Helda

Helsingin yliopisto

Helsingfors universitet

University of Helsinki
Advanced Search

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study

Show full item record


Download Download RIS format Share

Permalink

http://hdl.handle.net/10138/158846

Citation

Winkler , T W , Justice , A E , Graff , M , Barata , L , Feitosa , M F , Chu , S , Czajkowski , J , Esko , T , Fall , T , Kilpelainen , T O , Lu , Y , Magi , R , Mihailov , E , Pers , T H , Rueeger , S , Teumer , A , Ehret , G B , Ferreira , T , Heard-Costa , N L , Karjalainen , J , Lagou , V , Mahajan , A , Neinast , M D , Prokopenko , I , Simino , J , Teslovich , T M , Jansen , R , Westra , H-J , White , C C , Absher , D , Ahluwalia , T S , Ahmad , S , Albrecht , E , Alves , A C , Bragg-Gresham , J L , de Craen , A J M , Bis , J C , Bonnefond , A , Boucher , G , Cadby , G , Cheng , Y-C , Chiang , C W K , Delgado , G , Demirkan , A , Dueker , N , Eklund , N , Eiriksdottir , G , Eriksson , J , Feenstra , B , Fischer , K , Frau , F , Galesloot , T E , Geller , F , Goel , A , Gorski , M , Grammer , T B , Gustafsson , S , Haitjema , S , Hottenga , J-J , Huffman , J E , Jackson , A U , Jacobs , K B , Johansson , A , Kaakinen , M , Kleber , M E , Lahti , J , Leach , I M , Lehne , B , Liu , Y , Lo , K S , Lorentzon , M , Luan , J , Madden , P A F , Mangino , M , McKnight , B , Medina-Gomez , C , Monda , K L , Montasser , M E , Mueller , G , Mueller-Nurasyid , M , Nolte , I M , Panoutsopoulou , K , Pascoe , L , Paternoster , L , Rayner , N W , Renstrom , F , Rizzi , F , Rose , L M , Ryan , K A , Salo , P , Sanna , S , Scharnagl , H , Shi , J , Smith , A V , Southam , L , Stancakova , A , Steinthorsdottir , V , Strawbridge , R J , Sung , Y J , Tachmazidou , I , Tanaka , T , Thorleifsson , G , Trompet , S , Pervjakova , N , Tyrer , J P , Vandenput , L , van der Laan , S W , van der Velde , N , van Setten , J , van Vliet-Ostaptchouk , J V , Verweij , N , Vlachopoulou , E , Waite , L L , Wang , S R , Wang , Z , Wild , S H , Willenborg , C , Wilson , J F , Wong , A , Yang , J , Yengo , L , Yerges-Armstrong , L M , Yu , L , Zhang , W , Zhao , J H , Andersson , E A , Bakker , S J L , Baldassarre , D , Banasik , K , Barcella , M , Barlassina , C , Bellis , C , Benaglio , P , Blangero , J , Blueher , M , Bonnet , F , Bonnycastle , L L , Boyd , H A , Bruinenberg , M , Buchman , A S , Campbell , H , Chen , Y-D I , Chines , P S , Claudi-Boehm , S , Cole , J , Collins , F S , de Geus , E J C , de Groot , L C P G M , Dimitriou , M , Duan , J , Enroth , S , Eury , E , Farmaki , A-E , Forouhi , N G , Friedrich , N , Gejman , P V , Gigante , B , Glorioso , N , Go , A S , Gottesman , O , Graessler , J , Grallert , H , Grarup , N , Gu , Y-M , Broer , L , Ham , A C , Hansen , T , Harris , T B , Hartman , C A , Hassinen , M , Hastie , N , Hattersley , A T , Heath , A C , Henders , A K , Hernandez , D , Hillege , H , Holmen , O , Hovingh , K G , Hui , J , Husemoen , L L , Hutri-Kahonen , N , Hysi , P G , Illig , T , De Jager , P L , Jalilzadeh , S , Jorgensen , T , Jukema , J W , Juonala , M , Kanoni , S , Karaleftheri , M , Khaw , K T , Kinnunen , L , Kittner , S J , Koenig , W , Kolcic , I , Kovacs , P , Krarup , N T , Kratzer , W , Krueger , J , Kuh , D , Kumari , M , Kyriakou , T , Langenberg , C , Lannfelt , L , Lanzani , C , Lotay , V , Launer , L J , Leander , K , Lindstrom , J , Linneberg , A , Liu , Y-P , Lobbens , S , Luben , R , Lyssenko , V , Mannisto , S , Magnusson , P K , McArdle , W L , Menni , C , Merger , S , Milani , L , Montgomery , G W , Morris , A P , Narisu , N , Nelis , M , Ong , K K , Palotie , A , Perusse , L , Pichler , I , Pilia , M G , Pouta , A , Rheinberger , M , Ribel-Madsen , R , Richards , M , Rice , K M , Rice , T K , Rivolta , C , Salomaa , V , Sanders , A R , Sarzynski , M A , Scholtens , S , Scott , R A , Scott , W R , Sebert , S , Sengupta , S , Sennblad , B , Seufferlein , T , Silveira , A , Slagboom , P E , Smit , J H , Sparso , T H , Stirrups , K , Stolk , R P , Stringham , H M , Swertz , M A , Swift , A J , Syvanen , A-C , Tan , S-T , Thorand , B , Toenjes , A , Tremblay , A , Tsafantakis , E , van der Most , P J , Voelker , U , Vohl , M-C , Vonk , J M , Waldenberger , M , Walker , R W , Wennauer , R , Widen , E , Willemsen , G , Wilsgaard , T , Wright , A F , Zillikens , M C , van Dijk , S C , van Schoor , N M , Asselbergs , F W , de Bakker , P I W , Beckmann , J S , Beilby , J , Bennett , D A , Bergman , R N , Bergmann , S , Boeger , C A , Boehm , B O , Boerwinkle , E , Boomsma , D I , Bornstein , S R , Bottinger , E P , Bouchard , C , Chambers , J C , Chanock , S J , Chasman , D I , Cucca , F , Cusi , D , Dedoussis , G , Erdmann , J , Eriksson , J G , Evans , D A , de Faire , U , Farrall , M , Ferrucci , L , Ford , I , Franke , L , Franks , P W , Froguel , P , Gansevoort , R T , Gieger , C , Gronberg , H , Gudnason , V , Gyllensten , U , Hall , P , Hamsten , A , van der Harst , P , Hayward , C , Heliovaara , M , Hengstenberg , C , Hicks , A A , Hingorani , A , Hofman , A , Hu , F , Huikuri , H V , Hveem , K , James , A L , Jordan , J M , Jula , A , Kaehoenen , M , Kajantie , E , Kathiresan , S , Kiemeney , L A L M , Kivimaki , M , Knekt , P B , Koistinen , H A , Kooner , J S , Koskinen , S , Kuusisto , J , Maerz , W , Martin , N G , Laakso , M , Lakka , T A , Lehtimaki , T , Lettre , G , Levinson , D F , Lind , L , Lokki , M-L , Mantyselka , P , Melbye , M , Metspalu , A , Mitchell , B D , Moll , F L , Murray , J C , Musk , A W , Nieminen , M S , Njolstad , I , Ohlsson , C , Oldehinkel , A J , Oostra , B A , Palmer , L J , Pankow , J S , Pasterkamp , G , Pedersen , N L , Pedersen , O , Penninx , B W , Perola , M , Peters , A , Polasek , O , Pramstaller , P P , Psaty , B M , Qi , L , Quertermous , T , Raitakari , O T , Rankinen , T , Rauramaa , R , Ridker , P M , Rioux , J D , Rivadeneira , F , Rotter , J I , Rudan , I , den Ruijter , H M , Saltevo , J , Sattar , N , Schunkert , H , Schwarz , P E H , Shuldiner , A R , Sinisalo , J , Snieder , H , Sorensen , T I A , Spector , T D , Staessen , J A , Stefania , B , Thorsteinsdottir , U , Stumvoll , M , Tardif , J-C , Tremoli , E , Tuomilehto , J , Uitterlinden , A G , Uusitupa , M , Verbeek , A L M , Vermeulen , S H , Viikari , J S , Vitart , V , Voelzke , H , Vollenweider , P , Waeber , G , Walker , M , Wallaschofski , H , Wareham , N J , Watkins , H , Zeggini , E , Chakravarti , A , Clegg , D J , Cupples , L A , Gordon-Larsen , P , Jaquish , C E , Rao , D C , Abecasis , G R , Assimes , T L , Barroso , I , Berndt , S I , Boehnke , M , Deloukas , P , Fox , C S , Groop , L C , Hunter , D J , Ingelsson , E , Kaplan , R C , McCarthy , M I , Mohlke , K L , O'Connell , J R , Schlessinger , D , Strachan , D P , Stefansson , K , van Duijn , C M , Hirschhorn , J N , Lindgren , C M , Heid , I M , North , K E , Borecki , I B , Kutalik , Z & Loos , R J F 2015 , ' The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study ' , PLoS Genetics , vol. 11 , no. 10 , 1005378 . https://doi.org/10.1371/journal.pgen.1005378

Title: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study
Author: Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F.; Chu, Su; Czajkowski, Jacek; Esko, Tonu; Fall, Tove; Kilpelainen, Tuomas O.; Lu, Yingchang; Magi, Reedik; Mihailov, Evelin; Pers, Tune H.; Rueeger, Sina; Teumer, Alexander; Ehret, Georg B.; Ferreira, Teresa; Heard-Costa, Nancy L.; Karjalainen, Juha; Lagou, Vasiliki; Mahajan, Anubha; Neinast, Michael D.; Prokopenko, Inga; Simino, Jeannette; Teslovich, Tanya M.; Jansen, Rick; Westra, Harm-Jan; White, Charles C.; Absher, Devin; Ahluwalia, Tarunveer S.; Ahmad, Shafqat; Albrecht, Eva; Alves, Alexessander Couto; Bragg-Gresham, Jennifer L.; de Craen, Anton J. M.; Bis, Joshua C.; Bonnefond, Amelie; Boucher, Gabrielle; Cadby, Gemma; Cheng, Yu-Ching; Chiang, Charleston W. K.; Delgado, Graciela; Demirkan, Ayse; Dueker, Nicole; Eklund, Niina; Eiriksdottir, Gudny; Eriksson, Joel; Feenstra, Bjarke; Fischer, Krista; Frau, Francesca; Galesloot, Tessel E.; Geller, Frank; Goel, Anuj; Gorski, Mathias; Grammer, Tanja B.; Gustafsson, Stefan; Haitjema, Saskia; Hottenga, Jouke-Jan; Huffman, Jennifer E.; Jackson, Anne U.; Jacobs, Kevin B.; Johansson, Asa; Kaakinen, Marika; Kleber, Marcus E.; Lahti, Jari; Leach, Irene Mateo; Lehne, Benjamin; Liu, Youfang; Lo, Ken Sin; Lorentzon, Mattias; Luan, Jian'an; Madden, Pamela A. F.; Mangino, Massimo; McKnight, Barbara; Medina-Gomez, Carolina; Monda, Keri L.; Montasser, May E.; Mueller, Gabriele; Mueller-Nurasyid, Martina; Nolte, Ilja M.; Panoutsopoulou, Kalliope; Pascoe, Laura; Paternoster, Lavinia; Rayner, Nigel W.; Renstrom, Frida; Rizzi, Federica; Rose, Lynda M.; Ryan, Kathy A.; Salo, Perttu; Sanna, Serena; Scharnagl, Hubert; Shi, Jianxin; Smith, Albert Vernon; Southam, Lorraine; Stancakova, Alena; Steinthorsdottir, Valgerdur; Strawbridge, Rona J.; Sung, Yun Ju; Tachmazidou, Ioanna; Tanaka, Toshiko; Thorleifsson, Gudmar; Trompet, Stella; Pervjakova, Natalia; Tyrer, Jonathan P.; Vandenput, Liesbeth; van der Laan, Sander W.; van der Velde, Nathalie; van Setten, Jessica; van Vliet-Ostaptchouk, Jana V.; Verweij, Niek; Vlachopoulou, Efthymia; Waite, Lindsay L.; Wang, Sophie R.; Wang, Zhaoming; Wild, Sarah H.; Willenborg, Christina; Wilson, James F.; Wong, Andrew; Yang, Jian; Yengo, Loic; Yerges-Armstrong, Laura M.; Yu, Lei; Zhang, Weihua; Zhao, Jing Hua; Andersson, Ehm A.; Bakker, Stephan J. L.; Baldassarre, Damiano; Banasik, Karina; Barcella, Matteo; Barlassina, Cristina; Bellis, Claire; Benaglio, Paola; Blangero, John; Blueher, Matthias; Bonnet, Fabrice; Bonnycastle, Lori L.; Boyd, Heather A.; Bruinenberg, Marcel; Buchman, Aron S.; Campbell, Harry; Chen, Yii-Der Ida; Chines, Peter S.; Claudi-Boehm, Simone; Cole, John; Collins, Francis S.; de Geus, Eco J. C.; de Groot, Lisette C. P. G. M.; Dimitriou, Maria; Duan, Jubao; Enroth, Stefan; Eury, Elodie; Farmaki, Aliki-Eleni; Forouhi, Nita G.; Friedrich, Nele; Gejman, Pablo V.; Gigante, Bruna; Glorioso, Nicola; Go, Alan S.; Gottesman, Omri; Graessler, Juergen; Grallert, Harald; Grarup, Niels; Gu, Yu-Mei; Broer, Linda; Ham, Annelies C.; Hansen, Torben; Harris, Tamara B.; Hartman, Catharina A.; Hassinen, Maija; Hastie, Nicholas; Hattersley, Andrew T.; Heath, Andrew C.; Henders, Anjali K.; Hernandez, Dena; Hillege, Hans; Holmen, Oddgeir; Hovingh, Kees G.; Hui, Jennie; Husemoen, Lise L.; Hutri-Kahonen, Nina; Hysi, Pirro G.; Illig, Thomas; De Jager, Philip L.; Jalilzadeh, Shapour; Jorgensen, Torben; Jukema, J. Wouter; Juonala, Markus; Kanoni, Stavroula; Karaleftheri, Maria; Khaw, Kay Tee; Kinnunen, Leena; Kittner, Steven J.; Koenig, Wolfgang; Kolcic, Ivana; Kovacs, Peter; Krarup, Nikolaj T.; Kratzer, Wolfgang; Krueger, Janine; Kuh, Diana; Kumari, Meena; Kyriakou, Theodosios; Langenberg, Claudia; Lannfelt, Lars; Lanzani, Chiara; Lotay, Vaneet; Launer, Lenore J.; Leander, Karin; Lindstrom, Jaana; Linneberg, Allan; Liu, Yan-Ping; Lobbens, Stephane; Luben, Robert; Lyssenko, Valeriya; Mannisto, Satu; Magnusson, Patrik K.; McArdle, Wendy L.; Menni, Cristina; Merger, Sigrun; Milani, Lili; Montgomery, Grant W.; Morris, Andrew P.; Narisu, Narisu; Nelis, Mari; Ong, Ken K.; Palotie, Aarno; Perusse, Louis; Pichler, Irene; Pilia, Maria G.; Pouta, Anneli; Rheinberger, Myriam; Ribel-Madsen, Rasmus; Richards, Marcus; Rice, Kenneth M.; Rice, Treva K.; Rivolta, Carlo; Salomaa, Veikko; Sanders, Alan R.; Sarzynski, Mark A.; Scholtens, Salome; Scott, Robert A.; Scott, William R.; Sebert, Sylvain; Sengupta, Sebanti; Sennblad, Bengt; Seufferlein, Thomas; Silveira, Angela; Slagboom, P. Eline; Smit, Jan H.; Sparso, Thomas H.; Stirrups, Kathleen; Stolk, Ronald P.; Stringham, Heather M.; Swertz, Morris A.; Swift, Amy J.; Syvanen, Ann-Christine; Tan, Sian-Tsung; Thorand, Barbara; Toenjes, Anke; Tremblay, Angelo; Tsafantakis, Emmanouil; van der Most, Peter J.; Voelker, Uwe; Vohl, Marie-Claude; Vonk, Judith M.; Waldenberger, Melanie; Walker, Ryan W.; Wennauer, Roman; Widen, Elisabeth; Willemsen, Gonneke; Wilsgaard, Tom; Wright, Alan F.; Zillikens, M. Carola; van Dijk, Suzanne C.; van Schoor, Natasja M.; Asselbergs, Folkert W.; de Bakker, Paul I. W.; Beckmann, Jacques S.; Beilby, John; Bennett, David A.; Bergman, Richard N.; Bergmann, Sven; Boeger, Carsten A.; Boehm, Bernhard O.; Boerwinkle, Eric; Boomsma, Dorret I.; Bornstein, Stefan R.; Bottinger, Erwin P.; Bouchard, Claude; Chambers, John C.; Chanock, Stephen J.; Chasman, Daniel I.; Cucca, Francesco; Cusi, Daniele; Dedoussis, George; Erdmann, Jeanette; Eriksson, Johan G.; Evans, Denis A.; de Faire, Ulf; Farrall, Martin; Ferrucci, Luigi; Ford, Ian; Franke, Lude; Franks, Paul W.; Froguel, Philippe; Gansevoort, Ron T.; Gieger, Christian; Gronberg, Henrik; Gudnason, Vilmundur; Gyllensten, Ulf; Hall, Per; Hamsten, Anders; van der Harst, Pim; Hayward, Caroline; Heliovaara, Markku; Hengstenberg, Christian; Hicks, Andrew A.; Hingorani, Aroon; Hofman, Albert; Hu, Frank; Huikuri, Heikki V.; Hveem, Kristian; James, Alan L.; Jordan, Joanne M.; Jula, Antti; Kaehoenen, Mika; Kajantie, Eero; Kathiresan, Sekar; Kiemeney, Lambertus A. L. M.; Kivimaki, Mika; Knekt, Paul B.; Koistinen, Heikki A.; Kooner, Jaspal S.; Koskinen, Seppo; Kuusisto, Johanna; Maerz, Winfried; Martin, Nicholas G.; Laakso, Markku; Lakka, Timo A.; Lehtimaki, Terho; Lettre, Guillaume; Levinson, Douglas F.; Lind, Lars; Lokki, Marja-Liisa; Mantyselka, Pekka; Melbye, Mads; Metspalu, Andres; Mitchell, Braxton D.; Moll, Frans L.; Murray, Jeffrey C.; Musk, Arthur W.; Nieminen, Markku S.; Njolstad, Inger; Ohlsson, Claes; Oldehinkel, Albertine J.; Oostra, Ben A.; Palmer, Lyle J.; Pankow, James S.; Pasterkamp, Gerard; Pedersen, Nancy L.; Pedersen, Oluf; Penninx, Brenda W.; Perola, Markus; Peters, Annette; Polasek, Ozren; Pramstaller, Peter P.; Psaty, Bruce M.; Qi, Lu; Quertermous, Thomas; Raitakari, Olli T.; Rankinen, Tuomo; Rauramaa, Rainer; Ridker, Paul M.; Rioux, John D.; Rivadeneira, Fernando; Rotter, Jerome I.; Rudan, Igor; den Ruijter, Hester M.; Saltevo, Juha; Sattar, Naveed; Schunkert, Heribert; Schwarz, Peter E. H.; Shuldiner, Alan R.; Sinisalo, Juha; Snieder, Harold; Sorensen, Thorkild I. A.; Spector, Tim D.; Staessen, Jan A.; Stefania, Bandinelli; Thorsteinsdottir, Unnur; Stumvoll, Michael; Tardif, Jean-Claude; Tremoli, Elena; Tuomilehto, Jaakko; Uitterlinden, Andre G.; Uusitupa, Matti; Verbeek, Andre L. M.; Vermeulen, Sita H.; Viikari, Jorma S.; Vitart, Veronique; Voelzke, Henry; Vollenweider, Peter; Waeber, Gerard; Walker, Mark; Wallaschofski, Henri; Wareham, Nicholas J.; Watkins, Hugh; Zeggini, Eleftheria; Chakravarti, Aravinda; Clegg, Deborah J.; Cupples, L. Adrienne; Gordon-Larsen, Penny; Jaquish, Cashell E.; Rao, D. C.; Abecasis, Goncalo R.; Assimes, Themistocles L.; Barroso, Ines; Berndt, Sonja I.; Boehnke, Michael; Deloukas, Panos; Fox, Caroline S.; Groop, Leif C.; Hunter, David J.; Ingelsson, Erik; Kaplan, Robert C.; McCarthy, Mark I.; Mohlke, Karen L.; O'Connell, Jeffrey R.; Schlessinger, David; Strachan, David P.; Stefansson, Kari; van Duijn, Cornelia M.; Hirschhorn, Joel N.; Lindgren, Cecilia M.; Heid, Iris M.; North, Kari E.; Borecki, Ingrid B.; Kutalik, Zoltan; Loos, Ruth J. F.
Contributor organization: Institute for Molecular Medicine Finland
Helsinki Collegium for Advanced Studies
Behavioural Sciences
University of Helsinki
Transplantation Laboratory
Medicum
Research Programs Unit
Research Programme of Molecular Medicine
Aarno Palotie / Principal Investigator
Elisabeth Ingrid Maria Widen / Principal Investigator
Clinicum
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Children's Hospital
Lastentautien yksikkö
Department of Medicine
Marja-Liisa Lokki / Principal Investigator
Kardiologian yksikkö
Leif Groop Research Group
Quantitative Genetics
Developmental Psychology Research Group
Genomics of Neurological and Neuropsychiatric Disorders
Genomic Discoveries and Clinical Translation
Date: 2015-10
Language: eng
Number of pages: 42
Belongs to series: PLoS Genetics
ISSN: 1553-7404
DOI: https://doi.org/10.1371/journal.pgen.1005378
URI: http://hdl.handle.net/10138/158846
Abstract: Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (>= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
Subject: SELF-REPORTED HEIGHT
FAT DISTRIBUTION
MASS INDEX
LIFE-COURSE
BIOLOGICAL PATHWAYS
NATURAL MENOPAUSE
PERIPHERAL-BLOOD
WEIGHT-GAIN
COMMON SNPS
LOCI
3111 Biomedicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
The_Influence_o ... ssociations_with_Adult.pdf 1.455Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record