Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death

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Liljestrand , J M , Havulinna , A S , Paju , S , Mannisto , S , Salomaa , V & Pussinen , P J 2015 , ' Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death ' , Journal of Dental Research , vol. 94 , no. 8 , pp. 1055-1062 . https://doi.org/10.1177/0022034515586352

Title: Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death
Author: Liljestrand, J. M.; Havulinna, A. S.; Paju, S.; Mannisto, S.; Salomaa, V.; Pussinen, P. J.
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2015-08
Language: eng
Number of pages: 8
Belongs to series: Journal of Dental Research
ISSN: 0022-0345
URI: http://hdl.handle.net/10138/157414
Abstract: Periodontitis, the main cause of tooth loss in the middle-aged and elderly, associates with the risk of atherosclerotic vascular disease. The objective was to study the capability of the number of missing teeth in predicting incident cardiovascular diseases (CVDs), diabetes, and all-cause death. The National FINRISK 1997 Study is a Finnish population-based survey of 8,446 subjects with 13 y of follow-up. Dental status was recorded at baseline in a clinical examination by a trained nurse, and information on incident CVD events, diabetes, and death was obtained via national registers. The registered CVD events included coronary heart disease events, acute myocardial infarction, and stroke. In Cox regression analyses, having >= 5 teeth missing was associated with 60% to 140% increased hazard for incident coronary heart disease events (P <0.020) and acute myocardial infarction (P <0.010). Incident CVD (P <0.043), diabetes (P <0.040), and death of any cause (P <0.019) were associated with >= 9 missing teeth. No association with stroke was observed. Adding information on missing teeth to established risk factors improved risk discrimination of death (P = 0.0128) and provided a statistically significant net reclassification improvement for all studied end points. Even a few missing teeth may indicate an increased risk of CVD, diabetes, or all-cause mortality. When individual risk factors for chronic diseases are assessed, the number of missing teeth could be a useful additional indicator for general medical practitioners.
Subject: periodontitis
tooth extraction
cardiovascular diseases
partially edentulous jaw
edentulous mouth
diabetes mellitus
CORONARY-HEART-DISEASE
TOOTH LOSS
PERIODONTAL-DISEASE
VASCULAR-DISEASE
ORAL INFECTIONS
FOLLOW-UP
ALL-CAUSE
RISK
ASSOCIATION
POPULATION
313 Dentistry
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