Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance

Show full item record



Permalink

http://hdl.handle.net/10138/159323

Citation

Yki-Jarvinen , H 2015 , ' Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance ' Nutrients , vol. 7 , no. 11 , pp. 9127-9138 . DOI: 10.3390/nu7115454

Title: Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance
Author: Yki-Jarvinen, Hannele
Contributor: University of Helsinki, Department of Medicine
Date: 2015-11
Language: eng
Number of pages: 12
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/159323
Abstract: Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disorders ranging from simple steatosis (non-alcoholic fatty liver, NAFL) to non-alcoholic steatohepatitis (NASH) and cirrhosis. NAFL increases the risk of liver fibrosis. If the liver is fatty due to causes of insulin resistance such as obesity and physical inactivity, it overproduces glucose and triglycerides leading to hyperinsulinemia and a low high-density lipoprotein (HDL) cholesterol concentration. The latter features predispose to type 2 diabetes and cardiovascular disease (CVD). Understanding the impact of nutritional modulation of liver fat content and insulin resistance is therefore of interest for prevention and treatment of NAFLD. Hypocaloric, especially low carbohydrate ketogenic diets rapidly decrease liver fat content and associated metabolic abnormalities. However, any type of caloric restriction seems effective long-term. Isocaloric diets containing 16%-23% fat and 57%-65% carbohydrate lower liver fat compared to diets with 43%-55% fat and 27%-38% carbohydrate. Diets rich in saturated (SFA) as compared to monounsaturated (MUFA) or polyunsaturated (PUFA) fatty acids appear particularly harmful as they increase both liver fat and insulin resistance. Overfeeding either saturated fat or carbohydrate increases liver fat content. Vitamin E supplementation decreases liver fat content as well as fibrosis but has no effect on features of insulin resistance.
Subject: saturated fat
carbohydrate
fructose
liver fat
steatosis
DE-NOVO LIPOGENESIS
RANDOMIZED CONTROLLED-TRIAL
FRUCTOSE CORN SYRUP
VISCERAL FAT
DIETARY-FAT
CONFERS SUSCEPTIBILITY
INTRAHEPATIC LIPIDS
METABOLIC SYNDROME
GLUCOSE-PRODUCTION
HEPATIC STEATOSIS
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
nutrients_07_05454.pdf 1.032Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record