Browsing by Subject "NORWAY"

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  • Vesa, Juho Antti; Kantola, Anu; Binderkrantz, Anne Skorkjaer (2018)
  • Hellstrand, Julia Ingrid Sofia; Nisén, Jessica; Myrskylä, Mikko (2020)
    The ongoing period fertility decline in the Nordic countries is particularly strong in Finland, where the total fertility rate (TFR) reached an all-time low of 1.41 in 2018. We analyse the decrease in Finland's TFR in 2010–17, and assess its consequences for cohort fertility using complementary approaches. Decomposition of this fertility decline shows that first births and women aged <30 are making the largest contributions. However, women aged 30–39 are also, for the first time in decades, experiencing a sustained fertility decline. Tempo adjustments to the TFR suggest that quantum change is part of the decline. Several forecasting methods indicate that cohort fertility is likely to decline from the long-lasting level of 1.85–1.95 to 1.75 or lower among women born in the mid-1980s. Without an exceptionally strong recovery in fertility, Finnish cohort fertility is likely to decline to levels currently observed among countries with very low fertility.
  • Elstad, Eyvind; Juuti, Kalle; Christophersen, Knut-Andreas; Solhaug, Trond; Turmo, Are (2021)
    The purpose of this study was to explore antecedents of Finnish and Norwegian student teachers’ prospective commitment to work as teachers or pursue other careers. Are student teachers’ perceptions of coherence between the theoretical and practical elements of the teaching programme related to their commitment to work as teachers or to pursue other careers? For Finnish student teachers, strong associations emerged between the theory-practice interaction in supervision and student teachers’ prospective commitment to work as teachers. Norwegian student teachers exhibited strong associations between personalised feedback and their prospective commitment to teaching. Implications for practice and further research are discussed.
  • Daltveit, Dagrun Slettebo; Klungsoyr, Kari; Engeland, Anders; Ekbom, Anders; Gissler, Mika; Glimelius, Ingrid; Grotmol, Tom; Madanat-Harjuoja, Laura; Ording, Anne Gulbech; Saether, Solbjorg Makalani Myrtveit; Sorensen, Henrik Toft; Troisi, Rebecca; Bjørge, Tone (2020)
    OBJECTIVE To examine associations between birth defects and cancer from birth into adulthood. DESIGN Population based nested case-control study. SETTING Nationwide health registries in Denmark, Finland, Norway, and Sweden. PARTICIPANTS 62 295 cancer cases (0-46 years) and 724 542 frequency matched controls (matched on country and birth year), born between 1967 and 2014. MAIN OUTCOME MEASURES Relative risk of cancer in relation to major birth defects, estimated as odds ratios with 99% confidence intervals from logistic regression models. RESULTS Altogether, 3.5% (2160/62 295) of cases and 2.2% (15 826/724 542) of controls were born with major birth defects. The odds ratio of cancer for people with major birth defects compared with those without was 1.74 (99% confidence interval 1.63 to 1.84). For individuals with non-chromosomal birth defects, the odds ratio of cancer was 1.54 (1.44 to 1.64); for those with chromosomal anomalies, the odds ratio was 5.53 (4.67 to 6.54). Many structural birth defects were associated with later cancer in the same organ system or anatomical location, such as defects of the eye, nervous system, and urinary organs. The odds ratio of cancer increased with number of defects and decreased with age, for both non-chromosomal and chromosomal anomalies. The odds ratio of cancer in people with any non-chromosomal birth defect was lower in adults (>= 20 years: 1.21, 1.09 to 1.33) than in adolescents (15-19 years: 1.58, 1.31 to 1.90) and children (0-14 years: 2.03, 1.85 to 2.23). The relative overall cancer risk among adults with chromosomal anomalies was markedly reduced from 11.3 (9.35 to 13.8) in children to 1.50 (1.01 to 2.24). Among adults, skeletal dysplasia (odds ratio 3.54, 1.54 to 8.15), nervous system defects (1.76, 1.16 to 2.65), chromosomal anomalies (1.50, 1.01 to 2.24), genital organs defects (1.43, 1.14 to 1.78), and congenital heart defects (1.28, 1.02 to 1.59) were associated with overall cancer risk. CONCLUSIONS The increased risk of cancer in individuals with birth defects persisted into adulthood, both for nonchromosomal and chromosomal anomalies. Further studies on the molecular mechanisms involved are warranted.
  • Vauhkonen, Jari (2020)
    Key Message Tree-level forest inventory data are becoming increasingly available, which motivates the use of these data for decision-making. However, airborne inventories carried out tree-by-tree typically include systematic errors, which can propagate to objective function variables used to determine optimal forest management. Effects of under-detection focused on the smallest trees on predicted immediate harvest profits and future expectation values were assessed assuming different sites and interest rates. Management decisions based on the erroneous information caused losses of 0-17% of the total immediate and future expected income of Scots pine stands. Context Optimal decisions on how to manage forest stands can depend on the absence or presence of intermediate and understory trees. Yet, these tree strata are likely prone to inventory errors. Aims The aim of this study is to examine implications of making stand management decisions based on data that include systematic errors resembling those typically observed in airborne inventories carried out tree-by-tree. Methods Stand management instructions were developed based on theoretical diameter distribution functions simulated to have different shape, scale, and frequency parameters corresponding to various degrees of under-detection focused on the smallest trees. Immediate harvest income and future expectation value were derived based on various management alternatives simulated. Results Errors in diameter distributions affected the predicted harvest profits and future expectation values differently between the simulated alternatives and depending on site type and interest rate assumptions. As a result, different alternatives were considered as optimal management compared to the use of the error-free reference distributions. In particular, the use of no management or most intensive management alternatives became preferred over alternatives with intermediate harvesting intensities. Certain harvesting types such as thinning from below became preferred more often than what was optimal. The errors did not affect the selection of the management alternative in 71% of the simulations, whereas in the remaining proportion, relying on the erroneous information would have caused losing 2%, on average, and 17% at maximum, of the total immediate and future expected income. Conclusion The effects above might not have been discovered, if the results were validated for inventory totals instead of separately considering the immediate and future income and losses produced by the erroneous decisions. It is recommended not to separate but to integrate the inventory and planning systems for well-informed decisions.
  • Roikonen, Petri; Häkkinen, Antti (2019)
    This study analyses social heterogamy in western and southern Finland during the early stages of industrialisation, from 1700 to 1910. Marriage patterns are examined by comparing the social classes of spouses' parents, which can be understood as the social origin of the spouse. The rate of heterogamy within the freeholder class was only 19.8%, whereas it was 71.1% in the upper classes, 59.7% in the tenant class and 76.5% in the labour class. In addition, only roughly 20-30% of grooms whose fathers were landowners married brides from lower social classes. Certain individual- and family-level characteristics increased the odds of a heterogamous marriage: remarrying, age difference, being an illegitimate child or a single mother, and the first marriages of those in the labour class. Regarding macro-level variables, we found that higher rates of emigration and poor-relief recipients, along with having a larger Finnish-speaking population, led to higher levels of heterogamy. Other issues increasing the odds of heterogamy included living in the more urbanised or industrialised regions and moving to different regions. This study identified strict marriage patterns, which did not significantly change with respect to heterogamy. Nevertheless, indications exist that industrialisation and urbanisation began eroding the prevailing traditions.
  • Andreassen, Bettina Kulle; Stoer, Nathalie C.; Martinsen, Jan Ivar; Ursin, Giske; Weiderpass, Elisabete; Thoresen, G. Hege; Debernard, Karen Boldingh; Karlstad, Oystein; Pottegard, Anton; Friis, Soren (2019)
    Introduction Surveillance of unintended effects of pharmaceuticals (pharmacovigilance or drug safety) is crucial, as knowledge of rare or late side effects is limited at the time of the introduction of new medications into the market. Side effects of drugs may involve increased or decreased risk of cancer, but these typically appear after a long induction period. This fact, together with low incidences of many cancer types, limits the usefulness of traditional pharmacovigilance strategies, primarily based on spontaneous reporting of adverse events, to identify associations between drug use and cancer risk. Postmarketing observational pharmacoepidemiological studies are therefore crucial in the evaluation of drug-cancer associations. Methods and analysis The main data sources in this project will be the Norwegian Prescription Database and the Cancer Registry of Norway. The underlying statistical model will be based on a multiple nested case-control design including all adult (similar to 200 000) incident cancer cases within the age-range 18-85 years from 2007 through 2015 in Norway as cases. 10 cancer-free population controls will be individually matched to these cases with respect to birth year, sex and index date (date of cancer diagnosis). Drug exposure will be modelled as chronic user/non-user by counting prescriptions, and cumulative use by summarising all dispensions' daily defined doses over time. Conditional logistic regression models adjusted for comorbidity (National Patient Register), socioeconomic parameters (Statistics Norway), concomitant drug use and, for female cancers, reproduction data (Medical Birth Registry), will be applied to identify drug-use-cancer-risk associations. Ethics and dissemination The study is approved by the regional ethical committee and the Norwegian data protection authority. Results of the initial screening step and analysis pipeline will be described in a key paper. Subsequent papers will report the evaluation of identified signals in replication studies. Results will be published in peer-reviewed journals, at scientific conferences and through press releases.
  • Pukkala, Eero; Engholm, Gerda; Schmidt, Lise Kristine Hojsgaard; Storm, Hans; Khan, Staffan; Lambe, Mats; Pettersson, David; Olafsdottir, Elinborg; Tryggvadottir, Laufey; Hakanen, Tiina; Malila, Nea; Virtanen, Anni; Johannesen, Tom Borge; Laronningen, Siri; Ursin, Giske (2018)
    Background: The Nordic Cancer Registries are among the oldest population-based registries in the world, with more than 60 years of complete coverage of what is now a combined population of 26 million. However, despite being the source of a substantial number of studies, there is no published paper comparing the different registries. Therefore, we did a systematic review to identify similarities and dissimilarities of the Nordic Cancer Registries, which could possibly explain some of the differences in cancer incidence rates across these countries.Methods: We describe and compare here the core characteristics of each of the Nordic Cancer Registries: (i) data sources; (ii) registered disease entities and deviations from IARC multiple cancer coding rules; (iii) variables and related coding systems. Major changes over time are described and discussed.Results: All Nordic Cancer Registries represent a high quality standard in terms of completeness and accuracy of the registered data.Conclusions: Even though the information in the Nordic Cancer Registries in general can be considered more similar than any other collection of data from five different countries, there are numerous differences in registration routines, classification systems and inclusion of some tumors. These differences are important to be aware of when comparing time trends in the Nordic countries.
  • Hellstrand, Julia Ingrid Sofia; Nisén, Jessica; Miranda, Vitor; Fallesen, Peter; Dommermuth, Lars; Myrskylä, Mikko (2021)
    With historically similar patterns of high and stable cohort fertility and high levels of gender equality, the Nordic countries of Sweden, Finland, Norway, Denmark, and Iceland are seen as forerunners in demographic behavior. Furthermore. Nordic fertility trends have strongly influenced fertility theories. However, the period fertility decline that started around 2010 in many countries with relatively high fertility is particularly pronounced in the Nordic countries, raising the question of whether Nordic cohort fertility will also decline and deviate from its historically stable pattern. Using harmonized data across the Nordic countries, we comprehensively describe this period decline and analyze the extent to which it is attributable to tempo or quantum effects. Two key results stand out. First, the decline is mostly attributable to first births but can be observed across all ages from 15 to the mid -30s. This is a reversal from the previous trend in which fertility rates in the early 30s increased relatively steadily in those countries in the period 1980-2010. Second. tempo explains only part of the decline. Forecasts indicate that the average Nordic cohort fertility will decline from 2 children for the 1970 cohort to around 1.8 children for the late 1980s cohorts. Finland diverges from the other countries in terms of its lower expected cohort fertility (below 1.6), and Demnark and Sweden diverge from Finland. Iceland, and Norway in terms of their slower cohort fertility decline. These findings suggest that the conceptualization of the Nordic model of high and stable fertility may need to be revised.
  • Pekkala, Johanna; Blomgren, Jenni; Pietilainen, Olli; Lahelma, Eero; Rahkonen, Ossi (2017)
    Background: Musculoskeletal diseases and mental disorders are major causes of long-term sickness absence in Western countries. Although sickness absence is generally more common in lower occupational classes, little is known about class differences in diagnostic-specific absence over time. Focusing on Finland during 2005-2014, we therefore set out to examine the magnitude of and changes in absolute and relative occupational class differences in long-term sickness absence due to major diagnostic causes. Methods: A 70-per-cent random sample of Finns aged 25-64 linked to register data on medically certified sickness absence (of over 10 working days) in 2005-2014 was retrieved from the Social Insurance Institution of Finland. Information on occupational class was obtained from Statistics Finland and linked to the data. The study focused on female (n = 658,148-694,142) and male (n = 604,715-642,922) upper and lower non-manual employees and manual workers. The age-standardised prevalence, the Slope Index of Inequality (SII) and the Relative Index of Inequality (RII) were calculated for each study year to facilitate examination of the class differences. Results: The prevalence of each diagnostic cause of sickness absence declined during the study period, the most common causes being musculoskeletal diseases, mental disorders and injuries. The prevalence of other causes under scrutiny was less than 1 % annually. By far the largest absolute and relative differences were in musculoskeletal diseases among both women and men. Moreover, the absolute differences in both genders (p <0. 0001) and the relative differences in men (p <0.0001) narrowed over time as the prevalence declined most among manual workers. Both genders showed modest and stable occupational class differences in mental disorders. In the case of injuries, no major changes occurred in absolute differences but relative differences narrowed over time in men (p <0.0001) due to a strong decline in prevalence among manual workers. Class differences in the other studied diagnostic causes under scrutiny appeared negligible. Conclusions: By far the largest occupational class differences in long-term sickness absence concerned musculoskeletal diseases, followed by injuries. The results highlight potential targets for preventive measures aimed at reducing sickness absence and narrowing class differences in the future.
  • Handal, Marte; Skurtveit, Svetlana; Mahic, Milada; Øhman, Inger; Wikner, Birgitta Norstedt; Tjagvad, Christian; Kieler, Helle; Halmesmäki, Erja; Lund, Ingunn Olea (2020)
    Background: WHO guidelines emphasise the need for descriptions of clinical practice and observational studies on risk and benefits of pharmacotherapies in pregnancy. The aims of the present study were to: (1) Describe opioid maintenance treatment (OMT) in the Scandinavian countries in general, and specifically for pregnant women, (2) Describe a project which utilises a new approach using registry-linkage data to examine associations between prenatal exposure to OMT and child outcomes: a Scandinavian cohort study of pregnant women in OMT during pregnancy (ScopeOMT). Data: Guidelines describing the treatment of persons with opioid use disorders in general, and specifically for pregnant women. Scandinavian registry-linkage data from ScopeOMT. Results: Registry data show that approximately 800 pregnant women received OMT during pregnancy in the period of the ScopeOMT study. Similarities across the Scandinavian countries include access to free healthcare and treatment; multidisciplinary teams trained to support pregnant women in OMT; buprenorphine as the recommended drug when initiating therapy; and a holistic focus on the patients' lives. An important difference is that Norwegian women who use illegal substances that may harm the foetus may be admitted - voluntarily, or against their will - for parts of, or the remainder of the pregnancy to inpatient treatment at specialised clinics. Conclusion: Many similarities in the treatment provided to opioid-dependent persons in the Scandinavian countries place this area in an excellent position to combine the efforts and carry out observational studies concerning the safety of OMT during pregnancy.
  • Gong, Zheng; Evans, David A. D.; Elming, Sten-Åke; Söderlund, Ulf; Salminen, Johanna M. (2018)
  • Sköld, Amilla; Bjorge, Tone; Ekbom, Anders; Engeland, Anders; Gissler, Mika; Grotmol, Tom; Madanat-Harjuoja, Laura; Ording, Anne Gulbech; Trabert, Britton; Tretli, Steinar; Troisi, Rebecca; Sorensen, Henrik Toft; Glimelius, Ingrid (2020)
    Background Non-epithelial ovarian cancers are divided into sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Whereas parity and other pregnancy-related factors are protective for epithelial ovarian cancer, their associations with SCSTs and GCTs remains unclear. Methods Using data from the medical birth registries from Denmark, Finland, Norway and Sweden, we compared all parous women with a diagnosis of SCSTs (n = 420) or GCTs (n = 345) 1970-2013 with up to 10 parous controls (SCSTs n = 4041; GCTs n = 2942) matched on the cases' birth year and country. We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of associations between pregnancy-related factors and SCSTs and GCTs. Results The risk of SCSTs, but not GCTs, decreased with higher age at last birth [>= 40 versus
  • Veikkolainen, Toni Henri Kristian; Kukkonen, Ilmo Tapio; Näslund, Jens-Ove (2019)
    In northern Europe, radiogenic heat production of surface rocks has been extensively studied in Finland and Norway alike. This paper presents a heat production analysis of Sweden, based on a rock outcrop data compilation obtained from the Geological Survey of Sweden (SGU). The study area comprises Precambrian Shield, Caledonian and platform cover areas. Altogether 39933 samples with uranium, thorium and potassium concentration (C-U, C-Th and C-K) and density () data were available. Heat production (HP) was calculated using raw point data, binning on a regular grid, and averaging by bedrock units in the geological map. Methods based on raw point data and grid-based binning resulted in HP values of 2.5 +/- 4.1 and 2.5 +/- 5.6 Wm(-3), respectively, while averaging by lithology produced a lower value of 2.4 +/- 1.7 Wm(-3). Limiting the lithology-based averaging to Precambrian bedrockareas resulted in heat production of 2.4 +/- 1.6 Wm(-3). Due to the small geographic extent of area covered by sediments, this is similar to the Precambrian-only value. Regardless of the calculation method, heat production in Sweden is considerably higher than the corresponding value for Finland. The Swedish platform cover had apparently the lowestheat production (1.0 +/- 1.8 Wm(-3)) of all units but the presence of Precambrian rocks below the sediments means that this value strongly misleads if used to represent the entire upper crust. Svecokarelian (Svecofennian) and Sveconorwegian rocks, which comprised 94.0 per cent of all individual observations, had heat production values of 2.6 +/- 1.8 and 1.7 +/- 1.4 mu Wm(-3), respectively. Although the Swedish data still have large spatial gaps when compared to Finnish data, most bedrock units in Sweden are covered. It is obvious that the higher heat flow of Sweden compared to that of Finland is caused by near-surface (i.e. upper crustal) heat production, and crustal differentiation in Sweden is also larger.