Browsing by Subject "mismatch negativity (MMN)"

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  • Grimaldi, Mirko; Sisinni, Bianca; Fivela, Barbara Gili; Invitto, Sara; Resta, Donatella; Alku, Paava; Brattico, Elvira (2014)
  • Henttonen, Pentti (Helsingfors universitet, 2016)
    The aim of the present study was to investigate the relationship between autonomic arousal, activation and auditory change detection in musicians and non-musicians, as reflected by the mismatch negativity (MMN) component of event-related potential response and cardiovascular activity measured in heart rate. 20 musicians and 20 non-musicians were included in the study. An oddball paradigm composed of stimuli deviating in three difficulty levels from standard tone in pitch, duration and location was utilized with two conditions of passive listening, which were followed by intermittent active listening tasks. Only pitch and duration deviants were analysed. Musicians exhibited greater MMN amplitudes, shorter MMN latencies and superior behavioral performance evidenced by discrimination accuracy and reaction time. The effects were observed for both pitch and duration deviants. Musicians' resting heart rates were lower during pre-experiment and both pre-task baselines, indicating higher cardiovascular efficiency. Greater task-related heart rate acceleration in active listening was observed in the musician group than in the non-musician group. MMN amplitude to pitch deviants during passive listening tasks correlated positively with behavioral accuracy in active discrimination tasks. Faster heart rate during active listening predicted better task performance in musician group, whereas the effect was opposite in non-musician group. In musician group, higher heart rate increased the task performance more for subjects with smaller MMN amplitudes. These data thus imply that cortically measured preattentive auditory discrimination capacity is reciprocally connected to the arousal dimension of autonomic nervous system's activity and that musical expertise affects this relationship. Results add support to the evidence of musicians' superior auditory change detection capacity measured in event-related potentials and behavioral performance, while providing new insights to the role of psychophysiological arousal in sound processing and other mental tasks.
  • Nowak, Kamila; Oron, Anna; Szymaszek, Aneta; Leminen, Miika; Naatanen, Risto; Szelag, Elzbieta (2016)
    The present study investigates age-related changes in duration discrimination in millisecond time domain. We tested young (N = 20, mean age = 24.5, SD = 2.97) and elderly (N = 20, mean age = 65.2, SD = 2.94) subjects using the mismatch negativity (MMN) paradigm. White-noise bursts of two different durations (50 and 10 ms) were presented in two oddball blocks. In one block (Increment Condition), the repetitive sequence of 10 ms standards was interspersed by occasional 50 ms deviants. In the Decrement Condition, the roles of the two stimuli were reversed. We analyzed the P1-N1 complex, MMN and P3a and found the effect of age for all these components. Moreover, the impact of stimulus presentation condition (increment/decrement) was observed for MMN and P3a. Our results confirmed the previous evidence for deteriorated duration discrimination in elderly people. Additionally, we found that this effect may be influenced by procedural factors.
  • Seppänen, Miia (Helsingfors universitet, 2005)
    Previous exploratory studies suggest that pre-attentive auditory processing of musicians differ depending on the strategies they use in music practicing and performance. This study aimed at systematically determining whether there are differences in neural sound processing and behavioral measures between musicians preferring and not-preferring aural strategies including improvising, playing by ear and rehearsing by listening recordings. Participants were assigned into aural (n = 13) and non-aural (n = 11) groups according to how much they employ aural strategies, as determined by a questionnaire. The amplitude, latency, and scalp topography of the memory-related mismatch negativity (MMN) component of the event-related brain potentials were investigated with the so-called ‘optimal’ paradigm probing simple sound feature processing and with the ‘transposed-melody’ paradigm, probing complex sound pattern processing. Further, their behavioral accuracy in sound perception was tested with an attentive discrimination task in the transposed-melody paradigm and with the AMMA musicality test. Results showed that there were group differences both at the pre-attentive and behavioral levels of sound processing. First, in the optimal paradigm, the MMN morphology for the isolated sound features was similar between groups but its MMN amplitude, latency and topography for different sound features differed. Second, in the ‘transposed-melody’ paradigm, MMN was larger for the deviant that changed its contour as compared with the deviant that changed the last tone and thus the interval between the two last tones of the melody. The Contour-MMN amplitude as determined in the beginning of the recordings correlated with the subsequent behavioral discrimination accuracy in attentive condition. However, there were no group differences in the behavioral discrimination both deviants being detected equally well. The Interval-MMN amplitudes decreased especially in the aural group after the attentive condition. Moreover, the Interval-MMN latency in the non-aural group prolonged after the attentive condition as compared to the preceding condition whereas in the aural group the MMN latency shortened. No changes were seen in the Contour-MMN between conditions with either of the groups. Third, the non-aural group outperformed the aural group in the AMMA musicality test (Tonal subtest and Total scores). Additionally, AMMA scores (especially the Rhythm) correlated significantly with the Contour-MMN amplitudes after the attentive condition. Taken together, the present results suggest that practice strategies do not affect musicians' pre-attentive processing of simple sound features but might affect complex sound pattern processing. Complex sound pattern processing related also to the attentive behavioral performance in all musicians. While providing new insights into behavioral and neural differences between musicians preferring different practice strategies, results only partially support previous findings concerning discriminatory accuracy of violation within complex sound pattern learning.
  • Tervaniemi, Mari; Huotilainen, Minna; Brattico, Elvira (2014)
  • Torppa, Ritva; Kuuluvainen, Soila; Lipsanen, Jari (2022)
    Objective: The aim of the present study was to investigate speech processing development in children with normal hearing (NH) and cochlear implants (CI) groups using a multifeature event-related potential (ERP) paradigm. Singing is associated to enhanced attention and speech perception. Therefore, its connection to ERPs was investigated in the CI group. Methods: The paradigm included five change types in a pseudoword: two easy- (duration, gap) and three difficult-to-detect (vowel, pitch, intensity) with CIs. The positive mismatch responses (pMMR), mismatch negativity (MMN), P3a and late differentiating negativity (LDN) responses of preschoolers (below 6 years 9 months) and schoolchildren (above 6 years 9 months) with NH or CIs at two time points (T1, T2) were investigated with Linear Mixed Modeling (LMM). For the CI group, the association of singing at home and ERP development was modeled with LMM. Results: Overall, responses elicited by the easy- and difficult to detect changes differed between the CI and NH groups. Compared to the NH group, the CI group had smaller MMNs to vowel duration changes and gaps, larger P3a responses to gaps, and larger pMMRs and smaller LDNs to vowel identity changes. Preschoolers had smaller P3a responses and larger LDNs to gaps, and larger pMMRs to vowel identity changes than schoolchildren. In addition, the pMMRs to gaps increased from T1 to T2 in preschoolers. More parental singing in the CI group was associated with increasing pMMR and less parental singing with decreasing P3a amplitudes from T1 to T2. Conclusion: The multifeature paradigm is suitable for assessing cortical speech processing development in children. In children with CIs, cortical discrimination is often reflected in pMMR and P3a responses, and in MMN and LDN responses in children with NH. Moreover, the cortical speech discrimination of children with CIs develops late, and over time and age, their Frontiers in Neuroscience 01 frontiersin.org Torppa et al. 10.3389/fnins.2022.976767 speech sound change processing changes as does the processing of children with NH. Importantly, multisensory activities such as parental singing can lead to improvement in the discrimination and attention shifting toward speech changes in children with CIs. These novel results should be taken into account in future research and rehabilitation.