What is synergy? The Saariselka agreement revisited

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http://hdl.handle.net/10138/159268

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Tang , J , Wennerberg , K & Aittokallio , T 2015 , ' What is synergy? The Saariselka agreement revisited ' , Frontiers in Pharmacology , vol. 6 , 181 . https://doi.org/10.3389/fphar.2015.00181

Title: What is synergy? The Saariselka agreement revisited
Author: Tang, Jing; Wennerberg, Krister; Aittokallio, Tero
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2015-09-01
Language: eng
Number of pages: 5
Belongs to series: Frontiers in Pharmacology
ISSN: 1663-9812
URI: http://hdl.handle.net/10138/159268
Abstract: Many biological or chemical agents when combined interact with each other and produce a synergistic response that cannot be predicted based on the single agent responses alone. However, depending on the postulated null hypothesis of non-interaction, one may end up in different interpretations of synergy. Two popular reference models for null hypothesis include the Bliss independence model and the Loewe additivity model, each of which is formulated from different perspectives. During the last century, there has been an intensive debate on the suitability of these synergy models, both of which are theoretically justified and also in practice supported by different schools of scientists. More than 20 years ago, there was a community effort to make a consensus on the terminology one should use when claiming synergy. The agreement was formulated at a conference held in Saariselka, Finland in 1992, stating that one should use the terms Bliss synergy or Loewe synergy to avoid ambiguity in the underlying models. We review the theoretical relationships between these models and argue that one should combine the advantages of both models to provide a more consistent definition of synergy and antagonism.
Subject: definition of synergy
drug combinations
Bliss and Loewe models
interaction barometer
consensus agreement
DRUG-COMBINATION
ENZYMATIC-HYDROLYSIS
IN-VITRO
THERAPY
MODEL
ANTAGONISM
ADDITIVITY
EFFICACY
317 Pharmacy
3111 Biomedicine
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