Heart valve tissue engineering : how far is the bedside from the bench?

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Sanz-Garcia , A , Oliver-De-La-Cruz , J , Mirabet , V , Gandia , C , Villagrasa , A , Sodupe , E & Escobedo-Lucea , C 2015 , ' Heart valve tissue engineering : how far is the bedside from the bench? ' , Expert reviews in molecular medicine , vol. 17 , 16 . https://doi.org/10.1017/erm.2015.15

Title: Heart valve tissue engineering : how far is the bedside from the bench?
Author: Sanz-Garcia, Andres; Oliver-De-La-Cruz, Jorge; Mirabet, Vicente; Gandia, Carolina; Villagrasa, Alejandro; Sodupe, Enrique; Escobedo-Lucea, Carmen
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
Date: 2015-09-24
Language: eng
Number of pages: 25
Belongs to series: Expert reviews in molecular medicine
ISSN: 1462-3994
URI: http://hdl.handle.net/10138/159359
Abstract: Heart disease, including valve pathologies, is the leading cause of death worldwide. Despite the progress made thanks to improving transplantation techniques, a perfect valve substitute has not yet been developed: once a diseased valve is replaced with current technologies, the newly implanted valve still needs to be changed some time in the future. This situation is particularly dramatic in the case of children and young adults, because of the necessity of valve growth during the patient's life. Our review focuses on the current status of heart valve (HV) therapy and the challenges that must be solved in the development of new approaches based on tissue engineering. Scientists and physicians have proposed tissue-engineered heart valves (TEHVs) as the most promising solution for HV replacement, especially given that they can help to avoid thrombosis, structural deterioration and xenoinfections. Lastly, TEHVs might also serve as a model for studying human valve development and pathologies.
Subject: MESENCHYMAL STEM-CELLS
ENDOTHELIAL PROGENITOR CELLS
HUMAN AMNIOTIC-FLUID
VENTRICULAR OUTFLOW TRACT
UMBILICAL-CORD BLOOD
MARROW-DERIVED CELLS
AORTIC-VALVE
BONE-MARROW
EXTRACELLULAR-MATRIX
PULMONARY VALVE
1182 Biochemistry, cell and molecular biology
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