Browsing by Subject "Suicide"

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  • Kriikku, Pirkko; Ojanperä, Ilkka (2020)
    LÄHTÖKOHDAT Suomessa tehdään paljon oikeuslääketieteellisiä ruumiinavauksia ja niihin liittyviä oikeuskemiallisia tutkimuksia. Tämä mahdollistaa alkoholin, lääkkeiden, huumeiden ja palokaasujen aiheuttamien myrkytyskuolemien luotettavan seurannan. MENETELMÄT Tulokset koottiin kuolemansyyn selvittämiseen liittyvästä laboratorioaineistosta ja asiakirjoista keskittyen vuosiin 2014–2017. TULOKSET Alkoholimyrkytyskuolemat vähentyivät ajanjaksolla 279:stä 229:ään (18 %). Lääke- ja huumemyrkytykset vähenivät vuosina 2014–2016, mutta lisääntyivät jälleen vuonna 2017. Opioidimyrkytysten osuus lääke- ja huumemyrkytyksistä pienentyi tasaisesti 38 %:sta 31 %:iin. Buprenorfiinikuolemat olivat edelleen yleisiä. PÄÄTELMÄT Myrkytyskuolemien kokonaismäärä on vähentynyt tasaisesti vuoden 2006 jälkeen. Alkoholimyrkytyskuolemien määrän myönteinen kehitys heijastaa alkoholin kulutuksen vähenemistä. Suomessa opioidit eivät tällä hetkellä aiheuta vastaavaa uhkaa kuin monissa muissa maissa.
  • Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole A.; Angelopoulos, Elias; Ardau, Raffaella; Ayhan, Yavuz; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Becerra-Palars, Claudia; Bellivier, Frank; Belmaker, Robert H.; Berk, Michael; Bersudsky, Yuly; Bicakci, Sule; Birabwa-Oketcho, Harriet; Bjella, Thomas D.; Cabrera, Jorge; Cheung, Eric Y. Wo; Del Zompo, Maria; Dodd, Seetal; Donix, Markus; Etain, Bruno; Fagiolini, Andrea; Fountoulakis, Kostas N.; Frye, Mark A.; Gonzalez-Pinto, Ana; Gottlieb, John F.; Grof, Paul; Harima, Hirohiko; Henry, Chantal; Isometsä, Erkki T.; Janno, Sven; Kapczinski, Flavio; Kardell, Mathias; Khaldi, Slim; Kliwicki, Sebastian; Konig, Barbara; Kot, Timur L.; Krogh, Rikke; Kunz, Mauricio; Lafer, Beny; Landen, Mikael; Larsen, Erik R.; Lewitzka, Ute; Licht, Rasmus W.; Lopez-Jaramillo, Carlos; MacQueen, Glenda; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Melle, Ingrid; Meza-Urzua, Fatima; Ming, Mok Yee; Monteith, Scott; Morken, Gunnar; Mosca, Enrica; Mozzhegorova, Anton A.; Munoz, Rodrigo; Mythri, Starlin V.; Nacef, Fethi; Nadella, Ravi K.; Nery, Fabiano G.; Nielsen, Rene E.; O'Donovan, Claire; Omrani, Adel; Osher, Yamima; Sorensen, Helle Ostermark; Ouali, Uta; Ruiz, Yolanda Pica; Pilhatsch, Maximilian; Pinna, Marco; da Ponte, Francisco D. R.; Quiroz, Danilo; Ramesar, Raj; Rasgon, Natalie; Reddy, M. S.; Reif, Andreas; Ritter, Philipp; Rybakowski, Janusz K.; Sagduyu, Kemal; Raghuraman, Bharathram Sathur; Scippa, Angela M.; Severus, Emanuel; Simhandl, Christian; Stackhouse, Paul W.; Stein, Dan J.; Strejilevich, Sergio; Subramaniam, Mythily; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tagata, Hiromi; Tatebayashi, Yoshitaka; Tondo, Leonardo; Torrent, Carla; Vaaler, Arne E.; Vares, Edgar; Veeh, Julia; Vieta, Eduard; Viswanath, Biju; Yoldi-Negrete, Maria; Zetina, Mark; Zgueb, Yosra; Whybrow, Peter C. (2019)
    In many international studies, rates of completed suicide and suicide attempts have a seasonal pattern that peaks in spring or summer. This exploratory study investigated the association between solar insolation and a history of suicide attempt in patients with bipolar I disorder. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area on Earth. Data were collected previously from 5536 patients with bipolar I disorder at 50 collection sites in 32 countries at a wide range of latitudes in both hemispheres. Suicide related data were available for 3365 patients from 310 onset locations in 51 countries. 1047 (31.1%) had a history of suicide attempt. There was a significant inverse association between a history of suicide attempt and the ratio of mean winter solar insolation/mean summer solar insolation. This ratio is smallest near the poles where the winter insolation is very small compared to the summer insolation. This ratio is largest near the equator where there is relatively little variation in the insolation over the year. Other variables in the model that were positively associated with suicide attempt were being female, a history of alcohol or substance abuse, and being in a younger birth cohort. Living in a country with a state-sponsored religion decreased the association. (All estimated coefficients p <0.01). In summary, living in locations with large changes in solar insolation between winter and summer may be associated with increased suicide attempts in patients with bipolar disorder. Further investigation of the impacts of solar insolation on the course of bipolar disorder is needed.
  • O'Hare, Kirstie J. M.; Korhonen, Tellervo; Latvala, Antti; Kaprio, Jaakko; Linscott, Richard J. (2020)
    Subclinical psychosis, including schizotypal indicators and psychotic experiences, predicts future suicidal ideation. This relationship may reflect unmeasured confounding from environmental factors, genetic factors, or both. We used a genetically-informative twin design to understand if the association between subclinical psychosis and suicidal ideation is independent of shared genetic and environmental factors. We analysed cross-sectional associations of age-22 self-reported subclinical psychosis (positive, negative, and disorganised features) with suicidal ideation in twins participating in the FinnTwin12 study (maximum n = 1213). Then, we analysed the reverse association of age-14 suicidal ideation with age-22 subclinical psychosis. Associations were studied first among individuals and then within monozygotic (MZ) and dizygotic (DZ) pairs. Individual-level analyses showed that all subclinical psychosis factors were associated with suicidal ideation. In within-pair analyses, estimates of associations were lower for MZ pairs than DZ pairs, except for the negative schizotypy-suicidal ideation association where estimates were consistent across individual-level and within-pair analyses. Findings provide evidence that the association between negative features and suicide ideation is not explained by familial factors and may be causal, though the possibility of confounding by individual-specific environmental factors and reverse causation cannot be ruled out. The relationships of positive and disorganised subclinical psychosis features with suicidal ideation cannot be explained by confounding due to environmental factors shared between siblings, but their associations may be due to shared genetic factors. (C) 2020 Elsevier B.V. All rights reserved.
  • Mullins, Niamh; Kang, JooEun; Campos, Adrian I.; Coleman, Jonathan R.I.; Edwards, Alexis C.; Galfalvy, Hanga; Levey, Daniel F.; Lori, Adriana; Shabalin, Andrey; Starnawska, Anna; Su, Mei-Hsin; Watson, Hunna J.; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan D.; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo; Ripke, Stephan; Ware, Erin B.; Bergen, Andrew W.; Berrettini, Wade H.; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Wei J.; Chen, Hsi-Chung; Crawford, Steven; Crow, Scott; DiBlasi, Emily; Duriez, Philibert; Fernández-Aranda, Fernando; Fichter, Manfred M.; Gallinger, Steven; Glatt, Stephen J.; Gorwood, Philip; Guo, Yiran; Hakonarson, Hakon; Halmi, Katherine A.; Hwu, Hai-Gwo; Jain, Sonia; Jamain, Stéphane; Jiménez-Murcia, Susana; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Keel, Pamela K.; Kennedy, James L.; Klump, Kelly L.; Li, Dong; Liao, Shih-Cheng; Lieb, Klaus; Lilenfeld, Lisa; Liu, Chih-Min; Magistretti, Pierre J.; Marshall, Christian R.; Mitchell, James E.; Monson, Eric T.; Myers, Richard M.; Pinto, Dalila; Powers, Abigail; Ramoz, Nicolas; Roepke, Stefan; Rozanov, Vsevolod; Scherer, Stephen W.; Schmahl, Christian; Sokolowski, Marcus; Strober, Michael; Thornton, Laura M.; Treasure, Janet; Tsuang, Ming T.; Witt, Stephanie H.; Woodside, D. Blake; Yilmaz, Zeynep; Zillich, Lea; Adolfsson, Rolf; Agartz, Ingrid; Air, Tracy M.; Alda, Martin; Alfredsson, Lars; Andreassen, Ole A.; Anjorin, Adebayo; Appadurai, Vivek; Soler Artigas, María; der Auwera, Sandra Van; Azevedo, M. Helena; Bass, Nicholas; Bau, Claiton H.D.; Baune, Bernhard T.; Bellivier, Frank; Berger, Klaus; Biernacka, Joanna M.; Bigdeli, Tim B.; Binder, Elisabeth B.; Boehnke, Michael; Boks, Marco P.; Bosch, Rosa; Braff, David L.; Bryant, Richard; Budde, Monika; Byrne, Enda M.; Cahn, Wiepke; Casas, Miguel; Castelao, Enrique; Cervilla, Jorge A.; Chaumette, Boris; Cichon, Sven; Corvin, Aiden; Craddock, Nicholas; Craig, David; Degenhardt, Franziska; Djurovic, Srdjan; Edenberg, Howard J.; Fanous, Ayman H.; Foo, Jerome C.; Forstner, Andreas J.; Frye, Mark; Fullerton, Janice M.; Gatt, Justine M.; Gejman, Pablo V.; Giegling, Ina; Grabe, Hans J.; Green, Melissa J.; Grevet, Eugenio H.; Grigoroiu-Serbanescu, Maria; Gutierrez, Blanca; Guzman-Parra, Jose; Hamilton, Steven P.; Hamshere, Marian L.; Hartmann, Annette; Hauser, Joanna; Heilmann-Heimbach, Stefanie; Hoffmann, Per; Ising, Marcus; Jones, Ian; Jones, Lisa A.; Jonsson, Lina; Kahn, René S.; Kelsoe, John R.; Kendler, Kenneth S.; Kloiber, Stefan; Koenen, Karestan C.; Kogevinas, Manolis; Konte, Bettina; Krebs, Marie-Odile; Landén, Mikael; Lawrence, Jacob; Leboyer, Marion; Lee, Phil H.; Levinson, Douglas F.; Liao, Calwing; Lissowska, Jolanta; Lucae, Susanne; Mayoral, Fermin; McElroy, Susan L.; McGrath, Patrick; McGuffin, Peter; McQuillin, Andrew; Medland, Sarah E.; Mehta, Divya; Melle, Ingrid; Milaneschi, Yuri; Mitchell, Philip B.; Molina, Esther; Morken, Gunnar; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Nievergelt, Caroline M.; Nimgaonkar, Vishwajit; Nöthen, Markus M.; O’Donovan, Michael C.; Ophoff, Roel A.; Owen, Michael J.; Pato, Carlos; Pato, Michele T.; Penninx, Brenda W.J.H.; Pimm, Jonathan; Pistis, Giorgio; Potash, James B.; Power, Robert A.; Preisig, Martin; Quested, Digby; Ramos-Quiroga, Josep Antoni; Reif, Andreas; Ribasés, Marta; Richarte, Vanesa; Rietschel, Marcella; Rivera, Margarita; Roberts, Andrea; Roberts, Gloria; Rouleau, Guy A.; Rovaris, Diego L.; Rujescu, Dan; Sánchez-Mora, Cristina; Sanders, Alan R.; Schofield, Peter R.; Schulze, Thomas G.; Scott, Laura J.; Serretti, Alessandro; Shi, Jianxin; Shyn, Stanley I.; Sirignano, Lea; Sklar, Pamela; Smeland, Olav B.; Smoller, Jordan W.; Sonuga-Barke, Edmund J.S.; Spalletta, Gianfranco; Strauss, John S.; Świątkowska, Beata; Trzaskowski, Maciej; Turecki, Gustavo; Vilar-Ribó, Laura; Vincent, John B.; Völzke, Henry; Walters, James T.R.; Shannon Weickert, Cynthia; Weickert, Thomas W.; Weissman, Myrna M.; Williams, Leanne M.; Wray, Naomi R.; Zai, Clement C.; Ashley-Koch, Allison E.; Beckham, Jean C.; Hauser, Elizabeth R.; Hauser, Michael A.; Kimbrel, Nathan A.; Lindquist, Jennifer H.; McMahon, Benjamin; Oslin, David W.; Qin, Xuejun; Mattheisen, Manuel; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Andlauer, Till F.M.; Bacanu, Silviu-Alin; Bækvad-Hansen, Marie; Beekman, Aartjan T.F.; Bryois, Julien; Buttenschøn, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na; Christensen, Jane Hvarregaard; Clarke, Toni-Kim; Colodro-Conde, Lucía; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E.; Davies, Gail; Derks, Eske M.; Direk, Nese; Dolan, Conor V.; Dunn, Erin C.; Eley, Thalia C.; Escott-Price, Valentina; Hassan Kiadeh, Farnush Farhadi; Finucane, Hilary K.; Frank, Josef; Gaspar, Héléna A.; Gill, Michael; Goes, Fernando S.; Gordon, Scott D.; Weinsheimer, Shantel Marie; Wellmann, Jürgen; Willemsen, Gonneke; Wu, Yang; Xi, Simon; Yang, Jian; Zhang, Futao; Arolt, Volker; Boomsma, Dorret I.; Dannlowski, Udo; de Geus, E.J.C.; Depaulo, J. Raymond; Domenici, Enrico; Domschke, Katharina; Esko, Tõnu; Grove, Jakob; Hall, Lynsey S.; Hansen, Christine Søholm; Hansen, Thomas F.; Herms, Stefan; Hickie, Ian B.; Homuth, Georg; Horn, Carsten; Hottenga, Jouke-Jan; Hougaard, David M.; Howard, David M.; Jansen, Rick; Jorgenson, Eric; Knowles, James A.; Kohane, Isaac S.; Kraft, Julia; Kretzschmar, Warren W.; Kutalik, Zoltán; Li, Yihan; Lind, Penelope A.; MacIntyre, Donald J.; MacKinnon, Dean F.; Maier, Robert M.; Maier, Wolfgang; Marchini, Jonathan; Mbarek, Hamdi; Middeldorp, Christel M.; Mihailov, Evelin; Milani, Lili; Mondimore, Francis M.; Montgomery, Grant W.; Mostafavi, Sara; Nauck, Matthias; Ng, Bernard; Nivard, Michel G.; Nyholt, Dale R.; O’Reilly, Paul F.; Oskarsson, Hogni; Hayward, Caroline; Heath, Andrew C.; Lewis, Glyn; Li, Qingqin S.; Madden, Pamela A.F.; Magnusson, Patrik K.; Martin, Nicholas G.; McIntosh, Andrew M.; Metspalu, Andres; Mors, Ole; Nordentoft, Merete; Paciga, Sara A.; Pedersen, Nancy L.; Painter, Jodie N.; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; Peterson, Roseann E.; Peyrot, Wouter J.; Posthuma, Danielle; Quiroz, Jorge A.; Qvist, Per; Rice, John P.; Riley, Brien P.; Mirza, Saira Saeed; Schoevers, Robert; Schulte, Eva C.; Shen, Ling; Sigurdsson, Engilbert; Sinnamon, Grant C.B.; Smit, Johannes H.; Smith, Daniel J.; Stefansson, Hreinn; Steinberg, Stacy; Streit, Fabian; Strohmaier, Jana; Tansey, Katherine E.; Teismann, Henning; Teumer, Alexander; Thompson, Wesley; Thomson, Pippa A.; Thorgeirsson, Thorgeir E.; Traylor, Matthew; Treutlein, Jens; Trubetskoy, Vassily; Uitterlinden, André G.; Umbricht, Daniel; der Auwera, Sandra Van; van Hemert, Albert M.; Viktorin, Alexander; Visscher, Peter M.; Wang, Yunpeng; Webb, Bradley T.; Perlis, Roy H.; Porteous, David J.; Schaefer, Catherine; Stefansson, Kari; Tiemeier, Henning; Uher, Rudolf; Werge, Thomas; Lewis, Cathryn M.; Breen, Gerome; Børglum, Anders D.; Sullivan, Patrick F.; O’Connell, Kevin S.; Coombes, Brandon; Qiao, Zhen; Als, Thomas D.; Børte, Sigrid; Charney, Alexander W.; Drange, Ole Kristian; Gandal, Michael J.; Hagenaars, Saskia P.; Ikeda, Masashi; Kamitaki, Nolan; Krebs, Kristi; Panagiotaropoulou, Georgia; Schilder, Brian M.; Sloofman, Laura G.; Winsvold, Bendik S.; Won, Hong-Hee; Abramova, Liliya; Adorjan, Kristina; Al Eissa, Mariam; Albani, Diego; Alliey-Rodriguez, Ney; Antilla, Verneri; Antoniou, Anastasia; Baek, Ji Hyun; Bauer, Michael; Beins, Eva C.; Bergen, Sarah E.; Birner, Armin; Bøen, Erlend; Brum, Murielle; Brumpton, Ben M.; Brunkhorst-Kanaan, Nathalie; Byerley, William; Cairns, Murray; Casas, Miquel; Cervantes, Pablo; Cruceanu, Cristiana; Cuellar-Barboza, Alfredo; Cunningham, Julie; Curtis, David; Czerski, Piotr M.; Dale, Anders M.; Dalkner, Nina; David, Friederike S.; Dobbyn, Amanda L.; Douzenis, Athanassios; Elvsåshagen, Torbjørn; Ferrier, I. Nicol; Fiorentino, Alessia; Foroud, Tatiana M.; Forty, Liz; Frei, Oleksandr; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Garnham, Julie; Gelernter, Joel; Gizer, Ian R.; Gordon-Smith, Katherine; Greenwood, Tiffany A.; Guzman-Parra, José; Ha, Kyooseob; Haraldsson, Magnus; Hautzinger, Martin; Heilbronner, Urs; Hellgren, Dennis; Holmans, Peter A.; Huckins, Laura; Johnson, Jessica S.; Kalman, Janos L.; Kamatani, Yoichiro; Kittel-Schneider, Sarah; Koromina, Maria; Kranz, Thorsten M.; Kranzler, Henry R.; Kubo, Michiaki; Kupka, Ralph; Kushner, Steven A.; Lavebratt, Catharina; Leber, Markus; Lee, Heon-Jeong; Levy, Shawn E.; Lewis, Catrin; Lundberg, Martin; Magnusson, Sigurdur H.; Maihofer, Adam; Malaspina, Dolores; Maratou, Eirini; Martinsson, Lina; McGregor, Nathaniel W.; McKay, James D.; Medeiros, Helena; Millischer, Vincent; Moran, Jennifer L.; Morris, Derek W.; Mühleisen, Thomas W.; O’Brien, Niamh; O’Donovan, Claire; Olde Loohuis, Loes M.; Oruc, Lilijana; Papiol, Sergi; Pardiñas, Antonio F.; Perry, Amy; Pfennig, Andrea; Porichi, Evgenia; Raj, Towfique; Rapaport, Mark H.; DePaulo, J. Raymond; Regeer, Eline J.; Rivas, Fabio; Roth, Julian; Roussos, Panos; Ruderfer, Douglas M.; Senner, Fanny; Sharp, Sally; Shilling, Paul D.; Slaney, Claire; Sobell, Janet L.; Artigas, Maria Soler; Spijker, Anne T.; Stein, Dan J.; Terao, Chikashi; Toma, Claudio; Tooney, Paul; Tsermpini, Evangelia-Eirini; Vawter, Marquis P.; Vedder, Helmut; Xi, Simon; Xu, Wei; Kay Yang, Jessica Mei; Young, Allan H.; Young, Hannah; Zandi, Peter P.; Zhou, Hang; Psychiatry, HUNT All-In; Babadjanova, Gulja; Backlund, Lena; Bengesser, Susanne; Blackwood, Douglas H.R.; Carr, Vaughan J.; Catts, Stanley; Dikeos, Dimitris; Etain, Bruno; Ferentinos, Panagiotis; Gawlik, Micha; Gershon, Elliot S.; Henskens, Frans; Hillert, Jan; Hong, Kyung Sue; Hultman, Christina M.; Hveem, Kristian; Iwata, Nakao; Jablensky, Assen V.; Kirov, George; Lochner, Christine; Loughland, Carmel; Mathews, Carol A.; McMahon, Francis J.; Michie, Patricia; Mowry, Bryan; Neale, Benjamin M.; Nievergelt, Caroline M.; Oedegaard, Ketil J.; Olsson, Tomas; Pantelis, Chris; Patrinos, George P.; Reininghaus, Eva Z.; Saito, Takeo; Schall, Ulrich; Schalling, Martin; Scott, Rodney J.; Weickert, Cynthia Shannon; Stordal, Eystein; Vaaler, Arne E.; Vieta, Eduard; Waldman, Irwin D.; Zwart, John-Anker; Nurnberger, John I.; Stahl, Eli A.; Di Florio, Arianna; Adan, Roger A.H.; Ando, Tetsuya; Aschauer, Harald; Baker, Jessica H.; Bencko, Vladimir; Birgegård, Andreas; Boden, Joseph M.; Boehm, Ilka; Boni, Claudette; Perica, Vesna Boraska; Buehren, Katharina; Bulik, Cynthia M.; Burghardt, Roland; Carlberg, Laura; Cassina, Matteo; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dina, Christian; Dmitrzak-Weglarz, Monika; Martinez, Elisa Docampo; Duncan, Laramie E.; Egberts, Karin; Mattingsdal, Morten; McDevitt, Sara; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, James; Mitchell, Karen; Monteleone, Palmiero; Monteleone, Alessio Maria; Munn-Chernoff, Melissa A.; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; Olsen, Catherine M.; O’Toole, Julie K.; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Parker, Richard; Pearson, John F.; Ehrlich, Stefan; Escaramís, Geòrgia; Espeseth, Thomas; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fischer, Krista; Floyd, James A.B.; Föcker, Manuel; Foretova, Lenka; Forzan, Monica; Franklin, Christopher S.; Gambaro, Giovanni; Giuranna, Johanna; Giusti-Rodríquez, Paola; Gonidakis, Fragiskos; Gordon, Scott; Mayora, Monica Gratacos; Guillaume, Sébastien; Hanscombe, Ken B.; Hatzikotoulas, Konstantinos; Hebebrand, Johannes; Helder, Sietske G.; Henders, Anjali K.; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Hinney, Anke; Horwood, L. John; Hübel, Christopher; Petersen, Liselotte V.; Purves, Kirstin L.; Raevuori, Anu; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; Schmidt, Ulrike; Schork, Nicholas J.; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P. Eline; Slof-Op ‘t Landt, Margarita C.T.; Slopien, Agnieszka; Soranzo, Nicole; Sorbi, Sandro; Southam, Lorraine; Steen, Vidar W.; Huckins, Laura M.; Hudson, James I.; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jordan, Jennifer; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Kaprio, Jaakko; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J.H.; Kennedy, Martin A.; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl-Ri; Kirk, Katherine M.; Klareskog, Lars; Knudsen, Gun Peggy S.; Larsen, Janne T.; Le Hellard, Stephanie; Leppä, Virpi M.; Lichtenstein, Paul; Lin, Bochao Danae; Lundervold, Astri; Luykx, Jurjen; Maj, Mario; Mannik, Katrin; Marsal, Sara; Stuber, Garret D.; Szatkiewicz, Jin P.; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Tsitsika, Artemis; Tyszkiewicz-Nwafor, Marta; Tziouvas, Konstantinos; van Elburg, Annemarie A.; van Furth, Eric F.; Wade, Tracey D.; Wagner, Gudrun; Walton, Esther; Whiteman, David C.; Wichmann, H. Erich; Widen, Elisabeth; Yao, Shuyang; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Jungkunz, Martin; Dietl, Lydie; Schwarze, Cornelia E.; Dahmen, Norbert; Schott, Björn H.; Mobascher, Arian; Crivelli, Silvia; Dennis, Michelle F.; Harvey, Phillip D.; Carter, Bruce W.; Huffman, Jennifer E.; Jacobson, Daniel; Madduri, Ravi; Olsen, Maren K.; Pestian, John; Gaziano, J. Michael; Muralidhar, Sumitra; Ramoni, Rachel; Beckham, Jean; Chang, Kyong-Mi; O’Donnell, Christopher J.; Tsao, Philip; Breeling, James; Huang, Grant; Romero, J.P. Casas; Moser, Jennifer; Whitbourne, Stacey B.; Brewer, Jessica V.; Aslan, Mihaela; Connor, Todd; Argyres, Dean P.; Stephens, Brady; Brophy, Mary T.; Humphries, Donald E.; Selva, Luis E.; Do, Nhan; Shayan, Shahpoor; Cho, Kelly; Pyarajan, Saiju; Hauser, Elizabeth; Sun, Yan; Zhao, Hongyu; Wilson, Peter; McArdle, Rachel; Dellitalia, Louis; Mattocks, Kristin; Harley, John; Zablocki, Clement J.; Whittle, Jeffrey; Jacono, Frank; Gutierrez, Salvador; Gibson, Gretchen; Hammer, Kimberly; Kaminsky, Laurence; Villareal, Gerardo; Kinlay, Scott; Xu, Junzhe; Hamner, Mark; Mathew, Roy; Bhushan, Sujata; Iruvanti, Pran; Godschalk, Michael; Ballas, Zuhair; Ivins, Douglas; Mastorides, Stephen; Moorman, Jonathan; Gappy, Saib; Klein, Jon; Ratcliffe, Nora; Florez, Hermes; Okusaga, Olaoluwa; Murdoch, Maureen; Sriram, Peruvemba; Yeh, Shing Shing; Tandon, Neeraj; Jhala, Darshana; Aguayo, Samuel; Cohen, David; Sharma, Satish; Liangpunsakul, Suthat; Oursler, Kris Ann; Whooley, Mary; Ahuja, Sunil; Constans, Joseph; Meyer, Paul; Greco, Jennifer; Rauchman, Michael; Servatius, Richard; Gaddy, Melinda; Wallbom, Agnes; Morgan, Timothy; Stapley, Todd; Sherman, Scott; Ross, George; Tsao, Philip; Strollo, Patrick; Boyko, Edward; Meyer, Laurence; Gupta, Samir; Huq, Mostaqul; Fayad, Joseph; Hung, Adriana; Lichy, Jack; Hurley, Robin; Robey, Brooks; Striker, Robert; Erlangsen, Annette; Kessler, Ronald C.; Porteous, David; Ursano, Robert J.; Wasserman, Danuta; Coon, Hilary; Demontis, Ditte; Docherty, Anna R.; Kuo, Po-Hsiu; Mann, J. John; Rentería, Miguel E.; Stein, Murray B.; Willour, Virginia (2022)
    Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.
  • Radun, Igor; Radun, Jenni; Kaistinen, Jyrki; Olivier, Jake; Kecklund, Göran; Theorell, Tores (2019)
    Unlike hypothetical trolley problem studies and an ongoing ethical dilemma with autonomous vehicles, road users can face similar ethical dilemmas in real life. Swerving a heavy vehicle towards the road-side in order to avoid a head-on crash with a much lighter passenger car is often the only option available which could save lives. However, running off-road increases the probability of a roll-over and endangers the life of the heavy vehicle driver. We have created an experimental survey study in which heavy vehicle drivers randomly received one of two possible scenarios. We found that respondents were more likely to report they would ditch their vehicle in order to save the hypothetical driver who fell asleep than to save the driver who deliberately diverted their car towards the participant's heavy vehicle. Additionally, the higher the empathy score, the higher the probability of ditching a vehicle. Implications for autonomous vehicle programming are discussed. (C) 2019 Elsevier Ltd. All rights reserved.
  • Laukkala, Tanja; Jylhä, Pekka; Isometsä, Erkki; Koponen, Hannu; Marttunen, Mauri; Wahlbeck, Kristian; Laajasalo, Taina; Vuorio, Alpo; Pirkola, Sami (2020)
    • Suomi on kansainvälisesti verrattuna suurten itsemurhalukujen maa, vaikka viime vuosikymmeninä ¬kuolemat ovat pääsääntöisesti vähentyneet. • Itsetuhoinen käyttäytyminen liittyy useimmiten psykiatriseen sairauteen tai päihdeongelmiin. • Itsemurhayrityksen jälkeen keskeisiä ovat strukturoitu psykiatrinen arvio, turvasuunnitelman tekeminen ja aktiivinen perussairauksien hoito. • Lääkärin lakisääteiset velvoitteet ja läheisten tilanne tulee huomioida. • Psykososiaalisia, muuhun hoitoon liitettäviä lyhyitä erillisinterventioita tutkitaan aktiivisesti.
  • Jylhä, Pekka; Isometsä, Erkki (2020)
    Turvasuunnitelma on lyhytinterventio itsemurhaa yrittäneille potilaille sekä henkilöille, joiden itsemurhariskin arvioidaan muuten suurentuneen. Terveydenhuollon ammattilainen pyrkii yhdessä potilaan kanssa löytämään itsemurha-ajattelua laukaisevat tekijät ja tekemään suunnitelman, miten potilas voisi mahdollisissa tulevissa kriisitilanteissa hallita itsemurhaimpulssejaan vahingoittamatta itseään. Tarkoituksena on luoda ennalta määritelty lista selviytymisstrategioista, tukea antavista henkilöistä ja toiminnoista, joihin potilas voi olla yhteydessä tai joita potilas voi tehdä vähentääkseen välitöntä itsetuhoisen käyttäytymisen riskiään sekä etukäteen suojata itseään kuoleman aiheuttavien itsemurhamenetelmien saatavuudelta. Lisäksi pohditaan syitä, joiden vuoksi potilas haluaa elää. Interventiossa tuotetaan kirjallinen yhden sivun asiakirja potilaalle mukaan otettavaksi. Yhteistoiminta ja terapeuttinen yhteistyö ovat keskeistä turvasuunnitelman teossa ja potilaan sitouttamisessa hoitoon.
  • Pirkola, Sami; Eriksen, Heidi; Isometsä, Erkki; Joensuu, Aino; Jylhä, Pekka; Kekkonen, Virve; Koponen, Annu; Kuosmanen, Lauri; Laajasalo, Taina; Laukkala, Tanja; Marttunen, Mauri; Suominen, Kirsi; Wahlbeck, Kristian (2020)
  • Konttinen, Hanna; Peltonen, Markku (2019)
  • Halonen, Jaana I.; Koskinen, Aki; Varje, Pekka; Kouvonen, Anne; Hakanen, Jari J.; Väänänen, Ari (2018)
    Background: We defined gender-specific profiles of mental ill-health for the main occupational groups using three outcomes; antidepressant use, sickness absence (SA) due to depression, and suicides. We also examined which occupational groups had the highest risk of the outcomes, and compared the importance of their predictors. Methods: From a random register cohort of Finnish working age population, individuals in the six largest occupational groups in 2004 for men and women were included (N = 414 357). We used register data to define the first antidepressant purchase (i.e. use), the first long-term SA spell for depression, and suicide between Jan 1st 2005 and Dec 31st 2014. We assessed the risk of each outcome by occupational group with logistic regression models, and used dominance analysis to compare the relative importance of predictors. Results: In all six occupational groups for women, the prevalence of antidepressant use and SA for depression was higher than in the men's occupational groups. The opposite was observed for suicides. The risk of antidepressant use was lower, but the risk of suicide was 2-times higher among men in low vs. high-skilled occupations. Among women, a lower skill-level was associated with a higher risk of SA due to depression. Gender was the most important predictor of all outcomes. Limitations: We lacked information on history of medication use or health problems prior to follow-up. Conclusions: Gendered occupational status was an underlying factor explaining distinctive mental health profiles in the working population. Occupational class-dependent behavioural patterns related to mental health existed among men.
  • Stenberg, Jan-Henry; Blanco Sequeiros, Sanna; Holi, Matti; Kampman, Olli; Kieseppä, Tuula; Korkeila, Jyrki; Mäki, Pirjo; Wahlbeck, Kristian; Joffe, Grigori; Häll, Pasi; Joutsenniemi, Kaisla (2016)
    Psykologisia etähoitoja voidaan antaa reaaliaikaisesti tai toisaalta ajasta riippumatta. Erilaisia etähoitoja on moniin eri häiriöihin ja monet niistä ovat tutkitusti tehokkaita. Hoitojen lisäksi on toimivia mielenterveyden edistämisen, kriisiauttamisen ja itsemurhien ehkäisyn menetelmiä. Tekniikan ja tiedonlouhinnan kehitys tuo yhä merkittävämpiä apuvälineitä mielenterveyden häiriöiden hoitoon.
  • Lyyra, Markus (2018)
    Ensihoitoyksikkö sai hälytyksen myrkytyksen vuoksi. Yksikkö ehti hieman huonovointisen, mutta rauhallisen ja asiallisen potilaan luo muutamassa minuutissa.
  • Suomalainen, Laura; Seilo, Noora; Haravuori, Henna; Marttunen, Mauri (2018)
  • Kinnunen, Marina; Lönnqvist, Jouko; Ekelund, Jesper; Roine, Risto P.; Aaltonen, Leena-Maija; Mustajoki, Pertti (2016)
    It­se­mur­ha­vaa­raa on vai­kea en­na­koi­da. Po­ti­las voi teh­dä it­se­mur­han osas­to­hoi­don ai­ka­na tai ko­ti­lo­mal­laan, vaik­ka oli­si sai­raa­lan tai omai­sen val­von­nas­sa. On­gel­mal­li­sia ti­lan­tei­ta tu­lee eri­tyi­ses­ti sil­loin, kun hoi­don ko­ko­nais­vas­tuu on ha­jau­tet­tu, hen­ki­lö­kun­nan vaih­tu­vuus on suur­ta ja eri­tyi­ses­ti lo­ma-ai­koi­na, kun hen­ki­lö­kun­taa on liian vä­hän. Ta­pah­tu­nut­ta it­se­mur­haa tu­lee tar­kas­tel­la hen­ki­lö­kun­nan kans­sa sys­te­maat­ti­ses­ti ja tar­jo­ta työ­noh­jaus­ta ja tar­vit­taes­sa hoi­toa. Ta­pah­tu­man kiel­tä­mi­nen ja kap­se­loin­ti on kai­kil­le osa­puo­lil­le hai­tal­lis­ta.
  • Pelkonen, Samu (Helsingin yliopisto, 2020)
    Propranololi oli ensimmäinen laajaan kliiniseen käyttöön tullut beetasalpaaja, mutta sittemmin sen käyttö alkuperäisiin sydänsairausindikaatioihin on vähentynyt uusien selektiivisempien ja vesiliukoisempien beetasalpaajien tultua markkinoille. Propranololi ylittää suhteellisen rasvaliukoisena veriaivoesteen merkittävissä määrin ja tähän ominaisuuteen on liitetty siitä raportoidut harvinaiset neuropsykiatriset haitat. Tämän tutkielman tarkoituksena oli Suomessa vuosina 2016–2018 kuolleiden oikeuskemiallisen löydösaineiston perusteella selvittää ovatko vainajien propranololilöydökset yhteydessä itsemurhiin, lääke- ja huumausainemyrkytyksiin, väärinkäyttöepäilyihin ynnä muihin vastaaviin seikkoihin, kun verrokkina on lievemmin rasvaliukoinen beetasalpaaja metoprololi. Näiden beetasalpaajien kokoverikonsentraation ohella aineistoon yhdistettiin tieto mahdollisista muista löydöksistä, kuten etyylialkoholista, laittomista päihteistä sekä tietyistä pääasiassa keskushermostoon vaikuttavista lääkeaineista. Terveyden ja hyvinvoinnin laitoksen oikeustoksikologiayksikön vainajatapausten laboratoriotietokannasta haetuille tiedoille tehtiin tilastollisia testejä, jotka vahvistivat alkuperäisen hypoteesin. Propranololiryhmässä oli tilastollisesti merkitsevästi enemmän itsemurhia (RR 4,22), lääke- ja huumausainemyrkytyskuolemia (RR 6,79), väärinkäyttötapauksia (RR 10,18) ja alkoholilöydöksiä (RR 1,51). Lisäksi propranololiryhmässä itse beetasalpaajaa löytyi mahdollisesti myrkytysoireita aiheuttavana pitoisuutena, verrattuna terapeuttisena pidetyn plasmakonsentraation ylärajaan, tilastollisesti merkitsevästi (RR 2,02) useammin kuin metoprololitapauksissa. Retrospektiivinen tutkimusasetelma sekä aineiston tyyppi asettavat omat rajansa kausaliteettien arvioinnille, mutta propranololin yhteys edellä mainittuihin tekijöihin oli kiistämätöntä. Ei kuitenkaan voida todeta näiden löydösten välttämättä vahventavan epäilyä propranololin mahdollisesta väärinkäyttöpotentiaalista. On tiedossa, että propranolia käytetään sen valmisteyhteenvedossa mainittujen käyttöaiheiden ulkopuolisesti muun muassa esiintymisjännityksen lieventämiseen. Lopuksi voidaan joka tapauksessa todeta, että kliinisessä työssä hoidettaessa propranololia käyttävää potilasta mahdolliset harvinaiset neuropsykiatriset haitat on hyvä pitää muiden seikkojen muassa mielessä, sillä potilas tämän puolesta kuuluu riskiryhmään. (222 sanaa)
  • Baryshnikov, Ilya; RosenstrÖm, Tom; Jylha, Pekka; Koivisto, Maaria; Mantere, Outi; Suominen, Kirsi; Melartin, Tarja; Vuorilehto, Maria; Holma, Mikael; Riihimäki, Kirsi; Isometsä, Erkki T. (2018)
    Background: Hopelessness is a common experience of patients with depressive disorders (DD) and an important predictor of suicidal behaviour. However, stability and factors explaining state and trait variation of hopelessness in patients with DD over time are poorly known. Methods: Patients with DD (n = 406) from the Vantaa Depression Study and the Vantaa Primary Care Depression Study filled in the Beck Hopelessness Scale (BHS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Perceived Social Support Scale-Revised (PSSS-R), and Eysenck Personality Inventory-Q (EPI-Q) at baseline, at six and eighteen months, and at five years. We conducted a multilevel linear regression analyses predicting BHS with these covariates. Results: During the five-year follow-up half of the variance in BHS was attributable to between-patient variance (50.6%, CI = 41.2-61.5%), and the rest arose from within-patient variance and measurement errors. BDI and BAI explained 5.6% of within-patient and 28.4% of between-patient variance of BHS. High Neuroticism and low Extraversion explained 2.6% of the between-patient variance of BHS. PSSS-R explained 5% of between-patient variance and 1.7% of within-patient variance of BHS. Limitations: No treatment effects were controlled. Conclusions: Hopelessness varies markedly over time both within and between patients with depression; it is both state-and trait-related. Concurrent depressive and anxiety symptoms and low social support explain both state and trait variance, whereas high Neuroticism and low Extraversion explain only trait variance of hopelessness. These variations influence the utility of hopelessness as an indicator of suicide risk.
  • Kriikku, Pirkko; Ojanpera, Ilkka (2016)
    We reviewed the 33 727 postmortem toxicology investigations performed in Finland over a period of 5 years (2009-2013) and identified those in which the antidepressant bupropion was detected. Cases positive for other antidepressant drugs were reviewed for comparison. The postmortem toxicological examination included, in all cases, the routine screening and quantification of hundreds of drugs and poisons using quality-controlled methods. Bupropion was detected in 65 cases. A large proportion of the bupropion-positive deaths resulted from suicide (55%). In fatal poisoning cases found positive for bupropion, the proportion of suicide was even higher (77%). The measured median bupropion postmortem blood concentration (0.69 mg/L) was markedly higher than the normal therapeutic range in plasma in the treatment of depression (up to 0.1 mg/L) and even higher in fatal bupropion poisonings (13 mg/L). Only 14% of the deceased positive for bupropion were estimated to be drug abusers. However, nearly all of the drug abuse cases were from the last year of the study (2013), indicating a recent increase of the use of bupropion among drug abusers and possibly even abuse of bupropion itself. Suicide victims positive for bupropion were younger than those who died with other antidepressant drugs in their blood. In addition, the percentage of fatal poisonings among bupropion-positive postmortem cases was higher than among the users of other antidepressant drugs. Suicide was significantly more common among the deceased positive for bupropion than among users of other antidepressant drugs. An unknown degree of bupropion degradation before the assay and post-mortem redistribution of bupropion may have impacted the measured levels. Nonetheless, all post-mortem concentrations of bupropion were elevated and especially high concentrations were detected in suicides. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  • Szibor, Annett; Mäkitie, Antti; Aarnisalo, Antti A. (2019)
    Tinnitus is an auditory phantom sensation which can be a devastating condition for the affected person causing annoyance and discomfort. It may be associated with psychiatric conditions. Patients with highly annoying tinnitus and different comorbidities may have a higher risk of expressing suicidal behaviour and ideation. We aimed to review available reports on the prevalence of suicide and suicidal behaviour with tinnitus patients in order to collate current concepts and to identify possible alarming signs and risk factors. A comprehensive search for appropriate studies listed in PubMed, Ovid and Cochrane databases was conducted using appropriate keyword combinations. We identified 22 publications including original articles, case reports and reviews of which 10 fit our stringent search criteria. Most importantly, from the present studies it appears not feasible to univocally conclude on the co-incidence of tinnitus and suicide. This is due to methodological differences in these approaches, complex interrelations between tinnitus and other psychiatric comorbidities and confounding factors such as the inclusion of patients suffering from post-traumatic stress disorder. More concerted actions involving different medical disciplines are needed to reflect the ethiological heterogeneity of tinnitus and suicide or suicidal behaviour to test for a relationship.