Genetic Loci Associated with Allergic Sensitization in Lithuanians

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Sauliene , I , Greiciuviene , J , Sukiene , L , Juskeviciute , N , Benner , C , Zinkeviciene , A , Ripatti , S , Donner , K & Kainov , D 2015 , ' Genetic Loci Associated with Allergic Sensitization in Lithuanians ' , PLoS One , vol. 10 , no. 7 , 0134188 . https://doi.org/10.1371/journal.pone.0134188

Title: Genetic Loci Associated with Allergic Sensitization in Lithuanians
Author: Sauliene, Ingrida; Greiciuviene, Jurate; Sukiene, Laura; Juskeviciute, Neringa; Benner, Christian; Zinkeviciene, Aukse; Ripatti, Samuli; Donner, Kati; Kainov, Denis
Contributor organization: Institute for Molecular Medicine Finland
Clinicum
Samuli Olli Ripatti / Principal Investigator
Department of Public Health
Denis Kainov / Principal Investigator
Biostatistics Helsinki
Complex Disease Genetics
Date: 2015-07-27
Language: eng
Number of pages: 7
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0134188
URI: http://hdl.handle.net/10138/160425
Abstract: Allergic rhinitis (AR) is a common and complex disease. It is associated with environmental as well as genetic factors. Three recent genome-wide association studies (GWAS) reported altogether 47 single nucleotide polymorphisms (SNPs) associated with AR or allergic sensitization (AS) in Europeans and North Americans. Two follow up studies in Swedish and Chinese replicated 15 associations. In these studies individuals were selected based on the self-reported AR, or AR/AS diagnosed using blood IgE test or skin prick test (SPT), which were performed often without restriction to specific allergens. Here we performed third replication study in Lithuanians. We used SPT and carefully selected set of allergens prevalent in Lithuania, as well as Illumina Core Exome chip for SNP detection. We genotyped 270 SPT-positive individuals (137 Betulaceae -, 174 Poaceae-, 199 Artemisia-, 70 Helianthus-, 22 Alternaria-, 22 Cladosporium-, 140 mites-, 95 cat-and 97 dog dander-sensitive cases) and 162 SPT-negative controls. We found altogether 13 known SNPs associated with AS (p
Subject: GENOME-WIDE ASSOCIATION
RHINITIS
ASTHMA
METAANALYSIS
POPULATION
REPLICATION
PREVALENCE
3111 Biomedicine
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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