Relationships among Body Condition, Insulin Resistance and Subcutaneous Adipose Tissue Gene Expression during the Grazing Season in Mares

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http://hdl.handle.net/10138/160356

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Selim , S , Elo , K , Jaakkola , S , Karikoski , N , Boston , R , Reilas , T , Sarkijarvi , S , Saastamoinen , M & Kokkonen , T 2015 , ' Relationships among Body Condition, Insulin Resistance and Subcutaneous Adipose Tissue Gene Expression during the Grazing Season in Mares ' , PLoS One , vol. 10 , no. 5 , 0125968 . https://doi.org/10.1371/journal.pone.0125968

Title: Relationships among Body Condition, Insulin Resistance and Subcutaneous Adipose Tissue Gene Expression during the Grazing Season in Mares
Author: Selim, Shaimaa; Elo, Kari; Jaakkola, Seija; Karikoski, Ninja; Boston, Ray; Reilas, Tiina; Sarkijarvi, Susanna; Saastamoinen, Markku; Kokkonen, Tuomo
Contributor: University of Helsinki, Department of Agricultural Sciences
University of Helsinki, Department of Agricultural Sciences
University of Helsinki, Department of Agricultural Sciences
University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Department of Agricultural Sciences
Date: 2015-05-04
Language: eng
Number of pages: 20
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/160356
Abstract: Obesity and insulin resistance have been shown to be risk factors for laminitis in horses. The objective of the study was to determine the effect of changes in body condition during the grazing season on insulin resistance and the expression of genes associated with obesity and insulin resistance in subcutaneous adipose tissue (SAT). Sixteen Finnhorse mares were grazing either on cultivated high-yielding pasture (CG) or semi-natural grassland (NG) from the end of May to the beginning of September. Body measurements, intravenous glucose tolerance test (IVGTT), and neck and tailhead SAT gene expressions were measured in May and September. At the end of grazing, CG had higher median body condition score (7 vs. 5.4, interquartile range 0.25 vs. 0.43; P=0.05) and body weight (618 kg vs. 572 kg +/- 10.21 (mean +/- SEM); P=0.02), and larger waist circumference (P=0.03) than NG. Neck fat thickness was not different between treatments. However, tailhead fat thickness was smaller in CG compared to NG in May (P=0.04), but this difference disappeared in September. Greater basal and peak insulin concentrations, and faster glucose clearance rate (P=0.03) during IVGTT were observed in CG compared to NG in September. A greater decrease in plasma non-esterified fatty acids during IVGTT (P
Subject: PASTURE-ASSOCIATED LAMINITIS
HORMONE CONCENTRATIONS
ADIPONECTIN RECEPTORS
LIPID CONCENTRATIONS
CYTOKINE EXPRESSION
CONDITION SCORE
BLOOD HORMONE
RISK-FACTORS
WEIGHT-GAIN
DAIRY-COWS
412 Animal science, dairy science
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