Browsing by Subject "PLATELETS"

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  • Tietäväinen, Johanna; Laine, Outi; Mäkelä, Satu; Huhtala, Heini; Pörsti, Ilkka; Vaheri, Antti; Mustonen, Jukka (2021)
    Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982-2017. Patients' blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (n = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection.
  • Lassila, Riitta; Campbell, Robert (2019)
    Take home messages To understand the main interplay between coagulation system and inflammation and to recognize the key invasive infectious agents causing typical abnormalities in activation of blood platelets, coagulation and fibrinolysis. To capture, monitor and follow-up the clinical and laboratory phenotype and the management related to the pathophysiology of inflammation.
  • Picetti, Edoardo; Rossi, Sandra; Abu-Zidan, Fikri M.; Ansaloni, Luca; Armonda, Rocco; Baiocchi, Gian Luca; Bala, Miklosh; Balogh, Zsolt J.; Berardino, Maurizio; Biffl, Walter L.; Bouzat, Pierre; Buki, Andras; Ceresoli, Marco; Chesnut, Randall M.; Chiara, Osvaldo; Citerio, Giuseppe; Coccolini, Federico; Coimbra, Raul; Di Saverio, Salomone; Fraga, Gustavo P.; Gupta, Deepak; Helbok, Raimund; Hutchinson, Peter J.; Kirkpatrick, Andrew W.; Kinoshita, Takahiro; Kluger, Yoram; Leppäniemi, Ari; Maas, Andrew I. R.; Maier, Ronald V.; Minardi, Francesco; Moore, Ernest E.; Myburgh, John A.; Okonkwo, David O.; Otomo, Yasuhiro; Rizoli, Sandro; Rubiano, Andres M.; Sahuquillo, Juan; Sartelli, Massimo; Scalea, Thomas M.; Servadei, Franco; Stahel, Philip F.; Stocchetti, Nino; Taccone, Fabio S.; Tonetti, Tommaso; Velmahos, George; Weber, Dieter; Catena, Fausto (2019)
    The acute phase management of patients with severe traumatic brain injury (TBI) and polytrauma represents a major challenge. Guidelines for the care of these complex patients are lacking, and worldwide variability in clinical practice has been documented in recent studies. Consequently, the World Society of Emergency Surgery (WSES) decided to organize an international consensus conference regarding the monitoring and management of severe adult TBI polytrauma patients during the first 24 hours after injury. A modified Delphi approach was adopted, with an agreement cut-off of 70%. Forty experts in this field (emergency surgeons, neurosurgeons, and intensivists) participated in the online consensus process. Sixteen recommendations were generated, with the aim of promoting rational care in this difficult setting.