Browsing by Subject "Knee"

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  • Pihlajamaki, Harri K.; Parviainen, Mickael C.; Kautiainen, Hannu; Kiviranta, Ilkka (2017)
    Background: Musculoskeletal disorders and injuries are common causes of morbidity and loss of active, physically demanding training days in military populations. We evaluated the incidence, diagnosis, and risk factors of knee disorders and injuries in male Finnish military conscripts. Methods: The study population comprised 5 cohorts of 1000 men performing their military service, classified according to birth year (1969, 1974, 1979, 1984, and 1989). Follow-up time for each conscript was the individual conscript's full, completed military service period. Data for each man were collected from a standard pre-information questionnaire used by defense force healthcare officials and from all original medical reports of the garrison healthcare centers. Background variables for risk factor analysis included the conscripts' service data, i.e., service class (A, B), length of military service, age, height, weight, body mass index (BMI), underweight, overweight, obesity, smoking habit, education, diseases, injuries, and subjective symptoms. Results: Of the 4029 conscripts, 853 visited healthcare professionals for knee symptoms during their military service, and 103 of these had suffered a knee injury. Independent risk factors for the incidence of knee symptoms were: older age; service class A; overweight (BMI 25.0-29.9 kg/m(2)); smoking habit; comprehensive school education only; and self-reported previous symptoms of the musculoskeletal, respiratory, and gastrointestinal system. The majority of visits to garrison healthcare services due to knee symptoms occurred during the first few months of military service. Knee symptoms were negatively correlated with self-reported mental and behavioral disorders. Conclusions: The present study highlights the frequency of knee disorders and injuries in young men during physically demanding military training. One-fifth of the male conscripts visited defense force healthcare professionals due to knee symptoms during their service period. Independent risk factors for the incidence of knee symptoms during military service were age at military service; military service class A; overweight; smoking habit; comprehensive school education only; and self-reported previous symptoms of the musculoskeletal system, respiratory system, or gastrointestinal system. These risk factors should be considered when planning and implementing procedures to reduce knee disorders and injuries during compulsory military service.
  • Pihlajamäki, Harri K; Parviainen, Mickael C; Kautiainen, Hannu; Kiviranta, Ilkka (BioMed Central, 2017)
    Abstract Background Musculoskeletal disorders and injuries are common causes of morbidity and loss of active, physically demanding training days in military populations. We evaluated the incidence, diagnosis, and risk factors of knee disorders and injuries in male Finnish military conscripts. Methods The study population comprised 5 cohorts of 1000 men performing their military service, classified according to birth year (1969, 1974, 1979, 1984, and 1989). Follow-up time for each conscript was the individual conscript’s full, completed military service period. Data for each man were collected from a standard pre-information questionnaire used by defense force healthcare officials and from all original medical reports of the garrison healthcare centers. Background variables for risk factor analysis included the conscripts’ service data, i.e., service class (A, B), length of military service, age, height, weight, body mass index (BMI), underweight, overweight, obesity, smoking habit, education, diseases, injuries, and subjective symptoms. Results Of the 4029 conscripts, 853 visited healthcare professionals for knee symptoms during their military service, and 103 of these had suffered a knee injury. Independent risk factors for the incidence of knee symptoms were: older age; service class A; overweight (BMI 25.0–29.9 kg/m2); smoking habit; comprehensive school education only; and self-reported previous symptoms of the musculoskeletal, respiratory, and gastrointestinal system. The majority of visits to garrison healthcare services due to knee symptoms occurred during the first few months of military service. Knee symptoms were negatively correlated with self-reported mental and behavioral disorders. Conclusions The present study highlights the frequency of knee disorders and injuries in young men during physically demanding military training. One-fifth of the male conscripts visited defense force healthcare professionals due to knee symptoms during their service period. Independent risk factors for the incidence of knee symptoms during military service were age at military service; military service class A; overweight; smoking habit; comprehensive school education only; and self-reported previous symptoms of the musculoskeletal system, respiratory system, or gastrointestinal system. These risk factors should be considered when planning and implementing procedures to reduce knee disorders and injuries during compulsory military service.
  • Mattila, Katariina A.; Aronniemi, Johanna; Salminen, Päivi; Rintala, Risto J.; Kyrklund, Kristiina (2020)
    Background Intra-articular venous malformations of the knee are an uncommon cause of unilateral knee pain in children. Timely diagnosis is important because lesions with intrasynovial involvement can lead to joint space hemorrhage and secondary cartilage damage. Objective To describe our tertiary center's experience of diagnostics and typical magnetic resonance imaging (MRI) findings. Materials and methods A retrospective review of all patients
  • Kuitunen, Mikael (2019)
    Vanhemmat toivat 3,5 vuoden ikäisen pojan terveysaseman vastaanotolle. Lapsi oli ollut edellisestä iltapäivästä lähtien tavallista väsyneempi ja voimaton ja äidin mielestä poissaoleva muttei sekava.
  • Welling, Maiju; Kinnunen, Marina; Aaltonen, Leena-Maija; Roine, Risto P. (2018)
    Työntekijä ja työnantaja ovat velvollisia huolehtimaan riittävästä ammattiosaamisesta. Valvonta kuitenkin ontuu – ja potilasturvallisuus vaarantuu.
  • Vasara, Anna; Paatela, Teemu; Kiviranta, Ilkka (2016)
    •Al­le 40-vuo­tiai­den vam­ma­pe­räi­siä oi­rei­le­via rus­to­vau­rioi­ta voi­daan hoi­taa useil­la me­ne­tel­mil­lä. •Pie­niin vau­rioi­hin so­pi­via me­ne­tel­miä ovat mik­ro­mur­tu­ma­me­ne­tel­mä ja luu-rus­to­sy­lin­te­ri­siir­re. •Rus­to­so­lu­siir­re­hoi­to­jen hin­ta on nous­sut kor­keak­si, ei­vät­kä hoi­don edut mui­hin hoi­to­muo­toi­hin näh­den ole osoit­tau­tu­neet ko­vin suu­rik­si, jo­ten käyt­tö tu­li­si ra­joit­taa eri­tyis­ta­pauk­siin ja yk­sik­köi­hin, jois­sa me­ne­tel­mäs­tä on ko­ke­mus­ta. •Uu­te­na hoi­to­muo­to­na vai­kei­den rus­to­puu­tos­ten hoi­dos­sa voi­daan käyt­tää elin­luo­vut­ta­jil­ta saa­ta­via ­luu-rus­to­tuo­re­ku­dos­siir­tei­tä. •Uu­sien bio­ma­te­riaa­lei­hin tai me­sen­kyy­mi­kan­ta­so­lui­hin pe­rus­tu­vien hoi­to­muo­to­jen ke­hi­tys­työ on vil­kas­ta, mut­ta me­ne­tel­mät ovat edel­leen pääa­sias­sa ko­keel­li­sia. •Oi­reet­to­mia rus­to­vau­rioi­ta ei pi­dä hoi­taa ki­rur­gi­ses­ti, ei­kä rus­to­vau­rioi­den ki­rur­gi­ses­ta hoi­dos­ta ­ny­ky­me­ne­tel­min ole hyö­tyä ni­vel­ri­kon hoi­dos­sa.
  • Kontio, Tea; Heliovaara, Markku; Rissanen, Harri; Knekt, Paul; Aromaa, Arpo; Solovieva, Svetlana (2017)
    Background: Meniscal lesions are among the most common injuries of the knee, yet limited epidemiologic data is available on their risk factors. We investigated the association of lifestyle factors and physical strenuousness of work on knee injuries with a focus on meniscal lesions. Methods: We examined a nationally representative sample of persons aged 30 to 59 years, who participated in a comprehensive health examination (the Mini-Finland Health Survey). Subjects without any injury or osteoarthritis in the knee joint at baseline (n = 4713) were subsequently followed via the National Hospital Discharge Register up to 30 years. Results: During the follow-up, 338 knee injuries were identified of which 224 were meniscal lesions. Obesity and regular leisure time physical exercise were associated with an increased risk of first hospitalization due to meniscal lesions (hazard ratio (HR) 1.62 and 95% confidence interval (CI) 1.06-2.48 and 1.53, 95% CI 1.05-2.23, respectively). The types of sports predicting the highest risk of meniscal lesions were ballgames, gymnastics and jogging. Physical strenuousness of work did not predict meniscal lesion. The hazard of other knee injury was increased among those reporting irregular or regular physical exercise at baseline (HR 1.64, 95% CI 1.03-2.64 and 1.88 CI 1.05-2.36, respectively). Smoking or alcohol intake were not associated with knee injuries. Conclusions: Better safety measures in high-risk sports and weight control would likely improve the prevention of meniscal lesions in populations.
  • Kontio, Tea; Heliövaara, Markku; Rissanen, Harri; Knekt, Paul; Aromaa, Arpo; Solovieva, Svetlana (BioMed Central, 2017)
    Abstract Background Meniscal lesions are among the most common injuries of the knee, yet limited epidemiologic data is available on their risk factors. We investigated the association of lifestyle factors and physical strenuousness of work on knee injuries with a focus on meniscal lesions. Methods We examined a nationally representative sample of persons aged 30 to 59 years, who participated in a comprehensive health examination (the Mini-Finland Health Survey). Subjects without any injury or osteoarthritis in the knee joint at baseline (n = 4713) were subsequently followed via the National Hospital Discharge Register up to 30 years. Results During the follow-up, 338 knee injuries were identified of which 224 were meniscal lesions. Obesity and regular leisure time physical exercise were associated with an increased risk of first hospitalization due to meniscal lesions (hazard ratio (HR) 1.62 and 95% confidence interval (CI) 1.06–2.48 and 1.53, 95% CI 1.05–2.23, respectively). The types of sports predicting the highest risk of meniscal lesions were ballgames, gymnastics and jogging. Physical strenuousness of work did not predict meniscal lesion. The hazard of other knee injury was increased among those reporting irregular or regular physical exercise at baseline (HR 1.64, 95% CI 1.03–2.64 and 1.88 CI 1.05–2.36, respectively). Smoking or alcohol intake were not associated with knee injuries. Conclusions Better safety measures in high-risk sports and weight control would likely improve the prevention of meniscal lesions in populations.
  • Taipale, M.; Jakkula, E.; Kamarainen, O. -P; Gao, P.; Skarp, S.; Barral, S.; Kiviranta, I.; Kroger, H.; Ott, J.; Wei, G. -H.; Ala-Kokko, L.; Mannikko, M. (2016)
    Objective: The aim of the study was to identify genetic variants predisposing to primary hip and knee osteoarthritis (OA) in a sample of Finnish families. Methods: Genome wide analysis was performed using 15 independent families (279 individuals) originating from Central Finland identified as having multiple individuals with primary hip and/or knee OA. Targeted re-sequencing was performed for three samples from one 33-member, four-generation family contributing most significantly to the LOD score. In addition, exome sequencing was performed in three family members from the same family. Results: Genome wide linkage analysis identified a susceptibility locus on chromosome 2q21 with a multipoint LOD score of 3.91. Targeted re-sequencing and subsequent linkage analysis revealed a susceptibility insertion variant rs11446594. It locates in a predicted strong enhancer element region with maximum LOD score 3.42 under dominant model of inheritance. Insertion creates a recognition sequence for ELF3 and HMGA1 transcription factors. Their DNA-binding affinity is highly increased in the presence of A-allele compared to wild type null allele. Conclusion: A potentially novel functional OA susceptibility variant was identified by targeted resequencing. This variant locates in a predicted regulatory site and creates a recognition sequence for ELF3 and HMGA1 transcription factors that are predicted to play a significant role in articular cartilage homeostasis. (C) 2015 The Authors. Published by Elsevier Ltd and Osteoarthritis Research Society International.
  • Esrafilian, Amir; Stenroth, Lauri; Mononen, Mika E.; Vartiainen, Paavo; Tanska, Petri; Karjalainen, Pasi A.; Suomalainen, Juha-Sampo; Arokoski, Jari P. A.; Saxby, David J.; Lloyd, David G.; Korhonen, Rami K. (2022)
    Tissue-level mechanics (e.g., stress and strain) are important factors governing tissue remodeling and development of knee osteoarthritis (KOA), and hence, the success of physical rehabilitation. To date, no clinically feasible analysis toolbox has been introduced and used to inform clinical decision making with subject-specific in-depth joint mechanics of different activities. Herein, we utilized a rapid state-of-the-art electromyography-assisted musculoskeletal finite element analysis toolbox with fibril-reinforced poro(visco)elastic cartilages and menisci to investigate knee mechanics in different activities. Tissue mechanical responses, believed to govern collagen damage, cell death, and fixed charge density loss of proteoglycans, were characterized within 15 patients with KOA while various daily activities and rehabilitation exercises were performed. Results showed more inter-participant variation in joint mechanics during rehabilitation exercises compared to daily activities. Accordingly, the devised workflow may be used for designing subject-specific rehabilitation protocols. Further, results showed the potential to tailor rehabilitation exercises, or assess capacity for daily activity modifications, to optimally load knee tissue, especially when mechanically-induced cartilage degeneration and adaptation are of interest.