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Familial aggregation of early-onset cancers

Heikkinen, Sanna M. M.; Madanat-Harjuoja, Laura-Maria; Seppä, Karri J. M.; Rantanen, Matti E.; Hirvonen, Elli M.; Malila, Nea K.; Pitkäniemi, Janne M. (2020)

This registry-linkage study evaluates familial aggregation of cancer among relatives of a population-based series of early-onset (
Familial cancer risk in family members and spouses of patients with early-onset head and neck cancer

Mroueh, Rayan; Tanskanen, Tomas; Haapaniemi, Aaro; Salo, Tuula; Malila, Nea; Mäkitie, Antti; Pitkäniemi, Janne (2020)

Background Reported patterns of familial aggregation of head and neck cancer (HNC) vary greatly, with many studies hampered by the limited number of subjects. Methods Altogether 923 early-onset ( Results Of all early-onset HNC families, only 21 (2.3%) had familial HNC cancers at any age and less than five familial early onset HNC cancers among first-degree relatives. The cumulative risk of HNC for siblings by age 60 (0.52%) was at population level (0.33%). No increased familial risk of early-onset HNC could be discerned in family members (SIR 2.68, 95% CI 0.32-9.68 for first-degree relatives). Conclusions Our study indicates that the cumulative and relative familial risk of early-onset HNC is modest in the Finnish population and, at most, only a minor proportion of early-onset HNCs are due solely to inherited genetic mutations.