Browsing by Subject "OBLITERATION"

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  • Lindfors, Nina; Geurts, Jan; Drago, Lorenzo; Arts, J. J.; Juutilainen, Vesa; Hyvönen, Pekka; Suda, Arnold J.; Domenico, Aloj; Artiaco, Stefano; Alizadeh, Chingiz; Brychcy, Adrian; Bialecki, Jertzy; Romano, Carlo L. (Springer International Publishing AG, 2017)
    Advances in Experimental Medicine and Biology
    Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiotics as a two-stage procedure that uses autograft or allograft bone for filling of the cavitary defect. Bioactive glass (BAG-S53P4) is a bone substitute with proven antibacterial and bone bonding properties. One hundred and sixteen patients who had verified chronic osteomyelitis was treated using BAG-S53P4 as part of the treatment. Most of the patients had previously undergone numerous procedures, sometimes for decades. A register of patient data obtained from 11 centers from Finland, Italy, the Netherlands, Germany, Azerbaijan and Poland was set-up and continuously maintained at Helsinki University Central Hospital. The location of the osteomyelitis was mainly in the tibia followed by the femur and then the calcaneus. The median age of the patients was 48 years (15-87). The patients were either treated according to a one-stage procedure without local antibiotics (85 %) or by a two-stage procedure using antibiotic beads in the first procedure (15 %). The minimum follow-up was 1 year (12-95 months, median 31). The cure rate was 104/116, the total success rate 90 % and most of the patients showed a rapid recovery. The study shows that (BAG-S53P4) can be used in a one-stage procedure in treatment of osteomyelitis with excellent results.
  • Venermo, Maarit; Saarinen, J.; Eskelinen, Elina; Vähäaho, Sari M; Saarinen, Eva; Railo, Mikael; Uurto, I.; Salenius, J.; Albäck, Anders; Finnish Venous Study Collaborators (2016)
    BackgroundEndovenous ablation techniques and ultrasound-guided foam sclerotherapy (UGFS) have largely replaced open surgery for treatment of great saphenous varicose veins. This was a randomized trial to compare the effect of surgery, endovenous laser ablation (EVLA) (with phlebectomies) and UGFS on quality of life and the occlusion rate of the great saphenous vein (GSV) 12months after surgery. MethodsPatients with symptomatic, uncomplicated varicose veins (CEAP class C2-C4) were examined at baseline, 1month and 1year. Before discharge and at 1week, patients reported a pain score on a visual analogue scale. Preoperative and 1-year assessments included duplex ultrasound imaging and the Aberdeen Varicose Vein Severity Score (AVVSS). ResultsThe study included 214 patients: 65 had surgery, 73 had EVLA and 76 had UGFS. At 1year, the GSV was occluded or absent in 59 (97 per cent) of 61 patients after surgery, 71 (97 per cent) of 73 after EVLA and 37 (51 per cent) of 72 after UGFS (P <0001). The AVVSS improved significantly in comparison with preoperative values in all groups, with no significant differences between them. Perioperative pain was significantly reduced and sick leave shorter after UGFS (mean 1day) than after EVLA (8days) and surgery (12days). ConclusionIn comparison with open surgery and EVLA, UGFS resulted in equivalent improvement in quality of life but significantly higher residual GSV reflux at 12-month follow-up. Foam less effective