Browsing by Subject "MET"

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  • Kuony, Alison; Michon, Frederic (2017)
    As an element of the lacrimal apparatus, the lacrimal gland (LG) produces the aqueous part of the tear film, which protects the eye surface. Therefore, a defective LG can lead to serious eyesight impairment. Up to now, little is known about LG morphogenesis and subsequent maturation. In this study, we delineated elements of the cellular and molecular events involved in LG formation by using three epithelial markers, namely aSMA, Krt14, and Krt19. While aSMA marked a restricted epithelial population of the terminal end buds (TEBs) in the forming LG, Krt14 was found in the whole embryonic LG epithelial basal cell layer. Interestingly. Krt19 specifically labeled the presumptive ductal domain and subsequently, the luminal cell layer. By combining these markers, the Fucci reporter mouse strain and genetic fate mapping of the Krt14+ population, we demonstrated that LG epithelium expansion is fuelled by a patterned cell proliferation, and to a lesser extent by epithelial reorganization and possible mesenchymal-to-epithelial transition. We pointed out that this epithelial reorganization, which is associated with apoptosis, regulated the lumen formation. Finally, we showed that the inhibition of Notch signaling prevented the ductal identity from setting, and led to a LG covered by ectopic TEBs. Taken together our results bring a deeper understanding on LG morphogenesis, epithelial domain identity, and organ expansion.
  • Päivärinne, V.; Kautiainen, H.; Heinonen, A.; Kiviranta, I. (2018)
    To assess the relationship between physical activity (PA) in work, transport, domestic, and leisure-time domains (with sitting time included) and health-related quality of life (HRQoL) among young adult men. The long version of IPAQ and SF-36 Health Survey were used to assess PA and HRQoL, respectively, in 1425 voluntary 20- to 40-year-old Finnish male participants. Participants were divided into tertiles (MET-h/week): Lowest tertile (100 MET-h/week). The IPAQ domain leisure-time PA predicted positively the Physical Component Summary (PCS) (=0.11, 95% CI: 0.06 to 0.16) and Mental Component Summary (MCS) (=0.11, 95% CI: 0.05 to 0.16) dimensions. Occupational PA predicted negative relationships in the PCS (=-0.13, 95% CI: -0.19 to -0.07), and sitting time predicted negative relationships in the MCS dimension (=-0.13, 95% CI: -0.18 to -0.07). In addition, a linear relationship was found between total PA level (including sitting time) and all of the IPAQ domains (
  • Päivärinne, Ville; Kautiainen, Hannu; Heinonen, Ari; Kiviranta, Ilkka (2019)
    Purpose Leisure-time physical activity (LTPA) is known to be associated with positive health benefits, but the role of occupational physical demands remains inconsistent. The purpose of the current study was to assess the relationship between LTPA and work ability in different occupational physical activity (OPA) levels between young adult men. Methods We performed physical activity measurements in work and leisure time with the long version of International Physical Activity Questionnaire (IPAQ) and work ability with the Work Ability Index (WAI) in 921 Finnish employed male volunteer participants. The participants were divided into LTPA tertiles I (<8 MET-h/week), II (8-28 MET-h/week), and III (> 28 MET-h/week) and OPA tertiles I (0 MET-h/week), II (<64 MET-h/week), and III (>= 64 MET-h/week). Results There was a significant relationship between LTPA and WAI in OPA tertiles (adjusted for age, alcohol consumption, working class status, BMI, and employment years). Moreover, each LTPA tertile showed significant linear associations with WAI (P <0.001). Conclusion LTPA is positively associated with work ability among young adult men. More specifically, the relationships between LTPA and WAI were significantly greater in physically demanding jobs than in more passive jobs. Our results indicate the importance of LTPA, particularly with individuals under higher work-related physical strain.
  • The CMS collaboration; Sirunyan, A. M.; Eerola, P.; Kirschenmann, H.; Pekkanen, J.; Voutilainen, M.; Havukainen, J.; Heikkilä, J. K.; Järvinen, T.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Laurila, S.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Siikonen, H.; Tuominen, E.; Tuominiemi, J.; Tuuva, T. (2019)
    A search for a new high-mass resonance decaying to a tau lepton and a neutrino is reported. The analysis uses proton-proton collision data collected by the CMS experiment at the LHC at root s= 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). The search utilizes hadronically decaying tau leptons. No excess in the event yield is observed at high transverse masses of the tau and missing transverse momentum. An interpretation of results within the sequential standard model excludes W' boson masses below 4.0 TeV at 95% confidence level. Existing limits are also improved on models in which the W' boson decays preferentially to fermions of the third generation. Heavy W' bosons with masses less than 1.7-3.9 TeV, depending on the coupling in the non-universal G(221) model, are excluded at 95% confidence level. These are the most stringent limits on this model to date. (C) 2019 The Author(s). Published by Elsevier B.V.