten syöpää aiheuttavia mekanismeja pystytään paremmin kehittämään rokotteita.