Browsing by Subject "MIDDLE-AGED WOMEN"

Sort by: Order: Results:

Now showing items 1-3 of 3
  • Fogelholm, Mikael; Anderssen, Sigmund; Gunnarsdottir, Ingibjorg; Lahti-Koski, Marjaana (2012)
  • Lampio, Laura; Polo-Kantola, Paivi; Himanen, Sari-Leena; Kurki, Samu; Huupponen, Eero; Engblom, Janne; Heinonen, Olli J.; Polo, Olli; Saaresranta, Tarja (2017)
    Study Objectives: Menopausal transition is associated with increased dissatisfaction with sleep, but the effects on sleep architecture are conflicting. This prospective 6-year follow-up study was designed to evaluate the changes in sleep stages and sleep continuity that occur in women during menopausal transition. Methods: Sixty women (mean age 46.0 years, SD 0.9) participated. All women were premenopausal at baseline, and at the 6-year follow-up, women were in different stages of menopausal transition. Polysomnography was used to study sleep architecture at baseline and follow-up. The effects of aging and menopause (assessed as change in serum follicle-stimulating hormone [S-FSH]) on sleep architecture were evaluated using linear regression models. Results: After controlling for body mass index, vasomotor, and depressive symptoms, aging of 6 years resulted in shorter total sleep time (B -37.4, 95% confidence interval [CI] -71.5 to (-3.3)), lower sleep efficiency (B -6.5, 95% CI -12.7 to (-0.2)), as well as in increased transitions from slow-wave sleep (SWS) to wakefulness (B 1.0, 95% CI 0.1 to 1.9), wake after sleep onset (B 37.7, 95% CI 12.5 to 63.0), awakenings per hour (B 1.8, 95% CI 0.8 to 2.8), and arousal index (B 2.3, 95% CI 0.1 to 4.4). Higher S-FSH concentration in menopausal transition was associated with increased SWS (B 0.09, 95% CI 0.01 to 0.16) after controlling for confounding factors. Conclusions: A significant deterioration in sleep continuity occurs when women age from 46 to 52 years, but change from premenopausal to menopausal state restores some SWS.
  • Cartwright, Rufus; Kirby, Anna C.; Tikkinen, Kari A. O.; Mangera, Altaf; Thiagamoorthy, Gans; Rajan, Prabhakar; Pesonen, Jori; Ambrose, Chris; Gonzalez-Maffe, Juan; Bennett, Phillip; Palmer, Tom; Walley, Andrew; Järvelin, Marjo-Riitta; Chapple, Chris; Khullar, Vik (2015)