Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans

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Adiels , M , Mardinoglu , A , Taskinen , M-R & Boren , J 2015 , ' Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans ' , Frontiers in Physiology , vol. 6 , 342 . https://doi.org/10.3389/fphys.2015.00342

Title: Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans
Author: Adiels, Martin; Mardinoglu, Adil; Taskinen, Marja-Riitta; Boren, Jan
Other contributor: University of Helsinki, Research Programs Unit




Date: 2015-11-20
Language: eng
Number of pages: 8
Belongs to series: Frontiers in Physiology
ISSN: 1664-042X
DOI: https://doi.org/10.3389/fphys.2015.00342
URI: http://hdl.handle.net/10138/159778
Abstract: To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.
Subject: very low density lipoproteins
apoB
multocomnpartmental modeling
kinetics
stable isotopes
LOW-DENSITY LIPOPROTEINS
FATTY LIVER-DISEASE
A-I KINETICS
HEPARAN-SULFATE PROTEOGLYCANS
TYPE-2 DIABETIC MEN
APOLIPOPROTEIN B-100
NONALCOHOLIC STEATOHEPATITIS
MULTICOMPARTMENTAL MODEL
POSTPRANDIAL STATE
INSULIN-RESISTANCE
3111 Biomedicine
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