Browsing by Subject "MECHANISMS LINKING OBESITY"

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  • van der Kolk, Birgitta W.; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Paakkonen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A.; Andersson, Daniel P.; Männistö, Ville; Saris, Wim H.; Astrup, Arne; Ryden, Mikael; Blaak, Ellen E.; Pajukanta, Paivi; Pihlajamaki, Jussi; Pietiläinen, Kirsi H. (2021)
    Context: Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown. Objective: To investigate how SAT mitochondria change following diet-induced and bariatric surgery-induced weight-loss interventions in 4 independent weight-loss studies. Methods: The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up. Results: Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: -8.7 following LCD, -4.4 following weight maintenance; CRYO: IPA z-score: -5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001). Conclusions: Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.
  • Nyberg, Solja T.; Batty, G. David; Kivimäki, Mika (2019)