An ambient pressure cell is described for conducting synchrotron-based x-ray photoelectron spectroscopy (XPS) measurements during atomic layer deposition (ALD) processes. The instrument is capable of true in situ and operando experiments in which it is possible to directly obtain elemental and chemical information from the sample surface using XPS as the deposition process is ongoing. The setup is based on the ambient pressure XPS technique, in which sample environments with high pressure (several mbar) can be created without compromising the ultrahigh vacuum requirements needed for the operation of the spectrometer and the synchrotron beamline. The setup is intended for chemical characterization of the surface intermediates during the initial stages of the deposition processes. The SPECIES beamline and the ALD cell provide a unique experimental platform for obtaining new information on the surface chemistry during ALD half-cycles at high temporal resolution. Such information is valuable for understanding the ALD reaction mechanisms and crucial in further developing and improving ALD processes. We demonstrate the capabilities of the setup by studying the deposition of TiO2 on a SiO2 surface by using titanium(IV) tetraisopropoxide and water as precursors. Multiple core levels and the valence band of the substrate surface were followed during the film deposition using ambient pressure XPS.

We present an analysis of the main systematic effects that could impact the measurement of CMB polarization with the proposed CORE space mission. We employ timeline to-map simulations to verify that the CORE instrumental set-up and scanning strategy allow us to measure sky polarization to a level of accuracy adequate to the mission science goals. We also show how the CORE observations can be processed to mitigate the level of contamination by potentially worrying systematics, including intensity-to-polarization leakage due to bandpass mismatch, asymmetric main beams, pointing errors and correlated noise. We use analysis techniques that are well validated on data from current missions such as Planck to demonstrate how the residual contamination of the measurements by these effects can be brought to a level low enough not to hamper the scientific capability of the mission, nor significantly increase the overall error budget. We also present a prototype of the CORE photometric calibration pipeline, based on that used for Planck, and discuss its robustness to systematics, showing how CORE can achieve its calibration requirements. While a fine-grained assessment of the impact of systematics requires a level of knowledge of the system that can only be achieved in a future study phase, the analysis presented here strongly suggests that the main areas of concern for the CORE mission can be addressed using existing knowledge, techniques and algorithms.

The most widely used patient-reported outcome (PRO) measure for soft tissue sarcoma (STS) patients is the Toronto Extremity Salvage Score (TESS). The aim of the study was to validate and test the reliability of the TESS for patients with lower extremity STS based on Finnish population data. Patients were assessed using the TESS, the QLQ-C30 Function and Quality of life (QoL) modules, the 15D and the Musculoskeletal tumour Society (MSTS) score. The TESS was completed twice with a 2- to 4-week interval. The intraclass correlation coefficient (ICC) was used for test-retest reliability. Construct validity was tested for structural validity and convergent validity. Altogether 136 patients completed the TESS. A ceiling effect was noted as 21% of the patients scored maximum points. The ICC between first and second administration of the TESS was 0.96. The results of exploratory factor analysis together with high Cronbach's alpha (0.98) supported a unidimensional structure. The TESS correlated moderately with the MSTS score (rho = 0.59, p < 0.001) and strongly with the mobility dimension in the 15D HRQL instrument (rho = 0.76, p < 0.001) and the physical function in QLQ-C30 (rho = 0.83, p < 0.001). The TESS instrument is a comprehensive and reliable PRO measure. The TESS may be used as a validated single index score, for lower extremity STS patients for the measurement of a functional outcome. The TESS seems to reflect patients' HRQoL well after the treatment of lower extremity soft tissue sarcomas. (C) 2020 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Objectives: There is limited information of the health-related quality of life (HRQoL) after surgical treatment of chest wall tumors. This cross-sectional study aimed to assess long-term HRQoL after chest wall reconstruction following oncological resection. Methods: Seventy-eight patients having undergone chest wall tumor resection and reconstruction during 1997-2015 were invited to complete the 15D and QLQ-C30 HRQoL instruments. Results: Altogether, 55 patients (17 men and 38 women), with a mean (SD) age of 68 (14) years, completed the questionnaires (response rate 71%). Patients had been operated due to soft tissue sarcoma (n=16), advanced breast cancer (n=15), osteo- or chondrosarcoma (n=14), or other tumor (n=10). Median time after primary surgery was 66 (IQR 38, 141) months. The resection was full thickness in 29/55 cases and partial thickness in 26/55 cases. Chest wall reconstruction was required for 47/55 cases (85%). Reconstruction was performed using soft-tissue flap in eight cases, skeletal stabilizations with mesh or mesh-cement-mesh (sandwich method) in 15 cases, and skeletal stabilizations and soft-tissue flap in 24 cases. Patients' mean 15D score (0.878, SD 0.111) was comparable to that of the age- and gender-standardized general population (0.891, SD 0.041). Limitations in breathing and usual activities were noted. The QLQ-C30 cancer-specific HRQoL was 72 points (maximum 100). Scores in the QLQ-C30 Functional scales ranged from 78 (Physical) to 91 (Social). Conclusions: Long-term HRQoL in patients after chest wall reconstruction following oncological resection is fair and comparable to that of the general population. Limitations in breathing and usual activities can occur. (C) 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Background: The purpose was to quantify the decrement in health utility (referred as disutility) associated with knee osteoarthritis (OA) and different symptomatic and radiographic uni- and bilateral definitions of knee OA in a repeated measures design of persons with knee OA or at increased risk of developing knee OA. Methods: Data were obtained from the Osteoarthritis Initiative database. SF-12 health-related quality of life was converted into SF-6D utilities, and were then handled as the health utility loss by subtracting 1.000 from the utility score, yielding a negative value (disutility). Symptomatic OA was defined by radiographic findings (Kellgren-Lawrence, K-L, grade >= 2) and frequent knee pain in the same knee. Radiographic OA was defined by five different definitions (K-L >= 2 unilaterally / bilaterally, or the highest / mean / combination of K-L grades of both knees). Repeated measures generalized estimating equation (GEE) models were used to investigate disutility in relation to these different definitions. Results: Utility decreased with worsening of symptomatic or radiographic status of knee OA. The participants with bilateral and unilateral symptomatic knee OA had 0.03 (p <0.001) and 0.02 (p <0.001) points lower utility scores, respectively, compared with the reference group. The radiographic K-L grade 4 defined as the mean or the highest grade of both knees was related to a decrease of 0.04 (p <0.001) and 0.03 (p <0.001) points in utility scores, respectively, compared to the reference group. Conclusions: Knee OA is associated with diminished health-related quality of life. Health utility can be quantified in relation to both symptomatic and radiographic uni- and bilateral definitions of knee OA, and these definitions are associated with differing disutilities. The performance of symptomatic definition was better, indicating that pain experience is an important factor in knee OA related quality of life.

Introduction Approaches to economic evaluations of stroke therapies are varied and inconsistently described. An objective of the European Stroke Organisation (ESO) Health Economics Working Group is to standardise and improve the economic evaluations of interventions for stroke. Methods The ESO Health Economics Working Group and additional experts were contacted to develop a protocol and a guidance document for data collection for economic evaluations of stroke therapies. A modified Delphi approach, including a survey and consensus processes, was used to agree on content. We also asked the participants about resources that could be shared to improve economic evaluations of interventions for stroke. Results Of 28 experts invited, 16 (57%) completed the initial survey, with representation from universities, government, and industry. More than half of the survey respondents endorsed 13 specific items to include in a standard resource use questionnaire. Preferred functional/quality of life outcome measures to use for economic evaluations were the modified Rankin Scale (14 respondents, 88%) and the EQ-5D instrument (11 respondents, 69%). Of the 12 respondents who had access to data used in economic evaluations, 10 (83%) indicated a willingness to share data. A protocol template and a guidance document for data collection were developed and are presented in this article. Conclusion The protocol template and guidance document for data collection will support a more standardised and transparent approach for economic evaluations of stroke care.

We present results of noon-midnight meridional plane global hybrid-Vlasov simulations of the magnetotail ion dynamics under a steady southward interplanetary magnetic field using the Vlasiator model. The simulation results show magnetotail reconnection and formation of earthward and tailward fast plasma outflows. The hybrid-Vlasov approach allows us to study ion velocity distribution functions (VDFs) that are self-consistently formed during the magnetotail evolution. We examine the VDFs collected by virtual detectors placed along the equatorial magnetotail within earthward and tailward outflows and around the quasi-steady X line formed in the magnetotail at X approximate to -14 RE. This allows us to follow the evolution of VDFs during earthward and tailward motion of reconnected flux tubes as well as study signatures of unmagnetized ion motion in the weak magnetic field near the X line. The VDFs indicate actions of Fermi-type and betatron acceleration mechanisms, ion acceleration by the reconnection electric field, and Speiser-type motion of ions near the X line. The simulated VDFs are compared and show good agreement with VDFs observed in the magnetotail by the Time History of Events and Macroscale Interactions during Substorms (THEMIS) and Acceleration, Reconnection, Turbulence and Electrodynamics of Moon's Interaction with the Sun (ARTEMIS) spacecraft. We find that the VDFs become more gyrotropic but retain transverse anisotropy and counterstreaming ion beams when being convected earthward. The presented global hybrid-Vlasov simulation results are valuable for understanding physical processes of ion acceleration during magnetotail reconnection, interpretation of in situ observations, and for future mission development by setting requirements on pitch angle and energy resolution of upcoming instruments.

Context. Sheath regions ahead of coronal mass ejections (CMEs) are large-scale heliospheric structures that form gradually with CME expansion and propagation from the Sun. Turbulent and compressed sheaths could contribute to the acceleration of charged particles in the corona and in interplanetary space, but the relation of their internal structure to the particle energization process is still a relatively little studied subject. In particular, the role of sheaths in accelerating particles when the shock Mach number is low is a significant open research problem. Aims. This work seeks to provide new insights on the internal structure of CME-driven sheaths with regard to energetic particle enhancements. A good opportunity to achieve this aim was provided by multi-point, in-situ observations of a sheath region made by radially aligned spacecraft at 0.8 and similar to 1 AU (Solar Orbiter, the L1 spacecraft Wind and ACE, and BepiColombo) on April 19-21, 2020. The sheath was preceded by a weak and slowly propagating fast-mode shock. Methods. We apply a range of analysis techniques to in situ magnetic field, plasma and particle observations. The study focuses on smaller scale sheath structures and magnetic field fluctuations that coincide with energetic ion enhancements. Results. Energetic ion enhancements were identified in the sheath, but at different locations within the sheath structure at Solar Orbiter and L1. Magnetic fluctuation amplitudes at inertial-range scales increased in the sheath relative to the solar wind upstream of the shock, as is typically observed. However, when normalised to the local mean field, fluctuation amplitudes did not increase significantly; magnetic compressibility of fluctuation also did not increase within the sheath. Various substructures were found to be embedded within the sheath at the different spacecraft, including multiple heliospheric current sheet (HCS) crossings and a small-scale flux rope. At L1, the ion flux enhancement was associated with the HCS crossings, while at Solar Orbiter, the ion enhancement occurred within a compressed, small-scale flux rope. Conclusions. Several internal smaller-scale substructures and clear difference in their occurrence and properties between the used spacecraft was identified within the analyzed CME-driven sheath. These substructures are favourable locations for the energization of charged particles in interplanetary space. In particular, substructures that are swept from the upstream solar wind and compressed into the sheath can act as effective acceleration sites. A possible acceleration mechanism is betatron acceleration associated with a small-scale flux rope and warped HCS compressed in the sheath, while the contribution of shock acceleration to the latter cannot be excluded.