Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans

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http://hdl.handle.net/10138/159778

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Adiels , M , Mardinoglu , A , Taskinen , M-R & Boren , J 2015 , ' Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans ' , Frontiers in Physiology , vol. 6 , 342 . https://doi.org/10.3389/fphys.2015.00342

Titel: Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans
Författare: Adiels, Martin; Mardinoglu, Adil; Taskinen, Marja-Riitta; Boren, Jan
Upphovmannens organisation: Research Programs Unit
Marja-Riitta Taskinen Research Group
Department of Medicine
Diabetes and Obesity Research Program
Clinicum
Datum: 2015-11-20
Språk: eng
Sidantal: 8
Tillhör serie: Frontiers in Physiology
ISSN: 1664-042X
DOI: https://doi.org/10.3389/fphys.2015.00342
Permanenta länken (URI): http://hdl.handle.net/10138/159778
Abstrakt: To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.
Subject: very low density lipoproteins
apoB
multocomnpartmental modeling
kinetics
stable isotopes
LOW-DENSITY LIPOPROTEINS
FATTY LIVER-DISEASE
A-I KINETICS
HEPARAN-SULFATE PROTEOGLYCANS
TYPE-2 DIABETIC MEN
APOLIPOPROTEIN B-100
NONALCOHOLIC STEATOHEPATITIS
MULTICOMPARTMENTAL MODEL
POSTPRANDIAL STATE
INSULIN-RESISTANCE
3111 Biomedicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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