Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels

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Wei , H , Sagalajev , B , Yuzer , M A , Koivisto , A & Pertovaara , A 2015 , ' Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels ' , Neuroscience Letters , vol. 608 , pp. 12-17 .

Title: Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels
Author: Wei, Hong; Sagalajev, Boriss; Yuzer, M. Anil; Koivisto, Ari; Pertovaara, Antti
Contributor organization: Medicum
Department of Physiology
Antti Pertovaara / Principal Investigator
Date: 2015-11-03
Language: eng
Number of pages: 6
Belongs to series: Neuroscience Letters
ISSN: 0304-3940
Abstract: Pain per se may increase anxiety and conversely, anxiety may increase pain. Therefore, a positive feedback loop between anxiety and pain possibly contributes to pain and suffering in some pathophysiological pain conditions, such as that induced by peripheral nerve injury. Recent results indicate that transient receptor channels 4 and 5 (TRPC4/C5) in the amygdala have anxiogenic effects in rodents, while their role in chronic pain conditions is not known. Here, we studied whether the amygdaloid TRPC4/C5 that are known to have anxiogenic properties contribute to the maintenance of sensory or affective aspects of pain in an experimental model of peripheral neuropathy. Rats with a spared nerve injury (SNI) model of neuropathy in the left hind limb had a chronic cannula for microinjections of drugs into the right amygdala or the internal capsule (a control site). Sensory pain was assessed by determining mechanical hypersensitivity with calibrated monofilaments and affective pain by determining aversive place-conditioning. Amygdaloid treatment with ML-204, a TRPC4/C5 antagonist, produced a dose-related (5-10 mu g) antihypersensitivity effect, without obvious side-effects. Additionally, amygdaloid administration of ML-204 reduced affective-like pain behavior. In the internal capsule, ML-204 had no effect on hypersensitivity or affective-like pain in SNI animals. In healthy controls, amygdaloid administration of ML-204 failed to influence pain behavior induced by mechanical stimulation or noxious heat. The results indicate that the amygdaloid TRPC4/C5 contribute to maintenance of pain hypersensitivity and pain affect in neuropathy. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Subject: Amygdala
Aversive place-conditioning
Descending pain control
Neuropathic pain
Transient receptor potential channels 4 and 5
3112 Neurosciences
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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