Browsing by Subject "VELOCITY"

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  • Kulmala, Juha-Pekka; Korhonen, Marko T.; Ruggiero, Luca; Kuitunen, Sami; Suominen, Harri; Heinonen, Ari; Mikkola, Aki; Avela, Janne (2020)
    Age-related reduction in muscle force generation capacity is similarly evident across different lower limb muscle groups, yet decline in locomotor performance with age has been shown to depend primarily on reduced ankle extensor muscle function. To better understand why ageing has the largest detrimental effect on ankle joint function during locomotion, we examined maximal ankle and knee extensor force development during a two-leg hopping test in older and young men, and used these forces as a reference to calculate relative operating efforts for the knee and ankle extensors as participants walked, ran and sprinted. We found that, across locomotion modes in both age groups, ankle extensors operated at a greater relative effort compared to knee extensors; however, slightly less pronounced differences between ankle and knee extensor muscle efforts were present among older men, mainly due to a reduction in the ankle extensor force generation during locomotion modes. We consider these findings as evidence that reduced ankle push-off function in older age is driven by a tendency to keep ankle extensor effort during locomotion lower than it would otherwise be, which, in turn, may be an important self-optimisation strategy to prevent locomotor-induced fatigue of ankle extensor muscles.
  • Sen, Sayan; Ahmad, Yousif; Dehbi, Hakim-Moulay; Howard, James P.; Iglesias, Juan F.; Al-Lamee, Rasha; Petraco, Ricardo; Nijjer, Sukhjinder; Bhindi, Ravinay; Lehman, Sam; Walters, Darren; Sapontis, James; Janssens, Luc; Vrints, Christiaan J.; Khashaba, Ahmed; Laine, Mika; Van Belle, Eric; Krackhardt, Florian; Bojara, Waldemar; Going, Olaf; Haerle, Tobias; Indolfi, Ciro; Niccoli, Giampaolo; Ribichini, Flavio; Tanaka, Nobuhiro; Yokoi, Hiroyoshi; Takashima, Hiroaki; Kikuta, Yuetsu; Erglis, Andrejs; Vinhas, Hugo; Silva, Pedro Canas; Baptista, Sergio B.; Alghamdi, Ali; Hellig, Farrel; Koo, Bon-Kwon; Nam, Chang-Wook; Shin, Eun-Seok; Doh, Joon-Hyung; Brugaletta, Salvatore; Alegria-Barrero, Eduardo; Meuwissen, Martijin; Piek, Jan J.; van Royen, Niels; Sezer, Murat; Di Mario, Carlo; Gerber, Robert T.; Malik, Iqbal S.; Sharp, Andrew S. P.; Talwar, Suneel; Tang, Kare; Samady, Habib; Altman, John; Seto, Arnold H.; Singh, Jasvindar; Jeremias, Allen; Matsuo, Hitoshi; Kharbanda, Rajesh K.; Patel, Manesh R.; Serruys, Patrick; Escaned, Javier; Davies, Justin E. (2019)
    BACKGROUND Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR). OBJECTIVES The purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR within the DEFINE-FLAIR trial. METHODS MACE rates at 1 year were compared between groups (iFR and FFR) in patients whose physiological assessment led to LAD lesions being deferred. MACE was defined as a composite of cardiovascular death, myocardial infarction (MI), and unplanned revascularization at 1 year. Patients, and staff performing follow-up, were blinded to whether the decision was made with FFR or iFR. Outcomes were adjusted for age and sex. RESULTS A total of 872 patients had lesions deferred in the LAD (421 guided by FFR, 451 guided by iFR). The event rate with iFR was significantly lower than with FFR (2.44% vs. 5.26%; adjusted HR: 0.46; 95% confidence interval [CI]: 0.22 to 0.95; p = 0.04). This was driven by significantly lower unplanned revascularization with iFR and numerically lower MI (unplanned revascularization: 2.22% iFR vs. 4.99% FFR; adjusted HR: 0.44; 95% CI: 0.21 to 0.93; p = 0.03; MI: 0.44% iFR vs. 2.14% FFR; adjusted HR: 0.23; 95% CI: 0.05 to 1.07; p = 0.06). CONCLUSIONS iFR-guided deferral appears to be safe for patients with LAD lesions. Patients in whom iFR-guided deferral was performed had statistically significantly lower event rates than those with FFR-guided deferral. (c) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (
  • Annila, A. (2015)
    Spectrum of cosmic rays follows a broken power law over twelve orders of magnitude. Since ubiquitous power laws are manifestations of the principle of least action, we interpret the spectrum accordingly. Our analysis complies with understanding that low-energy particles originate mostly from rapidly receding sources throughout the cosmos. The flux peaks about proton rest energy whereafter it decreases because fewer and fewer receding sources are energetic enough to provide particles with high enough velocities to compensate for the recessional velocities. Above 10(15.6) eV the flux from the expanding Universe diminishes below the flux from the nearby nonexpanding part of the Universe. In this spectral feature, known as the "knee," we relate to a distance of about 1.3 Mpc where the gravitational potential tallies the energy density of free space. At higher energies particles decelerate in a dissipative manner to attain thermodynamic balance with the vacuum. At about 10(17.2) eV a distinct dissipative mechanism opens up for protons to slow down by electron-positron pair production. At about 10(19.6) eV a more effective mechanism opens up via pion production. All in all, the universal principle discloses that the broad spectrum of cosmic rays probes the structure of space from cosmic distances down to microscopic details.
  • Afonso, Marco Martins; Muratore-Ginanneschi, Paolo; Gama, Silvio M. A.; Mazzino, Andrea (2018)
    We investigate the large-scale transport properties of quasi-neutrally-buoyant inertial particles carried by incompressible zero-mean periodic or steady ergodic flows. We show howto compute large-scale indicators such as the inertial-particle terminal velocity and eddy diffusivity from first principles in a perturbative expansion around the limit of added-mass factor close to unity. Physically, this limit corresponds to the case where the mass density of the particles is constant and close in value to the mass density of the fluid, which is also constant. Our approach differs from the usual over-damped expansion inasmuch as we do not assume a separation of time scales between thermalization and small-scale convection effects. For a general flow in the class of incompressible zero-mean periodic velocity fields, we derive closed-form cell equations for the auxiliary quantities determining the terminal velocity and effective diffusivity. In the special case of parallel flows these equations admit explicit analytic solution. We use parallel flows to show that our approach sheds light onto the behavior of terminal velocity and effective diffusivity for Stokes numbers of the order of unity.
  • Korkalainen, Noora; Partanen, Lea; Räsänen, Juha; Yliherva, Anneli; Mäkikallio, Kaarin (2019)
    Aim: Long-term follow-up studies on children born with fetal growth restriction (FGR) have revealed a specific profile of neurocognitive difficulties, including problems with speech, language and literacy skills. We hypothesized that problems with communication skills, including language use and literacy skills of FGR children at primary school age are associated with prenatal circulatory changes. Methods: Ultrasonographic assessment of fetoplacental hemodynamics was performed prenatally in 77 fetuses. After a follow-up period of 8-10 years, assessment of reading and spelling skills using standardized tests and the Children's Communication Questionnaire (CCC-2) was performed to measure different language skills in 37 FGR children and 31 appropriately grown (AGA) controls, matched for gestational age. Results: Increased blood flow resistance in the umbilical artery (UA PI > 2 SD) during fetal life showed odds ratios of 3.5-19.1 for poor literacy and communication skills and need for speech and language therapy. Furthermore, FGR children with prenatal cerebral vasodilatation (cerebroplacental ratio (CPR) <-2 SD) had significantly poorer literacy and communication skills, at primary school age compared to the AGA controls. Abnormal CPR demonstrated odds ratios of 4.2-28.1 for poor literacy and communication skills and need for speech and language therapy. Conclusion: Increased blood flow resistance in the umbilical artery and cerebral vasodilatation are associated with poor communication, language, and literacy skills at early school age in children born with FGR. These findings indicate the need for continuous follow-up of this group and timely targeted support to ensure optimal academic outcomes.
  • Tiira, Timo; Janik, Tomasz; Skrzynic, Tymon; Komminaho, Kari; Heinonen, Aku; Veikkolainen, Toni; Väkevä, Sakari; Korja, Annakaisa (2020)
    The Kokkola–Kymi Deep Seismic Sounding profile crosses the Fennoscandian Shield in northwest-southeast (NW–SE) direction from Bothnian belt to Wiborg rapakivi batholith through Central Finland granitoid complex (CFGC). The 490-km refraction seismic line is perpendicular to the orogenic strike in Central Finland and entirely based on data from quarry blasts and road construction sites in years 2012 and 2013. The campaign resulted in 63 usable seismic record sections. The average perpendicular distance between these and the profile was 14 km. Tomographic velocity models were computed with JIVE3D program. The velocity fields of the tomographic models were used as starting points in the ray tracing modelling. Based on collected seismic sections a layer-cake model was prepared with the ray tracing package SEIS83. Along the profile, upper crust has an average thickness of 22 km average, and P-wave velocities (Vp) of 5.9–6.2 km/s near the surface, increasing downward to 6.25–6.40 km/s. The thickness of middle crust is 14 km below CFGC, 20 km in SE and 25 km in NW, but Vp ranges from 6.6 to 6.9 km/s in all parts. Lower crust has Vp values of 7.35–7.4 km/s and lithospheric mantle 8.2–8.25 km/s. Moho depth is 54 km in NW part, 63 km in the middle and 43 km in SW, yet a 55-km long section in the middle does not reveal an obvious Moho reflection. S-wave velocities vary from 3.4 km/s near the surface to 4.85 km/s in upper mantle, consistently with P-wave velocity variations. Results confirm the previously assumed high-velocity lower crust and depression of Moho in central Finland.
  • Capasso, R.; Mohr, J. J.; Saro, A.; Biviano, A.; Clerc, N.; Finoguenov, A.; Klein, M.; Grandis, S.; Collins, C.; Damsted, S.; Kirkpatrick, C.; Kukkola, A. (2020)
    We perform the calibration of the X-ray luminosity-mass scaling relation on a sample of 344 CODEX clusters with z <0.66 using the dynamics of their member galaxies. Spectroscopic follow-up measurements have been obtained from the SPIDERS survey, leading to a sample of 6658 red member galaxies. We use the Jeans equation to calculate halo masses, assuming an NFW mass profile and analysing a broad range of anisotropy profiles. With a scaling relation of the form L-X proportional to A(X)M(200c)(BX) E(z)(2)(1 + z)(gamma x), we find best-fitting parameters A(X) = 0.62(-0.06)(+0.05) (+/- 0.06) x 10(44) erg s(-)(1), B-X = 2.35(-0.18)(+0.21)(+/- 0.09), gamma(X) = -2.77(-1.05)(+1.06)(+/- 0.79), where we include systematic uncertainties in parentheses and for a pivot mass and redshift of 3 x 10(14) M-circle dot and 0.16, respectively. We compare our constraints with previous results, and we combine our sample with the SPT SZE-selected cluster subsample observed with XMM-Newton extending the validity of our results to a wider range of redshifts and cluster masses.
  • Lumme, E.; Pomoell, J.; Kilpua, E. K. J. (2017)
    Estimates of the photospheric magnetic, electric, and plasma velocity fields are essential for studying the dynamics of the solar atmosphere, for example through the derivative quantities of Poynting and relative helicity flux and using the fields to obtain the lower boundary condition for data-driven coronal simulations. In this paper we study the performance of a data processing and electric field inversion approach that requires only high-resolution and high-cadence line-of-sight or vector magnetograms, which we obtain from the Helioseismic and Magnetic Imager (HMI) onboard Solar Dynamics Observatory (SDO). The approach does not require any photospheric velocity estimates, and the lacking velocity information is compensated for using ad hoc assumptions. We show that the free parameters of these assumptions can be optimized to reproduce the time evolution of the total magnetic energy injection through the photosphere in NOAA AR 11158, when compared to recent state-of-the-art estimates for this active region. However, we find that the relative magnetic helicity injection is reproduced poorly, reaching at best a modest underestimation. We also discuss the effect of some of the data processing details on the results, including the masking of the noise-dominated pixels and the tracking method of the active region, neither of which has received much attention in the literature so far. In most cases the effect of these details is small, but when the optimization of the free parameters of the ad hoc assumptions is considered, a consistent use of the noise mask is required. The results found in this paper imply that the data processing and electric field inversion approach that uses only the photospheric magnetic field information offers a flexible and straightforward way to obtain photospheric magnetic and electric field estimates suitable for practical applications such as coronal modeling studies.
  • Lumme, E.; Kazachenko, M. D.; Fisher, G. H.; Welsch, B. T.; Pomoell, J.; Kilpua, E.K.J. (2019)
    We study how the input-data cadence affects the photospheric energy and helicity injection estimates in eruptive NOAA Active Region 11158. We sample the novel 2.25-minute vector magnetogram and Dopplergram data from the Helioseismic and Magnetic Imager (HMI) instrument onboard the Solar Dynamics Observatory (SDO) spacecraft to create input datasets of variable cadences ranging from 2.25 minutes to 24 hours. We employ state-of-the-art data processing, velocity, and electric-field inversion methods for deriving estimates of the energy and helicity injections from these datasets. We find that the electric-field inversion methods that reproduce the observed magnetic-field evolution through the use of Faraday's law are more stable against variable cadence: the PDFI (PTD-Doppler-FLCT-Ideal, where PTD refers to Poloidal-Toroidal Decomposition, and FLCT to Fourier Local Correlation Tracking) electric-field inversion method produces consistent injection estimates for cadences from 2.25 minutes up to two hours, implying that the photospheric processes acting on time scales below two hours contribute little to the injections, or that they are below the sensitivity of the input data and the PDFI method. On other hand, the electric-field estimate derived from the output of DAVE4VM (Differential Affine Velocity Estimator for Vector Magnetograms), which does not fulfill Faraday's law exactly, produces significant variations in the energy and helicity injection estimates in the 2.25 minutes - two hours cadence range. We also present a third, novel DAVE4VM-based electric-field estimate, which corrects the poor inductivity of the raw DAVE4VM estimate. This method is less sensitive to the changes of cadence, but it still faces significant issues for the lowest of considered cadences (two hours). We find several potential problems in both PDFI- and DAVE4VM-based injection estimates and conclude that the quality of both should be surveyed further in controlled environments.
  • Grandin, Maxime; Aikio, Anita T.; Kozlovsky, Alexander (2019)
    We study the properties and geoeffectiveness of solar wind high-speed streams (HSSs) emanating from coronal holes and associated with stream interaction regions (SIRs). This paper presents a statistical study of 588 SIR/HSS events with solar wind speed at 1 AU exceeding 500 km/s during 1995-2017, encompassing the decline of solar cycle 22 to the decline of cycle 24. Events are detected using measurements of the solar wind speed and the interplanetary magnetic field. Events misidentified as or interacting with interplanetary coronal mass ejections are removed by comparison with an existing interplanetary coronal mass ejection list. Using this SIR/HSS event catalog (list given in the supporting information), a superposed epoch analysis of key solar wind parameters is carried out. It is found that the number of SIR/HSSs peaks during the late declining phase of solar cycle (SC) 23, as does their velocity, but that their geoeffectiveness in terms of the AE and SYM-H indices is low. This can be explained by the anomalously low values of magnetic field during the extended solar minimum. Within SC23 and SC24, the highest geoeffectiveness of SIR/HSSs takes place during the early declining phases. Geoeffectiveness of SIR/HSSs continues to be up to 40% lower during SC24 than SC23, which can be explained by the solar wind properties.