Anti-inflammatory effects of flap and lymph node transfer

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http://hdl.handle.net/10138/159086

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Viitanen , T P , Visuri , M T , Sulo , E , Saarikko , A M & Hartiala , P 2015 , ' Anti-inflammatory effects of flap and lymph node transfer ' Journal of Surgical Research , vol. 199 , no. 2 , pp. 718-725 . DOI: 10.1016/j.jss.2015.04.041

Title: Anti-inflammatory effects of flap and lymph node transfer
Author: Viitanen, Tiina P.; Visuri, Mikko T.; Sulo, Eeva; Saarikko, Anne M.; Hartiala, Pauliina
Contributor: University of Helsinki, Syövän biologian tutkimusyksikkö/HTY (-2009)
Date: 2015-12
Language: eng
Number of pages: 8
Belongs to series: Journal of Surgical Research
ISSN: 0022-4804
URI: http://hdl.handle.net/10138/159086
Abstract: Background: Transfer of healthy tissue is commonly used in the treatment of complicated wounds and in reconstruction of tissue defects. Recently, microvascular lymph node transfer (LN) has been used to improve the lymphatic function in lymphedema patients. To elucidate the biological effects of flap transfer (with and without lymph nodes), we have studied the postoperative production of proinflammatory, anti-inflammatory, prolymphangiogenic and antilymphangiogenic cytokines, and growth factors (interleukin 1 alpha [IL-1 alpha], IL-1 beta, tumor necrosis factor alpha [TNF-alpha], IL-10, transforming growth factor beta 1 [TGF-beta 1], IL-4 and IL-13, and vascular endothelial growth factor C [VEGF-C] and VEGF-D) in postoperative wound exudate samples. Methods: Axillary wound exudate samples were analyzed from four patient groups: axillary lymph node dissection (ALND), microvascular breast reconstruction (BR), LN, and combined LN and BR (LN-BR). Results: The concentration of proinflammatory cytokines was low in all the flap transfer groups as opposed to the ALND group, which showed an extensive proinflammatory response. The level of anti-inflammatory and antifibrotic cytokine IL-10 was increased in the LN-BR group samples compared with the ALND and BR groups. In the LN and LN-BR groups, the cytokine profile showed an anti-inflammatory response. Conclusions: Transfer of healthy tissue hinders the proinflammatory response after surgery, which may explain the beneficial effects of flap transfer in various patient groups. In addition, flap transfer with lymph nodes seems to also promote an antifibrotic effect. The clinical effects of LN in lymphedema patients may be mediated by the increased production of prolymphangiogenic growth factor (VEGF-C) and antifibrotic cytokine (IL-10). (C) 2015 Elsevier Inc. All rights reserved.
Subject: Lymphedema
Lymphatic surgery
Proinflammatory cytokines
Anti-inflammatory cytokines
IL-10
CANCER-RELATED LYMPHEDEMA
BREAST RECONSTRUCTION
POSTMASTECTOMY LYMPHEDEMA
SCAR FORMATION
GROWTH-FACTORS
WOUND REPAIR
REGENERATION
CYTOKINES
DISEASE
LYMPHANGIOGENESIS
3126 Surgery, anesthesiology, intensive care, radiology
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