Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans

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dc.contributor.author Adiels, Martin
dc.contributor.author Mardinoglu, Adil
dc.contributor.author Taskinen, Marja-Riitta
dc.contributor.author Boren, Jan
dc.date.accessioned 2016-01-27T06:17:02Z
dc.date.available 2016-01-27T06:17:02Z
dc.date.issued 2015-11-20
dc.identifier.citation Adiels , M , Mardinoglu , A , Taskinen , M-R & Boren , J 2015 , ' Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans ' , Frontiers in Physiology , vol. 6 , 342 . https://doi.org/10.3389/fphys.2015.00342
dc.identifier.other PURE: 58478150
dc.identifier.other PURE UUID: fbbd5959-7565-45a1-a16c-9fd5cb14e0bc
dc.identifier.other WOS: 000366746900001
dc.identifier.other Scopus: 84949673329
dc.identifier.other ORCID: /0000-0002-6229-3588/work/90756966
dc.identifier.uri http://hdl.handle.net/10138/159778
dc.description.abstract To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Frontiers in Physiology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject very low density lipoproteins
dc.subject apoB
dc.subject multocomnpartmental modeling
dc.subject kinetics
dc.subject stable isotopes
dc.subject LOW-DENSITY LIPOPROTEINS
dc.subject FATTY LIVER-DISEASE
dc.subject A-I KINETICS
dc.subject HEPARAN-SULFATE PROTEOGLYCANS
dc.subject TYPE-2 DIABETIC MEN
dc.subject APOLIPOPROTEIN B-100
dc.subject NONALCOHOLIC STEATOHEPATITIS
dc.subject MULTICOMPARTMENTAL MODEL
dc.subject POSTPRANDIAL STATE
dc.subject INSULIN-RESISTANCE
dc.subject 3111 Biomedicine
dc.title Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans en
dc.type Review Article
dc.contributor.organization Research Programs Unit
dc.contributor.organization Marja-Riitta Taskinen Research Group
dc.contributor.organization Department of Medicine
dc.contributor.organization Diabetes and Obesity Research Program
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fphys.2015.00342
dc.relation.issn 1664-042X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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