Browsing by Subject "SKIN-CANCER"

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  • Neittaanmäki-Perttu, Noora; Gronroos, Mari; Jeskanen, Leila; Polonen, Ilkka; Ranki, Annamari; Saksela, Olli; Snellman, Erna (2015)
    Lentigo maligna (LM) is an in situ form of melanoma which can progress into invasive lentigo maligna melanoma (LMM). Variations in the pigmentation and thus visibility of the tumour make assessment of lesion borders challenging. We tested hyperspectral imaging system (HIS) in in vivo preoperative delineation of LM and LMM margins. We compared lesion margins delineated by HIS with those estimated clinically, and confirmed histologically. A total of 14 LMs and 5 LIVIMs in 19 patients were included. HIS analysis matched the histopathological analysis in 18/19 (94.7%) cases while in 1/19 (5.3%) cases HIS showed lesion extension not confirmed by histopathology (false positives). Compared to clinical examination, HIS defined lesion borders more accurately in 10/19 (52.6%) of cases (wider, n=7 or smaller, n=3) while in 8/19 (42.1%) cases lesion borders were the same as delineated clinically as confirmed histologically. Thus, HIS is useful for the detection of subclinical LM/LMM borders.
  • Barnes, Paul W.; Williamson, Craig E.; Lucas, Robyn M.; Robinson, Sharon A.; Madronich, Sasha; Paul, Nigel D.; Bornman, Janet F.; Bais, Alkiviadis F.; Sulzberger, Barbara; Wilson, Stephen R.; Andrady, Anthony L.; McKenzie, Richard L.; Neale, Patrick J.; Austin, Amy T.; Bernhard, Germar H.; Solomon, Keith R.; Neale, Rachel E.; Young, Paul J.; Norval, Mary; Rhodes, Lesley E.; Hylander, Samuel; Rose, Kevin C.; Longstreth, Janice; Aucamp, Pieter J.; Ballare, Carlos L.; Cory, Rose M.; Flint, Stephan D.; de Gruijl, Frank R.; Haeder, Donat-P; Heikkila, Anu M.; Jansen, Marcel A. K.; Pandey, Krishna K.; Robson, T. Matthew; Sinclair, Craig A.; Wangberg, Sten-Ake; Worrest, Robert C.; Yazar, Seyhan; Young, Antony R.; Zepp, Richard G. (2019)
    Changes in stratospheric ozone and climate over the past 40-plus years have altered the solar ultraviolet (UV) radiation conditions at the Earth's surface. Ozone depletion has also contributed to climate change across the Southern Hemisphere. These changes are interacting in complex ways to affect human health, food and water security, and ecosystem services. Many adverse effects of high UV exposure have been avoided thanks to the Montreal Protocol with its Amendments and Adjustments, which have effectively controlled the production and use of ozone-depleting substances. This international treaty has also played an important role in mitigating climate change. Climate change is modifying UV exposure and affecting how people and ecosystems respond to UV; these effects will become more pronounced in the future. The interactions between stratospheric ozone, climate and UV radiation will therefore shift over time; however, the Montreal Protocol will continue to have far-reaching benefits for human well-being and environmental sustainability.
  • Neittaanmäki-Perttu, Noora; Gronroos, Mari; Karppinen, Toni T.; Snellman, Erna; Rissanen, Pekka (2016)
    Daylight-mediated photodynamic therapy (DL-PDT) is considered as effective as conventional PDT using artificial light (light-emitting diode (LED)-PDT) for treatment of actinic keratoses (AK). This randomized prospective non-sponsored study assessed the cost-effectiveness of DL-PDT compared with LED-PDT. Seventy patients with 210 AKs were randomized to DL-PDT or LED-PDT groups. Effectiveness was assessed at 6 months. The costs included societal costs and private costs, including the time patients spent in treatment. Results are presented as incremental cost-effectiveness ratio (ICER). The total costs per patient were significantly lower for DL-PDT ((sic) 132) compared with LED-PDT ((sic) 170), giving a cost saving of (sic)38 (p = 0.022). The estimated probabilities for patients' complete response were 0.429 for DL-PDT and 0.686 for LED-PDT; a difference in probability of being healed of 0.257. ICER showed a monetary gain of (sic) 147 per unit of effectiveness lost. DL-PDT is less costly and less effective than LED-PDT. In terms of cost-effectiveness analysis, DL-PDT provides lower value for money compared with LED-PDT.