Diabetes, glucose tolerance, and the risk of sudden cardiac death

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dc.contributor.author Eranti, Antti
dc.contributor.author Kerola, Tuomas
dc.contributor.author Aro, Aapo L
dc.contributor.author Tikkanen, Jani T
dc.contributor.author Rissanen, Harri A
dc.contributor.author Anttonen, Olli
dc.contributor.author Junttila, M. J
dc.contributor.author Knekt, Paul
dc.contributor.author Huikuri, Heikki V
dc.date.accessioned 2016-02-24T05:29:47Z
dc.date.available 2016-02-24T05:29:47Z
dc.date.issued 2016-02-24
dc.identifier.citation BMC Cardiovascular Disorders. 2016 Feb 24;16(1):51
dc.identifier.uri http://hdl.handle.net/10138/160243
dc.description.abstract Abstract Background Diabetes predisposes to sudden cardiac death (SCD). However, it is uncertain whether greater proportion of cardiac deaths are sudden among diabetes patients than other subjects. It is also unclear whether the risk of SCD is pronounced already early in the course of the disease. The relationship of impaired glucose tolerance (IGT) and SCD is scarcely documented. Methods A general population cohort of 10594 middle-aged subjects (mean age 44 years, 52.6 % male, follow-up duration 35–41 years) was divided into diabetes patients (n = 82), subjects with IGT (n = 3806, plasma glucose ≥9.58 mmol/l in one-hour glucose tolerance test), and controls (n = 6706). Results Diabetes patients had an increased risk of SCD after adjustment confounders (hazard ratio 2.62, 95 % confidence interval 1.46–4.70, p = 0.001) but risk for non-sudden cardiac death was similarly increased and the proportion of SCD of cardiac deaths was not increased. The SCD risk persisted after exclusion of subjects with baseline cardiac disease or non-fatal cardiac events during the follow-up. Subjects with IGT were at increased risk for SCD (univariate hazard ratio 1.51; 95 % confidence interval 1.31–1.74; p < 0.001) and also for non-sudden cardiac deaths and non-fatal cardiac events but adjustments for other risk factors attenuated these effects. Conclusions Diabetes was associated with increased risk of SCD but also the risk of non-sudden cardiac death was similarly increased. The proportion of cardiac deaths being sudden in subjects with diabetes was not increased. The higher SCD risk in diabetes patients was independent of known cardiac disease at baseline or occurrence of non-fatal cardiac event during the follow-up.
dc.language.iso eng
dc.publisher BioMed Central
dc.title Diabetes, glucose tolerance, and the risk of sudden cardiac death en
dc.date.updated 2016-02-24T05:29:47Z
dc.type.uri http://purl.org/eprint/entityType/ScholarlyWork
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.rights.copyrightholder Eranti et al.

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