Anderson, Peter J.; de Miranda, Debora Marques; Albuquerque, Maicon Rodrigues; Indredavik, Marit Saebo; Evensen, Kari Anne; Van Lieshout, Ryan; Saigal, Saroj; Taylor, H. Gerry; Raikkonen, Katri; Kajantie, Eero; Marlow, Neil; Johnson, Samantha; Woodward, Lianne J.; Austin, Nicola; Nosarti, Chiara; Jaekel, Julia; Wolke, Dieter; Cheong, Jeanie Ly; Burnett, Alice; Treyvaud, Karli; Lee, Katherine J.; Doyle, Lex W.
(2021)
Background: Data on psychiatric disorders in survivors born very preterm (VP; Methods: This individual participant data (IPD) meta-analysis pooled data from eligible groups in the Adults born Preterm International Collaboration (APIC). Inclusion criteria included: 1) VP/VLBW group (birth weight 2499 g and/or gestational age >= 37 weeks), and 3) structured measure of psychiatric diagnoses using DSM or ICD criteria. Diagnoses of interest were Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Anxiety Disorder, Mood Disorder, Disruptive Behaviour Disorder (DBD), Eating Disorder, and Psychotic Disorder. A systematic search for eligible studies was conducted (PROSPERO Registration Number 47555). Findings: Data were obtained from 10 studies (1385 VP/VLBW participants, 1780 controls), using a range of instruments and approaches to assigning diagnoses. Those born VP/VLBW had ten times higher odds of meeting criteria for ASD (odds ratio [OR] 10.6, 95% confidence interval [CI] 2.50, 44.7), five times higher odds of meeting criteria for ADHD (OR 5.42, 95% CI 3.10, 9.46), twice the odds of meeting criteria for Anxiety Disorder (OR 1.91, 95% CI 1.36, 2.69), and 1.5 times the odds of meeting criteria for Mood Disorder (OR 1.51, 95% CI 1.08, 2.12) than controls. This pattern of findings was consistent within age (= 18 years) and sex subgroups. Interpretation: Our data suggests that individuals born VP/VLBW might have higher odds of meeting criteria for certain psychiatric disorders through childhood and into adulthood than term/NBW controls. Further research is needed to corroborate our results and identify factors associated with psychiatric disorders in individuals born VP/VLBW. (C) 2021 The Author(s). Published by Elsevier Ltd.