Browsing by Subject "disruption"

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  • Moliner, Rafael (Helsingin yliopisto, 2019)
    Classical and rapid-acting antidepressant drugs have been shown to reinstate juvenile-like plasticity in the adult brain, allowing mature neuronal networks to rewire in an environmentally-driven/activity-dependent process. Indeed, antidepressant drugs gradually increase expression of brain-derived neurotrophic factor (BDNF) and can rapidly activate signaling of its high-affinity receptor TRKB. However, the exact mechanism of action underlying drug-induced restoration of juvenile-like plasticity remains poorly understood. In this study we first characterized acute effects of classical and rapid-acting antidepressant drugs on the interaction between TRKB and postsynaptic density (PSD) proteins PSD-93 and PSD-95 in vitro. PSD proteins constitute the core of synaptic complexes by anchoring receptors, ion channels, adhesion proteins and various signaling molecules, and are also involved in protein transport and cell surface localization. PSD proteins have in common their role as key regulators of synaptic structure and function, although PSD-93 and PSD-95 are associated with different functions during development and have opposing effects on the state of plasticity in individual synapses and neurons. Secondly, we investigated changes in mobility of TRKB in dendritic structures in response to treatment with antidepressant drugs in vitro. We found that antidepressant drugs decrease anchoring of TRKB with PSD-93 and PSD-95, and can rapidly increase TRKB turnover in dendritic spines. Our results contribute to the mechanistic model explaining drug-induced restoration of juvenile-like neuronal plasticity, and may provide a common basis for the effects of antidepressant drugs.
  • Jakosuo, Katri (Future Academy, 2019)
    European Proceedings of Social and Behavioural Sciences
    Digitalisation and the platform economy have changed business and consumption patterns. Similarly, ways of working have also changed and become polarised as a result of automation, robots, e -commerce and blockchains bringing new innovations to the markets and changing earnings logic. Lower and middle-class jobs decrease or disappear, and high skilled roles increase. The new digital innovations and the progressive expansion of large platforms, such as Airbnb and Uber, have also placed pressure on the development of legislation, globally. The purpose of this study is to describe how digitalisation and the platform economy affect the service sector in general and how this disruption has implications for service sector companies, blue-collar workers and consumers. This research is based on qualitative content analysis. According to the results, digitalisation and the platform economy have both positive and negative effects. For example, these phenomena are expanding business markets and increasing the choice of consumers and the freedom of employees. On the other hand, the insecurity of employees and competition between local and global companies may increase uncontrollably. (C) 2019 Published by Future Academy www.FutureAcademy.org.uk