Browsing by Subject "feasibility study"

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  • Laine, Anna; Välimäki, Maritta; Pekurinen, Virve; Löyttyniemi, Eliisa; Marttunen, Mauri; Anttila, Minna (2019)
    Background: Web-based interventions are promising tools for increasing the understanding of illness and treatment among patients with serious mental disorders. Objective: This study aimed to test the feasibility and acceptability of a Web-based patient education intervention using a quasi-experimental cluster design to report feedback on patient education sessions and the website used and to report preliminary evidence of the intervention's impact on patients with schizophrenia spectrum disorder. Methods: A single-blind, parallel, quasi-experimental cluster study over a 6-month period comparing Web-based education (n=33) with a nonequivalent control group (treatment as usual, n=24) for people with schizophrenia spectrum disorder was conducted. Participants (N=57) were recruited from one psychiatric hospital (6 wards). Feasibility was assessed by participants' commitment (refusal rate, dropout rate) to the study. Acceptability was assessed as participants' commitment to the intervention. Patient education sessions and website feedback were assessed by the patients and health care professionals. The preliminary impact of the sessions on patients' self-efficacy, self-esteem, illness cognition, and knowledge level was measured at baseline and follow-ups (8 weeks, 6 months) with self-rated questionnaires. Results: The refusal rate among patients was high with no statistically significant difference (69% [74/107] in the intervention group, 76% [76/100] in the control group; P =.21). The same result was found for the dropout rates (48% [16/33] vs 58% [14/24]; P=. 46). The acceptability of the intervention was good; 31 participants out of 33 (94%) completed all five sessions. Feedback on the intervention was mainly positive; three out of four subscales of session were rated above the midpoint of 4.0. Feedback on the website was also positive, with a grade of good for content (69%, 20/29 patients; 75%, 21/28 professionals), layout (62%, 18/29 patients; 61%, 17/28 professionals), and usability (62%, 18/29 patients; and 68%, 19/28 professionals). The patients using the intervention had significantly higher scores 6 months after the sessions in self-efficacy (baseline mean 26.12, SD 5.64 vs 6-month mean 29.24, SD 6.05; P=.003) and regarding knowledge level about schizophrenia (mean 11.39, SD 4.65 vs 6-month mean 15.06, SD 5.26; P=. 002), and lower scores in the subscale of helplessness in illness cognition (mean 2.26, SD 0.96 vs 6-month mean 1.85, SD 0.59; P=.03). Differences from the control group were not significant. No differences were found in patients' self-esteem or other subscales in illness cognition. Conclusions: The patients were reluctant to participate in the study and tended to drop out before the follow-ups. Once they had participated, their acceptance of the intervention was high. A more effective recruitment strategy and monitoring method will be needed in future studies. To assess the impact of the intervention, a more rigorous study design with an adequately powered sample size will be used in cooperation with outpatient mental health services.
  • Kivijarvi, Antti; Aaltonen, Sanna; Välimäki, Vesa (2019)
    The aim of this paper is to investigate the potential of online group activities alongside one-to-one offline counselling in youth work targeted toward young adults not in employment or education. The study examines the feasibility of moderated anonymous online group (MAOG) discussions from a comprehensive standpoint, with reference to the perspectives of end-users, service providers and further research. The paper is based on a two-arm, quasi-experimental and mixed methods study. To this end, the data consists of group interviews with young adults and youth workers arranged at the beginning of the study, baseline and follow-up interviews, online discussion threads, as well as evaluations of the online group activities. The piloted intervention was most acceptable to young adults who suffered from loneliness and had difficulties in joining face-to-face groups. Most youth work professionals considered the pilot viable. Finally, several modifications are suggested prior to implementing an experimental setting to study the effectiveness of the intervention.
  • Castren, Sari; Mäkelä, Niklas; Haikola, Janne; Salonen, Anne H.; Crystal, Roger; Scheinin, Mika; Alho, Hannu (2019)
    Background and aim There is growing interest in the use of medication-assisted treatments for gambling disorder (GD). Opioid receptor antagonists are hypothesised to blunt the craving associated with gambling. This study was designed to assess the feasibility of using an intranasal naloxone spray to treat GD. Design An 8-week, open-label, uncontrolled pilot study. Setting A single study site in the capital region of Finland. Subjects Twenty problem gamblers (nine men) were randomised into two groups. Group A (n=10) took one dose into one nostril (2mg naloxone), as needed, with a maximum of 4 doses/day (max. 8mg/day). Group B (n=10) took one dose into each nostril (4mg naloxone) as needed, with a maximum of 4 doses/day (max. 16mg/day). Intervention Naloxone hydrochloride nasal spray. Measures Acceptability and feasibility of the intervention were assessed. Use of study medication, adverse events, gambling frequency and gambling expenditure were recorded in a mobile diary. Problem gambling: South Oaks Gambling Screen (SOGS), depressive symptoms: Beck Depression Inventory (BDI) and alcohol use: Alcohol Use Disorders Identification Test were recorded. Results Study completion rate was 90%. Acceptability and feasibility scores were high. Group B used intranasal naloxone more frequently than group A, and consequently used more naloxone. No serious adverse events were reported. The postintervention SOGS scores were lower (median=4 (IQR=3.75) versus preintervention scores (median=12 (IQR=4.75)). Depressive symptoms were reduced during the trial (preintervention BDI median=9, IQR=9vs postintervention BDI median=6, IQR=6). Conclusions The acceptability and feasibility of using intranasal naloxone were high, and no serious adverse events were reported. Preliminary results suggest mixed results in terms of gambling behaviour (ie, reduced frequency but not expenditure) and decreased depressive symptoms. Trial registration number EudraCT2016-001828-56