Rotation of galaxies is examined by the general principle of least action. This law of nature describes a system in its surroundings, here specifically a galaxy in the surrounding Universe. According to this holistic theory the gravitational potential due to all matter in the expanding Universe relates to the universal curvature which, in turn, manifests itself as the universal acceleration. Then the orbital velocities from the central bulge to distant perimeters are understood to balance both the galactic and universal acceleration. Since the galactic acceleration decreases with distance from the galaxy's center to its luminous edge, the orbital velocities of ever more distant stars and gas clouds tend toward a value that tallies the universal acceleration. This tiny term has been acknowledged earlier by including it as a parameter in the modified gravitational law, but here the tiny acceleration is understood to result from the gravitational potential that spans across the expanding Universe. This resolution of the galaxy rotation problem is compared with observations and contrasted with models of dark matter. Also, other astronomical observations that have been interpreted as evidence for dark matter are discussed in light of the least-action principle.

The on-going whole genome sequencing and whole cell assays of metabolites and proteins imply that complex systems could ultimately be mastered by perfecting knowledge into great detail. However, courses of nature are inherently intractable because flows of energy and their driving forces depend on each other. Thus no data will suffice to predict precisely the outcomes of e.g., engineering experiments. All path-dependent processes, most notably evolution in its entirety, display this capricious character of nature.

About a century ago, in the spirit of ancient atomism, the quantum of light was renamed the photon to suggest that it is the fundamental element of everything. Since the photon carries energy in its period of time, a flux of photons inexorably embodies a flow of time. Thus, time comprises periods as a trek comprises legs. The flows of quanta naturally select optimal paths (i.e., geodesics) to level out energy differences in the least amount of time. The corresponding flow equations can be written, but they cannot be solved. Since the flows affect their driving forces, affecting the flows, and so on, the forces (i.e., causes) and changes in motions (i.e., consequences) are inseparable. Thus, the future remains unpredictable. However, it is not all arbitrary but rather bounded by free energy. Eventually, when the system has attained a stationary state where forces tally, there are no causes and no consequences. Since there are no energy differences between the system and its surroundings, the quanta only orbit on and on. Thus, time does not move forward either but circulates.