Browsing by Subject "Sex"

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  • Forsblom, E.; Kakriainen, A.; Ruotsalainen, E.; Järvinen, A. (2018)
    Background Sex-related treatment inequalities are suggested to explain outcome differences between men and women in Staphylococcus aureus bacteremia (SAB). We compared patient characteristics, clinical management, infectious specialist consultation (ISC) and outcome in men and women with SAB. Methods Multicenter retrospective study of methicillin-sensitive (MS-) SAB patients categorized according to sex and ISC consultation provided within 7 days of diagnosis. Results Altogether 617 SAB patients were included in the analysis: 62% males and 38% females. Male sex was associated less often to nosocomial bacteremia (OR 0.69, 95% CI 0.50-0.96, p = 0.029) and more often to alcoholism (OR 2.25, 95% CI 1.31-3.87, p = 0.003). No sex-related differences were seen in basic or immunologic laboratory tests, illness severity, intensive care unit treatment or thromboembolic events. ISC was provided to most patients (94%) irrespective of sex. No differences were seen in clinical management of men or women: Transthoracic or -esophageal echocardiography (61% vs. 65%), deep infection (77% vs. 72%), infection removal (30% vs. 27%) and anti-staphylococcal antibiotics as first-line treatment (54% vs. 51%). However, male sex was connected to more frequent adjunctive rifampicin treatment (52% vs. 41%, p = 0.025). No difference in 28- or 90-day mortality (13% vs. 13% and 18% vs. 20%) or SAB relapse (0% vs. 1%) was observed between men and women. Propensity-score adjusted Cox proportional analysis gave no connection of sex to mortality within 90 days. Conclusion Patient characteristics, clinical management, ISC guidance, bacteremia relapse, and outcome did not differ in men and women with MS-SAB.
  • ARISE Investigators; Luethi, Nora; Bailey, Michael; Harjola, V-P; Okkonen, M.; Pettilä, V.; Sutinen, E.; Wilkman, E. (2020)
    Purpose: To assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock. Material and methods: Cohort study of the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial, an international randomized controlled trial comparing early goal-directed therapy (EGDT) to usual care in patients with early septic shock, conducted between October 2008 and April 2014. The primary exposure in this analysis was legal gender and the secondary exposure was pre-menopausal state defined by chronological age ( Results: 641 (40.3%) of all 1591 ARISE trial participants in the intention-to-treat population were females and overall, 337 (21.2%) (146 females) patients were 50 years of age or younger. After risk-adjustment, we could not identify any survival benefit for female patients at day 90 in the younger (50 years) age-group (aOR: 1.10 (0.81-1.49), p = .56). Similarly, there was no gender-difference in ICU, hospital, 1-year mortality nor quality of life measures. Conclusions: This post-hoc analysis of a large multi-center trial in early septic shock has shown no short- or long-term survival effect for women overall as well as in the pre-menopausal age-group. (C) 2019 Elsevier Inc. All rights reserved.
  • Laine, Merja K.; Kautiainen, Hannu; Gissler, Mika; Pennanen, Pirjo; Eriksson, Johan G. (2021)
    Background The impact of gestational diabetes mellitus (GDM) on the duration of breastfeeding varies between shortening and no impact. Breastfeeding seems to reduce both maternal and offspring risk for type 2 diabetes and offspring risk for overweight or obesity later in life. The aim of our study was to evaluate in primiparous women whether GDM had an influence on the duration of breastfeeding, and further, to evaluate the factors that influenced on the duration of breastfeeding. Methods The study cohort (N = 1089) consisted of all primiparous women with a Finnish background excluding women with pre-existing diabetes mellitus who lived in the city of Vantaa, Finland, gave birth to a singleton living child between 2009 and 2015, and with valid data on breastfeeding available. The diagnosis of GDM was based on a standard 75 g 2-h oral glucose tolerance test. Data were obtained from Finnish national registers and from the medical records of the city of Vantaa. Results No differences were observed in the duration of breastfeeding between women diagnosed with GDM and without GDM, 7.5 (Standard Deviation [SD] 3.7) months versus 7.9 (SD 3.5) months (p = 0.17). Women diagnosed with GDM breastfed boys for a longer duration than girls (maternal age, pre-pregnancy body mass index, marital status, educational attainment, duration of pregnancy, and smoking habits adjusted p = 0.042). Women who breastfed <6 months were younger, were more likely smokers, had shorter education, and higher pre-pregnancy body mass index than women who breastfed over 6 months (p <0.001 for linearity). Conclusions In primiparous women GDM did not influence breastfeeding duration. The positive health effects of breastfeeding should be emphasized especially in young, overweight and less educated women in order to minimize the risk of obesity and type 2 diabetes for themselves and their offspring.
  • Laine, Merja K; Kautiainen, Hannu; Gissler, Mika; Pennanen, Pirjo; Eriksson, Johan G (BioMed Central, 2021)
    Abstract Background The impact of gestational diabetes mellitus (GDM) on the duration of breastfeeding varies between shortening and no impact. Breastfeeding seems to reduce both maternal and offspring risk for type 2 diabetes and offspring risk for overweight or obesity later in life. The aim of our study was to evaluate in primiparous women whether GDM had an influence on the duration of breastfeeding, and further, to evaluate the factors that influenced on the duration of breastfeeding. Methods The study cohort (N = 1089) consisted of all primiparous women with a Finnish background excluding women with pre-existing diabetes mellitus who lived in the city of Vantaa, Finland, gave birth to a singleton living child between 2009 and 2015, and with valid data on breastfeeding available. The diagnosis of GDM was based on a standard 75 g 2-h oral glucose tolerance test. Data were obtained from Finnish national registers and from the medical records of the city of Vantaa. Results No differences were observed in the duration of breastfeeding between women diagnosed with GDM and without GDM, 7.5 (Standard Deviation [SD] 3.7) months versus 7.9 (SD 3.5) months (p = 0.17). Women diagnosed with GDM breastfed boys for a longer duration than girls (maternal age, pre-pregnancy body mass index, marital status, educational attainment, duration of pregnancy, and smoking habits adjusted p = 0.042). Women who breastfed < 6 months were younger, were more likely smokers, had shorter education, and higher pre-pregnancy body mass index than women who breastfed over 6 months (p <  0.001 for linearity). Conclusions In primiparous women GDM did not influence breastfeeding duration. The positive health effects of breastfeeding should be emphasized especially in young, overweight and less educated women in order to minimize the risk of obesity and type 2 diabetes for themselves and their offspring.
  • Ekman, Otto (Helsingin yliopisto, 2021)
    Denna pro gradu granskar kopplingen mellan sexualitet, samhällelig makt och våld i världsbilden hos unga män som dragits till högerextremistiska rörelser i dagens samhälle samt tidigare i historien. Den analyserar boken Ilman skriven av den finske högerextreme författaren och essäisten Timo Hännikäinen med hjälp av referenser från historie-, medie- och samtidsforskning för att placera den in i en bredare kulturell och politisk kontext. Avhandlingen undersöker hur en självupplevd känsla av ensamhet, sexuell frustration eller sexuell motvilja hänger samman med en bredare känsla av hotad makt och hotad manlighet och hur konkreta eller symboliska våldshandlingar kan fungera som ett sätt för män som känner sig hotade att försöka återerövra sin makt och agens. Den jämför Klaus Theweleits analyser av biografisk och fiktiv litteratur från 20-talets tyska frikårer i hans verk Mansfantasier med den irländska forskaren Angela Nagles kartläggning av misogyna internetforum i hennes verk Kill all Normies från 2017, och undersöker hur dessa båda respektive forskares teorier hänger samman och kan appliceras för att undersöka Hännikäinens bok. Avhandlingen innehåller också en mediekritisk analys av hur samtida massmediebevakning av de fenomen som avhandlingen undersöker kan inverka på hur de utformas. Syftet är att göra en tvärvetenskaplig analys av ett aktuellt fenomen för att ge upplägg till vidare forskning i flera olika riktningar. Slutsatsen av min undersökning är att hotet från ensamma, alienerade unga män i alla fall delvis sensationaliserats av massmedia och förvandlats till en så kallad ”moralpanik”, men att denna moralpanik i sig kan spela en roll för att radikalisera och politisera något som börjat som en subjektiv, personlig känsla av ensamhet eller alienation. Den visar också hur den grundläggande kopplingen mellan hotad sexualitet och politiskt våld inom den högerpopulistiska rörelsen har politiska rötter som sträcker sig ända tillbaka till denna rörelses uppkomst.
  • Agarwal, Arnav; Eryuzlu, Leyla N.; Cartwright, Rufus; Thorlund, Kristian; Tammela, Teuvo L. J.; Guyatt, Gordon H.; Auvinen, Anssi; Tikkinen, Kari A. O. (2014)