Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes.

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Oftedal , L , Selheim , F , Wahlsten , M , Sivonen , K , Doeskeland , S O & Herfindal , L 2010 , ' Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes. ' , Marine Drugs , vol. 8 , pp. 2659-2672 . https://doi.org/10.3390/md8102659

Title: Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes.
Author: Oftedal, Linn; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Doeskeland, Stein Ove; Herfindal, Lars.
Contributor organization: Department of Food and Nutrition
Cyanobacteria research
Date: 2010
Language: eng
Number of pages: 14
Belongs to series: Marine Drugs
ISSN: 1660-3397
DOI: https://doi.org/10.3390/md8102659
URI: http://hdl.handle.net/10138/159661
Abstract: The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial strains screened, more than half contained cell death-inducing activity. Several strains contained activity against AML cells, but not against non-malignant cells like hepatocytes and cardiomyoblasts. The apoptotic cell death induced by the various strains could be distinguished by the role of caspase activation and sensitivity to the recently detected chemotherapy-resistance-assocd. prosurvival protein LEDGF/p75. One strain (M44) was particularly promising since its activity counteracted the protective effect of LEDGF/p75 overexpressed in AML cells, acted synergistically with the anthracycline anticancer drug daunorubicin in AML cells, and protected cardiomyoblasts against the toxic effect of anthracyclines. We conclude that culturable benthic marine cyanobacteria from temperate environments provide a promising and hitherto underexploited source for novel antileukemic drugs. [on SciFinder(R)]
Description: M1 - Copyright (C) 2010 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2010:1325161(Journal; Online Computer File)
Subject: benthic cyanobacteria daunorubicin antitumor apoptosis acute myeloid leukemia
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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