Browsing by Subject "WORLDWIDE"

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  • Pärssinen, Olavi; Lassila, Essi; Kauppinen, Markku (2022)
    Purpose: To study the association of parents' reports about their children's near work and outdoor habits with myopia in their children. Methods: Data from a questionnaire study conducted in 1983 among Finnish schoolchildren were reanalyzed. Vision screening had been performed for all the schoolchildren (n = 4961) in the 1st, 5th, and 8th grades (7-, 11-, and 15-year-olds) in an area of Central Finland. The questionnaire, including information about myopia, was returned by 4305 (86.7%) participants. Items concerned parents' estimates of their child's habitual reading distance, time spent indoors as compared with age peers, daily near work, outdoors time, and parents' myopia. The associations of myopia with these factors were studied. Results: Myopia prevalence in those with a habitual close reading distance vs. others was 14.3% vs. 2.1%, 28.7% vs. 13.1% and 45.8% vs. 24.7% for the 7-, 11- and 15-year-olds (p < 0.001 in all age-groups). Myopia prevalence in children reported by their parents as spending more time indoors than age peers was 10.9% vs. 2.8% (p < 0.001), 25.0% vs. 14.7% (p = 0.004) and 41.9% vs. 25.7% (p < 0.001) in the three age groups. Myopia prevalence among those reported as spending both more time indoors and reading at a close distance vs. others was 44.2% vs. 11.9% (Fisher's exact t-test, p < 0.001). In the multiple logistic regression models, parental myopia almost doubled the risk of myopia in the 11- and 15-year-olds. ORs (95% CI) for myopia adjusted for parental myopia and sex were for close reading distance 7.381 (4.054-13.440), 2.382 (1.666-3.406), 2.237 (1.498-3.057), (p < 0.001), and for more time spent indoors, 3.692 (1.714-7.954), p = 0.001, 1.861 (1.157-2.992), p = 0.010), 1.700 (1.105-2.615), p = 0.016, in the three age groups. Conclusion: Children, especially 7-year-olds, reported by their parents as having a close reading distance and spending a lot of time indoors were associated with a higher risk for myopia.
  • Pärssinen, Olavi; Lassila, Essi; Kauppinen, Markku (2022)
    Purpose: To study the association of parents' reports about their children's near work and outdoor habits with myopia in their children. Methods: Data from a questionnaire study conducted in 1983 among Finnish schoolchildren were reanalyzed. Vision screening had been performed for all the schoolchildren (n = 4961) in the 1st, 5th, and 8th grades (7-, 11-, and 15-year-olds) in an area of Central Finland. The questionnaire, including information about myopia, was returned by 4305 (86.7%) participants. Items concerned parents' estimates of their child's habitual reading distance, time spent indoors as compared with age peers, daily near work, outdoors time, and parents' myopia. The associations of myopia with these factors were studied. Results: Myopia prevalence in those with a habitual close reading distance vs. others was 14.3% vs. 2.1%, 28.7% vs. 13.1% and 45.8% vs. 24.7% for the 7-, 11- and 15-year-olds (p < 0.001 in all age-groups). Myopia prevalence in children reported by their parents as spending more time indoors than age peers was 10.9% vs. 2.8% (p < 0.001), 25.0% vs. 14.7% (p = 0.004) and 41.9% vs. 25.7% (p < 0.001) in the three age groups. Myopia prevalence among those reported as spending both more time indoors and reading at a close distance vs. others was 44.2% vs. 11.9% (Fisher's exact t-test, p < 0.001). In the multiple logistic regression models, parental myopia almost doubled the risk of myopia in the 11- and 15-year-olds. ORs (95% CI) for myopia adjusted for parental myopia and sex were for close reading distance 7.381 (4.054-13.440), 2.382 (1.666-3.406), 2.237 (1.498-3.057), (p < 0.001), and for more time spent indoors, 3.692 (1.714-7.954), p = 0.001, 1.861 (1.157-2.992), p = 0.010), 1.700 (1.105-2.615), p = 0.016, in the three age groups. Conclusion: Children, especially 7-year-olds, reported by their parents as having a close reading distance and spending a lot of time indoors were associated with a higher risk for myopia.
  • CENTER-TBI Investigators; van Veen, Ernest; van der Jagt, Mathieu; Cnossen, Maryse C.; Maas, Andrew I. R.; de Beaufort, Inez D.; Menon, David K.; Citerio, Giuseppe; Stocchetti, Nino; Rietdijk, Wim J. R.; van Dijck, Jeroen T. J. M.; Kompanje, Erwin J. O.; Raj, Rahul (2018)
    BackgroundWe aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation.MethodsInvestigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%).ResultsRegarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time.ConclusionsThis study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
  • Koppatz, Hanna; Takala, Sini; Peltola, Katriina; But, Anna; Mäkisalo, Heikki; Nordin, Arno; Sallinen, Ville (2021)
    Introduction Gallbladder cancer (GBC) is a rare malignancy in Western population with poor prognosis. This study aimed to investigate the trends in GBC incidence, treatment pattern, and survival in Finland. Methods Patients diagnosed with primary GBC in a geographically defined area (Southern Finland Regional Cancer Center) during 2006-2017 were identified. Results Final cohort included 270 patients with GBC. The incidence was 1.32/100,000 persons, and it decreased 6.8 cases per million personyears during the study period. One hundred fifty-one (56%) patients were diagnosed at Stage IV. Fifty-one patients (19%) underwent curative-intent resection with 96% R0-resection rate. The median overall survival was 7.1 months and 5-year overall survival 11.6% for all patients, and 67.7 months and 56.8% after curative-intent resection, respectively. No improvement was noted over time in overall survival in patients with GBC, or in subgroups of different stages of GBC. Conclusions The incidence of GBC is slightly decreasing in Southern Finland, but survival has not improved over time.
  • Boettiger, B. W.; Bossaert, L. L.; Castren, M.; Cimpoesu, D.; Georgiou, M.; Greif, R.; Gruenfeld, M.; Lockey, A.; Lott, C.; Maconochie, I.; Melieste, R.; Monsieurs, K. G.; Nolan, J. P.; Perkins, G. D.; Raffay, V.; Schlieber, J.; Semeraro, F.; Soar, J.; Truhlar, A.; Van de Voorde, P.; Wyllie, J.; Wingen, S.; Board European Resuscitation Counc (2016)
  • Chaput, J. -P.; Barnes, J. D.; Tremblay, M. S.; Fogelholm, M.; Hu, G.; Lambert, E. V.; Maher, C.; Maia, J.; Olds, T.; Onywera, V.; Sarmiento, O. L.; Standage, M.; Tudor-Locke, C.; Katzmarzyk, P. T. (2018)
    ObjectiveStudies examining associations between movement behaviours (i.e. physical activity, sedentary behaviour and sleep duration) and obesity focus on average values of these movement behaviours, despite important within-country and between-country variability. A better understanding of movement behaviour inequalities is important for developing public health policies and behaviour-change interventions. The objective of this ecologic analysis at the country level was to determine if inequality in movement behaviours is a better correlate of obesity than average movement behaviour volume in children from all inhabited continents of the world. MethodsThis multinational, cross-sectional study included 6,128 children 9-11years of age. Moderate-to-vigorous physical activity (MVPA), total sedentary time (SED) and sleep period time were monitored over 7 consecutive days using waist-worn accelerometry. Screen time was self-reported. Inequality in movement behaviours was determined using Gini coefficients (ranging from 0 [complete equality] to 1 [complete inequality]). ResultsThe largest inequality in movement behaviours was observed for screen time (Gini of 0.32; medium inequality), followed by MVPA (Gini of 0.21; low inequality), SED (Gini of 0.07; low inequality) and sleep period time (Gini of 0.05; low inequality). Average MVPA (hd(-1)) was a better correlate of obesity than MVPA inequality (r=-0.77 vs. r=0.00, p=0.03). Average SED (hd(-1)) was also a better correlate of obesity than SED inequality (r=0.52 vs. r=-0.32, p=0.05). Differences in associations for screen time and sleep period time were not statistically significant. MVPA in girls was found to be disproportionally lower in countries with more MVPA inequality. ConclusionsFindings from this study show that average MVPA and SED should continue to be used in population health studies of children as they are better correlates of obesity than inequality in these behaviours. Moreover, the findings suggest that MVPA inequality could be greatly reduced through increases in girls' MVPA alone.
  • Bottiger, B. W.; Bossaert, L. L.; Castren, Maaret Kaarina; Cimpoesu, D.; Georgiou, M.; Greif, R.; Grunfeld, M.; Lockey, A.; Lott, C.; Maconochie, I.; Melieste, R.; Monsieurs, K. G.; Nolan, J. P.; Perkins, G. D.; Raffay, V.; Schlieber, J.; Semeraro, F.; Soar, J.; Truhlar, A.; Van de Voorde, P.; Wyllie, J.; Wingen, S. (2016)
  • Pärnänen, Katariina; Karkman, Antti; Hultman, Jenni; Lyra, Christina; Bengtsson-Palme, Johan; Larsson, D. G. Joakim; Rautava, Samuli; Isolauri, Erika; Salminen, Seppo; Kumar, Himanshu; Satokari, Reetta; Virta, Marko (2018)
    The infant gut microbiota has a high abundance of antibiotic resistance genes (ARGs) compared to adults, even in the absence of antibiotic exposure. Here we study potential sources of infant gut ARGs by performing metagenomic sequencing of breast milk, as well as infant and maternal gut microbiomes. We find that fecal ARG and mobile genetic element (MGE) profiles of infants are more similar to those of their own mothers than to those of unrelated mothers. MGEs in mothers' breast milk are also shared with their own infants. Termination of breastfeeding and intrapartum antibiotic prophylaxis of mothers, which have the potential to affect microbial community composition, are associated with higher abundances of specific ARGs, the composition of which is largely shaped by bacterial phylogeny in the infant gut. Our results suggest that infants inherit the legacy of past antibiotic consumption of their mothers via transmission of genes, but microbiota composition still strongly impacts the overall resistance load.
  • GBD 2020 Release 1 Vaccine Coverag; Galles, Natalie C.; Liu, Patrick Y.; Updike, Rachel L.; Meretoja, Tuomo J. (2021)
    Background Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. Methods For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dosespecific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in countryreported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. Findings By 2019, global coverage of third-dose DTP (DTP3; 81.6% [95% uncertainty interval 80.4-82 .7]) more than doubled from levels estimated in 1980 (39.9% [37.5-42.1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38.5% [35.4-41.3] in 1980 to 83.6% [82.3-84.8] in 2019). Third- dose polio vaccine (Pol3) coverage also increased, from 42.6% (41.4-44.1) in 1980 to 79.8% (78.4-81.1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from 56.8 million (52.6-60. 9) to 14.5 million (13.4-15.9). However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. Only 11 countries and territories were estimated to have reached the national GVAP target of at least 90% coverage for all assessed vaccines in 2019. Interpretation After achieving large gains in childhood vaccine coverage worldwide, in much of the world this progress was stalled or reversed from 2010 to 2019. These findings underscore the importance of revisiting routine immunisation strategies and programmatic approaches, recentring service delivery around equity and underserved populations. Strengthening vaccine data and monitoring systems is crucial to these pursuits, now and through to 2030, to ensure that all children have access to, and can benefit from, lifesaving vaccines. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
  • Li, Xuefei; Schmid, Bernhard; Wang, Fei; Paine, C. E. Timothy (2016)
    Growth rates are of fundamental importance for plants, as individual size affects myriad ecological processes. We determined the factors that generate variation in RGR among 14 species of trees and shrubs that are abundant in subtropical Chinese forests. We grew seedlings for two years at four light levels in a shade-house experiment. We monitored the growth of every juvenile plant every two weeks. After one and two years, we destructively harvested individuals and measured their functional traits and gas-exchange rates. After calculating individual biomass trajectories, we estimated relative growth rates using nonlinear growth functions. We decomposed the variance in log(RGR) to evaluate the relationships of RGR with its components: specific leaf area (SLA), net assimilation rate (NAR) and leaf mass ratio (LMR). We found that variation in NAR was the primary determinant of variation in RGR at all light levels, whereas SLA and LMR made smaller contributions. Furthermore, NAR was strongly and positively associated with area-based photosynthetic rate and leaf nitrogen content. Photosynthetic rate and leaf nitrogen concentration can, therefore, be good predictors of growth in woody species.
  • Linnakoski, Riikka; Forbes, Kristian M. (2019)
  • Alvarez, Elysia M.; Force, Lisa M.; Xu, Rixing; Compton, Kelly; Lu, Dan; Henrikson, Hannah Jacqueline; Kocarnik, Jonathan M.; Harvey, James D.; Pennini, Alyssa; Dean, Frances E.; Fu, Weijia; Vargas, Martina T.; Keegan, Theresa H. M.; Ariffin, Hany; Barr, Ronald D.; Erdomaeva, Yana Arturovna; Gunasekera, D. Sanjeeva; John-Akinola, Yetunde O.; Ketterl, Tyler G.; Kutluk, Tezer; Malogolowkin, Marcio Henrique; Mathur, Prashant; Radhakrishnan, Venkatraman; Ries, Lynn Ann Gloeckler; Rodriguez-Galindo, Carlos; Sagoyan, Garik Barisovich; Sultan, Iyad; Abbasi, Behzad; Abbasi-Kangevari, Mohsen; Abbasi-Kangevari, Zeinab; Abbastabar, Hedayat; Abdelmasseh, Michael; Abd-Elsalam, Sherief; Abdoli, Amir; Abebe, Haimanot; Abedi, Aidin; Abidi, Hassan; Abolhassani, Hassan; Ali, Hiwa Abubaker; Abu-Gharbieh, Eman; Achappa, Basavaprabhu; Acuna, Juan Manuel; Adedeji, Isaac Akinkunmi; Adegboye, Oyelola A.; Adnani, Qorinah Estiningtyas Sakilah; Advani, Shailesh M.; Afzal, Muhammad Sohail; Meybodi, Mohamad Aghaie; Ahadinezhad, Bahman; Ahinkorah, Bright Opoku; Ahmad, Sajjad; Ahmadi, Sepideh; Ahmed, Muktar Beshir; Rashid, Tarik Ahmed; Salih, Yusra Ahmed; Aiman, Wajeeha; Akalu, Gizachew Taddesse; Al Hamad, Hanadi; Alahdab, Fares; AlAmodi, Abdulhadi A.; Alanezi, Fahad Mashhour; Alanzi, Turki M.; Alem, Adugnaw Zeleke; Alem, Dejene Tsegaye; Alemayehu, Yosef; Alhalaiqa, Fadwa Naji; Alhassan, Robert Kaba; Ali, Saqib; Alicandro, Gianfranco; Alipour, Vahid; Aljunid, Syed Mohamed; Alkhayyat, Motasem; Alluri, Sunitha; Almasri, Nihad A.; Al-Maweri, Sadeq Ali; Almustanyir, Sami; Al-Raddadi, Rajaa M.; Alvis-Guzman, Nelson; Ameyaw, Edward Kwabena; Amini, Saeed; Amu, Hubert; Ancuceanu, Robert; Andrei, Catalina Liliana; Andrei, Tudorel; Ansari, Fereshteh; Ansari-Moghaddam, Alireza; Anvari, Davood; Anyasodor, Anayochukwu Edward; Arabloo, Jalal; Arab-Zozani, Morteza; Argaw, Ayele Mamo; Arshad, Muhammad; Arulappan, Judie; Aryannejad, Armin; Asemi, Zatollah; Jafarabadi, Mohammad Asghari; Atashzar, Mohammad Reza; Atorkey, Prince; Atreya, Alok; Attia, Sameh; Aujayeb, Avinash; Ausloos, Marcel; Avila-Burgos, Leticia; Awedew, Atalel Fentahun; Quintanilla, Beatriz Paulina Ayala; Ayele, Alemu Degu; Ayen, Solomon Shitu; Azab, Mohammed A.; Azadnajafabad, Sina; Azami, Hiva; Azangou-Khyavy, Mohammadreza; Jafari, Amirhossein Azari; Azarian, Ghasem; Azzam, Ahmed Y.; Bahadory, Saeed; Bai, Jianjun; Baig, Atif Amin; Baker, Jennifer L.; Banach, Maciej; Barnighausen, Till Winfried; Barone-Adesi, Francesco; Barra, Fabio; Barrow, Amadou; Basaleem, Huda; Batiha, Abdul-Monim Mohammad; Behzadifar, Masoud; Bekele, Niguss Cherie; Belete, Rebuma; Belgaumi, Uzma Iqbal; Bell, Arielle Wilder; Berhie, Alemshet Yirga; Bhagat, Devidas S.; Bhagavathula, Akshaya Srikanth; Bhardwaj, Nikha; Bhardwaj, Pankaj; Bhaskar, Sonu; Bhattacharyya, Krittika; Bhojaraja, Vijayalakshmi S.; Bibi, Sadia; Bijani, Ali; Biondi, Antonio; Birara, Setognal; Bjorge, Tone; Bolarinwa, Obasanjo Afolabi; Bolla, Srinivasa Rao; Boloor, Archith; Braithwaite, Dejana; Brenner, Hermann; Bulamu, Norma B.; Burkart, Katrin; Bustamante-Teixeira, Maria Teresa; Butt, Nadeem Shafique; Butt, Zahid A.; dos Santos, Florentino Luciano Caetano; Cao, Chao; Cao, Yin; Carreras, Giulia; Catala-Lopez, Ferran; Cembranel, Francieli; Cerin, Ester; Chakinala, Raja Chandra; Chakraborty, Promit Ananyo; Chattu, Vijay Kumar; Chaturvedi, Pankaj; Chaurasia, Akhilanand; Chavan, Prachi P.; Chimed-Ochir, Odgerel; Choi, Jee-Young Jasmine; Christopher, Devasahayam J.; Chu, Dinh-Toi; Chung, Michael T.; Conde, Joao; Costa, Vera Marisa; Daar, Omar B.; Dadras, Omid; Dahlawi, Saad M. A.; Dai, Xiaochen; Damiani, Giovanni; Amico, Emanuele D.; Dandona, Lalit; Dandona, Rakhi; Daneshpajouhnejad, Parnaz; Darwish, Amira Hamed; Daryani, Ahmad; De la Hoz, Fernando Pio; Debela, Sisay Abebe; Demie, Takele Gezahegn G.; Demissie, Getu Debalkie; Demissie, Zeleke Geto; Denova-Gutierrez, Edgar; Molla, Meseret Derbew; Desai, Rupak; Desta, Abebaw Alemayehu; Dhamnetiya, Deepak; Dharmaratne, Samath Dhamminda; Dhimal, Mandira Lamichhane; Dhimal, Meghnath; Dianatinasab, Mostafa; Didehdar, Mojtaba; Diress, Mengistie; Djalalinia, Shirin; Huyen Phuc Do; Doaei, Saeid; Dorostkar, Fariba; dos Santos, Wendel Mombaque; Drake, Thomas M.; Ekholuenetale, Michael; El Sayed, Iman; Zaki, Maysaa El Sayed; El Tantawi, Maha; El-Abid, Hassan; Elbahnasawy, Mostafa Ahmed; Elbarazi, Iffat; Elhabashy, Hala Rashad; Elhadi, Muhammed; El-Jaafary, Shaimaa; Enyew, Daniel Berhanie; Erkhembayar, Ryenchindorj; Eshrati, Babak; Eskandarieh, Sharareh; Faisaluddin, Mohammed; Fares, Jawad; Farooque, Umar; Fasanmi, Abidemi Omolara; Fatima, Wafa; Ferreira de Oliveira, Jose Miguel P.; Ferrero, Simone; Desideri, Lorenzo Ferro; Fetensa, Getahun; Filip, Irina; Fischer, Florian; Fisher, James L.; Foroutan, Masoud; Fukumoto, Takeshi; Gaal, Peter Andras; Gad, Mohamed M.; Gaewkhiew, Piyada; Gallus, Silvano; Garg, Tushar; Gemeda, Belete Negese Belete; Getachew, Tamiru; Ghafourifard, Mansour; Ghamari, Seyyed-Hadi; Ghashghaee, Ahmad; Ghassemi, Fariba; Ghith, Nermin; Gholami, Ali; Navashenaq, Jamshid Gholizadeh; Gilani, Syed Amir; Ginindza, Themba G.; Gizaw, Abraham Tamirat; Glasbey, James C.; Goel, Amit; Golechha, Mahaveer; Goleij, Pouya; Golinelli, Davide; Gopalani, Sameer Vali; Gorini, Giuseppe; Goudarzi, Houman; Goulart, Barbara Niegia Garcia; Grada, Ayman; Gubari, Mohammed Ibrahim Mohialdeen; Guerra, Maximiliano Ribeiro; Guha, Avirup; Gupta, Bhawna; Gupta, Sapna; Gupta, Veer Bala; Gupta, Vivek Kumar; Haddadi, Rasool; Hafezi-Nejad, Nima; Hailu, Alemayehu; Haj-Mirzaian, Arvin; Halwani, Rabih; Hamadeh, Randah R.; Hambisa, Mitiku Teshome; Hameed, Sajid; Hamidi, Samer; Haque, Shafiul; Hariri, Sanam; Haro, Josep Maria; Hasaballah, Ahmed; Hasan, S. M. Mahmudul; Hashemi, Seyedeh Melika; Hassan, Treska S.; Hassanipour, Soheil; Hay, Simon; Hayat, Khezar; Hebo, Sultan H.; Heidari, Golnaz; Heidari, Mohammad; Herrera-Serna, Brenda Yuliana; Herteliu, Claudiu; Heyi, Demisu Zenbaba; Hezam, Kamal; Hole, Michael K.; Holla, Ramesh; Horita, Nobuyuki; Hossain, Md Mahbub; Hossain, Mohammad Bellal; Hosseini, Mostafa; Hosseinzadeh, Ali; Hosseinzadeh, Mehdi; Hostiuc, Mihaela; Hostiuc, Sorin; Househ, Mowafa; Hsairi, Mohamed; Huang, Junjie; Hussein, Nawfal R.; Hwang, Bing-Fang; Ibitoye, Segun Emmanuel; Ilesanmi, Olayinka Stephen; Ilic, Irena M.; Ilic, Milena D.; Innos, Kaire; Irham, Lalu Muhammad; Islam, Rakibul M.; Islam, Sheikh Mohammed Shariful; Ismail, Nahlah Elkudssiah; Isola, Gaetano; Iwagami, Masao; Jacob, Louis; Jadidi-Niaragh, Farhad; Jain, Vardhmaan; Jakovljevic, Mihajlo; Janghorban, Roksana; Mamaghani, Amirreza Javadi; Jayaram, Shubha; Jayawardena, Ranil; Jazayeri, Seyed Behzad; Jebai, Rime; Jha, Ravi Prakash; Joo, Tamas; Joseph, Nitin; Joukar, Farahnaz; Jurisson, Mikk; Kaambwa, Billingsley; Kabir, Ali; Kalankesh, Leila R.; Kaliyadan, Feroze; Kamal, Zul; Kamath, Ashwin; Kandel, Himal; Kar, Sitanshu Sekhar; Karaye, Ibraheem M.; Karimi, Amirali; Kassa, Bekalu Getnet; Kauppila, Joonas H.; Bohan, Phillip M. Kemp; Kengne, Andre Pascal; Kerbo, Amene Abebe; Keykhaei, Mohammad; Khader, Yousef Saleh; Khajuria, Himanshu; Khalili, Neda; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khan, Maseer; Khan, Md Nuruzzaman; Khan, Moien A. B.; Khanali, Javad; Khayamzadeh, Maryam; Khosravizadeh, Omid; Khubchandani, Jagdish; Khundkar, Roba; Kim, Min Seo; Kim, Yun Jin; Kisa, Adnan; Kisa, Sezer; Kissimova-Skarbek, Katarzyna; Kolahi, Ali-Asghar; Kopec, Jacek A.; Koteeswaran, Rajasekaran; Laxminarayana, Sindhura Lakshmi Koulmane; Koyanagi, Ai; Kugbey, Nuworza; Kumar, G. Anil; Kumar, Nithin; Kwarteng, Alexander; La Vecchia, Carlo; Lan, Qing; Landires, Ivan; Lasrado, Savita; Lauriola, Paolo; Ledda, Caterina; Lee, Sang-woong; Lee, Wei-Chen; Lee, Yeong Yeh; Lee, Yo Han; Leigh, James; Leong, Elvynna; Li, Bingyu; Li, Jiarui; Li, Ming-Chieh; Lim, Stephen S.; Liu, Xuefeng; Lobo, Stany W.; Loureiro, Joana A.; Lugo, Alessandra; Lunevicius, Raimundas; Abd El Razek, Hassan Magdy; Razek, Muhammed Magdy Abd El; Mahmoudi, Morteza; Majeed, Azeem; Makki, Alaa; Male, Shilpa; Malekpour, Mohammad-Reza; Malekzadeh, Reza; Malik, Ahmad Azam; Mamun, Mohammed A.; Manafi, Navid; Mansour-Ghanaei, Fariborz; Mansouri, Borhan; Mansournia, Mohammad Ali; Martini, Santi; Masoumi, Seyedeh Zahra; Matei, Clara N.; Mathur, Manu Raj; McAlinden, Colm; Mehrotra, Ravi; Mendoza, Walter; Menezes, Ritesh G.; Mentis, Alexios-Fotios A.; Meretoja, Tuomo J.; Mersha, Amanual Getnet; Mesregah, Mohamed Kamal; Mestrovic, Tomislav; Jonasson, Junmei Miao; Miazgowski, Bartosz; Michalek, Irmina Maria; Miller, Ted R.; Mingude, Alemu Basazin; Mirmoeeni, Seyyedmohammadsadeq; Mirzaei, Hamed; Misra, Sanjeev; Mithra, Prasanna; Mohammad, Karzan Abdulmuhsin; Mohammadi, Mokhtar; Mohammadi, Seyyede Momeneh; Mohammadian-Hafshejani, Abdollah; Mohammadpourhodki, Reza; Mohammed, Arif; Mohammed, Shafiu; Mohammed, Teroj Abdulrahman; Moka, Nagabhishek; Mokdad, Ali H.; Molokhia, Mariam; Momtazmanesh, Sara; Monasta, Lorenzo; Moni, Mohammad Ali; Moradi, Ghobad; Moradi, Yousef; Moradzadeh, Maliheh; Moradzadeh, Rahmatollah; Moraga, Paula; Morrison, Shane Douglas; Mostafavi, Ebrahim; Khaneghah, Amin Mousavi; Mpundu-Kaambwa, Christine; Mubarik, Sumaira; Mwanri, Lillian; Nabhan, Ashraf F.; Nagaraju, Shankar Prasad; Nagata, Chie; Naghavi, Mohsen; Naimzada, Mukhammad David; Naldi, Luigi; Nangia, Vinay; Naqvi, Atta Abbas; Swamy, Sreenivas Narasimha; Narayana, Aparna Ichalangod; Nayak, Biswa Prakash; Nayak, Vinod C.; Nazari, Javad; Nduaguba, Sabina Onyinye; Negoi, Ionut; Negru, Serban Mircea; Nejadghaderi, Seyed Aria; Nepal, Samata; Kandel, Sandhya Neupane; Nggada, Haruna Asura; Nguyen, Cuong Tat; Nnaji, Chukwudi A.; Nosrati, Hamed; Nouraei, Hasti; Nowroozi, Ali; Nunez-Samudio, Virginia; Nwatah, Vincent Ebuka; Nzoputam, Chimezie Igwegbe; Oancea, Bogdan; Odukoya, Oluwakemi Ololade; Oguntade, Ayodipupo Sikiru; Oh, In-Hwan; Olagunju, Andrew T.; Olagunju, Tinuke O.; Olakunde, Babayemi Oluwaseun; Oluwasanu, Mojisola Morenike; Omar, Emad; Bali, Ahmed Omar; Ong, Sokking; Onwujekwe, Obinna E.; Ortega-Altamirano, Doris; Otstavnov, Nikita; Otstavnov, Stanislav S.; Oumer, Bilcha; Owolabi, Mayowa O.; Mahesh, P. A.; Padron-Monedero, Alicia; Padubidri, Jagadish Rao; Pakshir, Keyvan; Pana, Adrian; Pandey, Anamika; Pardhan, Shahina; Kan, Fatemeh Pashazadeh; Pasovic, Maja; Patel, Jenil R.; Pati, Siddhartha; Pattanshetty, Sanjay M.; Paudel, Uttam; Pereira, Renato B.; Peres, Mario F. P.; Perianayagam, Arokiasamy; Postma, Maarten J.; Pourjafar, Hadi; Pourshams, Akram; Prashant, Akila; Pulakunta, Thejodhar; Qadir, Mirza Muhammad Fahd Fahd; Rabiee, Mohammad; Rabiee, Navid; Radfar, Amir; Radhakrishnan, Raghu Anekal; Rafiee, Ata; Rafiei, Alireza; Rafiei, Sima; Rahim, Fakher; Rahimzadeh, Shadi; Rahman, Mosiur; Rahman, Muhammad Aziz; Rahmani, Amir Masoud; Rajesh, Aashish; Ramezani-Doroh, Vajiheh; Ranabhat, Kamal; Ranasinghe, Priyanga; Rao, Chythra R.; Rao, Sowmya J.; Rashedi, Sina; Rashidi, Mohammad-Mahdi; Rath, Goura Kishor; Rawaf, David Laith; Rawaf, Salman; Rawal, Lal; Rawassizadeh, Reza; Razeghinia, Mohammad Sadegh; Regasa, Misganu Teshoma; Renzaho, Andre M. 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L.; Fitzmaurice, Christina; Bleyer, Archie; Bhakta, Nickhill; Gebremeskel, Teferi Gebru (2022)
    Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
  • Saarela, Ville; Karvonen, Elina; Stoor, Katri; Hagg, Pasi; Luodonpaa, Marja; Kuoppala, Jaana; Taanila, Anja; Tuulonen, Anja (2013)