Browsing by Subject "dental caries"

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  • Rautava, Jaana; Gürsoy, Ulvi K.; Kullström, Adrian; Kononen, Eija; Sorsa, Timo; Tervahartiala, Taina; Gürsoy, Mervi (2020)
    The diagnostic accuracy of point-of-care (PoC) applications may be compromised in individuals with additional inflammatory conditions. This cross-sectional study examined the performance of a commercial oral rinse active matrix metalloproteinase-8 (aMMP-8) PoC immunotest in individuals with (n = 47) and without Crohn's disease (CD) (n = 41). Oral rinse collected from the participants was analyzed by the PoC immunotest. Molecular forms and fragments of salivary MMP-8 were detected by western immunoblotting. The sensitivity of the immunotest for periodontitis was 60.0% in the CD group and 90.0% in the control group. The respective specificity was 75.0% and 80.0%. In both groups, clinical diagnosis of periodontitis exhibited a significant association with the immunotest results, however, the odds ratio (OR) was more than ten-fold in controls (OR 54.3, 95% CI: 3.1-953, p = 0.006) in comparison to CD patients (OR 5.2, 95% CI: 1.3-21.6, p = 0.022). According to Western immunoblot results, the immunotest MMP-8 positivity was not related to elevated levels of molecular forms and fragments of MMP-8 in the CD group, as in the control group. The diagnostic accuracy of the aMMP-8 PoC oral rinse immunotest is reduced in CD patients, which may be related to lower levels or undetectable complexes.
  • Niskanen, Mirka Carita; Mattila, Pauli Taneli; Niinimaa, Ahti Olavi; Vehkalahti, Miira Marjaliisa; Knuuttila, Matti (2020)
    Objective: The aim was to evaluate the association of behavioural and socioeconomic factors with the occurrence of periodontal disease and dental caries, paying special attention to the simultaneous occurrence of these diseases. Materials and methods: The study population consisted of 5255 dentate persons aged >= 30 years from a nationally representative survey. Caries and probing pocket depth were recorded by tooth and calculated in relation to the number of existing teeth. The groups were: non-affected (A), the two most affected quintiles for periodontal disease with little or no dental caries (B), the two most affected quintiles for dental caries with little or no periodontal disease (C) and the two most affected quintiles for both periodontal disease and dental caries (D). Presence of dental plaque was determined, and behavioural and socioeconomic factors were established. Results: Dental plaque, smoking, lack of regular dental check-ups, older age and a basic level of education were strongly associated with the simultaneous occurrence of periodontal disease and dental caries. Conclusions: There are many behavioural and socioeconomic factors that associate with the occurrence of both periodontal disease and dental caries. These factors also increase the risk of individuals having these diseases simultaneously.
  • Karttunen, Anni (Helsingin yliopisto, 2022)
    Tutkimuksen tarkoitus: Lehmänmaitoa korvaavien kasvipohjaisten juomien kulutus on kasvanut maailmanlaajuisesti viime vuosina. Kasvipohjaisia juomia markkinoidaan terveellisenä vaihtoehtona lehmänmaidolle, vaikka varsinaista tutkimustietoa kasvipohjaisten juomien terveysvaikutuksista löytyy verrattain vähän erityisesti suun terveyden osalta. Tämän tutkielman tarkoituksena on perehtyä maitoa korvaavien kasvipohjaisten juomien ja suun terveyden yhteyteen. Materiaalit ja menetelmät: Tutkielma koostuu kirjallisuuskatsauksesta, jonka aineisto on haettu toukokuussa 2020 Pubmedin ja Google Scholarin tietokannoista. Aineistosta valikoitiin artikkelit, jotka käsittelivät kasvipohjaisten juomien yhteyttä suun terveyteen tai kasvipohjaisten juomien ravitsemuksellista laatua, jolla voitiin olettaa olevan merkitystä suun terveyteen. Tulokset: Eri kasvipohjaisten juomien välillä havaittiin suuria eroja mutans-streptokokkien biofilmin muodostuksen ja sokereista fermentoitavien happojen tuotannon suhteen. Kasvipohjaisten juomien sisältämä sokeri on vapaata sokeria ja siten bakteerien hyödynnettävissä. Tulosten pohjalta useat kasvipohjaiset juomat, erityisesti makeutetut, saattavat olla kariogeenisia eli hammaskariesta aiheuttavia. Kasvipohjaisten juomien ravintoainepitoisuuksissa on suurta vaihtelua muun muassa kalsium-, fosfaatti-, D-vitamiini- ja fluoridipitoisuuksien suhteen. Johtopäätökset: Korvatessa ruokavaliossa lehmänmaito kasvipohjaisilla juomilla on otettava huomioon mahdolliset terveysvaikutukset. Ravitsemusneuvonnassa sekä karieksen hallinnan suunnitelmissa ensisijaisena suosituksena tulisi kasvipohjaisten juomien osalta olla sokeroimattomien kasvipohjaisten juomien käyttö sokeroitujen sijaan. Kasvipohjaisten juomien ravintoainepitoisuudet tulisi ilmoittaa selkeästi pakkausten ravintoarvomerkinnöissä, jotta kuluttajilla olisi mahdollisuus vertailla tuotteita ja huomioida sekä yleisterveyteen että suun terveyteen vaikuttavat tekijät.
  • Turck, Dominique; EFSA NDA Panel (2017)
    Following an application from Cargill R&D Centre Europe, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No1924/2006 via the Competent Authority of Belgium, the EFSA Panelon Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to sugar-free hard confectionery with at least 90% erythritol and reduction of dental plaque which reduces the risk of caries. The food proposed by the applicant as the subject of the health claim, sugar-free hard confectionery with at least 90% erythritol, is sufficiently characterised. In the context of this application, the weight of dental plaque, and/or the counts of Streptococcusmutans in dental plaque, and/or the concentration of organic acids in plaque (primarily acetic acid and lactic acid) can be considered as risk factor(s) in the development of dental caries, as long as evidence is provided that the consumption of the food that is the subject of the health claim reduces one or more of the proposed risk factors and the incidence of dental caries. One human intervention study did not show an effect of sugar-free hard confectionery with at least 90% erythritol on the incidence of dental caries in children on either mixed or permanent dentition. The Panelconcludes that a cause and effect relationship has not been established between the consumption of sugar-free hard confectionery with at least 90% erythritol and reduction of dental plaque which reduces the risk of dental caries.
  • Wuollet, Emma; Laisi, Sakari; Alaluusua, Satu; Waltimo-Sirén, Janna (2018)
    The aim of this study was to investigate if a developmental enamel defect known as Molar-Incisor Hypomineralization (MIH) is associated with dental caries. Socioeconomic status (SES) was examined as a confounding factor between caries and MIH. In this cross-sectional study, 636 children, aged 8 to 13 years, from three towns (two rural areas and one urban area) in Finland were examined for MIH in line with the criteria of the European Academy of Paediatric Dentistry. Caries status for permanent teeth was recorded as decayed, missing and filled teeth (DMFT). Caries experience (DMFT > 0) in the first permanent molars (FPMs) was set as an outcome. SES was determined using a questionnaire completed by parents. The prevalence of MIH was 18.1%. The mean DMFT in FPMs for children with MIH was higher than for their peers, 1.03 +/- 1.25 vs. 0.32 +/- 0.80 (p = 0.000, Mann-Whitney U test). In a multivariate analysis using the generalized linear mixed model where locality, SES, age and MIH were taken into account as caries risk indicators, MIH was the strongest risk indicator of caries in FPMs (Odds Ratio: 6.60, 95% Confidence Interval: 3.83-11.39, p = 0.000). According to the study results, children with MIH have a higher risk for dental caries than children without MIH.