Browsing by Subject "High risk"

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  • Ebner, Matthias; Sentler, Carmen; Harjola, Veli-Pekka; Bueno, Hector; Lerchbaumer, Markus H.; Hasenfuss, Gerd; Eckardt, Kai-Uwe; Konstantinides, Stavros; Lankeit, Mareike (2021)
    Aims The 2019 European Society of Cardiology (ESC) guidelines provide a revised definition of high-risk pulmonary embolism (PE) encompassing three clinical presentations: Cardiac arrest, obstructive shock, and persistent hypotension. This study investigated the prognostic implications of this new definition. Methods and results Data from 784 consecutive PE patients prospectively enrolled in a single-centre registry were analysed. Study outcomes include an in-hospital adverse outcome (PE-related death or cardiopulmonary resuscitation) and in-hospital all-cause mortality. Overall, 86 patients (11.0%) presented with high-risk PE and more often had an adverse outcome (43.0%) compared to intermediate-high-risk patients (6.1%; P Conclusion The revised ESC 2019 guidelines definition of high-risk PE stratifies subgroups at different risk of in-hospital adverse outcomes and all-cause mortality. Risk prediction can be improved by using an optimised venous lactate cut-off value to diagnose obstructive shock, which might help to better assess the risk-to-benefit ratio of systemic thrombolysis in different subgroups of high-risk patients.
  • Bu-Pasha, Shakila (2020)
    Article 35 of the General Data Protection Regulation (GDPR) states that data controllers are required to carry out data protection impact assessment (DPIA) if a processing operation, particularly involving the use of new technologies, is ‘likely to result in a high risk to the rights and freedoms of natural persons’. The focus in this paper is on the role and responsibilities of data controllers in a smart city platform in assessing ‘high risk’ and the importance of impact assessment in relation to data processing with the latest technologies for the protection of personal data.