Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

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dc.contributor.author Sobral-Leite, Marcelo
dc.contributor.author Wesseling, Jelle
dc.contributor.author Smit, Vincent T H B M
dc.contributor.author Nevanlinna, Heli
dc.contributor.author van Miltenburg, Martine H
dc.contributor.author Sanders, Joyce
dc.contributor.author Hofland, Ingrid
dc.contributor.author Blows, Fiona M
dc.contributor.author Coulson, Penny
dc.contributor.author Patrycja, Gazinska
dc.contributor.author Schellens, Jan H M
dc.contributor.author Fagerholm, Rainer
dc.contributor.author Heikkilä, Päivi
dc.contributor.author Aittomäki, Kristiina
dc.contributor.author Blomqvist, Carl
dc.contributor.author Provenzano, Elena
dc.contributor.author Ali, Hamid R
dc.contributor.author Figueroa, Jonine
dc.contributor.author Sherman, Mark
dc.contributor.author Lissowska, Jolanta
dc.contributor.author Mannermaa, Arto
dc.contributor.author Kataja, Vesa
dc.contributor.author Kosma, Veli-Matti
dc.contributor.author Hartikainen, Jaana M
dc.contributor.author Phillips, Kelly-Anne
dc.contributor.author Couch, Fergus J
dc.contributor.author Olson, Janet E
dc.contributor.author Vachon, Celine
dc.contributor.author Visscher, Daniel
dc.contributor.author Brenner, Hermann
dc.contributor.author Butterbach, Katja
dc.contributor.author Arndt, Volker
dc.contributor.author Holleczek, Bernd
dc.contributor.author Hooning, Maartje J
dc.contributor.author Hollestelle, Antoinette
dc.contributor.author Martens, John W M
dc.contributor.author van Deurzen, Carolien H M
dc.contributor.author van de Water, Bob
dc.contributor.author Broeks, Annegien
dc.contributor.author Chang-Claude, Jenny
dc.contributor.author Chenevix-Trench, Georgia
dc.contributor.author Easton, Douglas F
dc.contributor.author Pharoah, Paul D P
dc.contributor.author García-Closas, Montserrat
dc.contributor.author de Graauw, Marjo
dc.contributor.author Schmidt, Marjanka K
dc.date.accessioned 2015-07-03T03:42:21Z
dc.date.available 2015-07-03T03:42:21Z
dc.date.issued 2015-07-02
dc.identifier.citation BMC Medicine. 2015 Jul 02;13(1):156
dc.identifier.uri http://hdl.handle.net/10138/155631
dc.description.abstract Abstract Background Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6 % versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05–1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91–1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17–2.45). Conclusions ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.
dc.publisher BioMed Central
dc.title Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis
dc.date.updated 2015-07-03T03:42:21Z
dc.language.rfc3066 en
dc.rights.holder Sobral-Leite et al.
dc.type.uri http://purl.org/eprint/entityType/ScholarlyWork
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/type/JournalArticle

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