Browsing by Subject "PARANASAL SINUSES"

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  • Vähämurto, Pauli; Silventoinen, Kaija; Vento, Seija; Karjalainen-Lindsberg, Marja-Liisa; Haapaniemi, Aaro; Back, Leif; Mannisto, Susanna; Leppa, Sirpa; Makitie, Antti A. (2016)
    Sinonasally located lymphoid malignancies are rare lesions with first symptoms similar to other obstructive conditions. Additionally, they often coexist with nasal inflammation and mucosal necrosis. Therefore, time from the first symptoms to diagnosis tends to be long. Awareness and early diagnosis of this disease entity could improve treatment outcome. Altogether, 142 patients with sinonasal or nasopharyngeal (i.e. sinonasal tract, SNT) lymphoid malignancies, diagnosed and treated at the Helsinki University Hospital, during a 39-year period from 1975 to 2013, were retrospectively reviewed. There were 90 males (63 %) and 52 females (37 %) with a median age of 64 years (range 26-92). Eighty-four percent of the patients had primary diseases and 16 % had relapses of lymphoid malignancies primarily diagnosed at other locations. The mean duration of symptoms prior to diagnosis was 4.8 months (range 0.5-24). The most common histological entity was diffuse large B-cell lymphoma (43 %), followed by plasmacytoma (18 %). The most common location was nasopharynx (58 %) followed by nasal cavity (44 %) and paranasal sinuses (35 %). Sixty-nine percent of the lesions were at a single anatomic location of the sinonasal tract. Fifty-two percent of the cases were of Ann Arbor Stage I. Lymphoid malignancies form an important and diverse group in the differential diagnosis of SNT tumours. They most often present with general obstructive nasal symptoms due to tumour location. Most of them are primary lesions, highlighting the importance of an accurate diagnosis as early as possible.
  • Leivo, Ilmo; Holmila, Reetta; Luce, Danièle; Steiniche, Torben; Dictor, Michael; Heikkilä, Pirjo; Husgafvel‐pursiainen, Kirsti; Wolff, Henrik (2021)
    Sinonasal intestinal‐type adenocarcinoma is strongly associated with hardwood dust ex-posure. Non‐intestinal‐type adenocarcinoma is a rarer and less well‐known subtype considered not to be related with wood dust exposure. We determined the relative numbers of these two tumor types in 56 sinonasal adenocarcinoma patients in France and Finland, relating them with carefully assessed wood dust exposure histories. Diagnostic workup including immunohistochemistry for the intestinal markers CDX2 and CK20 indicated that the proportions of the two tumors differed significantly between France and Finland. In Finnish samples non‐intestinal adenocarcinomas were more common than intestinal‐type adenocarcinomas (12 non‐intestinal vs. nine intestinal), while in the French samples the reverse was true (six non‐intestinal vs. 29 intestinal). Such remarkably dis-similar occurrence of these tumors in France and Finland presumably reflects different pathogenetic circumstances in the two countries, and perhaps their different patterns of wood dust exposure. In France the main source of wood dust is from hardwoods. In Finland it is derived from softwoods. This is the first systematic comparison of the occurrence of intestinal‐type adenocarcinoma and non-intestinal‐type adenocarcinoma in two countries with different wood usage. It appears to be the first systematic study on differences in wood dust exposure between intestinal‐type adenocarci-noma and non‐intestinal‐type adenocarcinoma.