Browsing by Subject "resin acid"

Sort by: Order: Results:

Now showing items 1-2 of 2
  • Saha, Sani (Helsingin yliopisto, 2021)
    Immunodeficiency in neonatal piglet is one of the major causes of pre-weaning mortality. Colostrum supply cytokines to newborn piglets, which play an important role in formation of their immune mechanism. This study aims to identify the relationship between sow’s blood and colostrum cytokines, and effect of resin acid-enriched composition (RAC) in sow’s blood and colostrum cytokines concentration. RAC is a plant extract of coniferous tree, and it is composed of resin acids and fatty acids which exert immunomodulatory function. Two experiments were conducted in two different farms where RAC was supplemented in the diet of late gestation sows, starting from one week before of expected farrowing date till farrowing. Multiplex immunoassay was used to determine the interferon alpha (IFN-α), interferon gamma (IFN-ɣ), interleukin 1 (IL-1), interleukin 10 (IL-10), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor alpha (TNF-α) and interleukin 12p40 (IL-12p40) cytokines concentration in blood and colostrum of sow collected within 2 hours of the birth of first piglets. There were significant (p < 0.05) positive correlations between sow’s blood and colostrum cytokines concentration. RAC-fed sows had significantly (p < 0.05) higher level of IL-1 and showed positive tendency (p = 0.1) to increase TNF-α cytokine level in blood. Colostrum level of IFN- ɣ, IL-1 and IL-12p40 had also positive tendency (p = 0.1) to rise in RAC supplemented sow. On this basis, it is proposed that application of RAC in late gestation sow diet enhance the cytokine production in sow’s blood, and blood cytokines levels are positively correlated with colostrum cytokines.
  • Uddin, Md Karim; Hasan, Shah Md. Kamrul; Mahmud, Md Rayhan; Peltoniemi, Olli; Oliviero, Claudio (2021)
    The weaning process represents a delicate phase for piglets, and is often characterized by lower feed intake, lower weight gain, diarrhea, and ultimately increased mortality. We aimed to determine the effects of RAC supplementation in diets on improving piglet growth and vitality, reducing post-weaning diarrhea, and enhancing gut health. In a 2 × 2 × 2 factorial experiment, we selected forty sows and their piglets. Piglets were followed until seven weeks of age. There were no significant differences found between RAC treated and control piglets until weaning (p = 0.26). However, three weeks after weaning, RAC treated piglets had higher body weight and average daily growth (ADG) than the control piglets (p = 0.003). In addition, the piglets that received RAC after weaning, irrespective of mother or prior creep feed treatment, had lower post-weaning diarrhea (PWD) and fecal myeloperoxidase (MPO) level than control piglets. Gut microbiota analysis in post-weaning piglets revealed that RAC supplementation significantly increased Lachnospiraceae_unclassified, Blautia, Butyricicoccus, Gemmiger and Holdemanella, and decreased Bacteroidales_unclassified. Overall, RAC supplementation to piglets modulated post-weaning gut microbiota, improved growth performance after weaning, reduced post-weaning diarrhea and reduced fecal myeloperoxidase levels. We therefore consider RAC to be a potential natural feed supplement to prevent enteric infections and improve growth performance in weaning piglets.