Vapor as a carrier of toxicity in a health troubled building

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http://hdl.handle.net/10138/156121

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Salo , J , Andersson , A M A , Mikkola , R O , Kredics , L , Viljanen , M & Salkinoja-Salonen , M S 2015 , Vapor as a carrier of toxicity in a health troubled building . in Healthy Buildings Europe 2015 : Sources & Exposure . , ID526 , International Society of Indoor Air Quality and Climate - ISIAQ , Eindhoven , Healthy buildings conference , Endhoven , Netherlands , 18/05/2015 .

Title: Vapor as a carrier of toxicity in a health troubled building
Author: Salo, Johanna; Andersson, Aino Maria Alice; Mikkola, Raimo Olavi; Kredics, Laszlo; Viljanen, Martti; Salkinoja-Salonen, Mirja Sinikka
Contributor: University of Helsinki, Department of Food and Nutrition
University of Helsinki, Aalto University
University of Helsinki, Department of Food and Nutrition
Publisher: International Society of Indoor Air Quality and Climate - ISIAQ
Date: 2015-05-18
Language: eng
Number of pages: 8
Belongs to series: Healthy Buildings Europe 2015 Sources & Exposure
URI: http://hdl.handle.net/10138/156121
Abstract: Penicillium expansum was identified as a major contaminant in indoor air, settled dust and materials of several buildings connected to indoor air related health complaints. This fungus emitted large quantities of exudates when cultivated on laboratory media. The exudates proved toxic towards four different mammalian test cells up to 10000 fold dilution. Toxins identified by LC-MS/MS were communesins and chaetoglobosin. Air dispersal of the toxic exudates was investigated with an experimental set-up where natural convection was generated by temperature gradient. It was found that the exudate with the contained toxins became airborne transported from the warmer surface to the colder surface. The results thus demonstrate transportation of microbially produced toxic substances across the air space. The role of liquid emissions from indoor molds represents a novel mechanism for human exposure in mold contaminated buildings. In this paper we report that vapor condensed from the indoor air of building affected with molds Aspergillus versicolor, Aspergillus calidoustus and Penicillium expansum contained substances that were acutely toxic when exposed to mammalian cells in vitro. The results encourage further study of condensed indoor water vapor as a tool to assess the presence of airborne substances with possible adverse health effects.
Subject: 212 Civil and Construction engineering
airborne toxicity
antifungal
mycotoxin
indoor moisture
indoor mold
sick building
Penicillium expansum
chaetoglobosin
communesin
Aspergillus calidoustus
Aspergillus versicolor
cork insulation
in vitro toxicity
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